Phagocytosis Is the Main CR3-Mediated Function Affected by the Lupus-Associated Variant of CD11b in Human Myeloid Cells

ITAM-Coupled Receptors Inhibit IFNAR Signaling and Alter Macrophage Responses to TLR4 and Listeria monocytogenes

(2012) L. Huynh et al.   JOURNAL OF IMMUNOLOGY

Evaluation of genetic association between an ITGAM non-synonymous SNP (rs1143679) and multiple autoimmune diseases

(2011) Juan-Manuel Anaya et al.   AUTOIMMUNITY REVIEWS

In vivo functional analysis and genetic modification of in vitro-derived mouse neutrophils

(2011) Jacqueline U. McDonald et al.   FASEB JOURNAL

A Systemic Lupus Erythematosus-associated R77H Substitution in the CD11b Chain of the Mac-1 Integrin Compromises Leukocyte Adhesion and Phagocytosis

(2011) Matthew MacPherson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A small CD11b+human B1 cell subpopulation stimulates T cells and is expanded in lupus

(2011) Daniel O. Griffin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Association Study of ITGAM, ITGAX, and CD58 Autoimmune Risk Loci in Systemic Sclerosis: Results from 2 Large European Caucasian Cohorts

(2011) B. COUSTET et al.   JOURNAL OF RHEUMATOLOGY

Effective Caspase Inhibition Blocks Neutrophil Apoptosis and Reveals Mcl-1 as Both a Regulator and a Target of Neutrophil Caspase Activation

(2011) David J. Wardle et al.   PLoS One

Hoxb8 conditionally immortalised macrophage lines model inflammatory monocytic cells with important similarity to dendritic cells

(2010) Marcela Rosas et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Indirect Inhibition of Toll-like Receptor and Type I Interferon Responses by ITAM-Coupled Receptors and Integrins

(2010) Lu Wang et al.   IMMUNITY

The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b

(2010) Chunzhang Cao et al.   JOURNAL OF CLINICAL INVESTIGATION

Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b

(2010) Chaofeng Han et al.   NATURE IMMUNOLOGY

Genome-Wide Association Study in Asian Populations Identifies Variants in ETS1 and WDFY4 Associated with Systemic Lupus Erythematosus

(2010) Wanling Yang et al.   PLoS Genetics

Evaluation of imputation-based association in and around the integrin- -M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE)

(2009) S. Han et al.   HUMAN MOLECULAR GENETICS

Normally occurring NKG2D+CD4+T cells are immunosuppressive and inversely correlated with disease activity in juvenile-onset lupus

(2009) Zhenpeng Dai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

(2009) Vesela Gateva et al.   NATURE GENETICS

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

(2009) Jian-Wen Han et al.   NATURE GENETICS

A nonsynonymous functional variant in integrin-αM (encoded by ITGAM) is associated with systemic lupus erythematosus

(2008) Swapan K Nath et al.   NATURE GENETICS

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

(2008) John B Harley et al.   NATURE GENETICS

Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus

(2008) Sergey V Kozyrev et al.   NATURE GENETICS

Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus

(2008) Robert R Graham et al.   NATURE GENETICS

Association of Systemic Lupus Erythematosus withC8orf13–BLKandITGAM–ITGAX

(2008) Geoffrey Hom et al.   NEW ENGLAND JOURNAL OF MEDICINE