Notch Regulation of Bone Development and Remodeling and Related Skeletal Disorders

Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells

(2011) Nilay Sethi et al.   CANCER CELL

The cautionary tale of side effects of chronic Notch1 inhibition

(2011) Sandra W. Ryeom   JOURNAL OF CLINICAL INVESTIGATION

Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis

(2011) Bertrand Isidor et al.   NATURE GENETICS

Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss

(2011) Michael A Simpson et al.   NATURE GENETICS

Loss of CHSY1, a Secreted FRINGE Enzyme, Causes Syndromic Brachydactyly in Humans via Increased NOTCH Signaling

(2010) Jing Tian et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Association of JAG1 with Bone Mineral Density and Osteoporotic Fractures: A Genome-wide Association Study and Follow-up Replication Studies

(2010) Annie W.C. Kung et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Notch3 in Human Breast Cancer Cell Lines Regulates Osteoblast-Cancer Cell Interactions and Osteolytic Bone Metastasis

(2010) Zhiyuan Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

RBPj -dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development

(2010) Y. Dong et al.   DEVELOPMENT

Two novel missense mutations in HAIRY-AND-ENHANCER-OF-SPLIT-7 in a family with spondylocostal dysostosis

(2010) Duncan B Sparrow et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Notch Signaling in the Immune System

(2010) Freddy Radtke et al.   IMMUNITY

Reciprocal Regulation of Notch and Nuclear Factor of Activated T-cells (NFAT) c1 Transactivation in Osteoblasts

(2010) Stefano Zanotti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HES1 (Hairy and Enhancer of Split 1) Is a Determinant of Bone Mass

(2010) Stefano Zanotti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osteosclerosis owing to Notch gain of function is solely Rbpj-dependent

(2010) Jianning Tao et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Ubiquitous overexpression of Hey1 transcription factor leads to osteopenia and chondrocyte hypertrophy in bone

(2009) Rishard Salie et al.   BONE

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Notch Signaling: The Core Pathway and Its Posttranslational Regulation

(2009) Mark E. Fortini   DEVELOPMENTAL CELL

Notch signaling contributes to the pathogenesis of human osteosarcomas

(2009) F. Engin et al.   HUMAN MOLECULAR GENETICS

Transcriptional regulation of bone and joint remodeling by NFAT

(2009) Despina Sitara et al.   IMMUNOLOGICAL REVIEWS

The notch-responsive transcription factor Hes-1 attenuates osteocalcin promoter activity in osteoblastic cells

(2009) Ying Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Notch and the Skeleton

(2009) S. Zanotti et al.   MOLECULAR AND CELLULAR BIOLOGY

Direct inhibition of the NOTCH transcription factor complex

(2009) Raymond E. Moellering et al.   NATURE

Notch pathway regulation of chondrocyte differentiation and proliferation during appendicular and axial skeleton development

(2009) T. J. Mead et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in the MESP2 Gene Cause Spondylothoracic Dysostosis/Jarcho-Levin Syndrome

(2008) Alberto S. Cornier et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutation of the fucose-specific β1,3 N-acetylglucosaminyltransferase LFNG results in abnormal formation of the spine

(2008) Sally L. Dunwoodie   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Critical Role of Notch Signaling in Osteosarcoma Invasion and Metastasis

(2008) P. Zhang et al.   CLINICAL CANCER RESEARCH

Notch Inhibits Osteoblast Differentiation and Causes Osteopenia

(2008) Stefano Zanotti et al.   ENDOCRINOLOGY

Mutation of HAIRY-AND-ENHANCER-OF-SPLIT-7 in humans causes spondylocostal dysostosis

(2008) D. B. Sparrow et al.   HUMAN MOLECULAR GENETICS

The Association of Notch2 and NF- B Accelerates RANKL-Induced Osteoclastogenesis

(2008) H. Fukushima et al.   MOLECULAR AND CELLULAR BIOLOGY

Dimorphic effects of Notch signaling in bone homeostasis

(2008) Feyza Engin et al.   NATURE MEDICINE

Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation

(2008) Matthew J Hilton et al.   NATURE MEDICINE

The many facets of Notch ligands

(2008) B D'Souza et al.   ONCOGENE

Notch3: from subtle structural differences to functional diversity

(2008) D Bellavia et al.   ONCOGENE