A Natural-Product Switch for a Dynamic Protein Interface

The natural product honokiol inhibits calcineurin inhibitor-induced and Ras-mediated tumor promoting pathways

(2013) Pallavi Banerjee et al.   CANCER LETTERS

Honokiol analogs: a novel class of anticancer agents targeting cell signaling pathways and other bioactivities

(2013) Ankit Kumar et al.   Future Medicinal Chemistry

Ordering a Dynamic Protein Via a Small-Molecule Stabilizer

(2013) Ningkun Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of α-helix-mediated protein–protein interactions using designed molecules

(2013) Valeria Azzarito et al.   Nature Chemistry

Honokiol Inhibits Non-Small Cell Lung Cancer Cell Migration by Targeting PGE2-Mediated Activation of β-Catenin Signaling

(2013) Tripti Singh et al.   PLoS One

Sekikaic Acid and Lobaric Acid Target a Dynamic Interface of the Coactivator CBP/p300

(2012) Chinmay Y. Majmudar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Noncanonical mechanisms to regulate nuclear receptor signaling

(2012) Prabodh Sadana   Future Medicinal Chemistry

“True” Antiandrogens—Selective Non-Ligand-Binding Pocket Disruptors of Androgen Receptor–Coactivator Interactions: Novel Tools for Prostate Cancer

(2012) Laura Caboni et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of the First Irreversible Small Molecule Inhibitors of the Interaction between the Vitamin D Receptor and Coactivators

(2012) Premchendar Nandhikonda et al.   JOURNAL OF MEDICINAL CHEMISTRY

Natural-product-derived fragments for fragment-based ligand discovery

(2012) Björn Over et al.   Nature Chemistry

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

Discovering Small-Molecule Estrogen Receptor α/Coactivator Binding Inhibitors: High-Throughput Screening, Ligand Development, and Models for Enhanced Potency

(2011) Aiming Sun et al.   ChemMedChem

Design and Structure of Stapled Peptides Binding to Estrogen Receptors

(2011) Chris Phillips et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

(2011) Jang Hyun Choi et al.   NATURE

Therapeutic applications of compounds in the Magnolia family

(2011) Young-Jung Lee et al.   PHARMACOLOGY & THERAPEUTICS

Structural Overview of the Nuclear Receptor Superfamily: Insights into Physiology and Therapeutics

(2010) Pengxiang Huang et al.   Annual Review of Physiology

Honokiol Increases ABCA1 Expression Level by Activating Retinoid X Receptor Beta

(2010) Cha-Gyun Jung et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Identification of a Naturally Occurring Rexinoid, Honokiol, That Activates the Retinoid X Receptor

(2010) Hitoshi Kotani et al.   JOURNAL OF NATURAL PRODUCTS

Alternative Inhibition of Androgen Receptor Signaling: Peptidomimetic Pyrimidines As Direct Androgen Receptor/Coactivator Disruptors

(2009) Jillian R. Gunther et al.   ACS Chemical Biology

Synthetic Retinoids: Structure-Activity Relationships

(2009) Jonathan H. Barnard et al.   CHEMISTRY-A EUROPEAN JOURNAL

Nuclear Receptor-Coregulator Interaction Profiling Identifies TRIP3 as a Novel Peroxisome Proliferator-activated Receptor γ Cofactor

(2009) Arjen Koppen et al.   MOLECULAR & CELLULAR PROTEOMICS

Minireview: Not Picking Pockets: Nuclear Receptor Alternate-Site Modulators (NRAMs)

(2009) Terry W. Moore et al.   MOLECULAR ENDOCRINOLOGY

The rise of fragment-based drug discovery

(2009) Christopher W. Murray et al.   Nature Chemistry

Synthesis and biological evaluation of guanylhydrazone coactivator binding inhibitors for the estrogen receptor

(2008) Andrew L. LaFrate et al.   BIOORGANIC & MEDICINAL CHEMISTRY