Sekikaic Acid and Lobaric Acid Target a Dynamic Interface of the Coactivator CBP/p300

Fine-Tuning Multiprotein Complexes Using Small Molecules

(2012) Andrea D. Thompson et al.   ACS Chemical Biology

Small-Molecule Stabilization of Protein-Protein Interactions: An Underestimated Concept in Drug Discovery?

(2012) Philipp Thiel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct and selective small-molecule activation of proapoptotic BAX

(2012) Evripidis Gavathiotis et al.   Nature Chemical Biology

Comparison of tertiary structures of proteins in protein-protein complexes with unbound forms suggests prevalence of allostery in signalling proteins

(2012) Lakshmipuram S Swapna et al.   BMC STRUCTURAL BIOLOGY

Conformational Control of the Binding of the Transactivation Domain of the MLL Protein and c-Myb to the KIX Domain of CREB

(2012) Elif Nihal Korkmaz et al.   PLoS Computational Biology

Caught in the Act: Covalent Cross-Linking Captures Activator–Coactivator Interactionsin Vivo

(2011) Malathy Krishnamurthy et al.   ACS Chemical Biology

Thermodynamics-based drug design: strategies for inhibiting protein–protein interactions

(2011) Arne Schön et al.   Future Medicinal Chemistry

Transient-state Kinetic Analysis of Transcriptional Activator·DNA Complexes Interacting with a Key Coactivator

(2011) Amberlyn M. Wands et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antioxidant activity of some lichen metabolites

(2011) Vinitha M. Thadhani et al.   NATURAL PRODUCT RESEARCH

The role of CREB signaling in Alzheimer’s disease and other cognitive disorders

(2011) Carlos A. Saura et al.   REVIEWS IN THE NEUROSCIENCES

A novel ring-expanded product with enhanced tyrosinase inhibitory activity from classical Fe-catalyzed oxidation of rosmarinic acid, a potent antioxidative Lamiaceae polyphenol

(2010) Aya Fujimoto et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Transcriptional tools: Small molecules for modulating CBP KIX-dependent transcriptional activators

(2010) Caleb A. Bates et al.   BIOPOLYMERS

Disrupting protein–protein interactions with non-peptidic, small molecule α-helix mimetics

(2010) Christopher G Cummings et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Leu628 of the KIX domain of CBP is a key residue for the interaction with the MLL transactivation domain

(2010) Munehito Arai et al.   FEBS LETTERS

Transcriptional Switches: Chemical Approaches to Gene Regulation

(2010) Lori W. Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allosteric regulation of protease activity by small molecules

(2010) Aimee Shen   Molecular BioSystems

Amphipathic Small Molecules Mimic the Binding Mode and Function of Endogenous Transcription Factors

(2009) Sara J. Buhrlage et al.   ACS Chemical Biology

A High-Resolution Interaction Map of Three Transcriptional Activation Domains with a Key Coactivator from Photo-Cross-Linking and Multiplexed Mass Spectrometry

(2009) Chinmay Y. Majmudar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Allosteric Switches: Remote Controls for Proteins

(2009) Thorsten Berg   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tra1 as a screening target for transcriptional activation domain discovery

(2009) Chinmay Y. Majmudar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Natural product inhibitors of protein–protein interactions mediated by Src-family SH2 domains

(2009) Bianca Sperl et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Systematic in vivo structure-function analysis of p300 in hematopoiesis

(2009) E. A. Kimbrel et al.   BLOOD

Discovery of a Small-Molecule Inhibitor of the KIX–KID Interaction

(2009) Bingbing X. Li et al.   CHEMBIOCHEM

Impact of Nonnatural Amino Acid Mutagenesis on the in Vivo Function and Binding Modes of a Transcriptional Activator

(2009) Chinmay Y. Majmudar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Observation of the Dynamic Process Underlying Allosteric Signal Transmission

(2009) Sven Brüschweiler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of transcription factors with small organic molecules

(2008) Thorsten Berg   CURRENT OPINION IN CHEMICAL BIOLOGY