Notch Signaling in Pancreatic Development

Wnt7b is required for epithelial progenitor growth and operates during epithelial-to-mesenchymal signaling in pancreatic development

(2015) Solomon Afelik et al.   DEVELOPMENTAL BIOLOGY

Notch signaling as a novel regulator of metabolism

(2015) Pengpeng Bi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Impact of Sox9 Dosage and Hes1-mediated Notch Signaling in Controlling the Plasticity of Adult Pancreatic Duct Cells in Mice

(2015) Shinichi Hosokawa et al.   Scientific Reports

Opposing Activities of Notch and Wnt Signaling Regulate Intestinal Stem Cells and Gut Homeostasis

(2015) Hua Tian et al.   Cell Reports

Significance of glycosylation in Notch signaling

(2014) Hideyuki Takeuchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Distinct requirements for beta-catenin in pancreatic epithelial growth and patterning

(2014) Brett K. Baumgartner et al.   DEVELOPMENTAL BIOLOGY

Differential regulation of Hes/Hey genes during inner ear development

(2014) Jelena Petrovic et al.   Developmental Neurobiology

Notch directly regulates the cell morphogenesis genes Reck, talin and trio in adult muscle progenitors

(2014) G. Pezeron et al.   JOURNAL OF CELL SCIENCE

MicroRNA-7a regulates pancreatic β cell function

(2014) Mathieu Latreille et al.   JOURNAL OF CLINICAL INVESTIGATION

Non-canonical Notch signaling represents an ancestral mechanism to regulate neural differentiation

(2014) Michael J Layden et al.   EvoDevo

Chromatin Effector Pygo2 Mediates Wnt-Notch Crosstalk to Suppress Luminal/Alveolar Potential of Mammary Stem and Basal Cells

(2013) Bingnan Gu et al.   Cell Stem Cell

Transcriptional control of mammalian pancreas organogenesis

(2013) David A. Cano et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

miR-375 Inhibits Proliferation of Mouse Pancreatic Progenitor Cells by Targeting YAP1

(2013) Zhen-Wu Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Notch-mediated post-translational control of Ngn3 protein stability regulates pancreatic patterning and cell fate commitment

(2013) Xiaoling Qu et al.   DEVELOPMENTAL BIOLOGY

Gene Regulatory Networks Governing Pancreas Development

(2013) H. Efsun Arda et al.   DEVELOPMENTAL CELL

Pak3 Promotes Cell Cycle Exit and Differentiation of  -Cells in the Embryonic Pancreas and Is Necessary to Maintain Glucose Homeostasis in Adult Mice

(2013) J. Piccand et al.   DIABETES

Wnt3a regulates proliferation, apoptosis and function of pancreatic NIT-1 beta cells via activation of IRS2/PI3K signaling

(2013) Shuyan Gui et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Noncanonical NOTCH Signaling Limits Self-Renewal of Human Epithelial and Induced Pluripotent Stem Cells through ROCK Activation

(2013) Takashi Yugawa et al.   MOLECULAR AND CELLULAR BIOLOGY

Cryopreserved mouse pancreatic acinar cells from long-term explant outgrowth cultures maintain their secretory phenotype after thawing

(2013) Merja Bläuer et al.   PANCREATOLOGY

Planar cell polarity controls directional Notch signaling in the Drosophila leg

(2012) A. Capilla et al.   DEVELOPMENT

Dishevelled limits Notch signalling through inhibition of CSL

(2012) G. M. Collu et al.   DEVELOPMENT

A Sox9/Fgf feed-forward loop maintains pancreatic organ identity

(2012) P. A. Seymour et al.   DEVELOPMENT

Different levels of Notch signaling regulate quiescence, renewal and differentiation in pancreatic endocrine progenitors

(2012) N. Ninov et al.   DEVELOPMENT

Notch-mediated patterning and cell fate allocation of pancreatic progenitor cells

(2012) S. Afelik et al.   DEVELOPMENT

A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation

(2012) H. P. Shih et al.   DEVELOPMENT

Colonization of the Satellite Cell Niche by Skeletal Muscle Progenitor Cells Depends on Notch Signals

(2012) Dominique Bröhl et al.   DEVELOPMENTAL CELL

MiR-18a regulates expression of the pancreatic transcription factor Ptf1a in pancreatic progenitor and acinar cells

(2012) Yankun Yang et al.   FEBS LETTERS

The ADAM family

(2012) Laura Christian   FLY

Determinants of Pancreatic Islet Development in Mice and Men: A Focus on the Role of Transcription Factors

(2012) Chia-Lei Vivian Lin et al.   Hormone Research in Paediatrics

The E3 Ligase Mind Bomb-1 (Mib1) Modulates Delta-Notch Signaling to Control Neurogenesis and Gliogenesis in the Developing Spinal Cord

(2012) Kyungjoon Kang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Redifferentiation of Expanded Human Pancreatic β-Cell-derived Cells by Inhibition of the NOTCH Pathway

(2012) Yael Bar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

On the role of lateral stabilization during early patterning in the pancreas

(2012) W. de Back et al.   Journal of the Royal Society Interface

RNA Profiling and Chromatin Immunoprecipitation-Sequencing Reveal that PTF1a Stabilizes Pancreas Progenitor Identity via the Control of MNX1/HLXB9 and a Network of Other Transcription Factors

(2012) N. Thompson et al.   MOLECULAR AND CELLULAR BIOLOGY

DDX5 is a positive regulator of oncogenic NOTCH1 signaling in T cell acute lymphoblastic leukemia

(2012) S Lin et al.   ONCOGENE

The Homeodomain-Containing Transcription Factors Arx and Pax4 Control Enteroendocrine Subtype Specification in Mice

(2012) Anthony Beucher et al.   PLoS One

Mind bomb 1 is required for pancreatic  -cell formation

(2012) S. Horn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch signaling in the pancreas: patterning and cell fate specification

(2012) Solomon Afelik et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Fringe benefits: Functional and structural impacts of O-glycosylation on the extracellular domain of Notch receptors

(2011) Nadia A Rana et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism

(2011) J. Ahnfelt-Ronne et al.   DEVELOPMENT

Lineage tracing reveals the dynamic contribution of Hes1+ cells to the developing and adult pancreas

(2011) D. Kopinke et al.   DEVELOPMENT

The Cdk4-E2f1 pathway regulates early pancreas development by targeting Pdx1+ progenitors and Ngn3+ endocrine precursors

(2011) S. Y. Kim et al.   DEVELOPMENT

Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas

(2011) Daniel Kopinke et al.   DEVELOPMENTAL BIOLOGY

MicroRNA-19b downregulates insulin 1 through targeting transcription factor NeuroD1

(2011) Zhen-Wu Zhang et al.   FEBS LETTERS

SOX9 regulates endocrine cell differentiation during human fetal pancreas development

(2011) Erin McDonald et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Hes6 Is Required for the Neurogenic Activity of Neurogenin and NeuroD

(2011) Kasumi Murai et al.   PLoS One

SEL1L deficiency impairs growth and differentiation of pancreatic epithelial cells

(2010) Shuai Li et al.   BMC DEVELOPMENTAL BIOLOGY

Wnt Proteins Are Self-Renewal Factors for Mammary Stem Cells and Promote Their Long-Term Expansion in Culture

(2010) Yi Arial Zeng et al.   Cell Stem Cell

Non-canonical activation of Notch signaling/target genes in vertebrates

(2010) Rajendran Sanalkumar et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Transdifferentiation of tadpole pancreatic acinar cells to duct cells mediated by Notch and stromelysin-3

(2010) Sandeep Mukhi et al.   DEVELOPMENTAL BIOLOGY

BCL6 Canalizes Notch-Dependent Transcription, Excluding Mastermind-like1 from Selected Target Genes during Left-Right Patterning

(2010) Daisuke Sakano et al.   DEVELOPMENTAL CELL

Nkx6 Transcription Factors and Ptf1a Function as Antagonistic Lineage Determinants in Multipotent Pancreatic Progenitors

(2010) Ashleigh E. Schaffer et al.   DEVELOPMENTAL CELL

A mouse model for monitoring islet cell genesis and developing therapies for diabetes

(2010) Y. Shimajiri et al.   Disease Models & Mechanisms

Adult pancreatic acinar cells dedifferentiate to an embryonic progenitor phenotype with concomitant activation of a senescence programme that is present in chronic pancreatitis

(2010) A. V. Pinho et al.   GUT

Convergence of Notch and β-catenin signaling induces arterial fate in vascular progenitors

(2010) Kohei Yamamizu et al.   JOURNAL OF CELL BIOLOGY

Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex

(2010) Tohru Ishitani et al.   NATURE CELL BIOLOGY

Notch signaling in pancreatic endocrine cell and diabetes

(2009) Wook Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Origin and evolution of the Notch signalling pathway: an overview from eukaryotic genomes

(2009) Eve Gazave et al.   BMC EVOLUTIONARY BIOLOGY

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Notch Signaling as Gatekeeper of Rat Acinar-to-β-Cell Conversion in Vitro

(2009) Luc Baeyens et al.   GASTROENTEROLOGY

Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window

(2009) C. Cras-Meneur et al.   GENES & DEVELOPMENT

ADAM10, the Rate-limiting Protease of Regulated Intramembrane Proteolysis of Notch and Other Proteins, Is Processed by ADAMS-9, ADAMS-15, and the γ-Secretase

(2009) Thomas Tousseyn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas

(2009) Maria L. Golson et al.   MECHANISMS OF DEVELOPMENT

Notch-responsive cells initiate the secondary transition in larval zebrafish pancreas

(2009) Michael J. Parsons et al.   MECHANISMS OF DEVELOPMENT

Conditional control of the differentiation competence of pancreatic endocrine and ductal cells by Fgf10

(2009) Sune Kobberup et al.   MECHANISMS OF DEVELOPMENT

MFng Is Dispensable for Mouse Pancreas Development and Function

(2009) P. Svensson et al.   MOLECULAR AND CELLULAR BIOLOGY

In Vivo Analysis of the Notch Receptor S1 Cleavage

(2009) Robert J. Lake et al.   PLoS One

miR-375 maintains normal pancreatic  - and  -cell mass

(2009) M. N. Poy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas

(2009) M. Rovira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conditional ablation of Notch signaling in pancreatic development

(2008) H. Nakhai et al.   DEVELOPMENT

Mouse Pancreatic Endocrine Cell Transcriptome Defined in the Embryonic Ngn3-Null Mouse

(2008) K. Juhl et al.   DIABETES

HES-1 Is Involved in Adaptation of Adult Human  -Cells to Proliferation In Vitro

(2008) Y. Bar et al.   DIABETES

Reduction of Ptf1a Gene Dosage Causes Pancreatic Hypoplasia and Diabetes in Mice

(2008) A. Fukuda et al.   DIABETES

The WNT signalling pathway and diabetes mellitus

(2008) T. Jin   DIABETOLOGIA

Pancreatic acinar-to-beta cell transdifferentiation in vitro

(2008) Kohtaro Minami   Frontiers in Bioscience-Landmark

Notch Signaling Is Required for Exocrine Regeneration After Acute Pancreatitis

(2008) Jens T. Siveke et al.   GASTROENTEROLOGY

Graded levels of Ptf1a differentially regulate endocrine and exocrine fates in the developing pancreas

(2008) P. D. S. Dong et al.   GENES & DEVELOPMENT

Genes controlling pancreas ontogeny

(2008) Claire Bonal et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Generation and Characterization of Ptf1a Antiserum and Localization of Ptf1a in Relation to Nkx6.1 and Pdx1 During the Earliest Stages of Mouse Pancreas Development

(2008) Jacob Hald et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia

(2008) J.-P. De La O et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA