Transcriptional control of mammalian pancreas organogenesis

Dynamic Chromatin Remodeling Mediated by Polycomb Proteins Orchestrates Pancreatic Differentiation of Human Embryonic Stem Cells

(2013) Ruiyu Xie et al.   Cell Stem Cell

Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration

(2013) F. C. Pan et al.   DEVELOPMENT

Gene Regulatory Networks Governing Pancreas Development

(2013) H. Efsun Arda et al.   DEVELOPMENTAL CELL

Development of the Human Pancreas From Foregut to Endocrine Commitment

(2013) R. E. Jennings et al.   DIABETES

Transcription factor gene MNX1 is a novel cause of permanent neonatal diabetes in a consanguineous family

(2013) A. Bonnefond et al.   DIABETES & METABOLISM

The Prrx1 homeodomain transcription factor plays a central role in pancreatic regeneration and carcinogenesis

(2013) M. Reichert et al.   GENES & DEVELOPMENT

Neurogenin3 Cooperates with Foxa2 to Autoactivate Its Own Expression

(2013) Miriam Ejarque et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reconstituting pancreas development from purified progenitor cells reveals genes essential for islet differentiation

(2013) T. Sugiyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Neurod1 Contributes to the Lineage Potential of Neurogenin3+ Endocrine Precursor Cells in the Pancreas

(2013) Teresa L. Mastracci et al.   PLoS Genetics

Nkx6.1 Controls a Gene Regulatory Network Required for Establishing and Maintaining Pancreatic Beta Cell Identity

(2013) Ashleigh E. Schaffer et al.   PLoS Genetics

Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma

(2012) Janel L. Kopp et al.   CANCER CELL

The transcriptional co-repressor Grg3/Tle3 promotes pancreatic endocrine progenitor delamination and  -cell differentiation

(2012) D. E. Metzger et al.   DEVELOPMENT

A Sox9/Fgf feed-forward loop maintains pancreatic organ identity

(2012) P. A. Seymour et al.   DEVELOPMENT

Notch-mediated patterning and cell fate allocation of pancreatic progenitor cells

(2012) S. Afelik et al.   DEVELOPMENT

A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation

(2012) H. P. Shih et al.   DEVELOPMENT

GATA6 Mutations Cause a Broad Phenotypic Spectrum of Diabetes From Pancreatic Agenesis to Adult-Onset Diabetes Without Exocrine Insufficiency

(2012) E. De Franco et al.   DIABETES

GATA believe it: new essential regulators of pancreas development

(2012) Santiago Rodríguez-Seguí et al.   JOURNAL OF CLINICAL INVESTIGATION

Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis

(2012) Shouhong Xuan et al.   JOURNAL OF CLINICAL INVESTIGATION

GATA4 and GATA6 control mouse pancreas organogenesis

(2012) Manuel Carrasco et al.   JOURNAL OF CLINICAL INVESTIGATION

RNA Profiling and Chromatin Immunoprecipitation-Sequencing Reveal that PTF1a Stabilizes Pancreas Progenitor Identity via the Control of MNX1/HLXB9 and a Network of Other Transcription Factors

(2012) N. Thompson et al.   MOLECULAR AND CELLULAR BIOLOGY

Mind bomb 1 is required for pancreatic  -cell formation

(2012) S. Horn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular pathways controlling pancreas induction

(2012) Kyle W. McCracken et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Signaling pathways regulating murine pancreatic development

(2012) Palle Serup   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Generation of beta cells from human pluripotent stem cells: Potential for regenerative medicine

(2012) Maria Cristina Nostro et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Planar Cell Polarity Controls Pancreatic Beta Cell Differentiation and Glucose Homeostasis

(2012) Cedric Cortijo et al.   Cell Reports

Targeting SOX17 in Human Embryonic Stem Cells Creates Unique Strategies for Isolating and Analyzing Developing Endoderm

(2011) Pei Wang et al.   Cell Stem Cell

Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism

(2011) J. Ahnfelt-Ronne et al.   DEVELOPMENT

Blood vessels restrain pancreas branching, differentiation and growth

(2011) J. Magenheim et al.   DEVELOPMENT

Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas

(2011) J. L. Kopp et al.   DEVELOPMENT

Lineage tracing reveals the dynamic contribution of Hes1+ cells to the developing and adult pancreas

(2011) D. Kopinke et al.   DEVELOPMENT

Nkx2.2 and Arx genetically interact to regulate pancreatic endocrine cell development and endocrine hormone expression

(2011) Teresa L. Mastracci et al.   DEVELOPMENTAL BIOLOGY

Ngn3+ endocrine progenitor cells control the fate and morphogenesis of pancreatic ductal epithelium

(2011) Judith Magenheim et al.   DEVELOPMENTAL BIOLOGY

Competence of failed endocrine progenitors to give rise to acinar but not ductal cells is restricted to early pancreas development

(2011) Anthony Beucher et al.   DEVELOPMENTAL BIOLOGY

Pancreatic β Cell Identity Is Maintained by DNA Methylation-Mediated Repression of Arx

(2011) Sangeeta Dhawan et al.   DEVELOPMENTAL CELL

Neurogenin3 initiates stepwise delamination of differentiating endocrine cells during pancreas development

(2011) Mathieu Gouzi et al.   DEVELOPMENTAL DYNAMICS

Pancreas organogenesis: From bud to plexus to gland

(2011) Fong Cheng Pan et al.   DEVELOPMENTAL DYNAMICS

Historical Perspective: Beginnings of the  -Cell: Current Perspectives in  -Cell Development

(2011) P. A. Seymour et al.   DIABETES

Permanent Neonatal Diabetes and Enteric Anendocrinosis Associated With Biallelic Mutations in NEUROG3

(2011) O. Rubio-Cabezas et al.   DIABETES

Transcriptional regulation of α-cell differentiation

(2011) N. C. Bramswig et al.   DIABETES OBESITY & METABOLISM

Transcriptomes of the major human pancreatic cell types

(2011) C. Dorrell et al.   DIABETOLOGIA

Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets

(2011) C. Dai et al.   DIABETOLOGIA

Immunohistochemical characterisation of cells co-producing insulin and glucagon in the developing human pancreas

(2011) M. J. Riedel et al.   DIABETOLOGIA

Pancreas-Specific Deletion of Prox1 Affects Development and Disrupts Homeostasis of the Exocrine Pancreas

(2011) Joby J. Westmoreland et al.   GASTROENTEROLOGY

Context-specific  -to- -cell reprogramming by forced Pdx1 expression

(2011) Y.-P. Yang et al.   GENES & DEVELOPMENT

LRH-1 and PTF1-L coregulate an exocrine pancreas-specific transcriptional network for digestive function

(2011) S. R. Holmstrom et al.   GENES & DEVELOPMENT

Nkx2.2 repressor complex regulates islet  -cell specification and prevents  -to- -cell reprogramming

(2011) J. B. Papizan et al.   GENES & DEVELOPMENT

Pancreatic ductal cells in development, regeneration, and neoplasia

(2011) Maximilian Reichert et al.   JOURNAL OF CLINICAL INVESTIGATION

GATA6 haploinsufficiency causes pancreatic agenesis in humans

(2011) Hana Lango Allen et al.   NATURE GENETICS

Chromatin "Prepattern" and Histone Modifiers in a Fate Choice for Liver and Pancreas

(2011) C.-R. Xu et al.   SCIENCE

Exocrine-to-endocrine differentiation is detectable only prior to birth in the uninjured mouse pancreas

(2010) Daniel Kopinke et al.   BMC DEVELOPMENTAL BIOLOGY

Deconstructing Pancreas Development to Reconstruct Human Islets from Pluripotent Stem Cells

(2010) Kristen D. McKnight et al.   Cell Stem Cell

Converting human pluripotent stem cells into β-cells: recent advances and future challenges

(2010) Christopher N Mayhew et al.   Current Opinion in Organ Transplantation

Epithelial dynamics of pancreatic branching morphogenesis

(2010) A. Villasenor et al.   DEVELOPMENT

Epithelial: Endothelial cross-talk regulates exocrine differentiation in developing pancreas

(2010) Christophe E. Pierreux et al.   DEVELOPMENTAL BIOLOGY

Nkx6 Transcription Factors and Ptf1a Function as Antagonistic Lineage Determinants in Multipotent Pancreatic Progenitors

(2010) Ashleigh E. Schaffer et al.   DEVELOPMENTAL CELL

Homozygous Mutations in NEUROD1 Are Responsible for a Novel Syndrome of Permanent Neonatal Diabetes and Neurological Abnormalities

(2010) O. Rubio-Cabezas et al.   DIABETES

Unique Arrangement of  - and  -Cells in Human Islets of Langerhans

(2010) D. Bosco et al.   DIABETES

Partial loss of pancreas endocrine and exocrine cells of human ARX-null mutation: Consideration of pancreas differentiation

(2010) Masayuki Itoh et al.   DIFFERENTIATION

Replacement of Rbpj With Rbpjl in the PTF1 Complex Controls the Final Maturation of Pancreatic Acinar Cells

(2010) Toshihiko Masui et al.   GASTROENTEROLOGY

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Rfx6 directs islet formation and insulin production in mice and humans

(2010) Stuart B. Smith et al.   NATURE

Vertebrate Endoderm Development and Organ Formation

(2009) Aaron M. Zorn et al.   Annual Review of Cell and Developmental Biology

Rac1 regulates pancreatic islet morphogenesis

(2009) Thomas U Greiner et al.   BMC DEVELOPMENTAL BIOLOGY

The Ectopic Expression of Pax4 in the Mouse Pancreas Converts Progenitor Cells into α and Subsequently β Cells

(2009) Patrick Collombat et al.   CELL

Cdc42-Mediated Tubulogenesis Controls Cell Specification

(2009) Gokul Kesavan et al.   CELL

Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development

(2009) Josselin Soyer et al.   DEVELOPMENT

Pancreatic neurogenin 3-expressing cells are unipotent islet precursors

(2009) R. Desgraz et al.   DEVELOPMENT

Neurog3 gene dosage regulates allocation of endocrine and exocrine cell fates in the developing mouse pancreas

(2009) Sui Wang et al.   DEVELOPMENTAL BIOLOGY

Sox17 Regulates Organ Lineage Segregation of Ventral Foregut Progenitor Cells

(2009) Jason R. Spence et al.   DEVELOPMENTAL CELL

Pancreatic Exocrine Duct Cells Give Rise to Insulin-Producing β Cells during Embryogenesis but Not after Birth

(2009) Myriam Solar et al.   DEVELOPMENTAL CELL

An endoderm-specific transcriptional enhancer from the mouseGata4gene requires GATA and homeodomain protein-binding sites for function in vivo

(2009) Anabel Rojas et al.   DEVELOPMENTAL DYNAMICS

Islet-1 is Required for the Maturation, Proliferation, and Survival of the Endocrine Pancreas

(2009) A. Du et al.   DIABETES

Glucose regulation of islet stress responses and β-cell failure in type 2 diabetes

(2009) J. C. Jonas et al.   DIABETES OBESITY & METABOLISM

Stem Cells to Pancreatic β-Cells: New Sources for Diabetes Cell Therapy

(2009) Tingxia Guo et al.   ENDOCRINE REVIEWS

Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window

(2009) C. Cras-Meneur et al.   GENES & DEVELOPMENT

The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice

(2009) Jennifer M. Oliver-Krasinski et al.   JOURNAL OF CLINICAL INVESTIGATION

One process for pancreatic β-cell coalescence into islets involves an epithelial–mesenchymal transition

(2009) Lori Cole et al.   JOURNAL OF ENDOCRINOLOGY

Endocrine Cell Clustering During Human Pancreas Development

(2009) Jongmin Jeon et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas

(2009) Maria L. Golson et al.   MECHANISMS OF DEVELOPMENT

Multiple, temporal-specific roles for HNF6 in pancreatic endocrine and ductal differentiation

(2009) Hongjie Zhang et al.   MECHANISMS OF DEVELOPMENT

pdx-1 function is specifically required in embryonic β cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis

(2008) Maureen Gannon et al.   DEVELOPMENTAL BIOLOGY

Myt1 and Ngn3 form a feed-forward expression loop to promote endocrine islet cell differentiation

(2008) Sui Wang et al.   DEVELOPMENTAL BIOLOGY

Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells

(2008) Jared S. Burlison et al.   DEVELOPMENTAL BIOLOGY

Developmental biology of the pancreas: A comprehensive review

(2008) George K. Gittes   DEVELOPMENTAL BIOLOGY

Transcriptional dynamics of endodermal organ formation

(2008) Richard I. Sherwood et al.   DEVELOPMENTAL DYNAMICS

Mouse Pancreatic Endocrine Cell Transcriptome Defined in the Embryonic Ngn3-Null Mouse

(2008) K. Juhl et al.   DIABETES

Clinical Heterogeneity in Patients With FOXP3 Mutations Presenting With Permanent Neonatal Diabetes

(2008) O. Rubio-Cabezas et al.   DIABETES CARE

Transcription factor expression in the developing human fetal endocrine pancreas

(2008) B. M. Lyttle et al.   DIABETOLOGIA

On the origin of the   cell

(2008) J. M. Oliver-Krasinski et al.   GENES & DEVELOPMENT

Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development

(2008) N. Gao et al.   GENES & DEVELOPMENT

Generation and Characterization of Ptf1a Antiserum and Localization of Ptf1a in Relation to Nkx6.1 and Pdx1 During the Earliest Stages of Mouse Pancreas Development

(2008) Jacob Hald et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Histone Deacetylase Inhibitors Modify Pancreatic Cell Fate Determination and Amplify Endocrine Progenitors

(2008) C. Haumaitre et al.   MOLECULAR AND CELLULAR BIOLOGY

Transcriptional Autoregulation Controls Pancreatic Ptf1a Expression during Development and Adulthood

(2008) T. Masui et al.   MOLECULAR AND CELLULAR BIOLOGY

Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo

(2008) Evert Kroon et al.   NATURE BIOTECHNOLOGY