Size does matter! Label-free detection of small molecule–protein interaction

Handheld high-throughput plasmonic biosensor using computational on-chip imaging

(2014) Arif E Cetin et al.   Light-Science & Applications

Solid-State NMR Approaches to Internal Dynamics of Proteins: From Picoseconds to Microseconds and Seconds

(2013) Alexey Krushelnitsky et al.   ACCOUNTS OF CHEMICAL RESEARCH

Binding of (5S)-Penicilloic Acid to Penicillin Binding Protein 3

(2013) Sander S. van Berkel et al.   ACS Chemical Biology

Novel Inhibitor Binding Site Discovery on HIV-1 Capsid N-Terminal Domain by NMR and X-ray Crystallography

(2013) Nathalie Goudreau et al.   ACS Chemical Biology

Crude to leads: a triple-pronged direct NMR approach in coordination with docking simulation

(2013) Sheraz A. K. Tanoli et al.   ANALYST

NMR-based analysis of protein–ligand interactions

(2013) Olivier Cala et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Determining the affinity and stoichiometry of interactions between unmodified proteins in solution using Biacore

(2013) Eric S. Day et al.   ANALYTICAL BIOCHEMISTRY

Transmembrane Protein Activation Refined by Site-Specific Hydration Dynamics

(2013) Sunyia Hussain et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design and Synthesis of Small-Molecule Fluorescent Photoprobes Targeted to Aminopeptdase N (APN/CD13) for Optical Imaging of Angiogenesis

(2013) Anke Hahnenkamp et al.   BIOCONJUGATE CHEMISTRY

Characterizing Carbohydrate-Protein Interactions by Nuclear Magnetic Resonance Spectroscopy

(2013) Carole A. Bewley et al.   BIOPOLYMERS

Label-free monitoring of cell-based assays: Combining impedance analysis with SPR for multiparametric cell profiling

(2013) S. Michaelis et al.   BIOSENSORS & BIOELECTRONICS

Molecular Recognition of Rosmarinic Acid fromSalvia sclareoidesExtracts by Acetylcholinesterase: A New Binding Site Detected by NMR Spectroscopy

(2013) Filipa Marcelo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Cell-based systems to assess nuclear receptor activation and their use in drug development

(2013) Judy L. Raucy et al.   DRUG METABOLISM REVIEWS

Recent progress in robot-based systems for crystallography and their contribution to drug discovery

(2013) Jean-Luc Ferrer et al.   Expert Opinion on Drug Discovery

Chip-calorimetric monitoring of biofilm eradication with antibiotics provides mechanistic information

(2013) Frida Mariana et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Biomolecular ligands screening using radiation damping difference WaterLOGSY spectroscopy

(2013) Peng Sun et al.   JOURNAL OF BIOMOLECULAR NMR

In vivoeffect confirmation of anti-androgenic compounds in sediment contact tests withPotamopyrgus antipodarum

(2013) Claudia Schmitt et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING

Small Molecule Fluorescent Ligands as Central Nervous System Imaging Probes

(2013) Jacques Joubert et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Label-free monitoring of T cell activation by the impedance-based xCELLigence system

(2013) Ni Guan et al.   Molecular BioSystems

The 'rule of three' for fragment-based drug discovery: where are we now?

(2013) Harren Jhoti et al.   NATURE REVIEWS DRUG DISCOVERY

Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

(2013) K. McCormack et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In silico discovery of small-molecule Ras inhibitors that display antitumor activity by blocking the Ras-effector interaction

(2013) F. Shima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decoding Signaling and Function of the Orphan G Protein-Coupled Receptor GPR17 with a Small-Molecule Agonist

(2013) S. Hennen et al.   Science Signaling

Characterization of biopharmaceuticals by NMR spectroscopy

(2013) David S. Wishart   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Fingerprinting differential active site constraints of ATPases

(2013) Stephan M. Hacker et al.   Chemical Science

Analytical Methodologies for the Determination of Endocrine Disrupting Compounds in Biological and Environmental Samples

(2013) Zoraida Sosa-Ferrera et al.   Biomed Research International

Biacore surface matrix effects on the binding kinetics and affinity of an antigen/antibody complex

(2012) Andrew W. Drake et al.   ANALYTICAL BIOCHEMISTRY

Label-free impedance responses of endogenous and synthetic chemokine receptor CXCR3 agonists correlate with Gi-protein pathway activation

(2012) Anne O. Watts et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Multiplexed specific label-free detection of NCI-H358 lung cancer cell line lysates with silicon based photonic crystal microcavity biosensors

(2012) Swapnajit Chakravarty et al.   BIOSENSORS & BIOELECTRONICS

Probing oxidative stress: Small molecule fluorescent sensors of metal ions, reactive oxygen species, and thiols

(2012) Lynne M. Hyman et al.   COORDINATION CHEMISTRY REVIEWS

From Laptop to Benchtop to Bedside: Structure-based Drug Design on Protein Targets

(2012) Lu Chen et al.   CURRENT PHARMACEUTICAL DESIGN

Hormones and Endocrine-Disrupting Chemicals: Low-Dose Effects and Nonmonotonic Dose Responses

(2012) Laura N. Vandenberg et al.   ENDOCRINE REVIEWS

Fragment-Based Screening by Protein Crystallography: Successes and Pitfalls

(2012) Zorik Chilingaryan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chemoinformatics and chemical genomics: potential utility ofin silicomethods

(2012) Luis G. Valerio et al.   JOURNAL OF APPLIED TOXICOLOGY

Ligand Binding Stepwise Disrupts Water Network in Thrombin: Enthalpic and Entropic Changes Reveal Classical Hydrophobic Effect

(2012) Adam Biela et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery and Optimization of New Benzimidazole- and Benzoxazole-Pyrimidone Selective PI3Kβ Inhibitors for the Treatment of Phosphatase and TENsin homologue (PTEN)-Deficient Cancers

(2012) Victor Certal et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Survey of the 2010 Quartz Crystal Microbalance Literature

(2012) Robert E. Speight et al.   JOURNAL OF MOLECULAR RECOGNITION

Reliable Determinations of Protein–Ligand Interactions by Direct ESI-MS Measurements. Are We There Yet?

(2012) Elena N. Kitova et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Recent developments and applications of saturation transfer difference nuclear magnetic resonance (STD NMR) spectroscopy

(2012) Jane L. Wagstaff et al.   Molecular BioSystems

Thermodynamic studies of ligand binding to the human homopentameric glycine receptor using isothermal titration calorimetry

(2012) Annemarie Beate Wöhri et al.   MOLECULAR MEMBRANE BIOLOGY

Advances in Biophysical and Bioanalytical Protein Characterization

(2012) Jennifer S. Laurence   MOLECULAR PHARMACEUTICS

Fragment-based lead discovery grows up

(2012) Monya Baker   NATURE REVIEWS DRUG DISCOVERY

Kinetic analysis of the estrogen receptor alpha using RIfS

(2011) Peter Fechner et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Solid-State NMR Studies of Amyloid Fibril Structure

(2011) Robert Tycko   Annual Review of Physical Chemistry

T-type voltage-gated calcium channels as targets for the development of novel pain therapies

(2011) Slobodan M Todorovic et al.   BRITISH JOURNAL OF PHARMACOLOGY

Guide to Receptors and Channels (GRAC), 5th edition

(2011) SPH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

STD and trNOESY NMR Study of Receptor-Ligand Interactions in Living Cancer Cells

(2011) Donatella Potenza et al.   CHEMBIOCHEM

Dynamic Changes of Acoustic Load and Complex Impedance as Reporters for the Cytotoxicity of Small Molecule Inhibitors

(2011) Marco Tarantola et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Chemical ‘Jekyll and Hyde’s: small-molecule inhibitors of developmental signaling pathways

(2011) Tomoyo Sakata et al.   CHEMICAL SOCIETY REVIEWS

Biomolecular interactions and tools for their recognition: focus on the quartz crystal microbalance and its diverse surface chemistries and applications

(2011) Cathy I. Cheng et al.   CHEMICAL SOCIETY REVIEWS

A Small Molecule Binding to the Coactivator CREB-Binding Protein Blocks Apoptosis in Cardiomyocytes

(2011) Jagat C. Borah et al.   CHEMISTRY & BIOLOGY

Targeting Norovirus Infection-Multivalent Entry Inhibitor Design Based on NMR Experiments

(2011) Christoph Rademacher et al.   CHEMISTRY-A EUROPEAN JOURNAL

Applications of saturation transfer difference NMR in biological systems

(2011) Anirban Bhunia et al.   DRUG DISCOVERY TODAY

Cytotoxicity of water-soluble fraction from biodiesel and its diesel blends to human cell lines

(2011) Daniela Morais Leme et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

STD-NMR: application to transient interactions between biomolecules—a quantitative approach

(2011) Jesus Angulo et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Macromolecular NMR spectroscopy for the non-spectroscopist

(2011) Ann H. Kwan et al.   FEBS Journal

Macromolecular NMR spectroscopy for the non-spectroscopist: beyond macromolecular solution structure determination

(2011) Michael Bieri et al.   FEBS Journal

Computational Screening for Active Compounds Targeting Protein Sequences: Methodology and Experimental Validation

(2011) Fei Wang et al.   Journal of Chemical Information and Modeling

Biosensor-based small molecule fragment screening with biolayer interferometry

(2011) Charles A. Wartchow et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Automated Protein–Ligand Interaction Screening by Mass Spectrometry

(2011) Hannah J. Maple et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Binding Mechanism of a Peptidic Cyclic Serine Protease Inhibitor

(2011) Longguang Jiang et al.   JOURNAL OF MOLECULAR BIOLOGY

Applications of isothermal titration calorimetry in pure and applied research-survey of the literature from 2010

(2011) Rajesh Ghai et al.   JOURNAL OF MOLECULAR RECOGNITION

Kinetic Studies of Dextransucrase Enzyme Reactions on a Substrate- or Enzyme-Immobilized 27 MHz Quartz Crystal Microbalance

(2011) Takanori Nihira et al.   LANGMUIR

Characterization of Novel Ligands of ERα, Erβ, and PPARγ: The Case of Halogenated Bisphenol A and Their Conjugated Metabolites

(2011) Anne Riu et al.   TOXICOLOGICAL SCIENCES

Critical aspects of biointerface design and their impact on biosensor development

(2010) Stella H. North et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Viscoelastic Sensing of Conformational Changes in Plasminogen Induced upon Binding of Low Molecular Weight Compounds

(2010) Erik Nilebäck et al.   ANALYTICAL CHEMISTRY

Real-Time Biomolecular Binding Detection Using a Sensitive Photonic Crystal Biosensor

(2010) Yunbo Guo et al.   ANALYTICAL CHEMISTRY

Biological actions of green tea catechins on cardiac troponin C

(2010) Naoto Tadano et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Small-Molecule Inhibitor of BCL6 Kills DLBCL Cells In Vitro and In Vivo

(2010) Leandro C. Cerchietti et al.   CANCER CELL

Ligand-Receptor Binding Affinities from Saturation Transfer Difference (STD) NMR Spectroscopy: The Binding Isotherm of STD Initial Growth Rates

(2010) Jesús Angulo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Association Constants of Pyridine and Piperidine Alkaloids to Amyloid ß Peptide Determined by Electrochemical Impedance Spectroscopy

(2010) I. Grabowska et al.   Current Alzheimer Research

Recent Advances in Ligand-Based Drug Design: Relevance and Utility of the Conformationally Sampled Pharmacophore Approach

(2010) Chayan Acharya et al.   Current Computer-Aided Drug Design

Cheminformatic Tools for Medicinal Chemists

(2010) Steven W. Muchmore et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fragment-Based Drug Discovery Applied to Hsp90. Discovery of Two Lead Series with High Ligand Efficiency

(2010) Christopher W. Murray et al.   JOURNAL OF MEDICINAL CHEMISTRY

Survey of the year 2009: applications of isothermal titration calorimetry

(2010) Robert J. Falconer et al.   JOURNAL OF MOLECULAR RECOGNITION

Modern Natural Products Drug Discovery and Its Relevance to Biodiversity Conservation

(2010) David G. I. Kingston   JOURNAL OF NATURAL PRODUCTS

4D-QSAR: Perspectives in Drug Design

(2010) Carolina H. Andrade et al.   MOLECULES

Protein denaturation and protein:drugs interactions from intrinsic protein fluorescence measurements at the nanolitre scale

(2010) Gaudet Matthieu et al.   PROTEIN SCIENCE

Functional Cell-Based Screening and Saturation Transfer Double-Difference NMR Have Identified Haplosamate A as a Cannabinoid Receptor Agonist

(2009) Alban Pereira et al.   ACS Chemical Biology

STD-NMR Studies Suggest that Two Acceptor Substrates for GlfT2, a Bifunctional Galactofuranosyltransferase Required for the Biosynthesis ofMycobacterium tuberculosisArabinogalactan, Compete for the Same Binding Site

(2009) Monica G. Szczepina et al.   CHEMBIOCHEM

A general electrochemical method for label-free screening of protein–small molecule interactions

(2009) Kevin J. Cash et al.   CHEMICAL COMMUNICATIONS

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Guidelines for the use of band-selective radiofrequency pulses in hetero-nuclear NMR: Example of longitudinal-relaxation-enhanced BEST-type 1H–15N correlation experiments

(2009) Ewen Lescop et al.   JOURNAL OF MAGNETIC RESONANCE

Group epitope mapping considering relaxation of the ligand (GEM-CRL): Including longitudinal relaxation rates in the analysis of saturation transfer difference (STD) experiments

(2009) Sebastian Kemper et al.   JOURNAL OF MAGNETIC RESONANCE

Fragment-based ligand discovery

(2009) M. Fischer et al.   MOLECULAR INTERVENTIONS

Development of Yondelis® (trabectedin, ET-743). A semisynthetic process solves the supply problem

(2009) Carmen Cuevas et al.   NATURAL PRODUCT REPORTS

Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds

(2009) Yan Feng et al.   NATURE REVIEWS DRUG DISCOVERY

Adding calorimetric data to decision making in lead discovery: a hot tip

(2009) John E. Ladbury et al.   NATURE REVIEWS DRUG DISCOVERY

Voltage-Gated Sodium Channels: Therapeutic Targets for Pain

(2009) Sulayman D. Dib-Hajj et al.   PAIN MEDICINE

An advanced biosensor for the prediction of estrogenic effects of endocrine-disrupting chemicals on the estrogen receptor alpha

(2008) Peter Fechner et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Two immunoassay formats for fully automated CRP detection in human serum

(2008) Christiane Albrecht et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Saturation transfer difference nuclear magnetic resonance study on the specific binding of ligand to protein

(2008) Zhusheng Ji et al.   ANALYTICAL BIOCHEMISTRY

Evaluation of Solvent Accessibility Epitopes for Different Dehydrogenase Inhibitors

(2008) Christian Ludwig et al.   ChemMedChem

Label-Free Cell-Based Assays for GPCR Screening

(2008) Ye Fang et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Solution NMR structure determination of proteins revisited

(2008) Martin Billeter et al.   JOURNAL OF BIOMOLECULAR NMR

NMR Experiments Reveal the Molecular Basis of Receptor Recognition by a Calicivirus

(2008) Christoph Rademacher et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein crystallization: from purified protein to diffraction-quality crystal

(2008) Naomi E Chayen et al.   NATURE METHODS

Perspectives on NMR in drug discovery: a technique comes of age

(2008) Maurizio Pellecchia et al.   NATURE REVIEWS DRUG DISCOVERY