Cancer chromosomal instability: therapeutic and diagnostic challenges

A breast cancer meta-analysis of two expression measures of chromosomal instability reveals a relationship with younger age at diagnosis and high risk histopathological variables

(2015) David Endesfelder et al.   Oncotarget

Targeting Karyotypic Complexity and Chromosomal Instability of Cancer Cells

(2012) Anna V. Roschke et al.   CURRENT DRUG TARGETS

DNA breaks and chromosome pulverization from errors in mitosis

(2012) Karen Crasta et al.   NATURE

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Relationship of Extreme Chromosomal Instability with Long-term Survival in a Retrospective Analysis of Primary Breast Cancer

(2011) R. Roylance et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Paradoxical Relationship between Chromosomal Instability and Survival Outcome in Cancer

(2011) N. J. Birkbak et al.   CANCER RESEARCH

Chromosomal Instability Confers Intrinsic Multidrug Resistance

(2011) A. J. X. Lee et al.   CANCER RESEARCH

Targeting Aneuploidy for Cancer Therapy

(2011) Eusebio Manchado et al.   CELL

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

(2011) Philip J. Stephens et al.   CELL

Identification of Aneuploidy-Selective Antiproliferation Compounds

(2011) Yun-Chi Tang et al.   CELL

Chromosomal Instability Substantiates Poor Prognosis in Patients with Diffuse Large B-cell Lymphoma

(2011) S. F. Bakhoum et al.   CLINICAL CANCER RESEARCH

Failure of Origin Activation in Response to Fork Stalling Leads to Chromosomal Instability at Fragile Sites

(2011) Efrat Ozeri-Galai et al.   MOLECULAR CELL

Studies of genomic copy number changes in human cancers reveal signatures of DNA replication stress

(2011) Aygül Dereli-Öz et al.   Molecular Oncology

Tumour evolution inferred by single-cell sequencing

(2011) Nicholas Navin et al.   NATURE

Chromosome Segregation Errors as a Cause of DNA Damage and Structural Chromosome Aberrations

(2011) A. Janssen et al.   SCIENCE

Merotelic kinetochore attachment: causes and effects

(2011) Juraj Gregan et al.   TRENDS IN CELL BIOLOGY

Large-scale analysis of chromosomal aberrations in cancer karyotypes reveals two distinct paths to aneuploidy

(2011) Michal Ozery-Flato et al.   GENOME BIOLOGY

Prognostic utility of chromosomal instability detected by fluorescence in situ hybridization in fine-needle aspirates from oral squamous cell carcinomas

(2010) Hiroaki Sato et al.   BMC CANCER

Patterns and incidence of chromosomal instability and their prognostic relevance in breast cancer subtypes

(2010) Marcel Smid et al.   BREAST CANCER RESEARCH AND TREATMENT

How Darwinian models inform therapeutic failure initiated by clonal heterogeneity in cancer medicine

(2010) M Gerlinger et al.   BRITISH JOURNAL OF CANCER

Identification of Aneuploidy-Tolerating Mutations

(2010) Eduardo M. Torres et al.   CELL

Chromosomal instability: A composite phenotype that influences sensitivity to chemotherapy

(2010) Sarah E. McClelland et al.   CELL CYCLE

Are aneuploidy and chromosome breakage caused by a CINgle mechanism?

(2010) Carlos Martínez-A et al.   CELL CYCLE

Proliferation of aneuploid human cells is limited by a p53-dependent mechanism

(2010) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY

Targeting chromosomal instability and tumour heterogeneity in HER2-positive breast cancer

(2010) Rebecca A. Burrell et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The Relationship between the Presence of Chromosomal Instability and Prognosis of Squamous Cell Carcinoma of the Lung: Fluorescence in situ Hybridization Analysis of Paraffin-embedded Tissue from 47 Korean Patients

(2010) Jung-Wan Yoo et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal

(2010) Rocio Sotillo et al.   NATURE

Aneuploidy confers quantitative proteome changes and phenotypic variation in budding yeast

(2010) Norman Pavelka et al.   NATURE

The landscape of somatic copy-number alteration across human cancers

(2010) Rameen Beroukhim et al.   NATURE

Genomic instability — an evolving hallmark of cancer

(2010) Simona Negrini et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genome-wide single-nucleotide polymorphism arrays in endometrial carcinomas associate extensive chromosomal instability with poor prognosis and unveil frequent chromosomal imbalances involved in the PI3-kinase pathway

(2010) S Murayama-Hosokawa et al.   ONCOGENE

Whole Chromosome Instability Caused by Bub1 Insufficiency Drives Tumorigenesis through Tumor Suppressor Gene Loss of Heterozygosity

(2009) Darren J. Baker et al.   CANCER CELL

Overexpression and Mislocalization of the Chromosomal Segregation Protein Separase in Multiple Human Cancers

(2009) R. Meyer et al.   CLINICAL CANCER RESEARCH

Making the Auroras glow: regulation of Aurora A and B kinase function by interacting proteins

(2009) Mar Carmena et al.   CURRENT OPINION IN CELL BIOLOGY

High hyperdiploid childhood acute lymphoblastic leukemia

(2009) Kajsa Paulsson et al.   GENES CHROMOSOMES & CANCER

Chromosomal instability and cancer: not just one CINgle mechanism

(2009) C R. Boland et al.   GUT

Chromosomal instability correlates with poor outcome in patients with myelodysplastic syndromes irrespectively of the cytogenetic risk group

(2009) Christoph E. Heilig et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A mechanism linking extra centrosomes to chromosomal instability

(2009) Neil J. Ganem et al.   NATURE

Complex landscapes of somatic rearrangement in human breast cancer genomes

(2009) Philip J. Stephens et al.   NATURE

Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

(2009) Andrew J. Holland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells

(2009) Aniek Janssen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromosomal instability determines taxane response

(2009) C. Swanton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer

(2008) Samanthi A. Perera et al.   CARCINOGENESIS

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes

(2008) M. Kwon et al.   GENES & DEVELOPMENT

Human Sgo1 downregulation leads to chromosomal instability in colorectal cancer

(2008) M Iwaizumi et al.   GUT

Association between chromosomal instability and prognosis in colorectal cancer: a meta-analysis

(2008) A Walther et al.   GUT

The gene expression signature of genomic instability in breast cancer is an independent predictor of clinical outcome

(2008) Jens K. Habermann et al.   INTERNATIONAL JOURNAL OF CANCER

Examining the link between chromosomal instability and aneuploidy in human cells

(2008) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY

Chromosome instability in resection margins predicts recurrence of oral squamous cell carcinoma

(2008) VE Bergshoeff et al.   JOURNAL OF PATHOLOGY

Chromosomal instability is a risk factor for poor prognosis of adenocarcinoma of the lung: Fluorescence in situ hybridization analysis of paraffin-embedded tissue from Korean patients

(2008) Chang-Min Choi et al.   LUNG CANCER

Overexpression of Separase induces aneuploidy and mammary tumorigenesis

(2008) N. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers

(2008) T. D. Barber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells

(2008) B. R. Williams et al.   SCIENCE

Defining ‘chromosomal instability’

(2008) Jochen B. Geigl et al.   TRENDS IN GENETICS