Article
Dentistry, Oral Surgery & Medicine
Mao Li, Zi-xin Wan, Yue-yang Tang, Xin-hua Liang, Ya-ling Tang
Summary: Immunohistochemical staining was used to detect the expression of TIM-3, Gal-9, and CD160 in SACC and their correlation with clinicopathological characteristics. The results showed that overexpression of TIM-3 and CD160 were associated with SACC recurrence, while high expression of Gal-9 was correlated with pathological classification. The average percentage of TILs in SACC was 18.2%, with a higher occurrence in minor salivary glands. There were positive correlations observed between the expression of TIM-3, Gal-9, and CD160 in tumor cells and TILs. These findings suggest that the density of TILs and the expression of TIM-3, Gal-9, and CD160 could be potential therapeutic targets in SACC.
Article
Allergy
Martina Konantz, Margaret Williams, Tamara Merkel, Antonia Reiss, Stefan Dirnhofer, Sara C. Meyer, Peter Valent, Tracy I. George, Alexandar Tzankov, Karin Hartmann
Summary: This study found that serum levels of TIM-3 and galectin-9 are increased in patients with advanced systemic mastocytosis. Additionally, TIM-3 and galectin-9 are expressed in bone marrow infiltrates in mastocytosis. These findings suggest that TIM-3 and galectin-9 could be explored as diagnostic markers and potential therapeutic targets in systemic mastocytosis, particularly in advanced forms.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Guanzhang Li, Ruoyu Huang, Wenhua Fan, Di Wang, Fan Wu, Fan Zeng, Mingchen Yu, You Zhai, Yuanhao Chang, Changqing Pan, Tao Jiang, Wei Yan, Hongjun Wang, Wei Zhang
Summary: The study revealed that 1p/19q chromosome deletion in gliomas is associated with activation of immune and inflammatory responses. The decreased expression level of CCAAT enhancer-binding protein alpha in samples with 1p/19q codeletion led to the downregulation of immune checkpoints Galectin-9 and TIM-3. The loss of chromosome 19q was identified as the main reason for promoting the antitumor immune response in gliomas.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anna Andrzejczak, Krzysztof Tupikowski, Anna Tomkiewicz, Bartosz Malkiewicz, Kuba Ptaszkowski, Aleksandra Domin, Tomasz Szydelko, Lidia Karabon
Summary: This study analyzed the influence of TIM-3 and LGALS9 polymorphisms on susceptibility to ccRCC and patient overall survival. The results indicate that variations within TIM-3 and LGALS9 genes are associated with ccRCC risk and OS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Siyu Liu, Chang Xu, Fan Yang, Lu Zong, Yizu Qin, Yufeng Gao, Qian Su, Tuantuan Li, Ye Li, Yuanhong Xu, Meijuan Zheng
Summary: The antiviral response of NK cells and CD8(+) T cells is weak in patients with CHB, and the overexpression of Gal-9 contributes to NK cell dysfunction and CD8(+) T cell exhaustion. Blocking Gal-9 or TIM-3 can restore the function of CD8(+) T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Qinyu Peng, Guoxin Zhang, Xiaodi Guo, Lijun Dai, Min Xiong, Zhaohui Zhang, Liam Chen, Zhentao Zhang
Summary: The Galectin-9/Tim-3 pathway plays a crucial role in the pathogenesis of Parkinson's disease by exacerbating microglial activation, neuroinflammation, oxidative stress, and dopaminergic neurodegeneration.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Riyao Yang, Linlin Sun, Ching-Fei Li, Yu-Han Wang, Jun Yao, Hui Li, Meisi Yan, Wei-Chao Chang, Jung-Mao Hsu, Jong-Ho Cha, Jennifer L. Hsu, Cheng-Wei Chou, Xian Sun, Yalan Deng, Chao-Kai Chou, Dihua Yu, Mien-Chie Hung
Summary: The study reveals that PD-1 contributes to exhausted T cell survival by binding to TIM-3 ligand Gal-9 and inhibiting Gal-9/TIM-3 induced cell death. Anti-Gal-9 therapy selectively expands intratumoral TIM-3(+) cytotoxic CD8 T cells and T-reg cells, while combination treatment with anti-Gal-9 and GITR agonist shows synergistic antitumor activity.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Hemn Mohammadpour, Takemasa Tsuji, Cameron R. MacDonald, Joseph L. Sarow, Hanna Rosenheck, Saeed Daneshmandi, Jingxin Qiu, Jee Eun Choi, Junko Matsuzaki, Agnieszka K. Witkiewicz, Kristopher Attwood, Bruce R. Blazar, Kunle Odunsi, Elizabeth A. Repasky, Philip L. McCarthy
Summary: Activated donor T cells express galectin-3 (Gal-3) after allo-HCT, which suppresses T cell activation and effector cytokine secretion, leading to decreased inflammation in murine aGvHD. Gal-3 overexpression in human T cells also suppresses cytotoxic T cells and prevents severe disease in xenogeneic aGvHD models.
Article
Biochemistry & Molecular Biology
JeongMin Sim, JeongMan Park, Suwan Kim, Sojung Hwang, KyoungSu Sung, Jung-Eun Lee, SeungHo Yang, Kyunggi Cho, SungHwan Lee, Jong-Seok Moon, JuWon Ahn, Jaejoon Lim
Summary: The expression of Tim-3/Gal-9 is associated with glioma malignancy and poor prognosis, and they regulate the formation and activation of the NLRC4 inflammasome. A blockade of Tim-3/Gal-9 may be beneficial in glioma therapy by reducing the inflammatory microenvironment through downregulating the NLRC4 inflammasome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Vandana Sharma, Prabin Kumar, Rajiv Kumar, Sushmita Chakraborty, Manju Namdeo, Sudha Sazawal, Uma Kanga, Tulika Seth, Dipendra Kumar Mitra
Summary: This study investigated the expression of immune cells in acquired aplastic anemia patients and found that the production of IFN-γ and perforin is associated with disease severity and response to immunosuppressive therapy.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Immunology
Huifang Xiong, Guohui Xue, Yuting Zhang, Shuang Wu, Qiaoyun Zhao, Rulin Zhao, Nanjin Zhou, Yong Xie
Summary: The study aimed to investigate the effects of Gal-9 on experimental colitis. The results showed that exogenous Gal-9 increased Tim-3 expression, inhibited the TLR4/NF-kappa B pathway, and alleviated TNBS-induced colitis in mice. However, it had no reducing effect on DSS-induced colitis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Sarah C. Edwards, Ann Hedley, Wilma H. M. Hoevenaar, Robert Wiesheu, Teresa Glauner, Anna Kilbey, Robin Shaw, Katerina Boufea, Nizar Batada, Shinya Hatano, Yasunobu Yoshikai, Karen Blyth, Crispin Miller, Kristina Kirschner, Seth B. Coffelt
Summary: This study reveals that different subsets of IL-17A-producing gamma delta T cells in the lung of mice are controlled by PD-1 and TIM-3 in steady-state and cancer. Vγ6(+) cells express high levels of PD-1, while Vγ4(+) cells upregulate TIM-3 in response to tumor-related stimulation. Inhibition of PD-1 or TIM-3 increases the numbers of Vγ6(+) and Vγ4(+) cells respectively. Moreover, genetic deletion of gamma delta T cells enhances responsiveness to anti-PD-1 and anti-TIM-3 immunotherapy in a mammary tumor model, indicating that IL-17A-producing gamma delta T cells contribute to immunotherapy resistance.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Immunology
Christa Pfeifhofer-Obermair, Piotr Tymoszuk, Manfred Nairz, Andrea Schroll, Gloria Klais, Egon Demetz, Sabine Engl, Natascha Brigo, Guenter Weiss
Summary: Iron inhibits the differentiation of naive CD4(+) T cells to protective Th1 lymphocytes by increasing TIM-3 expression. Blocking TIM-3 could restore Th1 cell differentiation and improve bacterial control in iron-loaded mice infected with S. Typhimurium, suggesting TIM-3 as a novel drug target for chronic infections with intracellular pathogens in iron loading diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shaoyu Li, Yuejie Zhu, Song Wang, Yujiao Li, Nannan Pang, Mengting An, Fengbo Zhang, Jianbing Ding
Summary: This study investigated the role of Tim-3/Galectin-9 in persistent infection of Echinococcus multilocularis (Em) and found that this signaling pathway may be involved in the development of Em infection by regulating the production of Th1 and Th2 cytokines.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Zhifang Chen, Di Dong, Yuejie Zhu, Nannan Pang, Jianbing Ding
Summary: In HPV positive cervical cancer patients, high levels of Tim-3 and Galectin-9 are associated with disease progression by promoting Treg cells to inhibit the cytotoxic function of Th1 and CD8+ T cells. The Tim-3/Galectin-9 pathway may serve as a new immunotherapy target for patients with HPV positive cervical cancer.
Article
Medicine, General & Internal
Zun-Qi Liu, Hai-Shi Wang, Yan Gu
INTERNAL AND EMERGENCY MEDICINE
(2017)
Letter
Immunology
Kai Mu, Jing Zhang, Yan Gu, Hongjuan Li, Hongmei Wang
JOURNAL OF CLINICAL IMMUNOLOGY
(2019)
Article
Orthopedics
Yange Gu, Wenshu Jin, Han Zhang, Zhiwei Shi, Yaohui Yue, Zhaolong Yan, Zhang Zhao, Shufeng Li, Xinfeng Yan
Summary: This study found that larger distances between the medial femoral head and the ilioischial line and sharp angle can lead to an earlier age at onset of pain in patients with developmental dysplasia of the hip (DDH), while small lateral center-edge angle (LCEA) and excessive distance between the medial femoral head and the ilioischial line are risk factors for severe pain.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Surgery
Wenshu Jin, Huaqiang Sun, Xudong Duan, Yange Gu, Zhang Zhao, Xinfeng Yan
Summary: This study introduces a surgical technique (the Y line technique) to control leg length discrepancy (LLD) after total hip arthroplasty, and explores its effectiveness and influencing factors. The results show that the Y line technique can effectively reduce postoperative LLD and the occurrence of severe unequal lengths in the lower extremities. This technique is of great significance in minimizing leg length discrepancy after surgery.
FRONTIERS IN SURGERY
(2023)
Article
Orthopedics
Yan-ge Gu, Zhi-wei Shi, Yao-hui Yue, Zhao-long Yan, Lu-xu Yin, Ye-yong Zhang, Hua-qiang Sun, Shu-feng Li, Xin-feng Yan
Summary: Overall functional scores significantly improved after PAO, with a reduction in pain symptoms. Patients with a preoperative lateral center edge angle >= 4.5 degrees demonstrated better joint function post-surgery.
ORTHOPAEDIC SURGERY
(2021)
