Article
Gastroenterology & Hepatology
Hidenobu Kojima, Kentaro Kadono, Hirofumi Hirao, Kenneth J. Dery, Taylor Torgerson, Siyuan Yao, Fady M. Kaldas, Douglas G. Farmer, Richard S. Blumberg, Jerzy W. Kupiec-Weglinski
Summary: This study reveals the association between T cell-specific CC1 signaling and OLT injury, showing that promoting T cell-intrinsic TIM-3 through interaction with liver-associated CC1 can suppress NF-KB in Kupffer cells and alleviate OLT damage.
Review
Oncology
Gerardo Cazzato, Eliano Cascardi, Anna Colagrande, Teresa Lettini, Alessandra Filosa, Francesca Arezzo, Carmelo Lupo, Nadia Casatta, Vera Loizzi, Cristina Pellegrini, Maria Concetta Fargnoli, Eugenio Maiorano, Gerolamo Cicco, Roberto Tamma, Giuseppe Ingravallo
Summary: T cell immunoglobulin and mucin domain 3 (TIM-3) is an inhibitory immunocheckpoint that has been investigated for its role in the tumour microenvironment of melanoma. This review provides the most up-to-date knowledge about TIM-3 in melanoma and discusses future prospects and potential applications.
Article
Multidisciplinary Sciences
Jung Yoon Pyo, Taejun Yoon, Sung Soo Ahn, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee
Summary: This study found altered concentrations of serum soluble immune checkpoint molecules in patients with ANCA-associated vasculitis (AAV), with sCD28 and sTIM-3 potentially serving as surrogate markers of AAV disease activity.
SCIENTIFIC REPORTS
(2022)
Article
Microbiology
Xiaowei Zhang, Cuiqin Liang, Hanzhong Wang, Zhengyuan Guo, Heng Rong, Jingdi Pan, Wei Li, Rongjuan Pei, Xinwen Chen, Zhiping Zhang, Xian-En Zhang, Zongqiang Cui
Summary: The study identified T-cell immunoglobulin and mucin domain 1 (TIM-1) as a cellular entry factor for tick-borne encephalitis virus (TBEV), mediating virus uptake and cointernalization into cells. In mice, TIM-1 deficiency reduced viral burden and pathogenesis significantly. This finding provides a potential target for antiviral development against TBEV.
Article
Microbiology
Xiaowei Zhang, Cuiqin Liang, Hanzhong Wang, Zhengyuan Guo, Heng Rong, Jingdi Pan, Wei Li, Rongjuan Pei, Xinwen Chen, Zhiping Zhang, Xian-En Zhang, Zongqiang Cui
Summary: This study identified T-cell immunoglobulin and mucin domain 1 (TIM-1) as a cellular entry factor for tick-borne encephalitis virus (TBEV), mediating the uptake of TBEV into cells. TIM-1 deficiency significantly reduced viral burden and pathogenesis, highlighting its importance in TBEV infection. This discovery provides a potential target for antiviral intervention and improves understanding of virus infection.
Review
Immunology
Huihui Chen, Jie Zha, Runyan Tang, Guochun Chen
Summary: Research has shown that dysfunctional immune cells play a role in the development of autoimmune diseases. The T cell immunoglobulin and mucin domaincontaining protein 3 (TIM-3) is expressed on the surfaces of various immune cells and is involved in regulating important biological processes. Understanding the structure and signaling pathways of TIM-3 and its interactions with ligands can provide insights into the pathogenesis and potential treatment of autoimmune diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Jared Kirui, Yara Abidine, Annasara Lenman, Koushikul Islam, Yong-Dae Gwon, Lisa Lasswitz, Magnus Evander, Marta Bally, Gisa Gerold
Summary: Chikungunya virus (CHIKV) is a mosquito-transmitted RNA virus characterized by acute and chronic arthritis. The transmembrane proteins T-cell immunoglobulin and mucin domain 1 (TIM-1) and Axl receptor tyrosine kinase (Axl) play important roles in the entry of enveloped viruses such as CHIKV.
Article
Parasitology
Hongbing Xie, Zhidan Li, Guangmei Zheng, Chunyan Yang, Xianbing Liu, Xiaoyan Xu, Yushan Ren, Chao Wang, Xuemei Hu
Summary: The study showed that Toxoplasma gondii infection can significantly downregulate the expression of Tim-3 on dDCs, leading to aberrant expression of functional molecules, ultimately resulting in dDC dysfunction and abnormal pregnancy outcomes.
PARASITES & VECTORS
(2022)
Article
Oncology
Liuyan Chen, Jilin Qing, Yangyang Xiao, Xiaomei Huang, Yanlin Chi, Zhizhong Chen
Summary: The study revealed that TIM-1 overexpression promoted cell migration and invasion, inhibited apoptosis in cervical cancer, and modulated the PI3K/AKT/p53 and PI3K/AKT/mTOR signaling pathways. It may serve as a candidate diagnostic biomarker for this disease.
Article
Oncology
Alycia Gardner, Alvaro de Mingo Pulido, Kay Hanggi, Sarah Bazargan, Alexis Onimus, Agnieszka Kasprzak, Jose R. Conejo-Garcia, Katarzyna A. Rejniak, Brian Ruffell
Summary: Blocking TIM-3 increases exposure of intratumoral CD8(+) T cells to cytokines from cDC1s, with CXCL9 playing a critical role in this process.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Immunology
Aravind Cherukuri, Kanishka Mohib, David M. Rothstein
Summary: Regulatory B cells (Bregs) play a role in ameliorating autoimmune diseases and preventing allograft rejection, but may hinder the effective clearance of pathogens and malignancies. TIM-1 has been proposed as a unifying marker for identifying Bregs with various inhibitory mechanisms beyond IL-10.
IMMUNOLOGICAL REVIEWS
(2021)
Review
Medicine, Research & Experimental
Ziyao Wang, Chen Chen, Yingzhen Su, Nengwen Ke
Summary: TIM-4 is a phosphatidylserine receptor mainly expressed on antigen-presenting cells, involved in the recognition and engulfment of apoptotic cells. Recent studies have shown that TIM-4 is abnormally expressed in various malignant tumor cells and plays a crucial role in tumor occurrence, development, and immune microenvironment. This review provides a comprehensive understanding of the expression, functions, and potential implications of TIM-4 in various disease processes.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2023)
Article
Medicine, Research & Experimental
Guohui Xue, Lin Hua, Dongsheng Liu, Meijun Zhong, Yuanwang Chen, Bin Zhou, Yong Xie, Junming Li
Summary: This study found that the percentage of CD14(+)Tim-4(+) cells increased in UC patients while the frequency of Treg cells decreased and MDSCs increased. The percentage of CD14(+)Tim-4(+) cells was significantly associated with disease severity, activity index, and inflammatory marker levels, and decreased after treatment, indicating its potential relevance to the pathogenesis of UC.
Article
Immunology
Wilton Gomez-Henao, Rafael Saavedra, Francisco Raul Chavez-Sanchez, Ricardo Lascurain, Edgar Zenteno, Eda Patricia Tenorio
Summary: The study shows that O-moesin can provide a costimulatory activation signal in both CD4(+) and CD8(+) T lymphocytes, promoting cell activation, proliferation, and IL-2 production.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Hiroyoshi Nishikawa, Shohei Koyama
Summary: With the widespread use of immunotherapies in cancer treatment, understanding the immune landscape in the tumor microenvironment has become crucial. Regulatory T cells (Tregs) play a key role in cancer immunity but also contribute to immune evasion by tumor cells. Targeting Tregs is considered a crucial aspect of cancer immunotherapy, especially in tumors with abundant Treg presence.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)