Sinonasal Solitary Chemosensory Cells “Taste” the Upper Respiratory Environment to Regulate Innate Immunity

Assessment of Trends in Antimicrobial Resistance in Chronic Rhinosinusitis

(2014) Neil Bhattacharyya et al.   ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY

Ca2+ signaling and fluid secretion by secretory cells of the airway epithelium

(2014) Robert J. Lee et al.   CELL CALCIUM

Taste Sensing in the Colon

(2014) Izumi Kaji et al.   CURRENT PHARMACEUTICAL DESIGN

Bitter and sweet taste receptors regulate human upper respiratory innate immunity

(2014) Robert J. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Acid-sensing cation channels: Structure, function, and pathophysiologic implications

(2014) E. E. Benarroch   NEUROLOGY

Genetic variations in taste receptors are associated with chronic rhinosinusitis: a replication study

(2014) Leandra Mfuna Endam et al.   International Forum of Allergy & Rhinology

The effect of diabetes mellitus on chronic rhinosinusitis and sinus surgery outcome

(2014) Zi Zhang et al.   International Forum of Allergy & Rhinology

Chronic Rhinosinusitis and Antibiotics: The Good, the Bad, and the Ugly

(2013) Joshua L. Kennedy et al.   American Journal of Rhinology & Allergy

Trends in Incidence and Susceptibility among Methicillin-Resistant Staphylococcus aureus Isolated from Intranasal Cultures Associated with Rhinosinusitis

(2013) Valin Rujanavej et al.   American Journal of Rhinology & Allergy

The Emerging Role of the Bitter Taste Receptor T2R38 in Upper Respiratory Infection and Chronic Rhinosinusitis

(2013) Robert J. Lee et al.   American Journal of Rhinology & Allergy

How do taste cells lacking synapses mediate neurotransmission? CALHM1, a voltage-gated ATP channel

(2013) Akiyuki Taruno et al.   BIOESSAYS

Vasoactive intestinal peptide regulates sinonasal mucociliary clearance and synergizes with histamine in stimulating sinonasal fluid secretion

(2013) Robert J. Lee et al.   FASEB JOURNAL

Taste receptors of the gut: emerging roles in health and disease

(2013) Inge Depoortere   GUT

Mouse nasal epithelial innate immune responses to Pseudomonas aeruginosa quorum-sensing molecules require taste signaling components

(2013) Robert J Lee et al.   Innate Immunity

Genetics of chronic rhinosinusitis: State of the field and directions forward

(2013) Joy Hsu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Host-microbial interactions in patients with chronic rhinosinusitis

(2013) Daniel L. Hamilos   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Antiviral Mechanisms of Human Defensins

(2013) Sarah S. Wilson et al.   JOURNAL OF MOLECULAR BIOLOGY

Diet Shapes the Evolution of the Vertebrate Bitter Taste Receptor Gene Repertoire

(2013) Diyan Li et al.   MOLECULAR BIOLOGY AND EVOLUTION

Taste perception: from the tongue to the testis

(2013) F. Li   MOLECULAR HUMAN REPRODUCTION

CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes

(2013) Akiyuki Taruno et al.   NATURE

Extrasensory perception: Odorant and taste receptors beyond the nose and mouth

(2013) Simon R. Foster et al.   PHARMACOLOGY & THERAPEUTICS

Solitary chemosensory cells and bitter taste receptor signaling in human sinonasal mucosa

(2013) Henry P. Barham et al.   International Forum of Allergy & Rhinology

Genetics of the taste receptor T2R38 correlates with chronic rhinosinusitis necessitating surgical intervention

(2013) Nithin D. Adappa et al.   International Forum of Allergy & Rhinology

The bitter taste receptor T2R38 is an independent risk factor for chronic rhinosinusitis requiring sinus surgery

(2013) Nithin D. Adappa et al.   International Forum of Allergy & Rhinology

Extensive Surgical and Comprehensive Postoperative Medical Management for Cystic Fibrosis Chronic Rhinosinusitis

(2012) Frank W. Virgin et al.   American Journal of Rhinology & Allergy

Acquired Cilia Dysfunction in Chronic Rhinosinusitis

(2012) David Gudis et al.   American Journal of Rhinology & Allergy

Neuronal expression of bitter taste receptors and downstream signaling molecules in the rat brainstem

(2012) Ozra Dehkordi et al.   BRAIN RESEARCH

G-Protein-Coupled Receptors in Intestinal Chemosensation

(2012) Frank Reimann et al.   Cell Metabolism

Sweet talk: insights into the nature and importance of glucose transport in lung epithelium

(2012) James P. Garnett et al.   EUROPEAN RESPIRATORY JOURNAL

Extraoral bitter taste receptors as mediators of off-target drug effects

(2012) Adam A. Clark et al.   FASEB JOURNAL

Molecular modulation of airway epithelial ciliary response to sneezing

(2012) Ke-Qing Zhao et al.   FASEB JOURNAL

Defective epithelial barrier in chronic rhinosinusitis: The regulation of tight junctions by IFN-γ and IL-4

(2012) Michael B. Soyka et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Why Mouse Airway Submucosal Gland Serous Cells Do Not Secrete Fluid in Response to cAMP Stimulation

(2012) Robert J. Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection

(2012) Robert J. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional characterization of bitter-taste receptors expressed in mammalian testis

(2012) J. Xu et al.   MOLECULAR HUMAN REPRODUCTION

Oral and extra-oral taste perception

(2012) Kurumi Yamamoto et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Evaluation of domestic and Yucatan swine nasal sinus anatomy as models for future sinonasal research of medications delivered by standard instruments used in functional endoscopic sinus surgery

(2012) Jay Ching Chieh Wang et al.   International Forum of Allergy & Rhinology

Taste receptor signalling - from tongues to lungs

(2011) S. C. Kinnamon   Acta Physiologica

Innate Immunity in the Respiratory Epithelium

(2011) Dane Parker et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Functional bitter taste receptors are expressed in brain cells

(2011) Nisha Singh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gut bitter taste receptor signalling induces ABCB1 through a mechanism involving CCK

(2011) Tae-Il Jeon et al.   BIOCHEMICAL JOURNAL

Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1

(2011) Bjoern O. Schroeder et al.   NATURE

Bacterial Pattern in Chronic Sinusitis and Cystic Fibrosis

(2011) Jose M. Godoy et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY

The Missing Sense Modality: The Immune System

(2011) Felice L Bedford   PERCEPTION

Glucose Depletion in the Airway Surface Liquid Is Essential for Sterility of the Airways

(2011) Alejandro A. Pezzulo et al.   PLoS One

Cholinergic chemosensory cells in the trachea regulate breathing

(2011) G. Krasteva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of taste receptors in Solitary Chemosensory Cells of rodent airways

(2011) Marco Tizzano et al.   BMC Pulmonary Medicine

Epithelial tight junction alterations in nasal polyposis

(2011) G. Aaron Rogers et al.   International Forum of Allergy & Rhinology

Bacteriology and Antibiotic Resistance in Chronic Rhinosinusitis

(2011) R. Peter Manes et al.   Facial Plastic Surgery Clinics of North America

Amiloride reduces the sweet taste intensity by inhibiting the human sweet taste receptor

(2010) Takamasa Imada et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Allelic Variation in TAS2R Bitter Receptor Genes Associates with Variation in Sensations from and Ingestive Behaviors toward Common Bitter Beverages in Adults

(2010) John E. Hayes et al.   CHEMICAL SENSES

cAMP-activated Ca2+ signaling is required for CFTR-mediated serous cell fluid secretion in porcine and human airways

(2010) Robert J. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Cilia Dysfunction

(2010) David A. Gudis et al.   OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA

Nasal chemosensory cells use bitter taste signaling to detect irritants and bacterial signals

(2010) M. Tizzano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormones

(2009) Zaza Kokrashvili et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Secretory effects of a luminal bitter tastant and expressions of bitter taste receptors, T2Rs, in the human and rat large intestine

(2009) Izumi Kaji et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Epithelium, Cilia, and Mucus: Their Importance in Chronic Rhinosinusitis

(2009) Marcelo B. Antunes et al.   IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA

Substance P stimulates human airway submucosal gland secretion mainly via a CFTR-dependent process

(2009) Jae Young Choi et al.   JOURNAL OF CLINICAL INVESTIGATION

Motile Cilia of Human Airway Epithelia Are Chemosensory

(2009) A. S. Shah et al.   SCIENCE

Solitary chemoreceptor cell survival is independent of intact trigeminal innervation

(2008) Brian Gulbransen et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Nasal Solitary Chemoreceptor Cell Responses to Bitter and Trigeminal Stimulants In Vitro

(2008) Brian D. Gulbransen et al.   JOURNAL OF NEUROPHYSIOLOGY

Substance P stimulates CFTR-dependent fluid secretion by mouse tracheal submucosal glands

(2008) Juan P. Ianowski et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Glucose homeostasis across human airway epithelial cell monolayers: role of diffusion, transport and metabolism

(2008) Kameljit K. Kalsi et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

TRPM5-Expressing Solitary Chemosensory Cells Respond to Odorous Irritants

(2007) Weihong Lin et al.   JOURNAL OF NEUROPHYSIOLOGY