Innate Immunity in the Respiratory Epithelium

NAIP and Ipaf Control Legionella pneumophila Replication in Human Cells

(2014) M. Vinzing et al.   JOURNAL OF IMMUNOLOGY

Airway Epithelial versus Immune Cell Stat1 Function for Innate Defense against Respiratory Viral Infection

(2014) L. P. Shornick et al.   JOURNAL OF IMMUNOLOGY

Innate Immunity Mediated by TLR5 as a Novel Antiinflammatory Target for Cystic Fibrosis Lung Disease

(2014) C. J. Blohmke et al.   JOURNAL OF IMMUNOLOGY

Mucosal Clearance of Capsule-Expressing Bacteria Requires Both TLR and Nucleotide-Binding Oligomerization Domain 1 Signaling

(2014) T. A. Zola et al.   JOURNAL OF IMMUNOLOGY

The Macrophage-Inducible C-Type Lectin, Mincle, Is an Essential Component of the Innate Immune Response to Candida albicans

(2014) C. A. Wells et al.   JOURNAL OF IMMUNOLOGY

Nod1, Nod2 and Nalp3 receptors, new potential targets in treatment of allergic rhinitis?

(2010) J. Bogefors et al.   ALLERGY

Cigarette Smoke Induces Epidermal Growth Factor Receptor-Dependent Redistribution of Apical MUC1 and Junctional β-Catenin in Polarized Human Airway Epithelial Cells

(2010) Ying-Ting Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Increased Cytokine Response of Rhinovirus-infected Airway Epithelial Cells in Chronic Obstructive Pulmonary Disease

(2010) Dina Schneider et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

TNF-α Is a Key Regulator of MUC1, an Anti-inflammatory Molecule, during AirwayPseudomonas aeruginosaInfection

(2010) Seongwon Choi et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Host Immune and Apoptotic Responses to Avian Influenza Virus H9N2 in Human Tracheobronchial Epithelial Cells

(2010) Zheng Xing et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Loss of Anion Transport without Increased Sodium Absorption Characterizes Newborn Porcine Cystic Fibrosis Airway Epithelia

(2010) Jeng-Haur Chen et al.   CELL

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Children with atopic histories exhibit impaired lipopolysaccharide-induced Toll-like receptor-4 signalling in peripheral monocytes

(2010) D. Préfontaine et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Rhinovirus induces MUC5AC in a human infection model and in vitro via NF- B and EGFR pathways

(2010) C. A. Hewson et al.   EUROPEAN RESPIRATORY JOURNAL

Dectin-2 Recognition of α-Mannans and Induction of Th17 Cell Differentiation Is Essential for Host Defense against Candida albicans

(2010) Shinobu Saijo et al.   IMMUNITY

CARD9 Mediates Dectin-2-induced IκBα Kinase Ubiquitination Leading to Activation of NF-κB in Response to Stimulation by the Hyphal Form ofCandida albicans

(2010) Liangkuan Bi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway

(2010) Tomohiro Watanabe et al.   JOURNAL OF CLINICAL INVESTIGATION

The adaptor molecule CARD9 is essential for tuberculosis control

(2010) Anca Dorhoi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10

(2010) Kindra M. Kelly-Scumpia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IFN Regulatory Factor 3 Contributes to the Host Response during Pseudomonas aeruginosa Lung Infection in Mice

(2010) S. O. Carrigan et al.   JOURNAL OF IMMUNOLOGY

Double-Stranded RNA Exacerbates Pulmonary Allergic Reaction through TLR3: Implication of Airway Epithelium and Dendritic Cells

(2010) D. Torres et al.   JOURNAL OF IMMUNOLOGY

Streptococcus pneumoniae induces expression of the antibacterial CXC chemokine MIG/CXCL9 via MyD88-dependent signaling in a murine model of airway infection

(2010) Mette Eliasson et al.   MICROBES AND INFECTION

The pattern recognition receptors Nod1 and Nod2 account for neutrophil recruitment to the lungs of mice infected with Legionella pneumophila

(2010) Mariana S. Frutuoso et al.   MICROBES AND INFECTION

Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity

(2010) Thomas B Clarke et al.   NATURE MEDICINE

Dynamic Innate Immune Responses of Human Bronchial Epithelial Cells to Severe Acute Respiratory Syndrome-Associated Coronavirus Infection

(2010) Tomoki Yoshikawa et al.   PLoS One

Cystic Fibrosis Pigs Develop Lung Disease and Exhibit Defective Bacterial Eradication at Birth

(2010) D. A. Stoltz et al.   Science Translational Medicine

Pneumolysin Activates the NLRP3 Inflammasome and Promotes Proinflammatory Cytokines Independently of TLR4

(2010) Edel A. McNeela et al.   PLoS Pathogens

Uric Acid Is a Danger Signal Activating NALP3 Inflammasome in Lung Injury Inflammation and Fibrosis

(2009) Pamela Gasse et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

TLR-4–Mediated Innate Immunity Is Reduced in Cystic Fibrosis Airway Cells

(2009) Gerrit John et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Toll-like receptor 5- and lymphotoxin β receptor-dependent epithelial Ccl20 expression involves the same NF-κB binding site but distinct NF-κB pathways and dynamics

(2009) Jean-Claude Sirard et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Inducible expression of beta defensins by human respiratory epithelial cells exposed to Aspergillus fumigatus organisms

(2009) Ludmila Alekseeva et al.   BMC MICROBIOLOGY

RNA Polymerase III Detects Cytosolic DNA and Induces Type I Interferons through the RIG-I Pathway

(2009) Yu-Hsin Chiu et al.   CELL

Mucins, Mucus, and Sputum

(2009) Judith A. Voynow et al.   CHEST

The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1

(2009) Paul G. Thomas et al.   IMMUNITY

Innate immune responses of airway epithelium to house dust mite are mediated through β-glucan–dependent pathways

(2009) Amy T. Nathan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Dectin-1 is Inducible and Plays an Essential Role for Mycobacteria-Induced Innate Immune Responses in Airway Epithelial Cells

(2009) Hye-Mi Lee et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice

(2009) Arash Shahangian et al.   JOURNAL OF CLINICAL INVESTIGATION

Type I interferon drives tumor necrosis factor–induced lethal shock

(2009) Liesbeth Huys et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP

(2009) Sarah M. McWhirter et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-8 Regulates Mucin Gene Expression at the Posttranscriptional Level in Lung Epithelial Cells

(2009) M. V. Bautista et al.   JOURNAL OF IMMUNOLOGY

Role of Double-Stranded RNA Pattern Recognition Receptors in Rhinovirus-Induced Airway Epithelial Cell Responses

(2009) Q. Wang et al.   JOURNAL OF IMMUNOLOGY

NLRP3 (NALP3, Cryopyrin) Facilitates In Vivo Caspase-1 Activation, Necrosis, and HMGB1 Release via Inflammasome-Dependent and -Independent Pathways

(2009) S. B. Willingham et al.   JOURNAL OF IMMUNOLOGY

Activation of the Nlrp3 Inflammasome by Streptococcus pyogenes Requires Streptolysin O and NF- B Activation but Proceeds Independently of TLR Signaling and P2X7 Receptor

(2009) J. Harder et al.   JOURNAL OF IMMUNOLOGY

Localization of Type I Interferon Receptor Limits Interferon-Induced TLR3 in Epithelial Cells

(2009) Jonathan M. Ciencewicki et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells

(2009) Giuseppe Mancuso et al.   NATURE IMMUNOLOGY

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate

(2009) Andrea Ablasser et al.   NATURE IMMUNOLOGY

House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells

(2009) Hamida Hammad et al.   NATURE MEDICINE

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Relationship between antimicrobial proteins and airway inflammation and infection in cystic fibrosis

(2009) Scott D. Sagel et al.   PEDIATRIC PULMONOLOGY

Innate Immune Responses of Pulmonary Epithelial Cells to Burkholderia pseudomallei Infection

(2009) Siew Hoon Sim et al.   PLoS One

Pseudomonas aeruginosa LPS or Flagellin Are Sufficient to Activate TLR-Dependent Signaling in Murine Alveolar Macrophages and Airway Epithelial Cells

(2009) Eloïse Raoust et al.   PLoS One

The NOD/RIP2 Pathway Is Essential for Host Defenses Against Chlamydophila pneumoniae Lung Infection

(2009) Kenichi Shimada et al.   PLoS Pathogens

NOD2, RIP2 and IRF5 Play a Critical Role in the Type I Interferon Response to Mycobacterium tuberculosis

(2009) Amit K. Pandey et al.   PLoS Pathogens

Multiple TLRs activate EGFR via a signaling cascade to produce innate immune responses in airway epithelium

(2008) Jonathan L. Koff et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Rhinovirus-Induced Major Airway Mucin Production Involves a Novel TLR3-EGFR–Dependent Pathway

(2008) Lingxiang Zhu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

TLR-Independent Type I Interferon Induction in Response to an Extracellular Bacterial Pathogen via Intracellular Recognition of Its DNA

(2008) Marie Charrel-Dennis et al.   Cell Host & Microbe

Expression and Secretion of Cathelicidin LL-37 in Human Epithelial Cells after Infection by Mycobacterium bovis Bacillus Calmette-Guerin

(2008) P. Mendez-Samperio et al.   Clinical and Vaccine Immunology

Mycoplasma pneumoniae induces airway epithelial cell expression of MUC5AC in asthma

(2008) M. Kraft et al.   EUROPEAN RESPIRATORY JOURNAL

CXCR3 LIGANDS CONTRIBUTE TO Th1-INDUCED INFLAMMATION BUT NOT TO HOMING OF Th1 CELLS INTO THE LUNG

(2008) Anne M. Manicone et al.   EXPERIMENTAL LUNG RESEARCH

Function of Nod-like receptors in microbial recognition and host defense

(2008) Luigi Franchi et al.   IMMUNOLOGICAL REVIEWS

Cigarette smoke increases Toll-like receptor 4 and modifies lipopolysaccharide-mediated responses in airway epithelial cells

(2008) Elisabetta Pace et al.   IMMUNOLOGY

Klebsiella pneumoniae Increases the Levels of Toll-Like Receptors 2 and 4 in Human Airway Epithelial Cells

(2008) V. Regueiro et al.   INFECTION AND IMMUNITY

ThePseudomonas aeruginosa TypeIII secretion system plays a dual role in the regulation of caspase-1 mediated IL-1β maturation

(2008) M. Galle et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Sustained desensitization to bacterial Toll-like receptor ligands after resolutionof respiratory influenza infection

(2008) Arnaud Didierlaurent et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Host Defence Peptide LL-37 Induces IL-6 Expression in Human Bronchial Epithelial Cells by Activation of the NF-κB Signaling Pathway

(2008) Jelena Pistolic et al.   Journal of Innate Immunity

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

(2008) You-Me Kim et al.   NATURE

TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon–response genes

(2008) Anna Yarilina et al.   NATURE IMMUNOLOGY

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

(2008) Jonathan C Kagan et al.   NATURE IMMUNOLOGY

Microbial Patterns Signaling via Toll-Like Receptors 2 and 5 Contribute to Epithelial Repair, Growth and Survival

(2008) Renat Shaykhiev et al.   PLoS One

Distinct TLR- and NLR-Mediated Transcriptional Responses to an Intracellular Pathogen

(2008) Jess H. Leber et al.   PLoS Pathogens

Pseudomonas aeruginosa activates caspase 1 through Ipaf

(2008) E. A. Miao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Production of bioactive human beta-defensin 5 and 6 in Escherichia coli by soluble fusion expression

(2008) Lei Huang et al.   PROTEIN EXPRESSION AND PURIFICATION

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

(2008) H. von Bernuth et al.   SCIENCE

Disruption of the CFTR Gene Produces a Model of Cystic Fibrosis in Newborn Pigs

(2008) C. S. Rogers et al.   SCIENCE

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE

Suppression of pulmonary innate host defence in smokers

(2008) C Herr et al.   THORAX

MUC1 Mucin Is a Negative Regulator of Toll-Like Receptor Signaling

(2007) Keiko Ueno et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

CXCR3 and CCR5 Chemokines in Induced Sputum From Patients With COPD

(2007) Claudia Costa et al.   CHEST