Personalized Respiratory Medicine: Exploring the Horizon, Addressing the Issues. Summary of a BRN-AJRCCM Workshop Held in Barcelona on June 12, 2014

Ivacaftor: From Bench to Bedside . . . and Back Again

(2014) Kevin Molloy et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Network Analysis in the Investigation of Chronic Respiratory Diseases. From Basics to Application

(2014) Diego Diez et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Relationship of DNA Methylation and Gene Expression in Idiopathic Pulmonary Fibrosis

(2014) Ivana V. Yang et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Analyzing networks of phenotypes in complex diseases: methodology and applications in COPD

(2014) Jen-hwa Chu et al.   BMC Systems Biology

Network medicine, multimorbidity and the lung in the elderly

(2014) R. Faner et al.   EUROPEAN RESPIRATORY JOURNAL

Integrated care pathways for airway diseases (AIRWAYS-ICPs)

(2014) J. Bousquet et al.   EUROPEAN RESPIRATORY JOURNAL

From ‘Solution Shop’ Model To ‘Focused Factory’ In Hospital Surgery: Increasing Care Value And Predictability

(2014) David Cook et al.   HEALTH AFFAIRS

Structure-energy-based predictions and network modelling of RASopathy and cancer missense mutations

(2014) C. Kiel et al.   Molecular Systems Biology

A draft map of the human proteome

(2014) Min-Sik Kim et al.   NATURE

Physiological data must remain confidential

(2014) Stephen Fairclough   NATURE

Learning from Big Health Care Data

(2014) Sebastian Schneeweiss   NEW ENGLAND JOURNAL OF MEDICINE

23andMe and the FDA

(2014) George J. Annas et al.   NEW ENGLAND JOURNAL OF MEDICINE

The path to personalised medicine in COPD

(2014) Alvar Agusti   THORAX

Cluster analysis in the COPDGene study identifies subtypes of smokers with distinct patterns of airway disease and emphysema

(2014) Peter J Castaldi et al.   THORAX

Modules, networks and systems medicine for understanding disease and aiding diagnosis

(2014) Mika Gustafsson et al.   Genome Medicine

Targeted omics and systems medicine: personalising care

(2014) Huan Zhang et al.   Lancet Respiratory Medicine

Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis

(2014) Michael H Cho et al.   Lancet Respiratory Medicine

Comorbidity of eczema, rhinitis, and asthma in IgE-sensitised and non-IgE-sensitised children in MeDALL: a population-based cohort study

(2014) Mariona Pinart et al.   Lancet Respiratory Medicine

Personalized Genetic Prediction: Too Limited, Too Expensive, or Too Soon?

(2013) John P.A. Ioannidis   ANNALS OF INTERNAL MEDICINE

The Association Between Health Care Quality and Cost

(2013) Peter S. Hussey et al.   ANNALS OF INTERNAL MEDICINE

Criteria for the use of omics-based predictors in clinical trials: explanation and elaboration

(2013) Lisa M McShane et al.   BMC Medicine

Beyond the diagnosis of idiopathic pulmonary fibrosis; the growing role of systems biology and stratified medicine

(2013) Toby M. Maher   CURRENT OPINION IN PULMONARY MEDICINE

Application of ’omics technologies to biomarker discovery in inflammatory lung diseases

(2013) Craig E. Wheelock et al.   EUROPEAN RESPIRATORY JOURNAL

Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells

(2013) Xiaobo Zhou et al.   GENOMICS

Redesigning Primary Care: A Strategic Vision To Improve Value By Organizing Around Patients’ Needs

(2013) Michael E. Porter et al.   HEALTH AFFAIRS

HEALTH TECHNOLOGY ASSESSMENT, VALUE-BASED DECISION MAKING, AND INNOVATION

(2013) Chris Henshall et al.   INTERNATIONAL JOURNAL OF TECHNOLOGY ASSESSMENT IN HEALTH CARE

Inflammatory Biomarkers and Exacerbations in Chronic Obstructive Pulmonary Disease

(2013) Mette Thomsen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Inevitable Application of Big Data to Health Care

(2013) Travis B. Murdoch et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Sputum neutrophil counts are associated with more severe asthma phenotypes using cluster analysis

(2013) Wendy C. Moore et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Improving data and knowledge management to better integrate health care and research

(2013) M. Cases et al.   JOURNAL OF INTERNAL MEDICINE

The shift to personalised and population medicine

(2013) J A Muir Gray   LANCET

Criteria for the use of omics-based predictors in clinical trials

(2013) Lisa M. McShane et al.   NATURE

Benefits and harms of roflumilast in moderate to severe COPD

(2013) Tsung Yu et al.   THORAX

Moving from the Oslerian paradigm to the post-genomic era: are asthma and COPD outdated terms?

(2013) Lowie E G W Vanfleteren et al.   THORAX

The bottom–up approach to defining life: deciphering the functional organization of biological cells via multi-objective representation of biological complexity from molecules to cells

(2013) Sathish Periyasamy et al.   Frontiers in Physiology

Polygenic risk and the development and course of asthma: an analysis of data from a four-decade longitudinal study

(2013) Daniel W Belsky et al.   Lancet Respiratory Medicine

A Population Approach to Precision Medicine

(2012) Muin J. Khoury et al.   AMERICAN JOURNAL OF PREVENTIVE MEDICINE

Personalized Medicine

(2012) Jacob I. Sznajder et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Editorial: Systems biology and personalized medicine - the future is now

(2012) Charles Auffray et al.   Biotechnology Journal

Quantifying your body: A how-to guide from a systems biology perspective

(2012) Larry Smarr   Biotechnology Journal

A framework for organizing and selecting quantitative approaches for benefit-harm assessment

(2012) Milo A Puhan et al.   BMC Medical Research Methodology

Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes

(2012) Rui Chen et al.   CELL

Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks

(2012) Michael J. Lee et al.   CELL

Developing New Drug Treatments in the Era of Network Medicine

(2012) E K Silverman et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Understanding the complexity of IgE-related phenotypes from childhood to young adulthood: A Mechanisms of the Development of Allergy (MeDALL) Seminar

(2012) Josep M. Antó et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Uncovering and tackling Europe's hidden respiratory illness

(2012) Klaus F Rabe et al.   LANCET

Epidemiology of multimorbidity and implications for health care, research, and medical education: a cross-sectional study

(2012) Karen Barnett et al.   LANCET

Preparing for Precision Medicine

(2012) Reza Mirnezami et al.   NEW ENGLAND JOURNAL OF MEDICINE

Persistent Systemic Inflammation is Associated with Poor Clinical Outcomes in COPD: A Novel Phenotype

(2012) Alvar Agustí et al.   PLoS One

Computational Medicine: Translating Models to Clinical Care

(2012) R. L. Winslow et al.   Science Translational Medicine

The COPD control panel: towards personalised medicine in COPD

(2012) Alvar Agusti et al.   THORAX

MeDALL (Mechanisms of the Development of ALLergy): an integrated approach from phenotypes to systems medicine

(2011) J. Bousquet et al.   ALLERGY

Expanding the Scope of Environmental Risk Assessment to Better Include Differential Vulnerability and Susceptibility

(2011) Joel Schwartz et al.   AMERICAN JOURNAL OF PUBLIC HEALTH

Asthma endotypes: A new approach to classification of disease entities within the asthma syndrome

(2011) Jan Lötvall et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A pharmacogenetic study of ADRB2 polymorphisms and indacaterol response in COPD patients

(2011) R Yelensky et al.   PHARMACOGENOMICS JOURNAL

Gene-Disease Network Analysis Reveals Functional Modules in Mendelian, Complex and Environmental Diseases

(2011) Anna Bauer-Mehren et al.   PLoS One

Fitness Trade-Offs and Environmentally Induced Mutation Buffering in Isogenic C. elegans

(2011) M. O. Casanueva et al.   SCIENCE

Systems medicine and integrated care to combat chronic noncommunicable diseases

(2011) Jean Bousquet et al.   Genome Medicine

A Systems Biology Approach Identifies Molecular Networks Defining Skeletal Muscle Abnormalities in Chronic Obstructive Pulmonary Disease

(2011) Nil Turan et al.   PLoS Computational Biology

DisGeNET: a Cytoscape plugin to visualize, integrate, search and analyze gene–disease networks

(2010) Anna Bauer-Mehren et al.   BIOINFORMATICS

Risk sharing arrangements for pharmaceuticals: potential considerations and recommendations for European payers

(2010) Jakub Adamski et al.   BMC HEALTH SERVICES RESEARCH

An Integrative Systems Biology Approach to Understanding Pulmonary Diseases

(2010) Charles Auffray et al.   CHEST

Systems Biology: An Approach

(2010) P Kohl et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Comparative Effectiveness And Personalized Medicine: Evolving Together Or Apart?

(2010) Robert Epstein et al.   HEALTH AFFAIRS

Effective knowledge management in translational medicine

(2010) Sándor Szalma et al.   Journal of Translational Medicine

Network medicine: a network-based approach to human disease

(2010) Albert-László Barabási et al.   NATURE REVIEWS GENETICS

Genomewide Association Studies and Assessment of the Risk of Disease

(2010) Teri A. Manolio   NEW ENGLAND JOURNAL OF MEDICINE

ELMOD2, a candidate gene for idiopathic pulmonary fibrosis, regulates antiviral responses

(2009) Ville Pulkkinen et al.   FASEB JOURNAL

Expansion of the prognostic assessment of patients with chronic obstructive pulmonary disease: the updated BODE index and the ADO index

(2009) Milo A Puhan et al.   LANCET

Edgetic perturbation models of human inherited disorders

(2009) Quan Zhong et al.   Molecular Systems Biology

Does Comparative-Effectiveness Research Threaten Personalized Medicine?

(2009) Alan M. Garber et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Strategy for Health Care Reform — Toward a Value-Based System

(2009) Michael E. Porter   NEW ENGLAND JOURNAL OF MEDICINE

Cell Type-Specific Importance of Ras-c-Raf Complex Association Rate Constants for MAPK Signaling

(2009) C. Kiel et al.   Science Signaling

Systems medicine: the future of medical genomics and healthcare

(2009) Charles Auffray et al.   Genome Medicine

A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci

(2009) Sreekumar G. Pillai et al.   PLoS Genetics