Review
Genetics & Heredity
Irati Romero-Garmendia, Koldo Garcia-Etxebarria
Summary: Colorectal cancer is a highly diagnosed cancer and the second leading cause of cancer-related death. Studying biomarkers for its diagnosis, prognosis, and treatment is essential for improving and personalizing colorectal cancer prevention and clinical management. Omic techniques provide an opportunity to better understand CRC and make personalized medicine possible, but also present challenges.
Review
Food Science & Technology
Hui Duan, Jinwei Li, Leilei Yu, Liuping Fan
Summary: Dietary restriction can delay aging by regulating nutrient-sensing pathways and gut microbiota. However, the effects of DR regimens on longevity remain controversial, with some studies suggesting that intermittent fasting influences longevity, while others suggest that restricted-carbohydrate or -protein diets determine health and longevity. Individual differences and DR-related factors play a significant role in explaining the controversial effects.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Pharmacology & Pharmacy
Kan Zhou, Zi-Zhan Li, Ze-Min Cai, Nian-Nian Zhong, Lei-Ming Cao, Fang-Yi Huo, Bing Liu, Qiu-Ji Wu, Lin-Lin Bu
Summary: Lymph node metastasis significantly affects the prognosis of cancer patients, and nanotheranostics can provide precise and effective disease diagnosis and treatment, offering a promising solution for the management of LNM patients and promoting the advancement of personalized medicine.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Multidisciplinary Sciences
Daniel M. Altmann, Rosemary J. Boyton
Summary: A diverse range of first-generation SARS-CoV-2 vaccines have been successful in controlling the COVID-19 pandemic, although inequitable distribution remains an issue. Future challenges include optimizing immunological boosting strategies and building an immune repertoire that can protect against upcoming viral variants.
Review
Microbiology
Robert F. Garry
Summary: Lassa virus is a locally endemic virus in West Africa that causes Lassa fever in humans through transmission from rodent reservoirs. Despite gaps in knowledge, efforts to develop countermeasures have increased due to frequent outbreaks and the potential risks posed by the virus.
NATURE REVIEWS MICROBIOLOGY
(2023)
Review
Neurosciences
Antonio F. Pardinas, Michael J. Owen, James T. R. Walters
Summary: Psychiatric genomics sheds light on psychiatric conditions and may lead to new drug targets, while psychiatric pharmacogenomics research has the potential to bring about rapid changes in clinical practice. However, challenges such as a lack of replication studies, inconsistencies in defining treatment outcomes, and insufficient investment in longitudinal data collections have hindered progress in this field.
Review
Cell Biology
Zakery N. Baker, Patrick Forny, David J. Pagliarini
Summary: Mitochondria are multifunctional organelles with diverse roles in cellular processes, bioenergetics, and disease. The development of a comprehensive mitochondrial protein map has revolutionized our understanding of mitochondrial biology and its clinical implications. Advances in technology and computational methods continue to refine this map, providing insights into new proteins and their functions.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Abdurrahman Coskun, Atefeh Zarepour, Ali Zarrabi
Summary: The concentration of biomolecules in living systems exhibits systematic and random variations. Systematic variations can be classified into ultradian, circadian, and infradian rhythms based on their frequency, while random biological variations include variations between individuals and within individuals. Physiological rhythms and random biological variations are important for predictive, preventive, and personalized laboratory medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Maria A. Pajares, Elena Hernandez-Gerez, Milos Pekny, Dolores Perez-Sala
Summary: Alexander disease is a rare neurodegenerative disorder caused by mutations in the glial fibrillary acidic protein, leading to characteristic aggregates in astrocytes. The impact of mutations on protein expression, posttranslational modifications, and protein-protein interactions of the mutant protein may impair astrocyte function and affect neurons. Experimental models are being developed to study the disease and potential therapeutic strategies.
NEURAL REGENERATION RESEARCH
(2023)
News Item
Computer Science, Hardware & Architecture
Keith Kirkpatrick
Summary: This article provides an overview of augmented reality head-up displays and their potential applications.
COMMUNICATIONS OF THE ACM
(2021)
Article
Health Care Sciences & Services
Alfredo Cesario, Marika D'Oria, Irene Simone, Stefano Patarnello, Vincenzo Valentini, Giovanni Scambia
Summary: Personalized medicine utilizes digital and technological solutions to drive innovation and generate new knowledge, while the open innovation paradigm effectively manages transformation in healthcare organizations. This article examines the transition from personalized medicine to personalized digital medicine in a large research hospital, discussing methods, challenges, and results.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Environmental Studies
Anthony Y. Ku, Chris Greig, Eric Larson
Summary: The journey to carbon neutrality requires significant capital investment and guidance from analytical models, but real-time feedback is crucial too. Nations and corporations are transitioning towards clean energy with a lack of confidence in the best route. Developing a navigation app for energy transition that provides real-time guidance would be beneficial, but requires integration of various elements and collaboration with tech companies.
ENERGY RESEARCH & SOCIAL SCIENCE
(2022)
Article
Environmental Studies
Jan Osicka, Filip Cernoch
Summary: By invading Ukraine and weaponizing its gas supplies to Europe, Russia has made natural gas unstable and costly. The implications of this war for European energy politics will lead to a focus on reducing energy vulnerability and accelerating decarbonization, possibly at the expense of further development of the EU integrated energy market.
ENERGY RESEARCH & SOCIAL SCIENCE
(2022)
Review
Engineering, Multidisciplinary
Jinfeng Ma, Lin Li, Haofan Wang, Yi Du, Junjie Ma, Xiaoli Zhang, Zhenliang Wang
Summary: The large-scale deployment of carbon capture and storage (CCS) is becoming increasingly urgent in the global path toward net zero emissions. Reviewing and learning from the examples and history of successful CCS practices in advanced countries will help other countries, including China, to promote and deploy CCS projects using scientific methods. The establishment of major science and technology CCS infrastructures in advanced countries has become the main source of CCS technological innovation, cost reduction, risk reduction, commercial promotion, and talent training.
Review
Computer Science, Information Systems
Auriol Degbelo
Summary: This article explores the importance of making geovisualizations FAIR and presents relevant approaches and research questions, discussing from the perspectives of computer, analyst, and developer. The proposed framework for FAIR geovisualizations and identified open questions are relevant for researchers working on online visualizations of geographic information that are findable, accessible, interoperable, and reusable.
INTERNATIONAL JOURNAL OF GEOGRAPHICAL INFORMATION SCIENCE
(2022)