Article
Anesthesiology
U. Misra, E. Gilvarry, J. Marshall, R. Hall, H. McLure, R. Mayall, S. El-Ghazali, N. Redfern, E. McGrady, C. Gerada
Summary: Anaesthetists have a higher incidence of substance use disorder, especially alcohol use disorder, compared to other doctors. The ease of access to various drugs may contribute to this issue. Suicide is presumed to be the cause of death in a significant number of anaesthetists. To prevent this, early recognition of substance use disorder, department and hospital support, and full engagement with treatment are crucial. Over 75% of anaesthetists can return to full practice if they fully cooperate with the required treatment and supervision.
Review
Substance Abuse
Jordan Stellern, Ke Bin Xiao, Erin Grennell, Marcos Sanches, Joshua L. Gowin, Matthew E. Sloan
Summary: Individuals with substance use disorders have greater difficulties in emotion regulation compared to individuals without substance use disorders. This difference is evident in all subscales of the Difficulties in Emotion Regulation Scale (DERS), with the largest deficits in the Strategies and Impulse subscales. The analysis also reveals a greater use of expressive suppression in individuals with substance use disorders.
Article
Psychiatry
Jonina Rabinowitz, Shaul Lev-Ran, Raz Gross
Summary: This study examined the association between past use of classic psychedelics (LSD, psilocybin, and peyote/mescaline) and substance use disorder. The results showed that past use of LSD and psilocybin was associated with increased odds of substance dependence or abuse, while past use of peyote/mescaline was associated with lower odds. Further research is needed to explore the reasons behind these differences.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Ting Fang, Meng-Nan Liu, Xiao-Yu Tian, Guan-Yi Lu, Fei Li, Xiaojie Zhang, Feng Liu, Wei Hao, Ning Wu, Hong Li, Jin Li
Summary: This study found that two variants of the FKBP5 gene (rs4713916A and rs6926133A) were associated with an increased risk of severe DD in patients with MAUD. These findings would help with the development of biological early warning markers and the creation of personalized treatment strategies for MAUD.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Neurosciences
Chen Mo, Zhenyao Ye, Yezhi Pan, Yuan Zhang, Qiong Wu, Chuan Bi, Song Liu, Braxton Mitchell, Peter Kochunov, L. Elliot Hong, Tianzhou Ma, Shuo Chen
Summary: This study proposes a new method for selecting causative variant candidates for nicotine addiction by jointly modeling SNP-wise inference results and the underlying structured network patterns of the linkage disequilibrium matrix. Applying this method to UK biobank data, 81 nicotine addiction-related SNPs were identified, which were highly correlated but physically distant and from different genes.
MOLECULAR AND CELLULAR NEUROSCIENCE
(2023)
Article
Psychology, Multidisciplinary
Silvia Casale, Giulia Fioravanti, Sara Bocci Benucci, Andrea Falone, Valdo Ricca, Francesco Rotella
Summary: This meta-analysis examines the relationship between Problematic Smartphone Use (PSU) and self-esteem. It finds a negative correlation between self-esteem and PSU, indicating that low self-esteem is an important characteristic of PSU. These findings emphasize the significance of addressing self-esteem and corresponding core beliefs in the prevention and treatment of PSU.
COMPUTERS IN HUMAN BEHAVIOR
(2022)
Article
Medicine, General & Internal
Tyrone L. Burleigh, Mark D. Griffiths, Alexander Sumich, Grace Y. Wang, Daria J. Kuss
Summary: The findings of the study suggest that gamers from different populations share similar at-risk behaviors, and these behaviors are more pronounced among abstinent substance use gamers, particularly among poly-substance use gamers. The study highlights the importance of considering integrated treatment approaches that address both substance use and other problematic behaviors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Psychiatry
Hong Yan, Shu Xiao, Siying Fu, Jiaying Gong, Zhangzhang Qi, Guanmao Chen, Pan Chen, Guixian Tang, Ting Su, Zibin Yang, Ying Wang
Summary: This multimodal meta-analysis reveals common impairments in both functional and structural domains in patients with substance use disorder (SUD), particularly in the anterior cingulate cortex/medial prefrontal cortex (ACC/mPFC). In addition, structural impairments are also observed in regions such as the insula, thalamus, striatum, and sensorimotor areas.
ACTA PSYCHIATRICA SCANDINAVICA
(2023)
Review
Public, Environmental & Occupational Health
Haiyang Ding, Bing Cao, Qixuan Sun
Summary: This meta-analysis examines the association between problematic internet use (PIU) and social anxiety in adolescents and young adults. The findings suggest that social anxiety is a predictor of the development of PIU in this population. Furthermore, the study also finds the possibility of a more global behavior pattern among contemporary adolescents and youth, with fewer differences between cultures, generations, and genders.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Pharmacology & Pharmacy
Theofanis Vavilis, Eleni Stamoula, Athanasios Sachinidis, Malamatenia Lamprinou, Ioannis Dardalas, Georgios Papazisis
Summary: This review examines the use of biopharmaceuticals in the treatment of substance use disorder (SUD). Biopharmaceutical approaches include active and passive immunization, metabolic enhancers, and genetic/epigenetic modulation. These approaches hold promise as next generation treatments for SUD.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Psychiatry
Nour Shaheen, Ahmed Shaheen, Can Sarica, Arun Singh, Mario Zanaty, Karim Johari, Andrew Yang, Theresa Zesiewicz, Brian Dalm, Yarema Bezchlibnyk, Andres M. Lozano, Oliver Flouty
Summary: A meta-analysis was conducted to evaluate the efficacy of deep brain stimulation (DBS) in treating substance use disorder (SUD) and reducing relapse rates. The results showed that DBS treatment significantly improved clinical SUD scales with an average improvement of 59.6%. The relapse rate was observed to be 8%. However, there was a large degree of heterogeneity among the included studies and more research is needed to better understand the factors that influence its effectiveness.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Nursing
Amanda Choflet, Judy Davidson, Kelly C. Lee, Gordon Ye, Arianna Barnes, Sidney Zisook
Summary: This study found significant differences between nurses who completed suicide and non-nurses in terms of substance use and mental health characteristics. Nurses were more likely to have substance use and mental health problems at the time of suicide, indicating potential opportunities for targeted interventions to reduce nurse suicide.
JOURNAL OF CLINICAL NURSING
(2021)
Review
Medicine, General & Internal
Aurelia Gay, Julien Cabe, Ingrid De Chazeron, Celine Lambert, Maxime Defour, Vikesh Bhoowabul, Thomas Charpeaud, Aurore Tremey, Pierre-Michel Llorca, Bruno Pereira, Georges Brousse
Summary: This meta-analysis examines the therapeutic potential of repetitive transcranial magnetic stimulation (rTMS) on addiction by targeting craving. The results suggest that active rTMS has a small effect in reducing craving, particularly in stimulant and behavioral addiction. No significant differences were found in the different combinations of target and frequency of stimulation, but a correlation between number of sessions and craving reduction was observed.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Psychology, Clinical
Xinglin Zeng, Xinyang Han, Dong Zheng, Ping Jiang, Zhen Yuan
Summary: Behavioral addiction and substance use disorder share similarities and differences in clinical symptoms, cognitive functions, and behavioral attributes. This study found common and distinct alterations in functional connectivity networks in the human brain for both addiction types, and these alterations were associated with clinical characteristics.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Neurosciences
Katherine M. Serafine, Laura E. O'Dell, Eric P. Zorrilla
Summary: Highly palatable foods and substances of abuse have similar effects on neurobiology, metabolism, and behavior, potentially increasing vulnerability to conditions such as obesity, binge eating disorder, and substance use disorders.
Article
Biochemistry & Molecular Biology
Jian Cao, Lizhen Wu, Shang-Min Zhang, Min Lu, William K. C. Cheung, Wesley Cai, Molly Gale, Qi Xu, Qin Yan
NUCLEIC ACIDS RESEARCH
(2016)
Article
Oncology
Molly Gale, Joyce Sayegh, Jian Cao, Michael Norcia, Peter Gareiss, Denton Hoyer, Jane S. Merkel, Qin Yan
Article
Multidisciplinary Sciences
Lauren P. Blair, Zongzhi Liu, Ramon Lorenzo D. Labitigan, Lizhen Wu, Dinghai Zheng, Zheng Xia, Erica L. Pearson, Fathima I. Nazeer, Jian Cao, Sabine M. Lang, Rachel J. Rines, Samuel G. Mackintosh, Claire L. Moore, Wei Li, Bin Tian, Alan J. Tackett, Qin Yan
Article
Biochemistry & Molecular Biology
Jian Cao, Dawei Li
JOURNAL OF CELLULAR BIOCHEMISTRY
(2018)
Article
Genetics & Heredity
Jian Cao, Xiangtao Liu, Shizhong Han, Clarence K. Zhang, Zongzhi Liu, Dawei Li
Article
Biochemistry & Molecular Biology
Joyce Sayegh, Jian Cao, Mike Ran Zou, Alfonso Morales, Lauren P. Blair, Michael Norcia, Denton Hoyer, Alan J. Tackett, Jane S. Merkel, Qin Yan
JOURNAL OF BIOLOGICAL CHEMISTRY
(2013)
Article
Biochemistry & Molecular Biology
Mike Ran Zou, Jian Cao, Zongzhi Liu, Sung Jin Huh, Kornelia Polyak, Qin Yan
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Cell Biology
Jian Cao, Zongzhi Liu, William K. C. Cheung, Minghui Zhao, Sophia Y. Chen, Siew Wee Chan, Carmen J. Booth, Don X. Nguyen, Qin Yan
Article
Biochemistry & Molecular Biology
Lizhen Wu, Jian Cao, Wesley L. Cai, Sabine M. Lang, John R. Horton, Daniel J. Jansen, Zongzhi Z. Liu, Jocelyn F. Chen, Meiling Zhang, Bryan T. Mott, Katherine Pohida, Ganesha Rai, Stephen C. Kales, Mark J. Henderson, Xin Hu, Ajit Jadhav, David J. Maloney, Anton Simeonov, Shu Zhu, Akiko Iwasaki, Matthew D. Hall, Xiaodong Cheng, Gerald S. Shadel, Qin Yan
Article
Biochemistry & Molecular Biology
Xun Chen, Jason Kost, Arvis Sulovari, Nathalie Wong, Winnie S. Liang, Jian Cao, Dawei Li
Article
Oncology
Molly Gale, Yao Li, Jian Cao, Zongzhi Zachary Liu, Marissa A. Holmbeck, Meiling Zhang, Sabine M. Lang, Lizhen Wu, Mariana Carmo, Swati Gupta, Keisuke Aoshima, Michael P. DiGiovanna, David F. Stern, David L. Rimm, Gerald S. Shadel, Xiang Chen, Qin Yan
Article
Oncology
Shanshan Zhang, Yu-Feng Zhou, Jian Cao, Stephen K. Burley, Hui-Yun Wang, X. F. Steven Zheng
Summary: The study demonstrates that mTOR promotes oncogenic chromatin remodeling by controlling ARID1A degradation, which is crucial for liver tumorigenesis and response to mTOR- and YAP-targeted therapies in hepatocellular carcinoma.
Article
Immunology
Qian Xiao, Xinyan Zhang, Liqun Tu, Jian Cao, Christian S. Hinrichs, Xiaolei Su
Summary: The activation of CAR-T cells is dependent on the size difference between the CAR-antigen pair and CD45. Increasing the size of CAR extracellular domains weakens CAR-T activation, while membrane-proximal epitopes activate CAR-Ts better than membrane-distal epitopes.
SCIENCE IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Hui Zheng, Lizhen Wu, Qian Xiao, Xin Meng, Alex Hafiz, Qin Yan, Renquan Lu, Jian Cao
Summary: DNA sensing through the cGAS-STING pathway is important in cancer immunosurveillance. Activation of STING in the tumor environment is an attractive approach to induce anti-tumor immunity, but it is limited due to epigenetic silencing of STING in many tumors. In this study, the inhibition of KDM5 family histone demethylases restored STING expression in breast cancer cells and activated the cGAS-STING pathway, showing the potential of KDM5 inhibitors as novel immune modulators in cancer therapies.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Yuanyue Zhang, Jacob T. Bailey, En Xu, Kunal Singh, Marieke Lavaert, Verena M. Link, Shanti D'Souza, Alex Hafiz, Jian Cao, Gaoyuan Cao, Derek B. Sant'Angelo, Wei Sun, Yasmine Belkaid, Avinash Bhandoola, Dorian B. McGavern, Qi Yang
Summary: The study demonstrates that MAIT cells in the meninges play a crucial role in preventing reactive oxidative species accumulation and preserving meningeal barrier integrity.