Size-dependent activation of CAR-T cells

Roadmap to affinity-tuned antibodies for enhanced chimeric antigen receptor T cell function and selectivity

(2022) Erica R. Vander Mause et al.   TRENDS IN BIOTECHNOLOGY

Structural details of monoclonal antibody m971 recognition of the membrane-proximal domain of CD22

(2021) June Ereño-Orbea et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Characterization of mechanisms positioning costimulatory complexes in immune synapses

(2021) Anastasios Siokis et al.   iScience

KTE-X19 CAR T-Cell Therapy in Relapsed or Refractory Mantle-Cell Lymphoma

(2020) Michael Wang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy

(2020) Wei Wu et al.   CELL

Rewired signaling network in T cells expressing the chimeric antigen receptor ( CAR )

(2020) Rui Dong et al.   EMBO JOURNAL

Senolytic CAR T cells reverse senescence-associated pathologies

(2020) Corina Amor et al.   NATURE

Cell–cell interfaces as specialized compartments directing cell function

(2020) Brian Belardi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Enhanced CAR-T activity against established tumors by polarizing human T cells to secrete interleukin-9

(2020) Lintao Liu et al.   Nature Communications

Modified CAR T cells targeting membrane-proximal epitope of mesothelin enhances the antitumor function against large solid tumor

(2019) Zhiwei Zhang et al.   Cell Death & Disease

Targeting cardiac fibrosis with engineered T cells

(2019) Haig Aghajanian et al.   NATURE

Enhanced CAR T cell expansion and prolonged persistence in pediatric patients with ALL treated with a low-affinity CD19 CAR

(2019) Sara Ghorashian et al.   NATURE MEDICINE

Size-Dependent Segregation Controls Macrophage Phagocytosis of Antibody-Opsonized Targets

(2018) Matthew H. Bakalar et al.   CELL

Rewiring T-cell responses to soluble factors with chimeric antigen receptors

(2018) ZeNan L Chang et al.   Nature Chemical Biology

Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity

(2018) A. J. Davenport et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of B-cell co-receptor CD19 in complex with antibody B43 reveals an unexpected fold

(2018) Alexey Teplyakov et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Spatial control of Draper receptor signaling initiates apoptotic cell engulfment

(2018) Adam P. Williamson et al.   JOURNAL OF CELL BIOLOGY

Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency

(2018) Judith Feucht et al.   NATURE MEDICINE

CD45 exclusion– and cross-linking–based receptor signaling together broaden FcεRI reactivity

(2018) James H. Felce et al.   Science Signaling

A Rational Strategy for Reducing On-Target Off-Tumor Effects of CD38-Chimeric Antigen Receptors by Affinity Optimization

(2017) Esther Drent et al.   MOLECULAR THERAPY

Balance of Anti-CD123 Chimeric Antigen Receptor Binding Affinity and Density for the Targeting of Acute Myeloid Leukemia

(2017) Silvia Arcangeli et al.   MOLECULAR THERAPY

Engineering HIV-Resistant, Anti-HIV Chimeric Antigen Receptor T Cells

(2017) Malika Hale et al.   MOLECULAR THERAPY

In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase

(2017) Catherine B. Carbone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular basis of human CD22 function and therapeutic targeting

(2017) June Ereño-Orbea et al.   Nature Communications

Supraphysiologic control over HIV-1 replication mediated by CD8 T cells expressing a re-engineered CD4-based chimeric antigen receptor

(2017) Rachel S. Leibman et al.   PLoS Pathogens

Signaling and Polarized Communication Across the T Cell Immunological Synapse

(2016) Michael L. Dustin et al.   Annual Review of Cell and Developmental Biology

Initiation of T cell signaling by CD45 segregation at 'close contacts'

(2016) Veronica T Chang et al.   NATURE IMMUNOLOGY

Size-dependent protein segregation at membrane interfaces

(2016) Eva M. Schmid et al.   Nature Physics

Reengineering chimeric antigen receptor T cells for targeted therapy of autoimmune disease

(2016) C. T. Ellebrecht et al.   SCIENCE

A T-cell-directed chimeric antigen receptor for the selective treatment of T-cell malignancies

(2015) M. Mamonkin et al.   BLOOD

Affinity-Tuned ErbB2 or EGFR Chimeric Antigen Receptor T Cells Exhibit an Increased Therapeutic Index against Tumors in Mice

(2015) X. Liu et al.   CANCER RESEARCH

Tuning Sensitivity of CAR to EGFR Density Limits Recognition of Normal Tissue While Maintaining Potent Antitumor Activity

(2015) H. G. Caruso et al.   CANCER RESEARCH

Inclusion of an IgG1-Fc spacer abrogates efficacy of CD19 CAR T cells in a xenograft mouse model

(2015) H Almåsbak et al.   GENE THERAPY

Chimeric Antigen Receptors With Mutated IgG4 Fc Spacer Avoid Fc Receptor Binding and Improve T Cell Persistence and Antitumor Efficacy

(2015) Mahesh Jonnalagadda et al.   MOLECULAR THERAPY

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

(2015) Adrienne H Long et al.   NATURE MEDICINE

Putting together structures of epidermal growth factor receptors

(2014) Nicholas J Bessman et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Retargeting of Human T Cells to Tumor-Associated MUC1: The Evolution of a Chimeric Antigen Receptor

(2014) S. Wilkie et al.   JOURNAL OF IMMUNOLOGY

Antigen Sensitivity of CD22-Specific Chimeric TCR Is Modulated by Target Epitope Distance from the Cell Membrane

(2014) S. E. James et al.   JOURNAL OF IMMUNOLOGY

The Nonsignaling Extracellular Spacer Domain of Chimeric Antigen Receptors Is Decisive for In Vivo Antitumor Activity

(2014) M. Hudecek et al.   Cancer Immunology Research

Chimeric Antigen Receptor–Modified T Cells for Acute Lymphoid Leukemia

(2013) Stephan A. Grupp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Anti-CD22-chimeric antigen receptors targeting B-cell precursor acute lymphoblastic leukemia

(2012) W. Haso et al.   BLOOD

Biophysical mechanism of T-cell receptor triggering in a reconstituted system

(2012) John R. James et al.   NATURE

Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia

(2011) David L. Porter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and characterization of fully human anti-CD22 monoclonal antibodies

(2010) Xiaodong Xiao et al.   mAbs

Modular Design of Immunological Synapses and Kinapses

(2009) M. L. Dustin   Cold Spring Harbor Perspectives in Biology

Redirection of Regulatory T Cells With Predetermined Specificity for the Treatment of Experimental Colitis in Mice

(2008) Eran Elinav et al.   GASTROENTEROLOGY