Epigenetically suppressed tumor cell intrinsic STING promotes tumor immune escape

Epigenetic STING silencing is developmentally conserved in gliomas and can be rescued by methyltransferase inhibition

(2022) Justin T. Low et al.   CANCER CELL

IFN-γ activates the tumor cell-intrinsic STING pathway through the induction of DNA damage and cytosolic dsDNA formation

(2022) Hui Xiong et al.   OncoImmunology

5‐Fluorouracil efficacy requires anti‐tumor immunity triggered by cancer‐cell‐intrinsic STING

(2021) Jingru Tian et al.   EMBO JOURNAL

The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING–IFN-β pathway

(2021) Mariko Takahashi et al.   NATURE IMMUNOLOGY

Epigenetic reprogramming of tumor cell–intrinsic STING function sculpts antigenicity and T cell recognition of melanoma

(2021) Rana Falahat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STING Agonists as Cancer Therapeutics

(2021) Afsaneh Amouzegar et al.   Cancers

LncRNA NEAT1 Interacted With DNMT1 to Regulate Malignant Phenotype of Cancer Cell and Cytotoxic T Cell Infiltration via Epigenetic Inhibition of p53, cGAS, and STING in Lung Cancer

(2020) Fang Ma et al.   Frontiers in Genetics

Galectin-9 promotes a suppressive microenvironment in human cancer by enhancing STING degradation

(2020) Chuan-xia Zhang et al.   Oncogenesis

HER2 recruits AKT1 to disrupt STING signalling and suppress antiviral defence and antitumour immunity

(2019) Shiying Wu et al.   NATURE CELL BIOLOGY

Cancer-Cell-Intrinsic cGAS Expression Mediates Tumor Immunogenicity

(2019) Linda Schadt et al.   Cell Reports

Mitigating SOX2-potentiated Immune Escape of Head and Neck Squamous Cell Carcinoma with a STING-inducing Nanosatellite Vaccine

(2018) Yee Sun Tan et al.   CLINICAL CANCER RESEARCH

Suppression of STING signaling through epigenetic silencing and missense mutation impedes DNA damage mediated cytokine production

(2018) Hiroyasu Konno et al.   ONCOGENE

KDM5 histone demethylases repress immune response via suppression of STING

(2018) Lizhen Wu et al.   PLOS BIOLOGY

Tumor-Derived cGAMP Triggers a STING-Mediated Interferon Response in Non-tumor Cells to Activate the NK Cell Response

(2018) Assaf Marcus et al.   IMMUNITY

Suppression of STING Associated with LKB1 Loss in KRAS-Driven Lung Cancer

(2018) Shunsuke Kitajima et al.   Cancer Discovery

Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity

(2018) Kelsey E. Sivick et al.   Cell Reports

Extrachromosomal telomere repeat DNA is linked to ALT development via cGAS-STING DNA sensing pathway

(2017) Yi-An Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Extrachromosomal telomere repeat DNA is linked to ALT development via cGAS-STING DNA sensing pathway

(2017) Yi-An Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lead optimization of a pyrazolo[1,5-a]pyrimidin-7(4H)-one scaffold to identify potent, selective and orally bioavailable KDM5 inhibitors suitable for in vivo biological studies

(2016) Jun Liang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Recurrent Loss of STING Signaling in Melanoma Correlates with Susceptibility to Viral Oncolysis

(2016) Tianli Xia et al.   CANCER RESEARCH

Carcinoma–astrocyte gap junctions promote brain metastasis by cGAMP transfer

(2016) Qing Chen et al.   NATURE

Deregulation of STING Signaling in Colorectal Carcinoma Constrains DNA Damage Responses and Correlates With Tumorigenesis

(2016) Tianli Xia et al.   Cell Reports

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

(2015) Leticia Corrales et al.   Cell Reports

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

Activated STING in a Vascular and Pulmonary Syndrome

(2014) Yin Liu et al.   NEW ENGLAND JOURNAL OF MEDICINE

E2 Proteins of High Risk Human Papillomaviruses Down-Modulate STING and IFN-κ Transcription in Keratinocytes

(2014) Nuchsupha Sunthamala et al.   PLoS One

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE