Triptolide Synergistically Enhances Temozolomide-Induced Apoptosis and Potentiates Inhibition of NF-κB Signaling in Glioma Initiating Cells

High-Throughput Chemical Screens Identify Disulfiram as an Inhibitor of Human Glioblastoma Stem Cells

(2015) Parvinder Hothi et al.   Oncotarget

Triptolide-mediated cell death in neuroblastoma occurs by both apoptosis and autophagy pathways and results in inhibition of nuclear factor–kappa B activity

(2013) Tara C.K. Krosch et al.   AMERICAN JOURNAL OF SURGERY

Herbal compound triptolide synergistically enhanced antitumor activity of amino-terminal fragment of urokinase

(2013) Yuli Lin et al.   Molecular Cancer

Triptolide Induces the Expression of miR-142-3p: A Negative Regulator of Heat Shock Protein 70 and Pancreatic Cancer Cell Proliferation

(2013) T. N. MacKenzie et al.   MOLECULAR CANCER THERAPEUTICS

Triptolide increases transcript and protein levels of survival motor neurons in human SMA fibroblasts and improves survival in SMA-like mice

(2012) Ya-Yun Hsu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Glioblastoma Cancer Stem-Like Cells

(2012) Edjah Kweku-Ebura Nduom et al.   CANCER JOURNAL

Synergistic anticancer activity of triptolide combined with cisplatin enhances apoptosis in gastric cancer in vitro and in vivo

(2012) Chia-Jung Li et al.   CANCER LETTERS

Triptolide with Potential Medicinal Value for Diseases of the Central Nervous System

(2012) Yan Zheng et al.   CNS Neuroscience & Therapeutics

NF-κB and the link between inflammation and cancer

(2012) Joseph A. DiDonato et al.   IMMUNOLOGICAL REVIEWS

Induction of cell-cycle arrest and apoptosis in glioblastoma stem-like cells by WP1193, a novel small molecule inhibitor of the JAK2/STAT3 pathway

(2012) Ke Sai et al.   JOURNAL OF NEURO-ONCOLOGY

Triptolide inhibits proliferation and invasion of malignant glioma cells

(2012) Haipeng Zhang et al.   JOURNAL OF NEURO-ONCOLOGY

Triptolide: structural modifications, structure–activity relationships, bioactivities, clinical development and mechanisms

(2012) Zhao-Li Zhou et al.   NATURAL PRODUCT REPORTS

CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2005-2009

(2012) T. A. Dolecek et al.   NEURO-ONCOLOGY

Triptolide Cooperates With Cisplatin to Induce Apoptosis in Gemcitabine-Resistant Pancreatic Cancer

(2012) Wenbo Zhu et al.   PANCREAS

Adult glioblastoma multiforme survival in the temozolomide era: A population-based analysis of Surveillance, Epidemiology, and End Results registries

(2011) Amy S. Darefsky et al.   CANCER

Involvement of MKP-1 and Bcl-2 in acquired cisplatin resistance in ovarian cancer cells

(2011) Juan Wang et al.   CELL CYCLE

The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy

(2011) P N Kelly et al.   CELL DEATH AND DIFFERENTIATION

Chemoresistance of glioblastoma cancer stem cells - much more complex than expected

(2011) Dagmar Beier et al.   Molecular Cancer

A Molecular Screening Approach to Identify and Characterize Inhibitors of Glioblastoma Stem Cells

(2011) K. Visnyei et al.   MOLECULAR CANCER THERAPEUTICS

Triptolide circumvents drug-resistant effect and enhances 5-fluorouracil antitumor effect on KB cells

(2010) Yuan-Wu Chen et al.   ANTI-CANCER DRUGS

NFκB inhibitors induce cell death in glioblastomas

(2010) Alfeu Zanotto-Filho et al.   BIOCHEMICAL PHARMACOLOGY

X-linked Inhibitor of Apoptosis: A Chemoresistance Factor or a Hollow Promise

(2010) H. Kashkar   CLINICAL CANCER RESEARCH

Vasculogenic mimicry–potential target for glioblastoma therapy: an in vitro and in vivo study

(2010) Yinsheng Chen et al.   MEDICAL ONCOLOGY

NFκB signaling in carcinogenesis and as a potential molecular target for cancer therapy

(2009) Han-Ming Shen et al.   APOPTOSIS

Triptolide simultaneously induces reactive oxygen species, inhibits NF-κB activity and sensitizes 5-fluorouracil in colorectal cancer cell lines

(2009) Bing Xu et al.   CANCER LETTERS

Glioma Stem Cell Lines Expanded in Adherent Culture Have Tumor-Specific Phenotypes and Are Suitable for Chemical and Genetic Screens

(2009) Steven M. Pollard et al.   Cell Stem Cell

Triptolide Inhibits Bcr-Abl Transcription and Induces Apoptosis in STI571-resistant Chronic Myelogenous Leukemia Cells Harboring T315I Mutation

(2009) X. Shi et al.   CLINICAL CANCER RESEARCH

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Triptolide cooperates with chemotherapy to induce apoptosis in acute myeloid leukemia cells

(2008) Arnaud Pigneux et al.   EXPERIMENTAL HEMATOLOGY

Expression of nuclear factor-κB in human astrocytomas: relation to pIκBa, vascular endothelial growth factor, Cox-2, microvascular characteristics, and survival

(2008) Penelope Korkolopoulou et al.   HUMAN PATHOLOGY

Correlation of O6-Methylguanine Methyltransferase (MGMT) Promoter Methylation With Clinical Outcomes in Glioblastoma and Clinical Strategies to Modulate MGMT Activity

(2008) Monika E. Hegi et al.   JOURNAL OF CLINICAL ONCOLOGY

Induction of MGMT expression is associated with temozolomide resistance in glioblastoma xenografts

(2008) Gaspar J. Kitange et al.   NEURO-ONCOLOGY

Cancer-specific enhancement of cisplatin-induced cytotoxicity with triptolide through an interaction of inactivated glycogen synthase kinase-3β with p53

(2008) Y Matsui et al.   ONCOGENE

Cancer stem cells and glioma

(2008) Sunit Das et al.   Nature clinical practice. Neurology