Triptolide with Potential Medicinal Value for Diseases of the Central Nervous System

Novel Anti-Inflammatory and Neuroprotective Agents for Parkinsons Disease

(2012) Li Lu et al.   CNS & Neurological Disorders-Drug Targets

Effects of triptolide on the synaptophysin expression of hippocampal neurons in the AD cellular model

(2012) Jing Nie et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Triptolide: structural modifications, structure–activity relationships, bioactivities, clinical development and mechanisms

(2012) Zhao-Li Zhou et al.   NATURAL PRODUCT REPORTS

Anti-inflammatory and neuroprotective effects of triptolide on traumatic brain injury in rats

(2012) Hung-Fu Lee et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Triptolide protects mice from ischemia/reperfusion injury by inhibition of IL-17 production

(2011) Chuanxing Wu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Triptolide and its expanding multiple pharmacological functions

(2011) Qiuyan Liu   INTERNATIONAL IMMUNOPHARMACOLOGY

Anti-Parkinsonian drug discovery from herbal medicines: What have we got from neurotoxic models?

(2011) Ju-Xian Song et al.   JOURNAL OF ETHNOPHARMACOLOGY

XPB, a subunit of TFIIH, is a target of the natural product triptolide

(2011) Denis V Titov et al.   Nature Chemical Biology

Priorities in Parkinson's disease research

(2011) Wassilios G. Meissner et al.   NATURE REVIEWS DRUG DISCOVERY

Triptolide (TPL) Inhibits Global Transcription by Inducing Proteasome-Dependent Degradation of RNA Polymerase II (Pol II)

(2011) Ying Wang et al.   PLoS One

Extract of Tripterygium wilfordii Hook F Protect Dopaminergic Neurons Against Lipopolysaccharide-Induced Inflammatory Damage

(2010) Yuxin Liu et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Triptolide: An inhibitor of a disintegrin and metalloproteinase 10 (ADAM10) in cancer cells

(2010) Ramani Soundararajan et al.   CANCER BIOLOGY & THERAPY

RNA polymerase – An important molecular target of triptolide in cancer cells

(2010) Jingxuan Pan   CANCER LETTERS

Report of 12 cases of ankylosing spondylitis patients treated with Tripterygium wilfordii

(2010) Wei Ji et al.   CLINICAL RHEUMATOLOGY

Role of triptolide in cell proliferation, cell cycle arrest, apoptosis and histone methylation in multiple myeloma U266 cells

(2010) Fei Zhao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Triptolide Induces Cell Death in Pancreatic Cancer Cells by Apoptotic and Autophagic Pathways

(2010) Nameeta Mujumdar et al.   GASTROENTEROLOGY

Triptolide promotes spinal cord repair by inhibiting astrogliosis and inflammation

(2010) Zhida Su et al.   GLIA

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

Triptolide functions as a potent angiogenesis inhibitor

(2009) Ming-Fang He et al.   INTERNATIONAL JOURNAL OF CANCER

Protective and therapeutic effect of triptolide in EAE explained by induction of major stress protein HSP70

(2009) Willem van Eden   JOURNAL OF NEUROIMMUNOLOGY

Oral administration of triptolide ameliorates the clinical signs of experimental autoimmune encephalomyelitis (EAE) by induction of HSP70 and stabilization of NF-κB/IκBα transcriptional complex

(2009) Pablo Kizelsztein et al.   JOURNAL OF NEUROIMMUNOLOGY

Triptolide is an inhibitor of RNA polymerase I and II-dependent transcription leading predominantly to down-regulation of short-lived mRNA

(2009) S. Vispe et al.   MOLECULAR CANCER THERAPEUTICS

Effects of triptolide from Tripterygium wilfordii on ERα and p53 expression in two human breast cancer cell lines

(2009) Jing Liu et al.   PHYTOMEDICINE

Triptolide alters histone H3K9 and H3K27 methylation state and induces G0/G1 arrest and caspase-dependent apoptosis in multiple myeloma in vitro

(2009) Fei Zhao et al.   TOXICOLOGY

Triptolide inhibits COX-2 expression and PGE2release by suppressing the activity of NF-κB and JNK in LPS-treated microglia

(2008) Yuntao Gong et al.   JOURNAL OF NEUROCHEMISTRY

Triptolide modulates T-cell inflammatory responses and ameliorates experimental autoimmune encephalomyelitis

(2008) Ying Wang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Therapeutic Strategies for Parkinson’s Disease: The Ancient Meets the Future—Traditional Chinese Herbal Medicine, Electroacupuncture, Gene Therapy and Stem Cells

(2008) Xuan Wang et al.   NEUROCHEMICAL RESEARCH

Triptolide protects against 1-methyl-4-phenyl pyridinium-induced dopaminergic neurotoxicity in rats: Implication for immunosuppressive therapy in Parkinson’s disease

(2008) Jun-Peng Gao et al.   Neuroscience Bulletin