Does ‘Strong Analgesic’ Equal ‘Strong Opioid’? Tapentadol and the Concept of ‘µ-Load’

Mechanistic evaluation of tapentadol in reducing the pain perception using in-vivo brain and spinal cord microdialysis in rats

(2017) Vijay Benade et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Prediction of response to tapentadol in chronic low back pain

(2016) M. Reimer et al.   EUROPEAN JOURNAL OF PAIN

Efficacy and Safety of Tapentadol Immediate Release Assessment in Treatment of Moderate to Severe Pain: A Systematic Review and Meta-Analysis

(2016) Jing-Ping Xiao et al.   PAIN MEDICINE

A Pooled Analysis Evaluating the Efficacy and Tolerability of Tapentadol Extended Release for Chronic, Painful Diabetic Peripheral Neuropathy

(2014) Sherwyn Schwartz et al.   CLINICAL DRUG INVESTIGATION

The Mu-Opioid Receptor Agonist/Noradrenaline Reuptake Inhibition (MOR–NRI) Concept in Analgesia: The Case of Tapentadol

(2014) Thomas M. Tzschentke et al.   CNS DRUGS

On subclasses of opioid analgesics

(2014) Robert B. Raffa   CURRENT MEDICAL RESEARCH AND OPINION

Lack of synergistic interaction between the two mechanisms of action of tapentadol in gastrointestinal transit

(2014) A. Cowan et al.   EUROPEAN JOURNAL OF PAIN

The Fentanyl Story

(2014) Theodore H. Stanley   JOURNAL OF PAIN

Bowel Function After Tapentadol and Oxycodone Immediate Release (IR) Treatment in Patients With Low Back or Osteoarthritis Pain

(2013) Winghan J. Kwong et al.   CLINICAL JOURNAL OF PAIN

Efficacy and safety of oral tapentadol extended release in Japanese and Korean patients with moderate to severe, chronic malignant tumor-related pain

(2013) Keiichiro Imanaka et al.   CURRENT MEDICAL RESEARCH AND OPINION

Effectiveness and safety of tapentadol prolonged release for severe, chronic low back pain with or without a neuropathic pain component: results of an open-label, phase 3b study

(2012) Ilona Steigerwald et al.   CURRENT MEDICAL RESEARCH AND OPINION

Mechanistic and functional differentiation of tapentadol and tramadol

(2012) Robert B Raffa et al.   EXPERT OPINION ON PHARMACOTHERAPY

Chronic pain – moving from symptom control to mechanism-based treatment

(2011) Joseph Pergolizzi   CURRENT MEDICAL RESEARCH AND OPINION

Systematic review of tapentadol in chronic severe pain

(2011) Rob Riemsma et al.   CURRENT MEDICAL RESEARCH AND OPINION

Synergistic Interaction between the Two Mechanisms of Action of Tapentadol in Analgesia

(2011) W. Schroder et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Pathophysiology of postoperative pain

(2011) Timothy J. Brennan   PAIN

Current Considerations for the Treatment of Severe Chronic Pain: The Potential for Tapentadol

(2011) Joseph Pergolizzi et al.   Pain Practice

Efficacy and safety of tapentadol prolonged release for chronic osteoarthritis pain and low back pain

(2010) Bernd Lange et al.   ADVANCES IN THERAPY

Efficacy and Safety of Tapentadol Extended Release Compared with Oxycodone Controlled Release for the Management of Moderate to Severe Chronic Pain Related to Osteoarthritis of the Knee

(2010) Marc Afilalo et al.   CLINICAL DRUG INVESTIGATION

Tapentadol hydrochloride: A centrally acting oral analgesic

(2010) William E. Wade et al.   CLINICAL THERAPEUTICS

On deriving the dose–effect relation of an unknown second component: An example using buprenorphine preclinical data

(2010) Ronald J. Tallarida et al.   DRUG AND ALCOHOL DEPENDENCE

Tapentadol and its two mechanisms of action: Is there a new pharmacological class of centrally-acting analgesics on the horizon?

(2010) Hans G. Kress   EUROPEAN JOURNAL OF PAIN

Differential contribution of opioid and noradrenergic mechanisms of tapentadol in rat models of nociceptive and neuropathic pain

(2010) Wolfgang Schröder et al.   EUROPEAN JOURNAL OF PAIN

Efficacy and safety of tapentadol extended release for the management of chronic low back pain: results of a prospective, randomized, double-blind, placebo- and active-controlled Phase III study

(2010) Robert Buynak et al.   EXPERT OPINION ON PHARMACOTHERAPY

Polypharmacology Directed Compound Data Mining: Identification of Promiscuous Chemotypes with Different Activity Profiles and Comparison to Approved Drugs

(2010) Ye Hu et al.   Journal of Chemical Information and Modeling

Central modulation of pain

(2010) Michael H. Ossipov et al.   JOURNAL OF CLINICAL INVESTIGATION

In vitro and in vivo characterization of tapentadol metabolites

(2010) R. Terlinden et al.   METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY

Long-term Safety and Tolerability of Tapentadol Extended Release for the Management of Chronic Low Back Pain or Osteoarthritis Pain

(2010) James E. Wild et al.   Pain Practice

Identification of an additional supraspinal component to the analgesic mechanism of action of buprenorphine

(2009) Zhe Ding et al.   BRITISH JOURNAL OF PHARMACOLOGY

Efficacy and tolerability of tapentadol immediate release and oxycodone HCl immediate release in patients awaiting primary joint replacement surgery for end-stage joint disease: A 10-day, phase III, randomized, double-blind, active- and placebo-controlled study

(2009) Craig Hartrick et al.   CLINICAL THERAPEUTICS

A randomized, double-blind, phase III study comparing multiple doses of tapentadol IR, oxycodone IR, and placebo for postoperative (bunionectomy) pain

(2009) Stephen E. Daniels et al.   CURRENT MEDICAL RESEARCH AND OPINION

Tolerability of tapentadol immediate release in patients with lower back pain or osteoarthritis of the hip or knee over 90 days: a randomized, double-blind study

(2009) Martin Hale et al.   CURRENT MEDICAL RESEARCH AND OPINION

Tapentadol, but not morphine, selectively inhibits disease-related thermal hyperalgesia in a mouse model of diabetic neuropathic pain

(2009) Thomas Christoph et al.   NEUROSCIENCE LETTERS

The efficacy and tolerability of multiple-dose tapentadol immediate release for the relief of acute pain following orthopedic (bunionectomy) surgery

(2008) Jens-Ulrich Stegmann et al.   CURRENT MEDICAL RESEARCH AND OPINION