Lack of synergistic interaction between the two mechanisms of action of tapentadol in gastrointestinal transit

Post Hoc Analyses of Data from a 90-Day Clinical Trial Evaluating the Tolerability and Efficacy of Tapentadol Immediate Release and Oxycodone Immediate Release for the Relief of Moderate to Severe Pain in Elderly and Nonelderly Patients

(2016) Gary Vorsanger et al.   Pain Research & Management

Tapentadol Extended Release for Chronic Pain Patients

(2013) Robert Taylor et al.   ADVANCES IN THERAPY

Bowel Function After Tapentadol and Oxycodone Immediate Release (IR) Treatment in Patients With Low Back or Osteoarthritis Pain

(2013) Winghan J. Kwong et al.   CLINICAL JOURNAL OF PAIN

Systematic review of tapentadol in chronic severe pain

(2011) Rob Riemsma et al.   CURRENT MEDICAL RESEARCH AND OPINION

A brief comparison of the pathophysiology of inflammatory versus neuropathic pain

(2011) Qinghao Xu et al.   Current Opinion in Anesthesiology

Synergistic antihypersensitive effects of pregabalin and tapentadol in a rat model of neuropathic pain

(2011) Thomas Christoph et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Synergistic Interaction between the Two Mechanisms of Action of Tapentadol in Analgesia

(2011) W. Schroder et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Pathophysiology of postoperative pain

(2011) Timothy J. Brennan   PAIN

Efficacy and safety of tapentadol prolonged release for chronic osteoarthritis pain and low back pain

(2010) Bernd Lange et al.   ADVANCES IN THERAPY

When does acute pain become chronic?

(2010) C Voscopoulos et al.   BRITISH JOURNAL OF ANAESTHESIA

Efficacy and Safety of Tapentadol Extended Release Compared with Oxycodone Controlled Release for the Management of Moderate to Severe Chronic Pain Related to Osteoarthritis of the Knee

(2010) Marc Afilalo et al.   CLINICAL DRUG INVESTIGATION

Safety and efficacy of tapentadol ER in patients with painful diabetic peripheral neuropathy: results of a randomized-withdrawal, placebo-controlled trial

(2010) Sherwyn Schwartz et al.   CURRENT MEDICAL RESEARCH AND OPINION

Differential contribution of opioid and noradrenergic mechanisms of tapentadol in rat models of nociceptive and neuropathic pain

(2010) Wolfgang Schröder et al.   EUROPEAN JOURNAL OF PAIN

Efficacy and safety of tapentadol extended release for the management of chronic low back pain: results of a prospective, randomized, double-blind, placebo- and active-controlled Phase III study

(2010) Robert Buynak et al.   EXPERT OPINION ON PHARMACOTHERAPY

The Determination and Application of Fixed-Dose Analgesic Combinations for Treating Multimodal Pain

(2010) Robert B. Raffa et al.   JOURNAL OF PAIN

Nociceptor sensitization in pain pathogenesis

(2010) Michael S Gold et al.   NATURE MEDICINE

The application of drug dose equivalence in the quantitative analysis of receptor occupation and drug combinations

(2010) Ronald J. Tallarida et al.   PHARMACOLOGY & THERAPEUTICS

Long-term Safety and Tolerability of Tapentadol Extended Release for the Management of Chronic Low Back Pain or Osteoarthritis Pain

(2010) James E. Wild et al.   Pain Practice

Efficacy and tolerability of tapentadol immediate release and oxycodone HCl immediate release in patients awaiting primary joint replacement surgery for end-stage joint disease: A 10-day, phase III, randomized, double-blind, active- and placebo-controlled study

(2009) Craig Hartrick et al.   CLINICAL THERAPEUTICS

Tolerability of tapentadol immediate release in patients with lower back pain or osteoarthritis of the hip or knee over 90 days: a randomized, double-blind study

(2009) Martin Hale et al.   CURRENT MEDICAL RESEARCH AND OPINION

Tapentadol immediate release for the relief of moderate-to-severe acute pain

(2009) Craig T Hartrick   EXPERT OPINION ON PHARMACOTHERAPY

Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity

(2009) Alban Latremoliere et al.   JOURNAL OF PAIN

Unmasking the tonic-aversive state in neuropathic pain

(2009) Tamara King et al.   NATURE NEUROSCIENCE

Tapentadol, but not morphine, selectively inhibits disease-related thermal hyperalgesia in a mouse model of diabetic neuropathic pain

(2009) Thomas Christoph et al.   NEUROSCIENCE LETTERS

The efficacy and tolerability of multiple-dose tapentadol immediate release for the relief of acute pain following orthopedic (bunionectomy) surgery

(2008) Jens-Ulrich Stegmann et al.   CURRENT MEDICAL RESEARCH AND OPINION