Mechanistic and functional differentiation of tapentadol and tramadol

Clinical Efficacy and Safety of Tapentadol Immediate Release in the Postoperative Setting

(2014) Stephen E. Daniels et al.   JOURNAL OF THE AMERICAN PODIATRIC MEDICAL ASSOCIATION

Tapentadol Extended Release

(2012) Sheridan M. Hoy   DRUGS

Unerwünschte Nebenwirkungen von Tapentadol im Vergleich zu Oxycodon

(2012) M. Merker et al.   SCHMERZ

Systematic review of tapentadol in chronic severe pain

(2011) Rob Riemsma et al.   CURRENT MEDICAL RESEARCH AND OPINION

The role of fragment-based and computational methods in polypharmacology

(2011) Giovanni Bottegoni et al.   DRUG DISCOVERY TODAY

Lessons Learned from Molecular Scaffold Analysis

(2011) Ye Hu et al.   Journal of Chemical Information and Modeling

Synergistic Interaction between the Two Mechanisms of Action of Tapentadol in Analgesia

(2011) W. Schroder et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Treatment of chronic non-cancer pain

(2011) Dennis C Turk et al.   LANCET

Probing the links between in vitro potency, ADMET and physicochemical parameters

(2011) M. Paul Gleeson et al.   NATURE REVIEWS DRUG DISCOVERY

Tramadol increases extracellular levels of serotonin and noradrenaline as measured by in vivo microdialysis in the ventral hippocampus of freely-moving rats

(2011) P. Bloms-Funke et al.   NEUROSCIENCE LETTERS

Thermodynamics of Ligand Binding and Efficiency

(2011) Charles H. Reynolds et al.   ACS Medicinal Chemistry Letters

Efficacy and safety of tapentadol prolonged release for chronic osteoarthritis pain and low back pain

(2010) Bernd Lange et al.   ADVANCES IN THERAPY

Efficacy and Safety of Tapentadol Extended Release Compared with Oxycodone Controlled Release for the Management of Moderate to Severe Chronic Pain Related to Osteoarthritis of the Knee

(2010) Marc Afilalo et al.   CLINICAL DRUG INVESTIGATION

Thermodynamics guided lead discovery and optimization

(2010) György G. Ferenczy et al.   DRUG DISCOVERY TODAY

Tapentadol and its two mechanisms of action: Is there a new pharmacological class of centrally-acting analgesics on the horizon?

(2010) Hans G. Kress   EUROPEAN JOURNAL OF PAIN

Differential contribution of opioid and noradrenergic mechanisms of tapentadol in rat models of nociceptive and neuropathic pain

(2010) Wolfgang Schröder et al.   EUROPEAN JOURNAL OF PAIN

Predicting Polypharmacology by Binding Site Similarity: From Kinases to the Protein Universe

(2010) Francesca Milletti et al.   Journal of Chemical Information and Modeling

Polypharmacology Directed Compound Data Mining: Identification of Promiscuous Chemotypes with Different Activity Profiles and Comparison to Approved Drugs

(2010) Ye Hu et al.   Journal of Chemical Information and Modeling

Molecular Shape and Medicinal Chemistry: A Perspective

(2010) Anthony Nicholls et al.   JOURNAL OF MEDICINAL CHEMISTRY

In vitro and in vivo characterization of tapentadol metabolites

(2010) R. Terlinden et al.   METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY

Opioid Rotation in the Management of Chronic Pain: Where Is the Evidence?

(2010) K.C.P. Vissers et al.   Pain Practice

Efficacy and tolerability of tapentadol immediate release and oxycodone HCl immediate release in patients awaiting primary joint replacement surgery for end-stage joint disease: A 10-day, phase III, randomized, double-blind, active- and placebo-controlled study

(2009) Craig Hartrick et al.   CLINICAL THERAPEUTICS

A randomized, double-blind, phase III study comparing multiple doses of tapentadol IR, oxycodone IR, and placebo for postoperative (bunionectomy) pain

(2009) Stephen E. Daniels et al.   CURRENT MEDICAL RESEARCH AND OPINION

Preclinical and early clinical investigations related to monoaminergic pain modulation

(2009) Kirsty Bannister et al.   Neurotherapeutics

Opioid Metabolism and Effects of Cytochrome P450

(2009) Gregory L. Holmquist   PAIN MEDICINE

Extended-Release Tramadol (ULTRAM??ER): A Pharmacotherapeutic, Pharmacokinetic, and Pharmacodynamic Focus on Effectiveness and Safety in Patients with Chronic/Persistent Pain

(2008) Robert L Barkin   AMERICAN JOURNAL OF THERAPEUTICS

Role of active metabolites in the use of opioids

(2008) Janet K. Coller et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY