The Mu-Opioid Receptor Agonist/Noradrenaline Reuptake Inhibition (MOR–NRI) Concept in Analgesia: The Case of Tapentadol

Mechanistic and functional differentiation of tapentadol and tramadol

(2012) Robert B Raffa et al.   EXPERT OPINION ON PHARMACOTHERAPY

Combination Therapy for Neuropathic Pain

(2011) Yakov Vorobeychik et al.   CNS DRUGS

The role of fragment-based and computational methods in polypharmacology

(2011) Giovanni Bottegoni et al.   DRUG DISCOVERY TODAY

Synergistic antihypersensitive effects of pregabalin and tapentadol in a rat model of neuropathic pain

(2011) Thomas Christoph et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Adjuvant analgesics in acute pain

(2011) Frances Lui et al.   EXPERT OPINION ON PHARMACOTHERAPY

Synergistic Interaction between the Two Mechanisms of Action of Tapentadol in Analgesia

(2011) W. Schroder et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The antinociceptive and antihyperalgesic effect of tapentadol is partially retained in OPRM1 (μ-opioid receptor) knockout mice

(2011) Babette Kögel et al.   NEUROSCIENCE LETTERS

Tapentadol increases levels of noradrenaline in the rat spinal cord as measured by in vivo microdialysis

(2011) Thomas M. Tzschentke et al.   NEUROSCIENCE LETTERS

Spinal 5-HT7 Receptors Play an Important Role in the Antinociceptive and Antihyperalgesic Effects of Tramadol and Its Metabolite, O-Desmethyltramadol, via Activation of Descending Serotonergic Pathways

(2010) Omer Yanarates et al.   ANESTHESIOLOGY

Pharmacotherapy of low back pain: targeting nociceptive and neuropathic pain components

(2010) Bart Morlion   CURRENT MEDICAL RESEARCH AND OPINION

Differential contribution of opioid and noradrenergic mechanisms of tapentadol in rat models of nociceptive and neuropathic pain

(2010) Wolfgang Schröder et al.   EUROPEAN JOURNAL OF PAIN

A greater role for the norepinephrine transporter than the serotonin transporter in murine nociception

(2010) F.S. Hall et al.   NEUROSCIENCE

Mu-opioid and noradrenergic α2-adrenoceptor contributions to the effects of tapentadol on spinal electrophysiological measures of nociception in nerve-injured rats

(2010) Lucy A. Bee et al.   PAIN

Central sensitization: Implications for the diagnosis and treatment of pain

(2010) Clifford J. Woolf   PAIN

Antiallodynic and Antihyperalgesic Effect of Milnacipran in Mice with Spinal Nerve Ligation

(2009) Takahiro Suzuki et al.   ANESTHESIA AND ANALGESIA

The Synergistic Interaction Between Morphine and Maprotiline After Intrathecal Injection in Rats

(2009) Vera L. A. Pettersen et al.   ANESTHESIA AND ANALGESIA

Neuropathic Pain: A Maladaptive Response of the Nervous System to Damage

(2009) Michael Costigan et al.   Annual Review of Neuroscience

Tapentadol, but not morphine, selectively inhibits disease-related thermal hyperalgesia in a mouse model of diabetic neuropathic pain

(2009) Thomas Christoph et al.   NEUROSCIENCE LETTERS

Preclinical and early clinical investigations related to monoaminergic pain modulation

(2009) Kirsty Bannister et al.   Neurotherapeutics

The nociceptin/orphanin FQ receptor: a target with broad therapeutic potential

(2008) David G. Lambert   NATURE REVIEWS DRUG DISCOVERY

Descending monoaminergic pain modulation: Bidirectional control and clinical relevance

(2008) E. E. Benarroch   NEUROLOGY