Role of Protein Tyrosine Phosphatases in Regulating the Immune System

PTPN2 restrains CD8+ T cell responses after antigen cross-presentation for the maintenance of peripheral tolerance in mice

(2014) Florian Wiede et al.   JOURNAL OF AUTOIMMUNITY

PTPN22 Controls the Germinal Center by Influencing the Numbers and Activity of T Follicular Helper Cells

(2014) C. J. Maine et al.   JOURNAL OF IMMUNOLOGY

The tyrosine phosphatase PTPN22 discriminates weak self peptides from strong agonist TCR signals

(2014) Robert J Salmond et al.   NATURE IMMUNOLOGY

PTPN22: the archetypal non-HLA autoimmunity gene

(2014) Stephanie M. Stanford et al.   Nature Reviews Rheumatology

Role of the Protein Tyrosine Phosphatase Shp2 in Homeostasis of the Intestinal Epithelium

(2014) Hironori Yamashita et al.   PLoS One

PTPN2 attenuates T-cell lymphopenia-induced proliferation

(2014) Florian Wiede et al.   Nature Communications

PTPN2 is Associated with Crohn’s Disease and Its Expression Is Regulated by NKX2-3

(2013) Wei Yu et al.   DISEASE MARKERS

Association of ZAP70 and PTPN6, but Not BANK1 or CLEC2D, with Inflammatory Bowel Disease in the Tunisian Population

(2013) Dorra Bouzid et al.   Genetic Testing and Molecular Biomarkers

The Autoimmunity-Associated Gene PTPN22 Potentiates Toll-like Receptor-Driven, Type 1 Interferon-Dependent Immunity

(2013) Yaya Wang et al.   IMMUNITY

Association Between the PTPN2 Gene and Crohnʼs Disease

(2013) Valerie Marcil et al.   INFLAMMATORY BOWEL DISEASES

A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models

(2013) Xuezhi Dai et al.   JOURNAL OF CLINICAL INVESTIGATION

PTPN22 Modulates Macrophage Polarization and Susceptibility to Dextran Sulfate Sodium-Induced Colitis

(2013) H.-H. Chang et al.   JOURNAL OF IMMUNOLOGY

Epithelial Tyrosine Phosphatase SHP-2 Protects against Intestinal Inflammation in Mice

(2013) G. Coulombe et al.   MOLECULAR AND CELLULAR BIOLOGY

Protein Tyrosine Phosphatase 1B Deficiency Ameliorates Murine Experimental Colitis via the Expansion of Myeloid-Derived Suppressor Cells

(2013) Jing Zhang et al.   PLoS One

Regulation of epithelial barrier function by the inflammatory bowel disease candidate gene, PTPN2

(2012) Declan F. McCole   Annals of the New York Academy of Sciences

The tyrosine phosphatase SHP-1 dampens murine Th17 development

(2012) I. S. Mauldin et al.   BLOOD

PTPN22 Silencing in the NOD Model Indicates the Type 1 Diabetes-Associated Allele Is Not a Loss-of-Function Variant

(2012) P. Zheng et al.   DIABETES

PTP1B and TCPTP - nonredundant phosphatases in insulin signaling and glucose homeostasis

(2012) Tony Tiganis   FEBS Journal

Selective Sequestration of STAT1 in the Cytoplasm via Phosphorylated SHP-2 Ameliorates Murine Experimental Colitis

(2012) X. Wu et al.   JOURNAL OF IMMUNOLOGY

PTPN2 Gene Variants Are Associated with Susceptibility to Both Crohn's Disease and Ulcerative Colitis Supporting a Common Genetic Disease Background

(2012) Jürgen Glas et al.   PLoS One

Strain-Dependent Differences in Bone Development, Myeloid Hyperplasia, Morbidity and Mortality in Ptpn2-Deficient Mice

(2012) Florian Wiede et al.   PLoS One

Lack of the Phosphatase PTPN22 Increases Adhesion of Murine Regulatory T Cells to Improve Their Immunosuppressive Function

(2012) R. J. Brownlie et al.   Science Signaling

New IBD genetics: common pathways with other diseases

(2011) C. W. Lees et al.   GUT

Differential association of two PTPN22 coding variants with Crohnʼs disease and ulcerative colitis

(2011) Lina-Marcela Diaz-Gallo et al.   INFLAMMATORY BOWEL DISEASES

Loss of downregulated in adenoma (DRA) impairs mucosal HCO3− secretion in murine ileocolonic inflammation

(2011) Fang Xiao et al.   INFLAMMATORY BOWEL DISEASES

Protein Tyrosine Phosphatase Nonreceptor Type 2 Regulates Autophagosome Formation in Human Intestinal Cells

(2011) Michael Scharl et al.   INFLAMMATORY BOWEL DISEASES

Crohnʼs disease-associated polymorphism within the PTPN2 gene affects muramyl-dipeptide-induced cytokine secretion and autophagy

(2011) Michael Scharl et al.   INFLAMMATORY BOWEL DISEASES

T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice

(2011) Florian Wiede et al.   JOURNAL OF CLINICAL INVESTIGATION

The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans

(2011) Laurence Menard et al.   JOURNAL OF CLINICAL INVESTIGATION

Altered B Cell Homeostasis Is Associated with Type I Diabetes and Carriers of the PTPN22 Allelic Variant

(2011) T. Habib et al.   JOURNAL OF IMMUNOLOGY

The autoimmune disease–associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness

(2011) Jinyi Zhang et al.   NATURE GENETICS

Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47

(2011) Carl A Anderson et al.   NATURE GENETICS

Susceptibility loci reported in genome-wide association studies are associated with Crohn’s disease in Canadian children

(2010) D. K. AMRE et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Loss of protein tyrosine phosphatase N2 potentiates epidermal growth factor suppression of intestinal epithelial chloride secretion

(2010) Michael Scharl et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The PTPN22 R263Q polymorphism is a risk factor for rheumatoid arthritis in Caucasian case-control samples

(2010) Luis Rodríguez-Rodríguez et al.   ARTHRITIS AND RHEUMATISM

Protein tyrosine phosphatase N2 regulates TNF -induced signalling and cytokine secretion in human intestinal epithelial cells

(2010) M. Scharl et al.   GUT

Protein Tyrosine Phosphatase non-Receptor Type 2 regulates IFN-γ-induced cytokine signaling in THP-1 monocytes

(2010) Michael Scharl et al.   INFLAMMATORY BOWEL DISEASES

Distinct and overlapping genetic loci in crohnʼs disease and ulcerative colitis: Correlations with pathogenesis

(2010) Matti Waterman et al.   INFLAMMATORY BOWEL DISEASES

Epithelial Myosin Light Chain Kinase Activation Induces Mucosal Interleukin-13 Expression to Alter Tight Junction Ion Selectivity

(2010) Christopher R. Weber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autoimmune-associated PTPN22 R620W Variation Reduces Phosphorylation of Lymphoid Phosphatase on an Inhibitory Tyrosine Residue

(2010) Edoardo Fiorillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci

(2010) Andre Franke et al.   NATURE GENETICS

Increased Susceptibility to Dextran Sulfate Sodium Induced Colitis in the T Cell Protein Tyrosine Phosphatase Heterozygous Mouse

(2010) Syed-Wajahat Hassan et al.   PLoS One

Comprehensive Expression Profiles of Genes for Protein Tyrosine Phosphatases in Immune Cells

(2010) Y. Arimura et al.   Science Signaling

Confirmation of Multiple Crohn's Disease Susceptibility Loci in a Large Dutch–Belgian Cohort

(2009) Rinse K Weersma et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

T-cell protein tyrosine phosphatase is a key regulator in immune cell signaling: lessons from the knockout mouse model and implications in human disease

(2009) Karen M. Doody et al.   IMMUNOLOGICAL REVIEWS

Polymorphisms of PTPN11 Coding SHP-2 as Biomarkers for Ulcerative Colitis Susceptibility in the Japanese Population

(2009) Yukiko Narumi et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation

(2009) Rachel Cooney et al.   NATURE MEDICINE

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus

(2008) V. Orru et al.   HUMAN MOLECULAR GENETICS

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis

(2008) Andre Franke et al.   NATURE GENETICS

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

Shared and Distinct Genetic Variants in Type 1 Diabetes and Celiac Disease

(2008) Deborah J. Smyth et al.   NEW ENGLAND JOURNAL OF MEDICINE