Harnessing Regulatory T Cells for the Treatment of Inflammatory Bowel Disease

Functional Impacts of the Intestinal Microbiome in the Pathogenesis of Inflammatory Bowel Disease

(2015) Jennifer Li et al.   INFLAMMATORY BOWEL DISEASES

Plasmacytoid Dendritic Cells Mediate Anti-inflammatory Responses to a Gut Commensal Molecule via Both Innate and Adaptive Mechanisms

(2014) Suryasarathi Dasgupta et al.   Cell Host & Microbe

Interleukin-10 Receptor Signaling in Innate Immune Cells Regulates Mucosal Immune Tolerance and Anti-Inflammatory Macrophage Function

(2014) Dror S. Shouval et al.   IMMUNITY

The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system

(2014) Thaher Pelaseyed et al.   IMMUNOLOGICAL REVIEWS

Classical Th1 Cells Obtain Colitogenicity by Co-existence of RORγt-expressing T Cells in Experimental Colitis

(2014) Keiichiro Saigusa et al.   INFLAMMATORY BOWEL DISEASES

Fecal Microbiota Transplantation Inducing Remission in Crohn’s Colitis and the Associated Changes in Fecal Microbial Profile

(2014) Dina Kao et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Continuous requirement for the TCR in regulatory T cell function

(2014) Andrew G Levine et al.   NATURE IMMUNOLOGY

Advances in IBD genetics

(2014) Johan Van Limbergen et al.   Nature Reviews Gastroenterology & Hepatology

Review article: the role of anti-TNF in the management of ulcerative colitis - past, present and future

(2013) S. Danese et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Review article: vitamin D and inflammatory bowel diseases

(2013) V. P. Mouli et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Polymorphisms in the IL2RA and IL2RB Genes in Inflammatory Bowel Disease Risk

(2013) Dorra Bouzid et al.   Genetic Testing and Molecular Biomarkers

Therapeutic Evaluation of Ex Vivo-Generated Versus Natural Regulatory T-cells in a Mouse Model of Chronic Gut Inflammation

(2013) Fridrik Karlsson et al.   INFLAMMATORY BOWEL DISEASES

Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis

(2013) Weicheng Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Active Crohn's disease is associated with low vitamin D levels

(2013) Søren Peter Jørgensen et al.   Journal of Crohns & Colitis

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota

(2013) Anna Cebula et al.   NATURE

Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

(2013) Koji Atarashi et al.   NATURE

Regulatory T cells: recommendations to simplify the nomenclature

(2013) Abul K Abbas et al.   NATURE IMMUNOLOGY

Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells

(2013) Nicola Gagliani et al.   NATURE MEDICINE

A Modular Organization of the Human Intestinal Mucosal Microbiota and Its Association with Inflammatory Bowel Disease

(2013) Maomeng Tong et al.   PLoS One

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

GPR15-Mediated Homing Controls Immune Homeostasis in the Large Intestine Mucosa

(2013) S. V. Kim et al.   SCIENCE

Low-Dose Interleukin-2 Therapy Restores Regulatory T Cell Homeostasis in Patients with Chronic Graft-Versus-Host Disease

(2013) K.-i. Matsuoka et al.   Science Translational Medicine

Controlling the frontier: Regulatory T-cells and intestinal homeostasis

(2013) Julia Bollrath et al.   SEMINARS IN IMMUNOLOGY

CD39 and CD73 in immunity and inflammation

(2013) Luca Antonioli et al.   TRENDS IN MOLECULAR MEDICINE

Novel regulatory therapies for prevention of Graft-versus-host disease

(2012) Joseph Leventhal et al.   BMC Medicine

Outer Membrane Vesicles of a Human Commensal Mediate Immune Regulation and Disease Protection

(2012) Yue Shen et al.   Cell Host & Microbe

Safety and Efficacy of Antigen-Specific Regulatory T-Cell Therapy for Patients With Refractory Crohn's Disease

(2012) Pierre Desreumaux et al.   GASTROENTEROLOGY

Geographical variation and incidence of inflammatory bowel disease among US women

(2012) Hamed Khalili et al.   GUT

T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development

(2012) Naganari Ohkura et al.   IMMUNITY

Associations Between Vitamin D Receptor Polymorphisms and Susceptibility to Ulcerative Colitis and Crohnʼs Disease

(2012) Le-Ning Xue et al.   INFLAMMATORY BOWEL DISEASES

IL-10R Polymorphisms Are Associated with Very-early-onset Ulcerative Colitis

(2012) Christopher J. Moran et al.   INFLAMMATORY BOWEL DISEASES

Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo

(2012) Mahesh Yadav et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dietary Folic Acid Promotes Survival of Foxp3+ Regulatory T Cells in the Colon

(2012) M. Kinoshita et al.   JOURNAL OF IMMUNOLOGY

IL-10 Produced by Induced Regulatory T Cells (iTregs) Controls Colitis and Pathogenic Ex-iTregs during Immunotherapy

(2012) E. G. Schmitt et al.   JOURNAL OF IMMUNOLOGY

Dendritic Cell-Specific Disruption of TGF-  Receptor II Leads to Altered Regulatory T Cell Phenotype and Spontaneous Multiorgan Autoimmunity

(2012) R. Ramalingam et al.   JOURNAL OF IMMUNOLOGY

Host-dependent control of early regulatory and effector T-cell differentiation underlies the genetic susceptibility of RAG2-deficient mouse strains to transfer colitis

(2012) V Valatas et al.   Mucosal Immunology

Extrathymically generated regulatory T cells control mucosal TH2 inflammation

(2012) Steven Z. Josefowicz et al.   NATURE

Reciprocal interactions of the intestinal microbiota and immune system

(2012) Craig L. Maynard et al.   NATURE

Structure, function and diversity of the healthy human microbiome

(2012)   NATURE

Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease

(2012) Luke Jostins et al.   NATURE

Ustekinumab Induction and Maintenance Therapy in Refractory Crohn's Disease

(2012) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Concise Review: Mesenchymal Stem Cells and Translational Medicine: Emerging Issues

(2012) Guangwen Ren et al.   Stem Cells Translational Medicine

Generation and Large-Scale Expansion of Human Inducible Regulatory T Cells That Suppress Graft-Versus-Host Disease

(2011) K. L. Hippen et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Mesenchymal Stem Cells: Mechanisms of Inflammation

(2011) Nora G. Singer et al.   Annual Review of Pathology-Mechanisms of Disease

Mesenchymal stem cells as an immunomodulatory therapeutic strategy for autoimmune diseases

(2011) Eyal Ben-Ami et al.   AUTOIMMUNITY REVIEWS

Treating Clostridium difficile Infection With Fecal Microbiota Transplantation

(2011) Johan S. Bakken et al.   Clinical Gastroenterology and Hepatology

Regulatory T Cells Suppress Development of Colitis, Blocking Differentiation of T-Helper 17 Into Alternative T-Helper 1 Cells

(2011) Tomohisa Sujino et al.   GASTROENTEROLOGY

Antibodies Against Tumor Necrosis Factor (TNF) Induce T-Cell Apoptosis in Patients With Inflammatory Bowel Diseases via TNF Receptor 2 and Intestinal CD14+ Macrophages

(2011) Raja Atreya et al.   GASTROENTEROLOGY

Higher Predicted Vitamin D Status Is Associated With Reduced Risk of Crohn's Disease

(2011) Ashwin N. Ananthakrishnan et al.   GASTROENTEROLOGY

Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn's disease

(2011) R. Ciccocioppo et al.   GUT

Apoptosis of regulatory T lymphocytes is increased in chronic inflammatory bowel disease and reversed by anti-TNF  treatment

(2011) C. Veltkamp et al.   GUT

Intestinal Tolerance Requires Gut Homing and Expansion of FoxP3+ Regulatory T Cells in the Lamina Propria

(2011) Usriansyah Hadis et al.   IMMUNITY

Th17 Cells Express Interleukin-10 Receptor and Are Controlled by Foxp3− and Foxp3+ Regulatory CD4+ T Cells in an Interleukin-10-Dependent Manner

(2011) Samuel Huber et al.   IMMUNITY

The Role of Retinoic Acid in Tolerance and Immunity

(2011) Jason A. Hall et al.   IMMUNITY

Genetics of inflammatory bowel disease in Asia: Systematic review and meta-analysis

(2011) Siew C. Ng et al.   INFLAMMATORY BOWEL DISEASES

Converging pathways lead to overproduction of IL-17 in the absence of vitamin D signaling

(2011) Danny Bruce et al.   INTERNATIONAL IMMUNOLOGY

Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection

(2011) Lawrence J. Brandt et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Functional Specializations of Intestinal Dendritic Cell and Macrophage Subsets That Control Th17 and Regulatory T Cell Responses Are Dependent on the T Cell/APC Ratio, Source of Mouse Strain, and Regional Localization

(2011) T. L. Denning et al.   JOURNAL OF IMMUNOLOGY

Regulatory T-Cell Responses to Low-Dose Interleukin-2 in HCV-Induced Vasculitis

(2011) David Saadoun et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease

(2011) John Koreth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Association of a common vitamin D-binding protein polymorphism with inflammatory bowel disease

(2011) Jyrki J. Eloranta et al.   Pharmacogenetics and Genomics

The Toll-Like Receptor 2 Pathway Establishes Colonization by a Commensal of the Human Microbiota

(2011) J. L. Round et al.   SCIENCE

Inflammatory Bowel Disease

(2010) Arthur Kaser et al.   Annual Review of Immunology

Role of transforming growth factor-β in inflammatory bowel disease and colitis-associated colon cancer

(2010) Linda A. Feagins   INFLAMMATORY BOWEL DISEASES

Role of the gut-associated and secondary lymphoid tissue in the induction of chronic colitis

(2010) Koichi Takebayashi et al.   INFLAMMATORY BOWEL DISEASES

Treatment of Refractory/Recurrent C. difficile-associated Disease by Donated Stool Transplanted Via Colonoscopy

(2010) Sonia S. Yoon et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Fecal Flora Reconstitution for Recurrent Clostridium difficile Infection: Results and Methodology

(2010) Faith Rohlke et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

Microbiota innate stimulation is a prerequisite for T cell spontaneous proliferation and induction of experimental colitis

(2010) Ting Feng et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Much Ado about Adenosine: Adenosine Synthesis and Function in Regulatory T Cell Biology

(2010) P. B. Ernst et al.   JOURNAL OF IMMUNOLOGY

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

(2010) A. M. Thornton et al.   JOURNAL OF IMMUNOLOGY

Characterization of Protective Human CD4+CD25+ FOXP3+ Regulatory T Cells Generated with IL-2, TGF-β and Retinoic Acid

(2010) Ling Lu et al.   PLoS One

Generation of regulatory dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders

(2010) H.-K. Kwon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota

(2010) J. L. Round et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical grade production of IL-10 producing regulatory Tr1 lymphocytes for cell therapy of chronic inflammatory diseases

(2009) Valérie Brun et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A Central Role for Induced Regulatory T Cells in Tolerance Induction in Experimental Colitis

(2009) D. Haribhai et al.   JOURNAL OF IMMUNOLOGY

Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

(2009) Xuyu Zhou et al.   NATURE IMMUNOLOGY

Inflammatory Bowel Disease and Mutations Affecting the Interleukin-10 Receptor

(2009) Erik-Oliver Glocker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ontogeny of FOXP3+ Regulatory T Cells in the Postnatal Human Small Intestinal and Large Intestinal Lamina Propria

(2009) Jörn-Hendrik Weitkamp et al.   PEDIATRIC AND DEVELOPMENTAL PATHOLOGY

Impact of the TCR Signal on Regulatory T Cell Homeostasis, Function, and Trafficking

(2009) Joong Kyu Kim et al.   PLoS One

Continuous generation of colitogenic CD4+ T cells in persistent colitis

(2008) Takayuki Tomita et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Smad7 Controls Resistance of Colitogenic T Cells to Regulatory T Cell-Mediated Suppression

(2008) Massimo C. Fantini et al.   GASTROENTEROLOGY

Adipose-Derived Mesenchymal Stem Cells Alleviate Experimental Colitis by Inhibiting Inflammatory and Autoimmune Responses

(2008) Manuel A. González et al.   GASTROENTEROLOGY

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

(2008) Yuri P. Rubtsov et al.   IMMUNITY

Linked T Cell Receptor and Cytokine Signaling Govern the Development of the Regulatory T Cell Repertoire

(2008) Matthew A. Burchill et al.   IMMUNITY

A Two-Step Process for Thymic Regulatory T Cell Development

(2008) Chan-Wang Joaquim Lio et al.   IMMUNITY

Intestinal barrier dysfunction in inflammatory bowel diseases

(2008) Michael A. McGuckin et al.   INFLAMMATORY BOWEL DISEASES

Identification of a new WASP and FKBP-like (WAFL) protein in inflammatory bowel disease: a potential marker gene for ulcerative colitis

(2008) Ing-Marie Viklund et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Exogenous administration of mesenchymal stem cells ameliorates dextran sulfate sodium-induced colitis via anti-inflammatory action in damaged tissue in rats

(2008) Fumio Tanaka et al.   LIFE SCIENCES

TGF-β1 and Smad7 in the regulation of IBD

(2008) G Monteleone et al.   Mucosal Immunology

ATP drives lamina propria TH17 cell differentiation

(2008) Koji Atarashi et al.   NATURE

Clinical Grade Treg: GMP Isolation, Improvement of Purity by CD127pos Depletion, Treg Expansion, and Treg Cryopreservation

(2008) Jorieke H. Peters et al.   PLoS One

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

(2008) K. Wing et al.   SCIENCE