Disrupted Tryptophan Metabolism Induced Cognitive Impairment in a Mouse Model of Sepsis-associated Encephalopathy

Indoleamine 2,3-dioxygenase-dependent neurotoxic kynurenine metabolism mediates inflammation-induced deficit in recognition memory

(2015) Jillian M. Heisler et al.   BRAIN BEHAVIOR AND IMMUNITY

Lipopolysaccharide-induced sepsis induces long-lasting affective changes in the mouse

(2015) Seán T. Anderson et al.   BRAIN BEHAVIOR AND IMMUNITY

Systemic Lipopolysaccharide Administration-Induced Cognitive Impairments are Reversed by Erythropoietin Treatment in Mice

(2015) Rong Gao et al.   INFLAMMATION

Activation of the kynurenine pathway is associated with striatal volume in major depressive disorder

(2015) Jonathan Savitz et al.   PSYCHONEUROENDOCRINOLOGY

The role of Nox2-derived ROS in the development of cognitive impairment after sepsis

(2014) Marina S Hernandes et al.   Journal of Neuroinflammation

Activation of brain indoleamine 2,3-dioxygenase contributes to epilepsy-associated depressive-like behavior in rats with chronic temporal lobe epilepsy

(2014) Wei Xie et al.   Journal of Neuroinflammation

Inflammation-sleep interface in brain disease: TNF, insulin, orexin

(2014) Ian A Clark et al.   Journal of Neuroinflammation

Putative Neuroprotective and Neurotoxic Kynurenine Pathway Metabolites Are Associated with Hippocampal and Amygdalar Volumes in Subjects with Major Depressive Disorder

(2014) Jonathan Savitz et al.   NEUROPSYCHOPHARMACOLOGY

The kynurenine pathway as a therapeutic target in cognitive and neurodegenerative disorders

(2013) Trevor W Stone et al.   BRITISH JOURNAL OF PHARMACOLOGY

Intracerebroventricular administration of lipopolysaccharide induces indoleamine-2,3-dioxygenase-dependent depression-like behaviors

(2013) Marcus A Lawson et al.   Journal of Neuroinflammation

Matrix Metalloproteinase-2 and Metalloproteinase-9 Activities are Associated with Blood–Brain Barrier Dysfunction in an Animal Model of Severe Sepsis

(2013) Felipe Dal-Pizzol et al.   MOLECULAR NEUROBIOLOGY

Il1-β Involvement in Cognitive Impairment after Sepsis

(2013) Francielle Mina et al.   MOLECULAR NEUROBIOLOGY

Class I Histone Deacetylase Inhibitor Valproic Acid Reverses Cognitive Deficits in a Mouse Model of Septic Encephalopathy

(2013) Jing Wu et al.   NEUROCHEMICAL RESEARCH

Expression of Tryptophan 2,3-Dioxygenase and Production of Kynurenine Pathway Metabolites in Triple Transgenic Mice and Human Alzheimer's Disease Brain

(2013) Wei Wu et al.   PLoS One

Indoleamine 2,3-dioxygenase inhibition attenuates lipopolysaccharide induced persistent microglial activation and depressive-like complications in fractalkine receptor (CX3CR1)-deficient mice

(2012) Angela W. Corona et al.   BRAIN BEHAVIOR AND IMMUNITY

Population Burden of Long-Term Survivorship After Severe Sepsis in Older Americans

(2012) Theodore J. Iwashyna et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Sepsis-associated encephalopathy

(2012) Teneille E. Gofton et al.   Nature Reviews Neurology

Neuroplastic changes in depression: A role for the immune system

(2012) Harris Eyre et al.   PSYCHONEUROENDOCRINOLOGY

Kynurenine 3-Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration

(2011) Daniel Zwilling et al.   CELL

Delirium as a predictor of long-term cognitive impairment in survivors of critical illness

(2010) Timothy D. Girard et al.   CRITICAL CARE MEDICINE

Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis

(2010) Theodore J. Iwashyna et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The new ‘5-HT’ hypothesis of depression: Cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression

(2010) M. Maes et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

New insights into the role of brain-derived neurotrophic factor in synaptic plasticity

(2009) Emily G. Waterhouse et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Decreased immobility in swimming test by homologous interferon-α in mice accompanied with increased cerebral tryptophan level and serotonin turnover

(2009) Jianping Wang et al.   NEUROSCIENCE LETTERS

Time-dependent behavioral recovery after sepsis in rats

(2008) Lisiane Tuon et al.   INTENSIVE CARE MEDICINE