Structure-based design of decoy chemokines as a way to explore the pharmacological potential of glycosaminoglycans

Guide to Receptors and Channels (GRAC), 5th edition

(2011) SPH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Chemokine oligomerization and interactions with receptors and glycosaminoglycans: The role of structural dynamics in function

(2011) C.L. Salanga et al.   EXPERIMENTAL CELL RESEARCH

The monomer-dimer equilibrium and glycosaminoglycan interactions of chemokine CXCL8 regulate tissue-specific neutrophil recruitment

(2011) Pavani Gangavarapu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Heparan Sulfate Proteoglycans

(2011) S. Sarrazin et al.   Cold Spring Harbor Perspectives in Biology

Generation of a humanized anti-glypican 3 antibody by CDR grafting and stability optimization

(2010) Kiyotaka Nakano et al.   ANTI-CANCER DRUGS

A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils

(2010) S. Massena et al.   BLOOD

Heparan sulfate proteoglycans in extravasation: assisting leukocyte guidance

(2010) Johanna et al.   Frontiers in Bioscience-Landmark

Immobilized Chemokine Fields and Soluble Chemokine Gradients Cooperatively Shape Migration Patterns of Dendritic Cells

(2010) Kathrin Schumann et al.   IMMUNITY

Rationally Evolving MCP-1/CCL2 into a Decoy Protein with Potent Anti-inflammatory Activityin Vivo

(2010) Anna Maria Piccinini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A New Monocyte Chemotactic Protein-1/Chemokine CC Motif Ligand-2 Competitor Limiting Neointima Formation and Myocardial Ischemia/Reperfusion Injury in Mice

(2010) Elisa A. Liehn et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Monomeric and Dimeric CXCL8 Are Both Essential for In Vivo Neutrophil Recruitment

(2010) Sandhya Thulasi Das et al.   PLoS One

Therapy with Nonglycosaminoglycan-Binding Mutant CCL7: A Novel Strategy to Limit Allograft Inflammation

(2009) S. Ali et al.   AMERICAN JOURNAL OF TRANSPLANTATION

A biophysical insight into the RANTES–glycosaminoglycan interaction

(2009) Angelika Rek et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Therapeutically targeting protein-glycan interactions

(2009) A Rek et al.   BRITISH JOURNAL OF PHARMACOLOGY

Anti-inflammatory therapy by intravenous delivery of non-heparan sulfate-binding CXCL12

(2009) Graeme O'Boyle et al.   FASEB JOURNAL

Chemokine patterning by glycosaminoglycans and interceptors

(2009) Antal Rot   Frontiers in Bioscience-Landmark

A novel CXCL8 protein-based antagonist in acute experimental renal allograft damage

(2009) Jens Bedke et al.   MOLECULAR IMMUNOLOGY

Engineering the glycosaminoglycan-binding affinity, kinetics and oligomerization behavior of RANTES: a tool for generating chemokine-based glycosaminoglycan antagonists

(2009) B. Brandner et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Glycanogenomics: A qPCR-approach to investigate biological glycan function

(2008) Evelyn C. Krenn et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Advances in Neutrophil Biology

(2008) Andrew S. Cowburn et al.   CHEST

An engineered monomer of CCL2 has anti-inflammatory properties emphasizing the importance of oligomerization for chemokine activity in vivo

(2008) Tracy M. Handel et al.   JOURNAL OF LEUKOCYTE BIOLOGY