The RUNX complex: reaching beyond haematopoiesis into immunity

Th17 cells in inflammation and autoimmunity

(2014) Ram Pyare Singh et al.   AUTOIMMUNITY REVIEWS

Runx1 and Cbf  regulate the development of Flt3+ dendritic cell progenitors and restrict myeloproliferative disorder

(2014) A. T. Satpathy et al.   BLOOD

iNKT Cells: Innate Lymphocytes with a Diverse Response

(2014) Marta Monteiro et al.   CRITICAL REVIEWS IN IMMUNOLOGY

The Transcription Factor T-bet Is Induced by IL-15 and Thymic Agonist Selection and Controls CD8αα+ Intraepithelial Lymphocyte Development

(2014) Christoph S.N. Klose et al.   IMMUNITY

Transcription Factor T-bet Regulates Intraepithelial Lymphocyte Functional Maturation

(2014) Bernardo S. Reis et al.   IMMUNITY

The Transcription Factors T-bet and Runx Are Required for the Ontogeny of Pathogenic Interferon-γ-Producing T Helper 17 Cells

(2014) Yan Wang et al.   IMMUNITY

Pro-inflammatory human Th17 cells selectively express P-glycoprotein and are refractory to glucocorticoids

(2014) Radha Ramesh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

RUNX1-dependent RAG1 deposition instigates human TCR-δ locus rearrangement

(2014) Agata Cieslak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cbfb deficiency results in differentiation blocks and stem/progenitor cell expansion in hematopoiesis

(2014) C Q Wang et al.   LEUKEMIA

Transcription Factor Runx3 Regulates Interleukin-15-Dependent Natural Killer Cell Activation

(2014) D. Levanon et al.   MOLECULAR AND CELLULAR BIOLOGY

Elephant shark genome provides unique insights into gnathostome evolution

(2014) Byrappa Venkatesh et al.   NATURE

TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4+ T cell fate and interact with Runx3 to silence Cd4 in CD8+ T cells

(2014) Farrah C Steinke et al.   NATURE IMMUNOLOGY

A Role for RUNX3 in Inflammation-Induced Expression of IL23A in Gastric Epithelial Cells

(2014) Yit Teng Hor et al.   Cell Reports

Disruption of Runx1 and Runx3 Leads to Bone Marrow Failure and Leukemia Predisposition due to Transcriptional and DNA Repair Defects

(2014) Chelsia Qiuxia Wang et al.   Cell Reports

Langerhans cells are generated by two distinct PU.1-dependent transcriptional networks

(2013) Michaël Chopin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dynamic regulatory network controlling TH17 cell differentiation

(2013) Nir Yosef et al.   NATURE

Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1

(2013) Chuan Wu et al.   NATURE

Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

(2013) Markus Kleinewietfeld et al.   NATURE

Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4+ T cell immunity

(2013) Bernardo Sgarbi Reis et al.   NATURE IMMUNOLOGY

Epstein-Barr Virus Nuclear Antigen 3C binds to BATF/IRF4 or SPI1/IRF4 composite sites and recruits Sin3A to repress CDKN2A

(2013) S. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical role of P1-Runx1 in mouse basophil development

(2012) K. Mukai et al.   BLOOD

Runx1–Cbfβ facilitates early B lymphocyte development by regulating expression of Ebf1

(2012) Wooseok Seo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of Postnatal Forebrain Amoeboid Microglial Cell Proliferation and Development by the Transcription Factor Runx1

(2012) M. Zusso et al.   JOURNAL OF NEUROSCIENCE

Clonal deletion and the fate of autoreactive thymocytes that survive negative selection

(2012) Leonid A Pobezinsky et al.   NATURE IMMUNOLOGY

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Novel function of the unique N-terminal region of RUNX1c in B cell growth regulation

(2012) G. Brady et al.   NUCLEIC ACIDS RESEARCH

RUNX3 Regulates Intercellular Adhesion Molecule 3 (ICAM-3) Expression during Macrophage Differentiation and Monocyte Extravasation

(2012) Ana Estecha et al.   PLoS One

Microbial Exposure During Early Life Has Persistent Effects on Natural Killer T Cell Function

(2012) T. Olszak et al.   SCIENCE

RUNX transcription factors: association with pediatric asthma and modulated by maternal smoking

(2011) Kathleen J. Haley et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Erythroid/Myeloid Progenitors and Hematopoietic Stem Cells Originate from Distinct Populations of Endothelial Cells

(2011) Michael J. Chen et al.   Cell Stem Cell

Lymphoid tissue inducer cells

(2011) David R. Withers   CURRENT BIOLOGY

RUNX Transcription Factor-Mediated Association of Cd4 and Cd8 Enables Coordinate Gene Regulation

(2011) Amélie Collins et al.   IMMUNITY

Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth

(2011) B. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate control of B cell responses

(2011) Andrea Cerutti et al.   TRENDS IN IMMUNOLOGY

Runx family genes, niche, and stem cell quiescence

(2010) Chelsia Qiuxia Wang et al.   BLOOD CELLS MOLECULES AND DISEASES

The novel RUNX3/p33 isoform is induced upon monocyte-derived dendritic cell maturation and downregulates IL-8 expression

(2010) Amaya Puig-Kröger et al.   IMMUNOBIOLOGY

Runx1/Cbf 2 Complexes Are Required for Lymphoid Tissue Inducer Cell Differentiation at Two Developmental Stages

(2010) M. Tachibana et al.   JOURNAL OF IMMUNOLOGY

Requirement for Runx Proteins in IgA Class Switching Acting Downstream of TGF- 1 and Retinoic Acid Signaling

(2010) K. Watanabe et al.   JOURNAL OF IMMUNOLOGY

Blood stem cells emerge from aortic endothelium by a novel type of cell transition

(2010) Karima Kissa et al.   NATURE

Multiple common variants for celiac disease influencing immune gene expression

(2010) Patrick C A Dubois et al.   NATURE GENETICS

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis

(2009) B. Jacob et al.   BLOOD

Regulation of bone development and extracellular matrix protein genes by RUNX2

(2009) Toshihisa Komori   CELL AND TISSUE RESEARCH

Transcriptional regulation in helper versus cytotoxic-lineage decision

(2009) Ichiro Taniuchi   CURRENT OPINION IN IMMUNOLOGY

Indispensable Role of the Runx1-Cbfβ Transcription Complex for In Vivo-Suppressive Function of FoxP3+ Regulatory T Cells

(2009) Akihiko Kitoh et al.   IMMUNITY

Runx proteins regulate Foxp3 expression

(2009) Ludovica Bruno et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs

(2009) Fernando Cruz-Guilloty et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+inducible regulatory T cells

(2009) Sven Klunker et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Downregulation of RUNX1 by RUNX3 Requires the RUNX3 VWRPY Sequence and Is Essential for Epstein-Barr Virus-Driven B-Cell Proliferation

(2009) G. Brady et al.   JOURNAL OF VIROLOGY

Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter

(2009) Michael J. Chen et al.   NATURE

Runx-CBFβ complexes control expression of the transcription factor Foxp3 in regulatory T cells

(2009) Dipayan Rudra et al.   NATURE IMMUNOLOGY

Core binding factors are necessary for natural killer cell development and cooperate with Notch signaling during T-cell specification

(2008) Y. Guo et al.   BLOOD

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Runt-related transcription factor 3 is associated with ulcerative colitis and shows epistasis with solute carrier family 22, members 4 and 5

(2008) Rinse K. Weersma et al.   INFLAMMATORY BOWEL DISEASES

Discriminating gene expression profiles of memory B cell subpopulations

(2008) Götz R.A. Ehrhardt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage

(2008) Takeshi Egawa et al.   NATURE IMMUNOLOGY

Interactions among the transcription factors Runx1, RORγt and Foxp3 regulate the differentiation of interleukin 17–producing T cells

(2008) Fuping Zhang et al.   NATURE IMMUNOLOGY

Of lineage and legacy: the development of mammalian hematopoietic stem cells

(2008) Elaine Dzierzak et al.   NATURE IMMUNOLOGY

Functions of natural killer cells

(2008) Eric Vivier et al.   NATURE IMMUNOLOGY

Repression of the Transcription Factor Th-POK by Runx Complexes in Cytotoxic T Cell Development

(2008) R. Setoguchi et al.   SCIENCE