Article
Biochemistry & Molecular Biology
Nitish Rana, Giuseppe Privitera, Hannah C. Kondolf, Katarzyna Bulek, Susana Lechuga, Carlo De Salvo, Daniele Corridoni, Agne Antanaviciute, Rebecca L. Maywald, Alexander M. Hurtado, Junjie Zhao, Emina H. Huang, Xiaoxia Li, E. Ricky Chan, Alison Simmons, Giorgos Bamias, Derek W. Abbott, Jason D. Heaney, Andrei I. Ivanov, Theresa T. Pizarro
Summary: Increased GSDMB in inflammatory bowel disease affects the restoration of epithelial barrier function and resolution of inflammation. Mechanistic experiments reveal that GSDMB deficiency impairs the increased proliferation and migration of epithelial cells during in vitro wound closure.
Article
Chemistry, Multidisciplinary
William W. Du, Javeria Qadir, Kevin Y. Du, Yu Chen, Nan Wu, Burton B. Yang
Summary: Current studies have shown that nuclear actin plays a significant role in the regulation of epithelial-mesenchymal transition (EMT). Different binding partners for nuclear F-actin and G-actin have been discovered, which respectively modulate EMT-promoting and EMT-repressing transcriptional events. Mechanistically, nuclear F-actin enhances the expression and stability of proteins involved in EMT promotion, while nuclear G-actin increases the expression and stability of proteins involved in EMT repression. The association between nuclear actin and EMT suggests that targeting nuclear actin dynamics for dysregulated EMT is a promising area for further study.
Article
Oncology
Tzu-Hsiu Tsai, Chien-Hung Gow, Yi-Nan Liu, Meng-Feng Tsai, Tzu-Hua Chang, Shang-Gin Wu, Min-Shu Hsieh, Kang-Yi Su, Jin-Yuan Shih
Summary: This study reveals that miR-503 regulates the invasion and metastasis of lung cancer cells by modulating the PTK7/FAK signaling pathway and inversely regulating EMT. These findings provide important insights into the role of miR-503 in cancer metastasis mechanism.
Article
Multidisciplinary Sciences
Uyen Q. Le, Nanyue Chen, Seetharaman Balasenthil, Eugene Lurie, Fei Yang, Suyu Liu, Laura Rubin, Luisa Maren Solis Soto, Maria Gabriela Raso, Harsh Batra, Aysegul A. Sahin, Ignacio I. Wistuba, Ann McNeill Killary
Summary: This study demonstrates that the tumor suppressor DEAR1/TRIM62 is a critical regulator of luminal cell fate, maintaining luminal differentiation and inhibiting stem cell properties and generation of basal-like progenitor populations. DEAR1 loss leads to enhanced mammosphere formation and accelerated luminal-basal transition. Additionally, DEAR1 could serve as a biomarker for prognostic diagnosis and targeted stem cell therapies in early onset TNBCs.
SCIENTIFIC REPORTS
(2022)
Review
Oncology
Xiaobo Zheng, Fuzhen Dai, Lei Feng, Hong Zou, Li Feng, Mingqing Xu
Summary: The interplay between epithelial-mesenchymal plasticity and cancer stem cells plays a crucial role in cancer progression, affecting the aggressiveness of tumor cells and their response to treatment. Understanding the dynamic nature of EMT as a hybrid state rather than a binary model is important for unraveling the complexities of cancer biology and developing targeted therapeutic interventions.
FRONTIERS IN ONCOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Y. Li, J. Zhang, W. Cai, C. Wang, Z. Yu, Z. Jiang, K. Lai, Y. Wang, G. Yang
Summary: The long-term success rate of dental implants can be improved by establishing a favorable biological sealing with a high-quality epithelial attachment. The application of mesenchymal stem cells (MSCs) holds promise for facilitating the soft tissue integration around implants, but the molecular mechanism is still unclear and the general application of MSC sheet for soft tissue integration is also relatively unexplored.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Cell & Tissue Engineering
Dongli Li, Junxiu Zhang, Zijia Liu, Yuanyuan Gong, Zhi Zheng
Summary: This study revealed that exosomal miR-27b derived from hucMSCs could reverse the EMT process induced by TGF-beta 2 by inhibiting HOXC6, suggesting the potential therapeutic role of the exosomal miR-27b/HOXC6 axis in ameliorating subretinal fibrosis.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Gastroenterology & Hepatology
Tianhao Weng, Dong Yan, Danrong Shi, Miaojin Zhu, Yizhi Liu, Zhigang Wu, Taoming Tang, Linwei Zhu, Hong Zhang, Hangping Yao, Lanjuan Li
Summary: The study reveals that MSP is an important biomarker in the progression of liver cirrhosis and can be utilized for patient prognostication. The MSP-RON pathway promotes hepatocytes EMT and fibrosis progression via the TGF-beta related pathway. Potential therapeutic strategies for liver cirrhosis targetting the MSP/RON pathway have been identified.
LIVER INTERNATIONAL
(2021)
Article
Medicine, Research & Experimental
Bo Wang, Chenguang Ding, Xiaoming Ding, Greg Tesch, Jin Zheng, PuYun Tian, Yang Li, Sharon Ricardo, Hsin-Hui Shen, Wujun Xue
Summary: This study investigated the regulatory function of WISP1 in kidney inflammation. The results showed that WISP1 can induce kidney inflammation and it can be prevented by inhibiting NF-KB. In addition, inhibition of WISP1 can suppress the production of inflammatory cytokines in macrophages and the proliferation of kidney fibroblasts. The increased expression of WISP1 in kidney inflammation models was also confirmed. Therefore, pharmacological blockade of WISP1 shows potential as a novel therapy for kidney inflammation.
Article
Oncology
Sadaaki Nishimura, Yurie Yamamoto, Atsushi Sugimoto, Shuhei Kushiyama, Shingo Togano, Kenji Kuroda, Tomohisa Okuno, Hiroaki Kasashima, Masaichi Ohira, Kiyoshi Maeda, Masakazu Yashiro
Summary: This study reveals the critical role of LCN2 in gastric cancer progression, involving its regulation of MMP2 activity and contribution to EMT signaling. Low LCN2 expression is associated with poor prognosis in gastric cancer patients.
Review
Biochemistry & Molecular Biology
Gengle Niu, Jin Hao, Surui Sheng, Fangyuan Wen
Summary: The T-box gene family controls embryonic development and is involved in cancer progression and metastasis. Cancer metastasis, characterized by therapy resistance, involves complex processes, with EMT triggering cancer cell invasiveness and CSCs contributing to cancer stemness. Targeting T-box genes as anticancer therapeutics holds potential in addressing these issues.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Review
Oncology
Evan M. McCabe, Theodore P. Rasmussen
Summary: The epithelial to mesenchymal transition (EMT) is a cellular process crucial in embryogenesis, where cancer stem cells (CSCs) play a role by differentiating and undergoing EMT. Long noncoding RNAs (lncRNAs) also have a role in CSCs and EMT, with the potential to serve as biomarkers and therapeutic targets in cancer progression.
SEMINARS IN CANCER BIOLOGY
(2021)
Review
Multidisciplinary Sciences
Ruina Li, Hui Xu, Xiaoling Gao
Summary: Epithelial-mesenchymal transition (EMT) is involved in the progression and metastasis of colorectal cancer (CRC), and dysregulation of non-coding RNA (ncRNA) is linked to EMT. CeRNA dysregulation-induced EMT, involving lncRNA, miRNA, and mRNA interactions, has attracted attention in CRC. Understanding the role of ceRNA networks and key transcription factors in EMT, as well as miRNAs and lncRNAs targeting genes for EMT promotion, is critical for exploring therapeutic targets in CRC.
Review
Biochemistry & Molecular Biology
Inese Briede, Dainis Balodis, Janis Gardovskis, Ilze Strumfa
Summary: Colorectal carcinoma ranks third by incidence and second by mortality globally, with high numbers of advanced cases. Cancer stem cells present a challenge to the treatment of metastatic colorectal cancer, with intricate associations between inflammation, epithelial-mesenchymal transition, and cancer stem cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Juliane Strietz, Stella S. Stepputtis, Marie Follo, Peter Bronsert, Elmar Stickeler, Jochen Maurer
Summary: Primary breast cancer stem cell (BCSC) cultures isolated from TNBC specimens have been established and shown to grow as tumor spheres under anchorage-independent culture conditions in vitro, while reliably forming tumors in mice when transplanted in limiting dilutions in vivo. Additionally, these BCSC xenograft tumors exhibit similar architecture and gene expression to the original patient tumor, suggesting a promising model for researching BCSC biology and testing new treatment options for TNBC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Reproductive Biology
Sarah L. Whiteley, Robert D. McCuaig, Clare E. Holleley, Sudha Rao, Arthur Georges
Summary: This study utilized automated staining and imaging platforms to provide immunofluorescent data for a reptile species with temperature-induced sex reversal, showing differences in protein dynamics between males, females, and sex-reversed females. The characterization of tissue-specific expression and cellular localization patterns of chromatin modifiers, histone marks, and environmental response proteins in the adult gonads of a dragon lizard provides new insights into the molecular characteristics of sex determination and maintenance.
BIOLOGY OF REPRODUCTION
(2022)
Editorial Material
Cell Biology
Cameron P. Bracken, Gregory J. Goodall
Summary: The passage discusses the complexity of epithelial-mesenchymal transition (EMT) and questions whether the process truly requires so many regulators or if there are many 'false positives' reported in the literature.
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2022)
Article
Hematology
Alexander C. Lewis, Victoria S. Pope, Melinda N. Tea, Manjun Li, Gus O. Nwosu, Thao M. Nguyen, Craig T. Wallington-Beddoe, Paul A. B. Moretti, Dovile Anderson, Darren J. Creek, Maurizio Costabile, Saira R. Ali, Chloe A. L. Thompson-Peach, B. Kate Dredge, Andrew G. Bert, Gregory J. Goodall, Paul G. Ekert, Anna L. Brown, Richard D'Andrea, Nirmal Robinson, Melissa R. Pitman, Daniel Thomas, David M. Ross, Briony L. Gliddon, Jason A. Powell, Stuart M. Pitson
Summary: In this study, the accumulation of ceramide in AML cells induced an apoptotic integrated stress response through the activation of transcription factor ATF4. This response led to the degradation of the prosurvival protein Mcl-1, resulting in cell death. Combination treatment with the Bcl-2 inhibitor venetoclax synergistically killed AML cells and reduced leukemic stem cells.
Review
Cell Biology
Daniel P. Neumann, Gregory J. Goodall, Philip A. Gregory
Summary: The RNA-binding protein Quaking (QKI) plays an important role in cellular differentiation, with different isoforms affecting neuronal, vascular, muscle, and monocyte cell differentiation as well as epithelial-mesenchymal transition in cancer progression. QKI isoforms control cell differentiation through regulating alternative splicing, mRNA stability and translation, and also have activities in gene transcription. These diverse functions of the QKI isoforms contribute to their broad influences on RNA metabolism and cellular differentiation.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2022)
Article
Oncology
Jenny Dunn, Robert D. McCuaig, Abel H. Y. Tan, Wen Juan Tu, Fan Wu, Kylie M. Wagstaff, Anjum Zafar, Sayed Ali, Himanshu Diwakar, Jane E. Dahlstrom, Elaine G. Bean, Jade K. Forwood, Sofiya Tsimbalyuk, Emily M. Cross, Kristine Hardy, Amanda L. Bain, Elizabeth Ahern, Riccardo Dolcetti, Roberta Mazzieri, Desmond Yip, Melissa Eastgate, Laeeq Malik, Peter Milburn, David A. Jans, Sudha Rao
Summary: The study found that a protein called nPKC-theta is enriched in circulating tumor cells (CTCs) in patients with triple-negative breast cancer (TNBC) brain metastases and immunotherapy-resistant metastatic melanoma, and is associated with poor survival in immunotherapy-resistant disease. A novel nPKC-theta inhibitor was designed to target nPKC-theta and showed potential in reducing mesenchymal cancer stem cell signatures in immunotherapy-resistant CTCs and TNBC xenografts.
Article
Oncology
Lap Hing Chi, Ryan S. N. Cross, Richard P. Redvers, Melissa Davis, Soroor Hediyeh-zadeh, Suresh Mathivanan, Monisha Samuel, Erin C. Lucas, Kellie Mouchemore, Philip A. Gregory, Cameron N. Johnstone, Robin L. Anderson
Summary: The activity of the MiR-21 gene plays an important role in the growth and metastasis of mammary tumors. Suppressing miR-21 in highly metastatic tumors leads to regression of primary tumor growth and alteration of immune infiltrate and gene expression. Additionally, miR-21 promotes tumor metastasis.
Article
Oncology
Vanessa M. Conn, Marta Gabryelska, John Toubia, Kirsty Kirk, Laura Gantley, Jason A. Powell, Gokhan Cildir, Shashikanth Marri, Ryan Liu, Brett W. Stringer, Scott Townley, Stuart T. Webb, He Lin, Saumya E. Samaraweera, Sheree Bailey, Andrew S. Moore, Mellissa Maybury, Dawei Liu, Alex D. Colella, Timothy Chataway, Craig T. Wallington-Gates, Lucie Walters, Jane Sibbons, Luke A. Seith, Vinay Tergaonkar, Richard J. D'Andrea, Stuart M. Pitson, Gregory J. Goodall, Simon J. Conn
Summary: The first step of oncogenesis is the acquisition of genetic mutations to initiate and sustain malignancy. In acute leukemias, the formation of a potent oncogene called the MLL recombinome by chromosomal translocations is a key example of this initiation phase. Circular RNAs (circRNAs), a type of covalently closed RNA molecules, are enriched within the MLL recombinome and can bind DNA to form circRNA:DNA hybrids (circR loops) at specific sites. These circR loops promote transcriptional pausing, chromatin re-organization, and DNA breakage, leading to the generation of clinically relevant chromosomal translocations and hastening disease onset in mouse leukemia xenograft models.
Article
Oncology
Winnie L. Kan, Urmi Dhagat, Kerstin B. Kaufmann, Timothy R. Hercus, Tracy L. Nero, Andy G. X. Zeng, John Toubia, Emma F. Barry, Sophie E. Broughton, Guillermo A. Gomez, Brooks A. Benard, Mara Dottore, Karen S. Cheung Tung Shing, Helena Boutzen, Saumya E. Samaraweera, Kaylene J. Simpson, Liqing Jin, Gregory J. Goodall, C. Glenn Begley, Daniel Thomas, Paul G. Ekert, Denis Tvorogov, Richard J. D'Andrea, John E. Dick, Michael W. Parker, Angel F. Lopez
Summary: Leukemia stem cells (LSC) possess distinct self-renewal and arrested differentiation properties. High interleukin-3 receptor (IL3R) levels in LSCs drive hexamer-mediated stemness programs and poor patient survival, while low ratios mediate differentiation. This study establishes a new paradigm in which alternative cytokine receptor stoichiometries differentially regulate cell fate.
Article
Anthropology
Kristine Hardy, Chris Ballard, Mathieu Leclerc
Summary: This paper provides a comprehensive summary of the forms and production processes of Agarabi pottery, combining published sources and unpublished records from ethnoarchaeological fieldwork amongst Agarabi speakers in the Kainantu District in 1987. Agarabi vessels are characterized by their elongated ovoid shape, pointed bases, and out-curving rims. The decoration, when present, consists of incisions or punctate impressions, often from multi-toothed combs. This study lays the foundation for further research on the cultural processes and historical trajectories that have shaped this unique Highlands ceramic ware.
JOURNAL OF ANTHROPOLOGICAL ARCHAEOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sunil Sapkota, Katherine A. Pillman, B. Kate Dredge, Dawei Liu, Julie M. Bracken, Saba Ataei Kachooei, Bradley Chereda, Philip A. Gregory, Cameron P. Bracken, Gregory J. Goodall
Summary: MiRNAs can repress gene expression by binding to mRNA 3 & PRIME;UTRs, and there is evidence that they also interact with CDS regions. However, the impact of CDS interactions may be limited, as extensive base-pairing is required. Although repression of endogenous genes through CDS interaction is possible, it likely only has modest effects on a small subset of targets.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biology
Ayla Orang, B. Kate Dredge, Chi Yau Liu, Julie M. Bracken, Chun-Hsien Chen, Laura Sourdin, Holly J. Whitfield, Rachael Lumb, Sarah Boyle, Melissa J. Davis, Michael S. Samuel, Philip A. Gregory, Yeesim Khew-Goodall, Gregory J. Goodall, Katherine A. Pillman, Cameron P. Bracken
Summary: Epithelial-mesenchymal transition is regulated by basonuclin-2 (BNC2), which controls the expression of specific collagens, matrix metalloproteases, and other matrisomal components. BNC2 also modulates the motile and invasive properties of cancers, and its high expression is associated with increasing cancer grade and poor patient prognosis.
LIFE SCIENCE ALLIANCE
(2023)
Article
Oncology
Yu Hin Tang, Anja Rockstroh, Kamil A. Sokolowski, Layla-Rose Lynam, Melanie Lehman, Erik W. Thompson, Philip A. Gregory, Colleen C. Nelson, Marianna Volpert, Brett G. Hollier
Summary: This study found that the cell-surface co-receptor NRP1 plays an important role in the development of claudin-low breast cancer, and its overexpression is associated with shorter survival in the case of relapse and metastasis. Inhibiting the expression of NRP1 can inhibit the proliferation of claudin-low cells and prolong survival in in vivo models. NRP1 inhibition can also suppress the expression of claudin-low tumor characteristics and has potent anti-tumor effects on claudin-low orthotopic xenografts.
BREAST CANCER RESEARCH
(2022)
Article
Oncology
Thomas U. Ahearn, Haoyu Zhang, Kyriaki Michailidou, Roger L. Milne, Manjeet K. Bolla, Joe Dennis, Alison M. Dunning, Michael Lush, Qin Wang, Irene L. Andrulis, Hoda Anton-Culver, Volker Arndt, Kristan J. Aronson, Paul L. Auer, Annelie Augustinsson, Adinda Baten, Heiko Becher, Sabine Behrens, Javier Benitez, Marina Bermisheva, Carl Blomqvist, Stig E. Bojesen, Bernardo Bonanni, Anne-Lise Borresen-Dale, Hiltrud Brauch, Hermann Brenner, Angela Brooks-Wilson, Thomas Bruening, Barbara Burwinkel, Saundra S. Buys, Federico Canzian, Jose E. Castelao, Jenny Chang-Claude, Stephen J. Chanock, Georgia Chenevix-Trench, Christine L. Clarke, J. Margriet Collee, Angela Cox, Simon S. Cross, Kamila Czene, Mary B. Daly, Peter Devilee, Thilo Dork, Miriam Dwek, Diana M. Eccles, D. Gareth Evans, Peter A. Fasching, Jonine Figueroa, Giuseppe Floris, Manuela Gago-Dominguez, Susan M. Gapstur, Jose A. Garcia-Saenz, Mia M. Gaudet, Graham G. Giles, Mark S. Goldberg, Anna Gonzalez-Neira, Grethe I. Grenaker Alnaes, Mervi Grip, Pascal Guenel, Christopher A. Haiman, Per Hall, Ute Hamann, Elaine F. Harkness, Bernadette A. M. Heemskerk-Gerritsen, Bernd Holleczek, Antoinette Hollestelle, Maartje J. Hooning, Robert N. Hoover, John L. Hopper, Anthony Howell, Milena Jakimovska, Anna Jakubowska, Esther M. John, Michael E. Jones, Audrey Jung, Rudolf Kaaks, Saila Kauppila, Renske Keeman, Elza Khusnutdinova, Cari M. Kitahara, Yon-Dschun Ko, Stella Koutros, Vessela N. Kristensen, Ute Kruger, Katerina Kubelka-Sabit, Allison W. Kurian, Kyriacos Kyriacou, Diether Lambrechts, Derrick G. Lee, Annika Lindblom, Martha Linet, Jolanta Lissowska, Ana Llaneza, Wing-Yee Lo, Robert J. MacInnis, Arto Mannermaa, Mehdi Manoochehri, Sara Margolin, Maria Elena Martinez, Catriona McLean, Alfons Meindl, Usha Menon, Heli Nevanlinna, William G. Newman, Jesse Nodora, Kenneth Offit, Hakan Olsson, Nick Orr, Tjoung-Won Park-Simon, Alpa Patel, Julian Peto, Guillermo Pita, Dijana Plaseska-Karanfilska, Ross Prentice, Kevin Punie, Katri Pylkas, Paolo Radice, Gad Rennert, Atocha Romero, Thomas Ruediger, Emmanouil Saloustros, Sarah Sampson, Dale P. Sandler, Elinor J. Sawyer, Rita K. Schmutzler, Minouk J. Schoemaker, Ben Schottker, Mark E. Sherman, Xiao-Ou Shu, Snezhana Smichkoska, Melissa C. Southey, John J. Spinelli, Anthony J. Swerdlow, Rulla M. Tamimi, William J. Tapper, Jack A. Taylor, Lauren R. Teras, Mary Beth Terry, Diana Torres, Melissa A. Troester, Celine M. Vachon, Carolien H. M. van Deurzen, Elke M. van Veen, Philippe Wagner, Clarice R. Weinberg, Camilla Wendt, Jelle Wesseling, Robert Winqvist, Alicja Wolk, Xiaohong R. Yang, Wei Zheng, Fergus J. Couch, Jacques Simard, Peter Kraft, Douglas F. Easton, Paul D. P. Pharoah, Marjanka K. Schmidt, Montserrat Garcia-Closas, Nilanjan Chatterjee
Summary: This study identifies breast cancer susceptibility variants that are associated with tumor features and intrinsic molecular subtypes, providing insights for subtype-specific risk prediction.
BREAST CANCER RESEARCH
(2022)
