Cytokine-producing B cells: a translational view on their roles in human and mouse autoimmune diseases

Assessing Inflammatory Bowel Disease-Associated Antibodies in Caucasian and First Nations Cohorts

(2016) Charles N Bernstein et al.   CANADIAN JOURNAL OF GASTROENTEROLOGY

Rapid induction of clinical remission by low-dose interleukin-2 in a patient with refractory SLE

(2015) Jens Y Humrich et al.   ANNALS OF THE RHEUMATIC DISEASES

A volcanic explosion of autoantibodies in systemic lupus erythematosus: A diversity of 180 different antibodies found in SLE patients

(2015) Gal Yaniv et al.   AUTOIMMUNITY REVIEWS

Regulatory plasma cells

(2015) Simon Fillatreau   CURRENT OPINION IN PHARMACOLOGY

Pathogenic functions of B cells in autoimmune diseases: IFN-γ production joins the criminal gang

(2015) Simon Fillatreau   EUROPEAN JOURNAL OF IMMUNOLOGY

B cells expressing IFN-γ suppress Treg-cell differentiation and promote autoimmune experimental arthritis

(2015) Susan A. Olalekan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations

(2015) Jimmy Z Liu et al.   NATURE GENETICS

Long-term Therapy With Interleukin 6 Receptor Blockade in Highly Active Neuromyelitis Optica Spectrum Disorder

(2015) Marius Ringelstein et al.   JAMA Neurology

Internalization of Rituximab and the Efficiency of B Cell Depletion in Rheumatoid Arthritis and Systemic Lupus Erythematosus

(2015) Venkat Reddy et al.   Arthritis & Rheumatology

Rituximab in Systemic Lupus Erythematosus and Lupus Nephritis

(2015) Hannah Beckwith et al.   NEPHRON CLINICAL PRACTICE

Expansion of Activated Peripheral Blood Memory B Cells in Rheumatoid Arthritis, Impact of B Cell Depletion Therapy, and Biomarkers of Response

(2015) Diana G. Adlowitz et al.   PLoS One

Expression of FcRL4 defines a pro-inflammatory, RANKL-producing B cell subset in rheumatoid arthritis

(2014) L Yeo et al.   ANNALS OF THE RHEUMATIC DISEASES

B-type suppression: A role played by “regulatory B cells” or “regulatory plasma cells”?

(2014) Stefanie Ries et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Interleukin-10-Producing Plasmablasts Exert Regulatory Function in Autoimmune Inflammation

(2014) Masanori Matsumoto et al.   IMMUNITY

Role of Regulatory B Cells in Chronic Intestinal Inflammation

(2014) Akihiko Oka et al.   INFLAMMATORY BOWEL DISEASES

Suppression of Proteoglycan-Induced Arthritis by Anti-CD20 B Cell Depletion Therapy Is Mediated by Reduction in Autoantibodies and CD4+ T Cell Reactivity

(2014) K. Hamel et al.   JOURNAL OF IMMUNOLOGY

TLR-Activated B Cells Suppress T Cell-Mediated Autoimmunity

(2014) V. Lampropoulou et al.   JOURNAL OF IMMUNOLOGY

Rituximab Efficiently Depletes Increased CD20-Expressing T Cells in Multiple Sclerosis Patients

(2014) Arumugam Palanichamy et al.   JOURNAL OF IMMUNOLOGY

Plasma Cells in the Mucosa of Patients with Inflammatory Bowel Disease Produce Granzyme B and Possess Cytotoxic Activities

(2014) M. L. Cupi et al.   JOURNAL OF IMMUNOLOGY

IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases

(2014) Ping Shen et al.   NATURE

Interleukin-35 induces regulatory B cells that suppress autoimmune disease

(2014) Ren-Xi Wang et al.   NATURE MEDICINE

A Novel MicroRNA-132-Surtuin-1 Axis Underlies Aberrant B-cell Cytokine Regulation in Patients with Relapsing-Remitting Multiple Sclerosis

(2014) Yusei Miyazaki et al.   PLoS One

Regulatory B Cells Are Inversely Associated with Disease Activity in Rheumatoid Arthritis

(2014) Jinhyun Kim et al.   YONSEI MEDICAL JOURNAL

Active systemic lupus erythematosus is associated with a reduced cytokine production by B cells in response to TLR9 stimulation

(2014) Julia Sieber et al.   ARTHRITIS RESEARCH & THERAPY

Murine Gammaherpesvirus M2 Protein Induction of IRF4 via the NFAT Pathway Leads to IL-10 Expression in B Cells

(2014) Udaya S. Rangaswamy et al.   PLoS Pathogens

Regulatory B10 Cells Are Decreased in Patients With Rheumatoid Arthritis and Are Inversely Correlated With Disease Activity

(2014) Claire I. Daien et al.   Arthritis & Rheumatology

Naturally secreted immunoglobulins limit B1 and MZ B-cell numbers through a microbiota-independent mechanism

(2013) A. C. Lino et al.   BLOOD

Role of interleukin-10 and interleukin-10 receptor in systemic lupus erythematosus

(2013) Hui Peng et al.   CLINICAL RHEUMATOLOGY

B Cells Secrete Eotaxin-1 in Human Inflammatory Bowel Disease

(2013) Mian Qasim Rehman et al.   INFLAMMATORY BOWEL DISEASES

The effect of B-cell depletion therapy on serological evidence of B-cell and plasmablast activation in patients with rheumatoid arthritis over multiple cycles of rituximab treatment

(2013) G. Cambridge et al.   JOURNAL OF AUTOIMMUNITY

MHC class II–dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies

(2013) Nicolas Molnarfi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Peritoneal Cavity Regulatory B Cells (B10 Cells) Modulate IFN- +CD4+ T Cell Numbers during Colitis Development in Mice

(2013) D. Maseda et al.   JOURNAL OF IMMUNOLOGY

Immunopathogenic mechanisms of systemic autoimmune disease

(2013) Marie Wahren-Herlenius et al.   LANCET

Rituximab in systemic lupus erythematosus: an updated systematic review and meta-analysis

(2013) B Duxbury et al.   LUPUS

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

(2013) Ashley H Beecham et al.   NATURE GENETICS

Emerging cell and cytokine targets in rheumatoid arthritis

(2013) Gerd R. Burmester et al.   Nature Reviews Rheumatology

CD19+CD24hiCD38hi B Cells Maintain Regulatory T Cells While Limiting TH1 and TH17 Differentiation

(2013) F. Flores-Borja et al.   Science Translational Medicine

B Cell-Specific Expression of Inducible Costimulator Ligand Is Necessary for the Induction of Arthritis in Mice

(2013) Keith M. Hamel et al.   Arthritis & Rheumatology

IL-10–Producing Regulatory B10 Cells Ameliorate Collagen-Induced Arthritis via Suppressing Th17 Cell Generation

(2012) Min Yang et al.   AMERICAN JOURNAL OF PATHOLOGY

Outcomes 5 years after response to rituximab therapy in children and adults with immune thrombocytopenia

(2012) V. L. Patel et al.   BLOOD

Mucosal CXCR4+IgG plasma cells contribute to the pathogenesis of human ulcerative colitis through FcγR-mediated CD14 macrophage activation

(2012) Michihide Uo et al.   GUT

B cell depletion in immune thrombocytopenia reveals splenic long-lived plasma cells

(2012) Matthieu Mahévas et al.   JOURNAL OF CLINICAL INVESTIGATION

Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin

(2012) Ulrike Harre et al.   JOURNAL OF CLINICAL INVESTIGATION

B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6–producing B cells

(2012) Tom A. Barr et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: IL-6-Dependent Autoimmune Disease: Dendritic Cells as a Sufficient, but Transient, Source

(2012) M. D. Leech et al.   JOURNAL OF IMMUNOLOGY

Multiple Courses of Rituximab Produce Sustained Clinical and Radiographic Efficacy and Safety in Patients with Rheumatoid Arthritis and an Inadequate Response to 1 or More Tumor Necrosis Factor Inhibitors: 5-Year Data from the REFLEX Study

(2012) E. C. KEYSTONE et al.   JOURNAL OF RHEUMATOLOGY

Interleukin-10 produced by B cells is crucial for the suppression of Th17/Th1 responses, induction of T regulatory type 1 cells and reduction of collagen-induced arthritis

(2012) Natalie A Carter et al.   ARTHRITIS RESEARCH & THERAPY

Optimising treatment in rheumatoid arthritis: a review of potential biological markers of response

(2011) P. Emery et al.   ANNALS OF THE RHEUMATIC DISEASES

Rituximab abrogates joint destruction in rheumatoid arthritis by inhibiting osteoclastogenesis

(2011) Maria J H Boumans et al.   ANNALS OF THE RHEUMATIC DISEASES

Cytokine mRNA profiling identifies B cells as a major source of RANKL in rheumatoid arthritis

(2011) L. Yeo et al.   ANNALS OF THE RHEUMATIC DISEASES

Follicular Helper CD4 T Cells (TFH)

(2011) Shane Crotty   Annual Review of Immunology

Inflammation and autoantibody markers identify rheumatoid arthritis patients with enhanced clinical benefit following rituximab treatment

(2011) Preeti Lal et al.   ARTHRITIS AND RHEUMATISM

Atacicept in patients with rheumatoid arthritis and an inadequate response to methotrexate: Results of a phase II, randomized, placebo-controlled trial

(2011) R. F. van Vollenhoven et al.   ARTHRITIS AND RHEUMATISM

A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus

(2011) Richard Furie et al.   ARTHRITIS AND RHEUMATISM

Increasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review

(2011) Natalie A. Molodecky et al.   GASTROENTEROLOGY

Randomised placebo-controlled trial of rituximab (anti-CD20) in active ulcerative colitis

(2011) K. Leiper et al.   GUT

Genetics of rheumatoid arthritis: what have we learned?

(2011) Marieke Bax et al.   IMMUNOGENETICS

B Cell-Derived IL-10 Does Not Regulate Spontaneous Systemic Autoimmunity in MRL.Faslpr Mice

(2011) L. L. Teichmann et al.   JOURNAL OF IMMUNOLOGY

Mice Lacking Endogenous IL-10-Producing Regulatory B Cells Develop Exacerbated Disease and Present with an Increased Frequency of Th1/Th17 but a Decrease in Regulatory T Cells

(2011) N. A. Carter et al.   JOURNAL OF IMMUNOLOGY

Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial

(2011) Sandra V Navarra et al.   LANCET

Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial

(2011) Ludwig Kappos et al.   LANCET

The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells

(2011) Erika Cretney et al.   NATURE IMMUNOLOGY

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

B cell-derived IL-10 suppresses inflammatory disease in Lyn-deficient mice

(2011) P. Scapini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Changes in B- and T-Lymphocyte and Chemokine Levels With Rituximab Treatment in Multiple Sclerosis

(2010) Laura Piccio et al.   ARCHIVES OF NEUROLOGY

Steady-state generation of mucosal IgA+ plasmablasts is not abrogated by B-cell depletion therapy with rituximab

(2010) H. E. Mei et al.   BLOOD

Signaling via the MyD88 Adaptor Protein in B Cells Suppresses Protective Immunity during Salmonella typhimurium Infection

(2010) Patricia Neves et al.   IMMUNITY

CD19+CD24hiCD38hi B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients

(2010) Paul A. Blair et al.   IMMUNITY

Genome-wide association identifies multiple ulcerative colitis susceptibility loci

(2010) Dermot P B McGovern et al.   NATURE GENETICS

Severe Ulcerative Colitis After Rituximab Therapy

(2010) D. S. Ardelean et al.   PEDIATRICS

Targeting B cells in immune-mediated inflammatory disease: A comprehensive review of mechanisms of action and identification of biomarkers

(2010) Thomas Dörner et al.   PHARMACOLOGY & THERAPEUTICS

Atacicept: targeting B cells in multiple sclerosis

(2010) Hans-Peter Hartung et al.   Therapeutic Advances in Neurological Disorders

Abnormal B-cell cytokine responses a trigger of T-cell-mediated disease in MS?

(2009) Amit Bar-Or et al.   ANNALS OF NEUROLOGY

Delayed acquisition of somatic hypermutations in repopulated IGD+CD27+ memory B cell receptors after rituximab treatment

(2009) Khalid Muhammad et al.   ARTHRITIS AND RHEUMATISM

Efficacy and safety of rituximab in moderately-to-severely active systemic lupus erythematosus: The randomized, double-blind, phase ii/iii systemic lupus erythematosus evaluation of rituximab trial

(2009) Joan T. Merrill et al.   ARTHRITIS AND RHEUMATISM

The ITP syndrome: pathogenic and clinical diversity

(2009) D. B. Cines et al.   BLOOD

An FcRn-Dependent Role for Anti-flagellin Immunoglobulin G in Pathogenesis of Colitis in Mice

(2009) Kanna Kobayashi et al.   GASTROENTEROLOGY

CXCL12 Is a constitutive and inflammatory chemokine in the intestinal immune system

(2009) Iris Dotan et al.   INFLAMMATORY BOWEL DISEASES

Absence of the Transcriptional Repressor Blimp-1 in Hematopoietic Lineages Reveals Its Role in Dendritic Cell Homeostatic Development and Function

(2009) Y.-H. Chan et al.   JOURNAL OF IMMUNOLOGY

Selective Targeting of B Cells with Agonistic Anti-CD40 Is an Efficacious Strategy for the Generation of Induced Regulatory T2-Like B Cells and for the Suppression of Lupus in MRL/lpr Mice

(2009) P. A. Blair et al.   JOURNAL OF IMMUNOLOGY

Hyperactivated B cells in human inflammatory bowel disease

(2009) Ansu Mammen Noronha et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Synovial Tissue Sublining CD68 Expression Is a Biomarker of Therapeutic Response in Rheumatoid Arthritis Clinical Trials: Consistency Across Centers

(2009) B. BRESNIHAN et al.   JOURNAL OF RHEUMATOLOGY

REL, encoding a member of the NF-κB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis

(2009) Peter K Gregersen et al.   NATURE GENETICS

Colitis immunoregulation by CD8+ T cell requires T cell cytotoxicity and B cell peptide antigen presentation

(2008) Michael McPherson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Helminth infections associated with multiple sclerosis induce regulatory B cells

(2008) Jorge Correale et al.   ANNALS OF NEUROLOGY

Rituximab in relapsing-remitting multiple sclerosis: A 72-week, open-label, phase I trial

(2008) Amit Bar-Or et al.   ANNALS OF NEUROLOGY

Anti-CD20 therapy in patients with rheumatoid arthritis: Predictors of response and B cell subset regeneration after repeated treatment

(2008) Petra Roll et al.   ARTHRITIS AND RHEUMATISM

Highly sensitive B cell analysis predicts response to rituximab therapy in rheumatoid arthritis

(2008) Shouvik Dass et al.   ARTHRITIS AND RHEUMATISM

Integration of B cells and CD8+ T in the protective regulation of systemic epithelial inflammation

(2008) Bo Wei et al.   CLINICAL IMMUNOLOGY

Ulcerative colitis following B lymphocyte depletion with rituximab in a patient with Graves' disease

(2008) D. E. Fassi et al.   GUT

B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis

(2008) Stephen L. Hauser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Matrix metalloproteinase-3 production by gut IgG plasma cells in chronic inflammatory bowel disease

(2007) John N. Gordon et al.   INFLAMMATORY BOWEL DISEASES