The potential role of retroviruses in autoimmunity

APOBEC3 enzymes restrict marginal zone B cells

(2015) Gabriele B. Beck-Engeser et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

ZNF10 inhibits HIV-1 LTR activity through interaction with NF-κB and Sp1 binding motifs

(2015) Hironori Nishitsuji et al.   FEBS LETTERS

Toll-like receptor 8 deletion accelerates autoimmunity in a mouse model of lupus through a Toll-like receptor 7-dependent mechanism

(2015) Ngoc Lan Tran et al.   IMMUNOLOGY

Activation of the innate immune response by endogenous retroviruses

(2015) Tara P. Hurst et al.   JOURNAL OF GENERAL VIROLOGY

Cutting Edge: DNase II Deficiency Prevents Activation of Autoreactive B Cells by Double-Stranded DNA Endogenous Ligands

(2015) Sudesh Pawaria et al.   JOURNAL OF IMMUNOLOGY

Cell-Intrinsic Expression of TLR9 in Autoreactive B Cells Constrains BCR/TLR7-Dependent Responses

(2015) Kerstin Nündel et al.   JOURNAL OF IMMUNOLOGY

Human Endogenous Retrovirus Type K (HERV-K) Particles Package and Transmit HERV-K–Related Sequences

(2015) Rafael Contreras-Galindo et al.   JOURNAL OF VIROLOGY

Structure Based Modeling of Small Molecules Binding to the TLR7 by Atomistic Level Simulations

(2015) Francesco Gentile et al.   MOLECULES

Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells

(2015) Edward J. Grow et al.   NATURE

Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9

(2015) Umeharu Ohto et al.   NATURE

Modulation of human endogenous retrovirus (HERV) transcription during persistent and de novo HIV-1 infection

(2015) Michelle Vincendeau et al.   Retrovirology

Endogenous viruses: Connecting recent and ancient viral evolution

(2015) Pakorn Aiewsakun et al.   VIROLOGY

Origins and evolution of viruses of eukaryotes: The ultimate modularity

(2015) Eugene V. Koonin et al.   VIROLOGY

Innate immune recognition of DNA: A recent history

(2015) Alan Dempsey et al.   VIROLOGY

Signaling in Lymphocyte Activation

(2015) Doreen Cantrell   Cold Spring Harbor Perspectives in Biology

Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases

(2015) Atsuo Kanno et al.   Nature Communications

TLR7 Influences Germinal Center Selection in Murine SLE

(2015) Alexis Boneparth et al.   PLoS One

Epigenetic Modulations in Activated Cells Early after HIV-1 Infection and Their Possible Functional Consequences

(2015) Juliana T. Maricato et al.   PLoS One

Autoimmune diseases in HIV-infected patients: 52 cases and literature review

(2014) Laura Iordache et al.   AUTOIMMUNITY REVIEWS

RNA:DNA hybrids are a novel molecular pattern sensed by TLR9

(2014) R. E. Rigby et al.   EMBO JOURNAL

Multiple evidence strands suggest that there may be as few as 19 000 human protein-coding genes

(2014) Iakes Ezkurdia et al.   HUMAN MOLECULAR GENETICS

Autoimmune Disorders Associated with Gain of Function of the Intracellular Sensor MDA5

(2014) Masahide Funabiki et al.   IMMUNITY

An autoreactive antibody from an SLE/HIV-1 individual broadly neutralizes HIV-1

(2014) Mattia Bonsignori et al.   JOURNAL OF CLINICAL INVESTIGATION

Evidence for Genes in Addition to Tlr7 in the Yaa Translocation Linked with Acceleration of Systemic Lupus Erythematosus

(2014) M.-L. Santiago-Raber et al.   JOURNAL OF IMMUNOLOGY

Identification of RNA Sequence Motifs Stimulating Sequence-Specific TLR8-Dependent Immune Responses

(2014) A. Forsbach et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: AIM2 and Endosomal TLRs Differentially Regulate Arthritis and Autoantibody Production in DNase II–Deficient Mice

(2014) Rebecca Baum et al.   JOURNAL OF IMMUNOLOGY

Intrinsic Self-DNA Triggers Inflammatory Disease Dependent on STING

(2014) Jeonghyun Ahn et al.   JOURNAL OF IMMUNOLOGY

TREX1 Deficiency Triggers Cell-Autonomous Immunity in a cGAS-Dependent Manner

(2014) A. Ablasser et al.   JOURNAL OF IMMUNOLOGY

Rheumatoid Arthritis is Associated with IgG Antibodies to Human Endogenous Retrovirus Gag Matrix: A Potential Pathogenic Mechanism of Disease?

(2014) P. N. Nelson et al.   JOURNAL OF RHEUMATOLOGY

Polyreactivity and Autoreactivity among HIV-1 Antibodies

(2014) Mengfei Liu et al.   JOURNAL OF VIROLOGY

Viruses as potential pathogenic agents in systemic lupus erythematosus

(2014) P Nelson et al.   LUPUS

Retroviral Transcriptional Regulation and Embryonic Stem Cells: War and Peace

(2014) Sharon Schlesinger et al.   MOLECULAR AND CELLULAR BIOLOGY

A phase IIa randomised clinical study of GNbAC1, a humanised monoclonal antibody against the envelope protein of multiple sclerosis-associated endogenous retrovirus in multiple sclerosis patients

(2014) Tobias Derfuss et al.   Multiple Sclerosis Journal

The enemy within: endogenous retroelements and autoimmune disease

(2014) Hannah E Volkman et al.   NATURE IMMUNOLOGY

TLR7 induces anergy in human CD4+ T cells

(2014) Margarita Dominguez-Villar et al.   NATURE IMMUNOLOGY

TLR8 on dendritic cells and TLR9 on B cells restrain TLR7-mediated spontaneous autoimmunity in C57BL/6 mice

(2014) B. Desnues et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pan-vertebrate comparative genomics unmasks retrovirus macroevolution

(2014) Alexander Hayward et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A modified dinucleotide motif specifies tRNA recognition by TLR7

(2014) Steffen Kaiser et al.   RNA

MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses

(2014) Ming Zeng et al.   SCIENCE

Concomitant systemic lupus erythematosus and HIV: Case series and literature review

(2014) Girish M. Mody et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Optimizing pharmacotherapy of systemic lupus erythematosus: the pharmacist role

(2014) Maryam Al Hussaini et al.   International Journal of Clinical Pharmacy

Cancer risk in systemic lupus: An updated international multi-centre cohort study

(2013) Sasha Bernatsky et al.   JOURNAL OF AUTOIMMUNITY

RNA recognition by human TLR8 can lead to autoimmune inflammation

(2013) Cristiana Guiducci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Overexpression of TLR7 promotes cell-intrinsic expansion and autoantibody production by transitional T1 B cells

(2013) Natalia V. Giltiay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Toll-Like Receptor 7 Inhibits Early Acute Retroviral Infection through Rapid Lymphocyte Responses

(2013) E. P. Browne   JOURNAL OF VIROLOGY

Human Endogenous Retrovirus Protein Activates Innate Immunity and Promotes Experimental Allergic Encephalomyelitis in Mice

(2013) Hervé Perron et al.   PLoS One

Structural Reorganization of the Toll-Like Receptor 8 Dimer Induced by Agonistic Ligands

(2013) H. Tanji et al.   SCIENCE

Our Viral Inheritance

(2013) R. A. Weiss et al.   SCIENCE

Evolution of different antiviral strategies in wild mouse populations exposed to different gammaretroviruses

(2013) Christine A. Kozak   Current Opinion in Virology

Retrovirus replication strategies

(2013) Ben Berkhout et al.   Current Opinion in Virology

Nucleic Acid-Sensing Toll-like Receptors Are Essential for the Control of Endogenous Retrovirus Viremia and ERV-Induced Tumors

(2012) Philipp Yu et al.   IMMUNITY

B Cell Tolerance and Positive Selection in Lupus

(2012) D. Eilat et al.   JOURNAL OF IMMUNOLOGY

Realities of virus sensing

(2012) Melissa Kane et al.   MICROBES AND INFECTION

Intrinsic antiviral immunity

(2012) Nan Yan et al.   NATURE IMMUNOLOGY

Dual signaling by innate and adaptive immune receptors is required for TLR7-induced B-cell-mediated autoimmunity

(2012) E. R. Walsh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV infection and HERV expression: a review

(2012) Antoinette C van der Kuyl   Retrovirology

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

Antiviral Mechanism and Biochemical Basis of the Human APOBEC3 Family

(2012) Mayumi Imahashi et al.   Frontiers in Microbiology

Autoimmune disease: A role for new anti-viral therapies?

(2011) David H. Dreyfus   AUTOIMMUNITY REVIEWS

Innate Immune Sensing of Retroviral Infection via Toll-like Receptor 7 Occurs upon Viral Entry

(2011) Melissa Kane et al.   IMMUNITY

Characterization of Human Endogenous Retroviral Elements in the Blood of HIV-1-Infected Individuals

(2011) R. Contreras-Galindo et al.   JOURNAL OF VIROLOGY

The Etiology of Multiple Sclerosis: Genetic Evidence for the Involvement of the Human Endogenous Retrovirus HERV-Fc1

(2011) Bjørn A. Nexø et al.   PLoS One

An autoimmune disease prevented by anti-retroviral drugs

(2011) Gabriele B Beck-Engeser et al.   Retrovirology

Dynamic control of endogenous retroviruses during development

(2011) Helen M. Rowe et al.   VIROLOGY

Innate Sensing of HIV-Infected Cells

(2011) Alice Lepelley et al.   PLoS Pathogens

Toll-like Receptor 7 Controls the Anti-Retroviral Germinal Center Response

(2011) Edward P. Browne   PLoS Pathogens

Role of endogenous retroviruses in murine SLE

(2010) Lucie Baudino et al.   AUTOIMMUNITY REVIEWS

Gaining a foothold: how HIV avoids innate immune recognition

(2010) Nan Yan et al.   CURRENT OPINION IN IMMUNOLOGY

Implication of Human Endogenous Retroviruses in the Development of Autoimmune Diseases

(2010) Eva Balada et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Lipopolysaccharide stress induces cell-type specific production of murine leukemia virus type-endogenous retroviral virions in primary lymphoid cells

(2010) D.-N. Kwon et al.   JOURNAL OF GENERAL VIROLOGY

Proviral silencing in embryonic stem cells requires the histone methyltransferase ESET

(2010) Toshiyuki Matsui et al.   NATURE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Activating systemic autoimmunity: B's, T's, and tolls

(2009) Mark J Shlomchik   CURRENT OPINION IN IMMUNOLOGY

Sequences derived from self-RNA containing certain natural modifications act as suppressors of RNA-mediated inflammatory immune responses

(2009) S. Tluk et al.   INTERNATIONAL IMMUNOLOGY

Self-Organized Criticality Theory of Autoimmunity

(2009) Ken Tsumiyama et al.   PLoS One

Syncytin-A knockout mice demonstrate the critical role in placentation of a fusogenic, endogenous retrovirus-derived, envelope gene

(2009) A. Dupressoir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Early onset of autoimmune disease by the retroviral integrase inhibitor raltegravir

(2009) G. B. Beck-Engeser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myd88 Is Required for an Antibody Response to Retroviral Infection

(2009) Edward P. Browne et al.   PLoS Pathogens

Host Restriction Factors Blocking Retroviral Replication

(2008) Daniel Wolf et al.   Annual Review of Genetics

The APOBEC3 Cytidine Deaminases: An Innate Defensive Network Opposing Exogenous Retroviruses and Endogenous Retroelements

(2008) Ya-Lin Chiu et al.   Annual Review of Immunology

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL

Endogenous retroviruses

(2008) C. Stocking et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

B-cell tolerance checkpoints in health and autoimmunity

(2008) Eric Meffre et al.   CURRENT OPINION IN IMMUNOLOGY

HIV immunology needs a new direction

(2008) Ruslan Medzhitov et al.   NATURE

Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections

(2008) Judith N Mandl et al.   NATURE MEDICINE