Structure Based Modeling of Small Molecules Binding to the TLR7 by Atomistic Level Simulations

Homology and Molecular Dynamics Models of Toll-Like Receptor 7 Protein and Its Dimerization

(2014) Chih-Yuan Tseng et al.   Chemical Biology & Drug Design

Imiquimod in the Treatment of Breast Cancer Skin Metastasis

(2014) Lisa Henriques et al.   JOURNAL OF CLINICAL ONCOLOGY

TLR7/8 agonists trigger immunostimulatory properties of human 6-sulfo LacNAc dendritic cells

(2013) Hanka Jähnisch et al.   CANCER LETTERS

Processing of Human Toll-like Receptor 7 by Furin-like Proprotein Convertases Is Required for Its Accumulation and Activity in Endosomes

(2013) Madeleine M. Hipp et al.   IMMUNITY

Routine Microsecond Molecular Dynamics Simulations with AMBER on GPUs. 2. Explicit Solvent Particle Mesh Ewald

(2013) Romelia Salomon-Ferrer et al.   Journal of Chemical Theory and Computation

Toll-Like Receptor 7 Agonists: Chemical Feature Based Pharmacophore Identification and Molecular Docking Studies

(2013) Hui Yu et al.   PLoS One

Structural Reorganization of the Toll-Like Receptor 8 Dimer Induced by Agonistic Ligands

(2013) H. Tanji et al.   SCIENCE

New developments in Toll-like receptor targeted therapeutics

(2012) Dympna J Connolly et al.   CURRENT OPINION IN PHARMACOLOGY

Resiquimod, a topical drug for viral skin lesions and skin cancer

(2012) Thomas Meyer et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Homology modeling a fast tool for drug discovery: Current perspectives

(2012) VK Vyas et al.   INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES

The application of Toll like receptors for cancer therapy

(2012) Eui Young So et al.   International Journal of Biological Sciences

The Normal-Mode Entropy in the MM/GBSA Method: Effect of System Truncation, Buffer Region, and Dielectric Constant

(2012) Samuel Genheden et al.   Journal of Chemical Information and Modeling

MMPBSA.py: An Efficient Program for End-State Free Energy Calculations

(2012) Bill R. Miller et al.   Journal of Chemical Theory and Computation

Routine Microsecond Molecular Dynamics Simulations with AMBER on GPUs. 1. Generalized Born

(2012) Andreas W. Götz et al.   Journal of Chemical Theory and Computation

Toll-like receptor 7 regulates pancreatic carcinogenesis in mice and humans

(2012) Atsuo Ochi et al.   JOURNAL OF CLINICAL INVESTIGATION

Variability in docking success rates due to dataset preparation

(2012) Christopher R. Corbeil et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Negative Regulation of the Type I Interferon Signaling Pathway by Synthetic Toll-Like Receptor 7 Ligands

(2012) Alexandra Forsbach et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Asparagine Endopeptidase Controls Anti-Influenza Virus Immune Responses through TLR7 Activation

(2012) Sophia Maschalidi et al.   PLoS Pathogens

Toll-Like Receptor 7 Agonist Therapy with Imidazoquinoline Enhances Cancer Cell Death and Increases Lymphocytic Infiltration and Proinflammatory Cytokine Production in Established Tumors of a Renal Cell Carcinoma Mouse Model

(2012) Eric C. Kauffman et al.   Journal of Oncology

A Point Mutation in the Amino Terminus of TLR7 Abolishes Signaling without Affecting Ligand Binding

(2011) Carlo Iavarone et al.   JOURNAL OF IMMUNOLOGY

The TLR7 Ligand 9-Benzyl-2-Butoxy-8-Hydroxy Adenine Inhibits IL-17 Response by Eliciting IL-10 and IL-10-Inducing Cytokines

(2011) A. Vultaggio et al.   JOURNAL OF IMMUNOLOGY

UniProt Knowledgebase: a hub of integrated protein data

(2011) M. Magrane et al.   Database-The Journal of Biological Databases and Curation

Dual or Triple Activation of TLR7, TLR8, and/or TLR9 by Single-Stranded Oligoribonucleotides

(2011) Alexandra Forsbach et al.   Nucleic Acid Therapeutics

Assessing the Performance of the MM/PBSA and MM/GBSA Methods. 1. The Accuracy of Binding Free Energy Calculations Based on Molecular Dynamics Simulations

(2010) Tingjun Hou et al.   Journal of Chemical Information and Modeling

A leucine-rich repeat assembly approach for homology modeling of the human TLR5-10 and mouse TLR11-13 ectodomains

(2010) Tiandi Wei et al.   JOURNAL OF MOLECULAR MODELING

Additive melanoma suppression with intralesional phospholipid-conjugated TLR7 agonists and systemic IL-2

(2010) Tomoko Hayashi et al.   MELANOMA RESEARCH

The antiviral activity of toll-like receptor 7 and 7/8 agonists

(2009) R.L. Miller et al.   DRUG NEWS & PERSPECTIVES

Impaired expression and function of toll-like receptor 7 in hepatitis C virus infection in human hepatoma cells

(2009) Serena Chang et al.   HEPATOLOGY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Homology modeling of human Toll-like receptors TLR7, 8, and 9 ligand-binding domains

(2009) Tiandi Wei et al.   PROTEIN SCIENCE

CL097, A TLR7/8 LIGAND, INHIBITS TLR-4-DEPENDENT ACTIVATION OF IRAK-M AND BCL-3 EXPRESSION

(2009) Branka Petricevic et al.   SHOCK

The generalized Born/volume integral implicit solvent model: Estimation of the free energy of hydration using London dispersion instead of atomic surface area

(2008) Paul Labute   JOURNAL OF COMPUTATIONAL CHEMISTRY

TLR7 and TLR8 as targets in cancer therapy

(2008) M P Schön et al.   ONCOGENE

The Use of TLR7 and TLR8 Ligands for the Enhancement of Cancer Immunotherapy

(2008) E. L. J. M. Smits et al.   ONCOLOGIST