Activation of the innate immune response by endogenous retroviruses

The transmembrane proteins contribute to immunodeficiencies induced by HIV-1 and other retroviruses

(2014) Joachim Denner   AIDS

Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease

(2014) Mark D. Turner et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

RNA:DNA hybrids are a novel molecular pattern sensed by TLR9

(2014) R. E. Rigby et al.   EMBO JOURNAL

Endogenous Retroviruses and the Development of Cancer

(2014) G. Kassiotis   JOURNAL OF IMMUNOLOGY

TREX1 Deficiency Triggers Cell-Autonomous Immunity in a cGAS-Dependent Manner

(2014) A. Ablasser et al.   JOURNAL OF IMMUNOLOGY

TLR ligands up-regulate Trex1 expression in murine conventional dendritic cells through type I Interferon and NF-κB-dependent signaling pathways

(2014) Jun Xu et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Unfixed Endogenous Retroviral Insertions in the Human Population

(2014) E. Marchi et al.   JOURNAL OF VIROLOGY

Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling

(2014) Gillian I Rice et al.   NATURE GENETICS

The enemy within: endogenous retroelements and autoimmune disease

(2014) Hannah E Volkman et al.   NATURE IMMUNOLOGY

The SKIV2L RNA exosome limits activation of the RIG-I-like receptors

(2014) Sterling C Eckard et al.   NATURE IMMUNOLOGY

The ribonuclease activity of SAMHD1 is required for HIV-1 restriction

(2014) Jeongmin Ryoo et al.   NATURE MEDICINE

The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity

(2014) Xinyi Lu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Trans-activation, post-transcriptional maturation, and induction of antibodies to HERV-K (HML-2) envelope transmembrane protein in HIV-1 infection

(2014) Henri-Alexandre Michaud et al.   Retrovirology

Evolution of the Retroviral Restriction Gene Fv1: Inhibition of Non-MLV Retroviruses

(2014) Melvyn W. Yap et al.   PLoS Pathogens

Impaired Clearance of Apoptotic Cells in Chronic Inflammatory Diseases: Therapeutic Implications

(2014) Zsuzsa Szondy et al.   Frontiers in Immunology

Immune Sensing of DNA

(2013) Søren R. Paludan et al.   IMMUNITY

Human endogenous retrovirus type K antibodies and mRNA as serum biomarkers of early-stage breast cancer

(2013) Feng Wang-Johanning et al.   INTERNATIONAL JOURNAL OF CANCER

HIV-1 gp120 Induces TLR2- and TLR4-Mediated Innate Immune Activation in Human Female Genital Epithelium

(2013) A. Nazli et al.   JOURNAL OF IMMUNOLOGY

Role of Nucleic Acid-Sensing TLRs in Diverse Autoantibody Specificities and Anti-Nuclear Antibody-Producing B Cells

(2013) Y. T. Koh et al.   JOURNAL OF IMMUNOLOGY

SAMHD1 Host Restriction Factor: A Link with Innate Immune Sensing of Retrovirus Infection

(2013) Alexandre Sze et al.   JOURNAL OF MOLECULAR BIOLOGY

Toll-Like Receptors in Antiviral Innate Immunity

(2013) Sandra N. Lester et al.   JOURNAL OF MOLECULAR BIOLOGY

Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies

(2013) Johnny C. Akers et al.   JOURNAL OF NEURO-ONCOLOGY

Toll-Like Receptor 7 Inhibits Early Acute Retroviral Infection through Rapid Lymphocyte Responses

(2013) E. P. Browne   JOURNAL OF VIROLOGY

Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study

(2013) Gillian I Rice et al.   LANCET NEUROLOGY

Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

(2013) John W. Schoggins et al.   NATURE

LGP2 Plays a Critical Role in Sensitizing mda-5 to Activation by Double-Stranded RNA

(2013) Kay S. Childs et al.   PLoS One

The Transmembrane Protein of the Human Endogenous Retrovirus - K (HERV-K) Modulates Cytokine Release and Gene Expression

(2013) Vladimir A. Morozov et al.   PLoS One

PNAS Plus: From the Cover: IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication

(2013) M. R. Jakobsen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endogenous retrovirus-K promoter: a landing strip for inflammatory transcription factors?

(2013) Mamneet Manghera et al.   Retrovirology

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

(2013) D. Gao et al.   SCIENCE

Innate immune detection of microbial nucleic acids

(2013) Claudia Gürtler et al.   TRENDS IN MICROBIOLOGY

Nucleic Acid-Sensing Toll-like Receptors Are Essential for the Control of Endogenous Retrovirus Viremia and ERV-Induced Tumors

(2012) Philipp Yu et al.   IMMUNITY

Autoimmunity Initiates in Nonhematopoietic Cells and Progresses via Lymphocytes in an Interferon-Dependent Autoimmune Disease

(2012) Alevtina Gall et al.   IMMUNITY

PAMPs and DAMPs: signal 0s that spur autophagy and immunity

(2012) Daolin Tang et al.   IMMUNOLOGICAL REVIEWS

From ancestral infectious retroviruses to bona fide cellular genes: Role of the captured syncytins in placentation

(2012) A. Dupressoir et al.   PLACENTA

Genomic HIV RNA Induces Innate Immune Responses through RIG-I-Dependent Sensing of Secondary-Structured RNA

(2012) Randi K. Berg et al.   PLoS One

Env-less endogenous retroviruses are genomic superspreaders

(2012) G. Magiorkinis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SAMHD1 restricts HIV-1 infection in dendritic cells (DCs) by dNTP depletion, but its expression in DCs and primary CD4+ T-lymphocytes cannot be upregulated by interferons

(2012) Corine St Gelais et al.   Retrovirology

Paleovirology and virally derived immunity

(2012) Amr Aswad et al.   TRENDS IN ECOLOGY & EVOLUTION

Immune Signaling by RIG-I-like Receptors

(2011) Yueh-Ming Loo et al.   IMMUNITY

A Human Endogenous Retrovirus K dUTPase Triggers a TH1, TH17 Cytokine Response: Does It Have a Role in Psoriasis?

(2011) Maria-Eugenia Ariza et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

TRIM5 is an innate immune sensor for the retrovirus capsid lattice

(2011) Thomas Pertel et al.   NATURE

An autoimmune disease prevented by anti-retroviral drugs

(2011) Gabriele B Beck-Engeser et al.   Retrovirology

Paleovirology—ghosts and gifts of viruses past

(2011) Maulik R Patel et al.   Current Opinion in Virology

Toll-like Receptor 7 Controls the Anti-Retroviral Germinal Center Response

(2011) Edward P. Browne   PLoS Pathogens

TLR-mediated up-regulation of serum retroviral gp70 is controlled by the Sgp loci of lupus-prone mice

(2010) Lucie Baudino et al.   JOURNAL OF AUTOIMMUNITY

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

Adaptive Evolution of Mus Apobec3 Includes Retroviral Insertion and Positive Selection at Two Clusters of Residues Flanking the Substrate Groove

(2010) Bradley Sanville et al.   PLoS Pathogens

The roles of TLRs, RLRs and NLRs in pathogen recognition

(2009) T. Kawai et al.   INTERNATIONAL IMMUNOLOGY

Selective Up-Regulation of Intact, but Not Defective env RNAs of Endogenous Modified Polytropic Retrovirus by the Sgp3 Locus of Lupus-Prone Mice

(2009) K. Yoshinobu et al.   JOURNAL OF IMMUNOLOGY

Interaction between Ebola Virus Glycoprotein and Host Toll-Like Receptor 4 Leads to Induction of Proinflammatory Cytokines and SOCS1

(2009) A. Okumura et al.   JOURNAL OF VIROLOGY

Multiple sclerosis-associated retroviral agent (MSRV)-stimulated cytokine production in patients with relapsing-remitting multiple sclerosis

(2009) M Saresella et al.   Multiple Sclerosis Journal

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

The SET Complex Acts as a Barrier to Autointegration of HIV-1

(2009) Nan Yan et al.   PLoS Pathogens

Human Endogenous Retrovirus K Triggers an Antigen-Specific Immune Response in Breast Cancer Patients

(2008) F. Wang-Johanning et al.   CANCER RESEARCH

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

(2008) Hiroki Kato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hypermutation of an Ancient Human Retrovirus by APOBEC3G

(2008) Y. N. Lee et al.   JOURNAL OF VIROLOGY