Sialic acids and autoimmune disease

CD24: from a Hematopoietic Differentiation Antigen to a Genetic Risk Factor for Multiple Autoimmune Diseases

(2015) Yixin Tan et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Siglec-G Deficiency Leads to Autoimmunity in Aging C57BL/6 Mice

(2015) Jennifer Müller et al.   JOURNAL OF IMMUNOLOGY

Sialyl Lewis x (CD15s) identifies highly differentiated and most suppressive FOXP3highregulatory T cells in humans

(2015) Makoto Miyara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protection in antibody- and T cell-mediated autoimmune diseases by antiinflammatory IgG Fcs requires type II FcRs

(2015) Benjamin M. Fiebiger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of Multifold Modified Sialosides as Human CD22/Siglec-2 Ligands with Nanomolar Activity on B-Cells

(2014) Horst Prescher et al.   ACS Chemical Biology

A missense single-nucleotide polymorphism in the sialic acid acetylesterase (SIAE) gene is associated with anti^|^ndash;PIT-1 antibody syndrome

(2014) Masaaki Yamamoto et al.   ENDOCRINE JOURNAL

Associations of genetic polymorphisms of Siglecs with human diseases

(2014) Takashi Angata   GLYCOBIOLOGY

TIM-1 Glycoprotein Binds the Adhesion Receptor P-Selectin and Mediates T Cell Trafficking during Inflammation and Autoimmunity

(2014) Stefano Angiari et al.   IMMUNITY

Autoreactive T Cells Escape Clonal Deletion in the Thymus by a CD24-Dependent Pathway

(2014) J. W. Carl et al.   JOURNAL OF IMMUNOLOGY

Siglecs Induce Tolerance to Cell Surface Antigens by BIM-Dependent Deletion of the Antigen-Reactive B Cells

(2014) Matthew S. Macauley et al.   JOURNAL OF IMMUNOLOGY

The Ligand-Binding Domain of Siglec-G Is Crucial for Its Selective Inhibitory Function on B1 Cells

(2014) S. Hutzler et al.   JOURNAL OF IMMUNOLOGY

Siglec-G Deficiency Leads to More Severe Collagen-Induced Arthritis and Earlier Onset of Lupus-like Symptoms in MRL/lpr Mice

(2014) S. Bokers et al.   JOURNAL OF IMMUNOLOGY

Extensive crosslinking of CD22 by epratuzumab triggers BCR signaling and caspase-dependent apoptosis in human lymphoma cells

(2014) Chien-Hsing Chang et al.   mAbs

Type I and type II Fc receptors regulate innate and adaptive immunity

(2014) Andrew Pincetic et al.   NATURE IMMUNOLOGY

A red meat-derived glycan promotes inflammation and cancer progression

(2014) Annie N. Samraj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of T cell trafficking by the T cell immunoglobulin and mucin domain 1 glycoprotein

(2014) Stefano Angiari et al.   TRENDS IN MOLECULAR MEDICINE

Development of an Autoimmune Syndrome Affecting the Skin and Internal Organs in P-Selectin Glycoprotein Ligand 1 Leukocyte Receptor-Deficient Mice

(2014) A. Pérez-Frías et al.   Arthritis & Rheumatology

Antigenic liposomes displaying CD22 ligands induce antigen-specific B cell apoptosis

(2013) Matthew S. Macauley et al.   JOURNAL OF CLINICAL INVESTIGATION

Copresentation of Antigen and Ligands of Siglec-G Induces B Cell Tolerance Independent of CD22

(2013) F. Pfrengle et al.   JOURNAL OF IMMUNOLOGY

Discovery of sialyl Lewis A and Lewis X modified protein cancer biomarkers using high density antibody arrays

(2013) Jung-hyun Rho et al.   Journal of Proteomics

M89V Sialic Acid Acetyl Esterase (SIAE) and All Other Non-Synonymous Common Variants of This Gene Are Catalytically Normal

(2013) Vasant Chellappa et al.   PLoS One

CD22 ligand-binding and signaling domains reciprocally regulate B-cell Ca2+ signaling

(2013) J. Muller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Siglecs as sensors of self in innate and adaptive immune responses

(2012) James C. Paulson et al.   Annals of the New York Academy of Sciences

Multifarious roles of sialic acids in immunity

(2012) Ajit Varki et al.   Annals of the New York Academy of Sciences

Siglecs and Immune Regulation

(2012) Shiv Pillai et al.   Annual Review of Immunology

Red Meat Consumption and Mortality

(2012) Qi Sun   ARCHIVES OF INTERNAL MEDICINE

The role of functionally defective rare germline variants of sialic acid acetylesterase in autoimmune Addison's disease

(2012) Earn H Gan et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Association of primary biliary cirrhosis with variants in the CLEC16A, SOCS1, SPIB and SIAE immunomodulatory genes

(2012) G M Hirschfield et al.   GENES AND IMMUNITY

Metabolism of Vertebrate Amino Sugars withN-Glycolyl Groups

(2012) Kalyan Banda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Siglec-8 as a drugable target to treat eosinophil and mast cell-associated conditions

(2012) Takumi Kiwamoto et al.   PHARMACOLOGY & THERAPEUTICS

Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids

(2012) P. X. Shaw et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD22 serves as a receptor for soluble IgM

(2011) Takahiro Adachi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Letter to the Glyco-Forum: Since there are PAMPs and DAMPs, there must be SAMPs? Glycan "self-associated molecular patterns" dampen innate immunity, but pathogens can mimic them

(2011) A. Varki   GLYCOBIOLOGY

Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction

(2011) Guo-Yun Chen et al.   NATURE BIOTECHNOLOGY

A rare penetrant mutation in CFH confers high risk of age-related macular degeneration

(2011) Soumya Raychaudhuri et al.   NATURE GENETICS

Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry

(2011) Karen A Hunt et al.   NATURE GENETICS

HMGB1 and RAGE in Inflammation and Cancer

(2010) Gary P. Sims et al.   Annual Review of Immunology

The human Cas1 protein: A sialic acid-specific O-acetyltransferase?

(2010) S. Arming et al.   GLYCOBIOLOGY

Novel mechanism for the generation of human xeno-autoantibodies against the nonhuman sialic acidN-glycolylneuraminic acid

(2010) Rachel E. Taylor et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD22 x Siglec-G Double-Deficient Mice Have Massively Increased B1 Cell Numbers and Develop Systemic Autoimmunity

(2010) J. Jellusova et al.   JOURNAL OF IMMUNOLOGY

In Situ transLigands of CD22 Identified by Glycan-Protein Photocross-linking-enabled Proteomics

(2010) T. N. C. Ramya et al.   MOLECULAR & CELLULAR PROTEOMICS

Functionally defective germline variants of sialic acid acetylesterase in autoimmunity

(2010) Ira Surolia et al.   NATURE

Uniquely human evolution of sialic acid genetics and biology

(2010) A. Varki   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Cytoskeleton Coordinates the Early Events of B-cell Activation

(2010) N. E. Harwood et al.   Cold Spring Harbor Perspectives in Biology

Meat Intake and Mortality

(2009) Rashmi Sinha et al.   ARCHIVES OF INTERNAL MEDICINE

Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium

(2009) T. Pham et al.   BLOOD

Sialic acids as regulators of molecular and cellular interactions

(2009) Roland Schauer   CURRENT OPINION IN STRUCTURAL BIOLOGY

Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo

(2009) Bao Hoa Duong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

From carbohydrate leads to glycomimetic drugs

(2009) Beat Ernst et al.   NATURE REVIEWS DRUG DISCOVERY

CD24 and Siglec-10 Selectively Repress Tissue Damage-Induced Immune Responses

(2009) G.-Y. Chen et al.   SCIENCE

Esterases and autoimmunity: the sialic acid acetylesterase pathway and the regulation of peripheral B cell tolerance

(2009) Shiv Pillai et al.   TRENDS IN IMMUNOLOGY

Diversity in specificity, abundance, and composition of anti-Neu5Gc antibodies in normal humans: Potential implications for disease

(2008) V. Padler-Karavani et al.   GLYCOBIOLOGY

CD22: an inhibitory enigma

(2008) Jennifer A. Walker et al.   IMMUNOLOGY

B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase

(2008) Annaiah Cariappa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Recapitulation of IVIG Anti-Inflammatory Activity with a Recombinant IgG Fc

(2008) R. M. Anthony et al.   SCIENCE

Sialic acids in human health and disease

(2008) Ajit Varki   TRENDS IN MOLECULAR MEDICINE