Advanced Microengineered Lung Models for Translational Drug Discovery

Microbial volatile communication in human organotypic lung models

(2017) Layla J. Barkal et al.   Nature Communications

Assessment of long-term cultivated human precision-cut lung slices as an ex vivo system for evaluation of chronic cytotoxicity and functionality

(2017) Vanessa Neuhaus et al.   Journal of Occupational Medicine and Toxicology

Organoids as a model system for studying human lung development and disease

(2016) Rohan R. Nadkarni et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Development and characterization of a naturally derived lung extracellular matrix hydrogel

(2016) Robert A. Pouliot et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Innovation in the pharmaceutical industry: New estimates of R&D costs

(2016) Joseph A. DiMasi et al.   JOURNAL OF HEALTH ECONOMICS

Early-Life Origins of Chronic Obstructive Pulmonary Disease

(2016) Fernando D. Martinez   NEW ENGLAND JOURNAL OF MEDICINE

Three-dimensional bioprinting of thick vascularized tissues

(2016) David B. Kolesky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Lung Spheroids as In Vitro Niches of Lung Progenitor Cells with Distinctive Paracrine and Plasticity Properties

(2016) Isotta Chimenti et al.   Stem Cells Translational Medicine

Commendation for Exposing Key Advantage of Organ Chip Approach

(2016) Kambez H. Benam et al.   Cell Systems

Matched-Comparative Modeling of Normal and Diseased Human Airway Responses Using a Microengineered Breathing Lung Chip

(2016) Kambez H. Benam et al.   Cell Systems

Engineered In Vitro Disease Models

(2015) Kambez H. Benam et al.   Annual Review of Pathology-Mechanisms of Disease

Economic Burden of COPD in the Presence of Comorbidities

(2015) David M. Mannino et al.   CHEST

Barriers to new drug development in respiratory disease

(2015) Peter J. Barnes et al.   EUROPEAN RESPIRATORY JOURNAL

Personalized medicine: Time for one-person trials

(2015) Nicholas J. Schork   NATURE

Small airway-on-a-chip enables analysis of human lung inflammation and drug responses in vitro

(2015) Kambez H Benam et al.   NATURE METHODS

Engineering an in vitro air-blood barrier by 3D bioprinting

(2015) Lenke Horváth et al.   Scientific Reports

3D Bioprinting of Vascularized, Heterogeneous Cell-Laden Tissue Constructs

(2014) David B. Kolesky et al.   ADVANCED MATERIALS

Lung Stem Cell Differentiation in Mice Directed by Endothelial Cells via a BMP4-NFATc1-Thrombospondin-1 Axis

(2014) Joo-Hyeon Lee et al.   CELL

Surveillance for emerging respiratory viruses

(2014) Jaffar A Al-Tawfiq et al.   LANCET INFECTIOUS DISEASES

Microfluidic organs-on-chips

(2014) Sangeeta N Bhatia et al.   NATURE BIOTECHNOLOGY

3D bioprinting of tissues and organs

(2014) Sean V Murphy et al.   NATURE BIOTECHNOLOGY

Bone marrow–on–a–chip replicates hematopoietic niche physiology in vitro

(2014) Yu-suke Torisawa et al.   NATURE METHODS

Development of an Innovative 3D Cell Culture System to Study Tumour - Stroma Interactions in Non-Small Cell Lung Cancer Cells

(2014) Arno Amann et al.   PLoS One

Printing three-dimensional tissue analogues with decellularized extracellular matrix bioink

(2014) Falguni Pati et al.   Nature Communications

Hydrogel scaffolds as in vitro models to study fibroblast activation in wound healing and disease

(2014) Megan E. Smithmyer et al.   Biomaterials Science

Simultaneous Generation of Gradients with Gradually Changed Slope in a Microfluidic Device for Quantifying Axon Response

(2013) Rong-Rong Xiao et al.   ANALYTICAL CHEMISTRY

Organs-on-a-chip for drug discovery

(2013) Šeila Selimović et al.   CURRENT OPINION IN PHARMACOLOGY

Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment

(2013) Kyung-Jin Jang et al.   Integrative Biology

Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation

(2013) Hyun Jung Kim et al.   Integrative Biology

Metabolic Characterization of Primary Rat Hepatocytes Cultivated in Parallel Microfluidic Biochips

(2013) Audrey Legendre et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Glia co-culture with neurons in microfluidic platforms promotes the formation and stabilization of synaptic contacts

(2013) Mingjian Shi et al.   LAB ON A CHIP

Electrofluidic pressure sensor embedded microfluidic device: a study of endothelial cells under hydrostatic pressure and shear stress combinations

(2013) Man-Chi Liu et al.   LAB ON A CHIP

Three-dimensional co-cultures of human endothelial cells and embryonic stem cell-derived pericytes inside a microfluidic device

(2013) Andries D. van der Meer et al.   LAB ON A CHIP

Phase II and Phase III attrition rates 2011–2012

(2013) John Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

Probing Functional Properties of Nociceptive Axons Using a Microfluidic Culture System

(2013) Christoforos Tsantoulas et al.   PLoS One

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Patient-Specific 3D Microfluidic Tissue Model for Multiple Myeloma

(2013) Wenting Zhang et al.   TISSUE ENGINEERING PART C-METHODS

Threats to Validity in the Design and Conduct of Preclinical Efficacy Studies: A Systematic Review of Guidelines for In Vivo Animal Experiments

(2013) Valerie C. Henderson et al.   PLOS MEDICINE

Microcirculation System with a Dialysis Part for Bioassays Evaluating Anticancer Activity and Retention

(2012) Yuki Imura et al.   ANALYTICAL CHEMISTRY

On chip porous polymer membranes for integration of gastrointestinal tract epithelium with microfluidic ‘body-on-a-chip’ devices

(2012) Mandy Brigitte Esch et al.   BIOMEDICAL MICRODEVICES

BBB ON CHIP: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function

(2012) L. M. Griep et al.   BIOMEDICAL MICRODEVICES

Zonation related function and ubiquitination regulation in human hepatocellular carcinoma cells in dynamic vs. static culture conditions

(2012) Shu Cheng et al.   BMC GENOMICS

Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB)

(2012) Ross Booth et al.   LAB ON A CHIP

Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow

(2012) Hyun Jung Kim et al.   LAB ON A CHIP

A modular approach to create a neurovascular unit-on-a-chip

(2012) Anil Kumar H. Achyuta et al.   LAB ON A CHIP

Chip-Based Comparison of the Osteogenesis of Human Bone Marrow- and Adipose Tissue-Derived Mesenchymal Stem Cells under Mechanical Stimulation

(2012) Sang-Hyug Park et al.   PLoS One

An Orally Active TRPV4 Channel Blocker Prevents and Resolves Pulmonary Edema Induced by Heart Failure

(2012) Kevin S. Thorneloe et al.   Science Translational Medicine

Precision cut lung slices as an efficient tool for in vitro lung physio-pharmacotoxicology studies

(2012) Jean-Paul Morin et al.   XENOBIOTICA

Muscle on a chip: In vitro contractility assays for smooth and striated muscle

(2012) Anna Grosberg et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Acute Exacerbations of Chronic Obstructive Pulmonary Disease

(2011) Mona Bafadhel et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Analysis of transcriptomic and proteomic profiles demonstrates improved Madin-Darby canine kidney cell function in a renal microfluidic biochip

(2011) Leila Choucha Snouber et al.   BIOTECHNOLOGY PROGRESS

Exploring lung physiology in health and disease with lung slices

(2011) Michael J. Sanderson   PULMONARY PHARMACOLOGY & THERAPEUTICS

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Principles of early drug discovery

(2010) JP Hughes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Murine in vitro model of the blood–brain barrier for evaluating drug transport

(2010) Gilda Shayan et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Patterning osteogenesis by inducible gene expression in microfluidic culture systems

(2010) Yue Zhang et al.   Integrative Biology

How to improve R&D productivity: the pharmaceutical industry's grand challenge

(2010) Steven M. Paul et al.   NATURE REVIEWS DRUG DISCOVERY

Cystic fibrosis lung disease starts in the small airways: Can we treat it more effectively?

(2010) Harm A.W.M. Tiddens et al.   PEDIATRIC PULMONOLOGY

Reconstituting Organ-Level Lung Functions on a Chip

(2010) D. Huh et al.   SCIENCE

Efficient Generation of Schwann Cells from Human Embryonic Stem Cell-Derived Neurospheres

(2010) Lina Ziegler et al.   Stem Cell Reviews and Reports

Molecular regulation of cigarette smoke induced-oxidative stress in human retinal pigment epithelial cells: implications for age-related macular degeneration

(2009) Kurt M. Bertram et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure

(2009) Kurt R. Stenmark et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Evaluation of a microfluidic based cell culture platform with primary human hepatocytes for the prediction of hepatic clearance in human

(2009) P. Chao et al.   BIOCHEMICAL PHARMACOLOGY

A microfluidic hepatic coculture platform for cell-based drug metabolism studies

(2009) Eric Novik et al.   BIOCHEMICAL PHARMACOLOGY

Serum IP-10 as a Biomarker of Human Rhinovirus Infection at Exacerbation of COPD

(2009) Jennifer K. Quint et al.   CHEST

TRPV4 Channels Mediate Cyclic Strain–Induced Endothelial Cell Reorientation Through Integrin-to-Integrin Signaling

(2009) Charles K. Thodeti et al.   CIRCULATION RESEARCH

Anatomy, pathology, and physiology of the tracheobronchial tree: Emphasis on the distal airways

(2009) Dallas M. Hyde et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Design and testing of biological scaffolds for delivering reparative cells to target sites in the lung

(2009) Edward P. Ingenito et al.   Journal of Tissue Engineering and Regenerative Medicine

A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells

(2009) Kyung-Jin Jang et al.   LAB ON A CHIP

Smoking cessation in chronic obstructive pulmonary disease

(2009) Donald P. Tashkin et al.   RESPIRATORY MEDICINE

Animal models of chronic obstructive pulmonary disease

(2008) Joanne L. Wright et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Characterization of microfluidic human epidermal keratinocyte culture

(2008) Adrian T. O’Neill et al.   CYTOTECHNOLOGY

Severe childhood asthma: a common international approach?

(2008) Andrew Bush et al.   LANCET

Hydrogels in drug delivery: Progress and challenges

(2008) Todd R. Hoare et al.   POLYMER

Animal models of asthma and chronic obstructive pulmonary disease

(2008) Brendan J. Canning et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Ex vivo testing of immune responses in precision-cut lung slices

(2008) M. Henjakovic et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Incorporation of 3T3-L1 Cells To Mimic Bioaccumulation in a Microscale Cell Culture Analog Device for Toxicity Studies

(2004) Kwanchanok Viravaidya et al.   BIOTECHNOLOGY PROGRESS

The Design and Fabrication of Three-Chamber Microscale Cell Culture Analog Devices with Integrated Dissolved Oxygen Sensors

(2004) Aaron Sin et al.   BIOTECHNOLOGY PROGRESS