Article
Medicine, Research & Experimental
Yuanke Li, Zhen Zhao, Chien-Yu Lin, Yanli Liu, Kevin F. Staveley-OCarroll, Guangfu Li, Kun Cheng
Summary: This study investigated silencing the PCBP2 gene through siRNA to reverse the accumulation of type I collagen in PDAC tumor stroma. The use of nanocomplex significantly reduced ECM production and enhanced drug penetration through desmoplastic tumor stroma. In a mouse model, the combination of PCBP2 siRNA nanocomplex with gemcitabine effectively suppressed tumor progression.
Article
Oncology
Yusuke Yoshida, Yoshitsugu Nakanishi, Tomoko Mitsuhashi, Hiroyuki Yamamoto, Mariko O. O. Hayashi, Mitsunobu Oba, Takeo Nitta, Takashi Ueno, Toru Yamada, Masato Ono, Shota Kuwabara, Yutaka Hatanaka, Satoshi Hirano
Summary: This study aimed to investigate the impact of different pathological reaction categories on the prognosis of patients with extrahepatic cholangiocarcinomas (EHCCs). The results showed that the pathological reaction category was significantly associated with tumor invasiveness, as well as overall survival and relapse-free survival rates.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Cell Biology
Helen J. S. Jones, Chris Cunningham, Hanne A. Askautrud, Havard E. Danielsen, David J. Kerr, Enric Domingo, Tim Maughan, Simon J. Leedham, Viktor H. Koelzer
Summary: After local excision of early rectal cancer, accurate assessment of recurrence risk is crucial. Current measures are suboptimal, so this study assessed three measures of tumor stromal content in a cohort of rectal cancer patients without prior radiotherapy. The ratio of desmoplastic to inflamed stroma determined by a deep neural network was found to be the most powerful predictor of disease recurrence.
Review
Pathology
Yu Toda, Yuichi Yamada, Kenichi Kohashi, Shin Ishihara, Yoshihiro Ito, Yosuke Susuki, Kengo Kawaguchi, Izumi Kinoshita, Daisuke Kiyozawa, Taro Mori, Yusuke Kuboyama, Yuki Tateishi, Hidetaka Yamamoto, Toshifumi Fujiwara, Nokitaka Setsu, Makoto Endo, Yoshihiro Matsumoto, Yasuharu Nakashima, Masaaki Mawatari, Yoshinao Oda
Summary: Patients with synovial sarcoma who have moderate or severe desmoplastic reaction (DR) have a poorer prognosis, suggesting that DR could be an important prognostic factor.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Oncology
J. F. Huisman, I. J. H. Schoenaker, R. M. Brohet, O. Reerink, H. van der Sluis, F. C. P. Moll, E. de Boer, J. C. de Graaf, W. H. de Vos tot Nederveen Cappel, G. L. Beets, H. L. van Westreenen
Summary: The study demonstrates that the introduction of structured multidisciplinary response evaluation leads to a significant decrease in patients with locally advanced rectal cancer achieving complete response after nCRT, reducing the need for surgery and improving stoma-free survival rates.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Cell Biology
Akihiro Sakai, Yuichiro Nakashima, Yu Miyashita, Tadakazu Ao, Yasue Kimura, Eiji Shinto, Eiji Oki, Mototsugu Shimokawa, Hideki Ueno, Yoshinao Oda, Masaki Mori
Summary: This study evaluated the prognostic value of desmoplastic reaction (DR) categorisation in esophageal squamous cell carcinoma (OSCC) patients. The results showed that immature DR was an independent poor prognostic factor in OSCC patients, while the mature DR group had the best survival rates.
Article
Biochemical Research Methods
Yixiao Lin, Sitai Kou, Haolin Nie, Hongbo Luo, Ahmed Eltahir, Will Chapman Jr, Steven Hunt, Mathew Mutch, Quing Zhu
Summary: A deep learning model combining ultrasound and photoacoustic imaging has been developed to accurately identify complete responders after rectal cancer preoperative treatment, improving clinical care for patients.
BIOMEDICAL OPTICS EXPRESS
(2023)
Article
Oncology
Hideki Ueno, Yoshiki Kajiwara, Yoich Ajioka, Tamotsu Sugai, Shigeki Sekine, Megumi Ishiguro, Atsuo Takashima, Yukihide Kanemitsu
Summary: This study investigates the diagnostic criteria for the desmoplastic reaction classification being used in the JCOG1805 study, which aims to elucidate the value of adjuvant chemotherapy in stage II colorectal cancer patients with pathological risk factors of recurrence.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Surgery
H. E. Haak, G. L. Beets, K. Peeters, P. J. Nelemans, V. Valentini, C. Rodel, L. Kuo, F. A. Calvo, J. Garcia-Aguilar, R. Glynne-Jones, S. Pucciarelli, J. Suarez, G. Theodoropoulos, S. Biondo, D. M. J. Lambregts, R. G. H. Beets-Tan, M. Maas
Summary: This study found that the risk of nodal metastases (ypN+) after chemoradiotherapy increases with advancing ypT category in locally advanced rectal cancer patients. Patients with ypN+ disease had lower 5-year disease-free survival and overall survival rates than patients with ypN0 tumors, with ypN+ status being an independent predictor of recurrence and death. Therefore, the presence of residual cancer cells in lymph nodes following (chemo)radiotherapy should be considered in treatment decision-making, especially when contemplating organ-preserving strategies.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Multidisciplinary Sciences
Seung Yeun Chung, Hirotoshi Takiyama, Jae Hyun Kang, Jee Suk Chang, Byung Soh Min, Hiroshi Tsuji, Shigeru Yamada, Woong Sub Koom
Summary: This study compared the effectiveness of carbon ion radiotherapy (CIRT) and X-ray radiotherapy (XRT) for the treatment of locoregional rectal cancer recurrence. The results showed that CIRT had better outcomes in terms of local control, overall survival, and late toxicity rate compared to XRT.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Weerapat Suwanthanma, Saowanee Kitudomrat, Chakrapan Euanorasetr
Summary: The study investigated the clinical and pathological outcomes of locally advanced rectal cancer patients treated with neoadjuvant chemoradiation followed by curative surgery, identifying tumor length and lymph node involvement as potential predictive factors for pathological complete response. Patients achieving pCR showed higher 5-year disease-free and overall survival rates compared to non-pCR patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Toru Tochigi, Sophia C. Kamran, Anushri Parakh, Yoshifumi Noda, Balaji Ganeshan, Lawrence S. Blaszkowsky, David P. Ryan, Jill N. Allen, David L. Berger, Jennifer Y. Wo, Theodore S. Hong, Avinash Kambadakone
Summary: This study assessed the use of CT-based fractal dimension and texture analysis in predicting the therapeutic response to nCRT in patients with locally advanced rectal cancer. The research found that fractal dimension was a significant parameter for predicting the efficacy of nCRT.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiandong Leng, K. M. Shihab Uddin, William Chapman, Hongbo Luo, Sitai Kou, Eghbal Amidi, Guang Yang, Deyali Chatterjee, Anup Shetty, Steve Hunt, Matthew Mutch, Quing Zhu
Summary: The study reported the development of an imaging system comprising an endorectal coregistered photoacoustic/US system and convolutional neural network for assessing rectal cancer treatment response. The PAM CNN model showed unique imaging markers in differentiating changes in tumor treatment response and demonstrated high diagnostic performance.
Article
Multidisciplinary Sciences
Reem Mislati, Taylor P. Uccello, Zixi Lin, Katia T. Iliza, Kimani C. Toussaint, Scott A. Gerber, Marvin M. Doyley
Summary: This study found that shear wave elastography can provide valuable insights into tumor response to radiation therapy, helping distinguish radiation-responsive from radiation-non-responsive tumors and shedding light on changes in the tumor microenvironment that may affect radiation response.
SCIENTIFIC REPORTS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jaeseung Shin, Nieun Seo, Song-Ee Baek, Nak-Hoon Son, Joon Seok Lim, Nam Kyu Kim, Woong Sub Koom, Sungwon Kim
Summary: This study evaluated radiomics models based on T2-weighted imaging and diffusion-weighted MRI for predicting pCR after nCRT in LARC and compared their performance with visual assessment by radiologists. The results showed that the MRI-based radiomics model had better classification performance than experienced radiologists for diagnosing pathologic complete response in patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy.