Extracellular Influences: Molecular Subclasses and the Microenvironment in Pancreatic Cancer

Hypoxia-inducible factor-2α promotes tumor progression and has crosstalk with Wnt/β-catenin signaling in pancreatic cancer

(2017) Qi Zhang et al.   Molecular Cancer

Stromal SPOCK1 supports invasive pancreatic cancer growth

(2017) Veronique L. Veenstra et al.   Molecular Oncology

Molecular subtypes in cancers of the gastrointestinal tract

(2017) Maarten F. Bijlsma et al.   Nature Reviews Gastroenterology & Hepatology

Prolonged exposure to extracellular lumican restrains pancreatic adenocarcinoma growth

(2017) X Li et al.   ONCOGENE

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

(2017) Orianne Olivares et al.   Nature Communications

Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer

(2017) Julienne L. Carstens et al.   Nature Communications

Functional heterogeneity in tumor-derived human pancreatic stellate cells: Differential expression of HGF and implications for mitogenic signaling and migration in pancreatic cancer cells

(2017) Vegard Tjomsland et al.   Oncotarget

Matrix stiffness induces epithelial–mesenchymal transition and promotes chemoresistance in pancreatic cancer cells

(2017) A J Rice et al.   Oncogenesis

Prognostic relevance of molecular subtypes and master regulators in pancreatic ductal adenocarcinoma

(2016) Rekin’s Janky et al.   BMC CANCER

Hypoxia regulates ABCG2activity through the activivation of ERK1/2/HIF-1α and contributes to chemoresistance in pancreatic cancer cells

(2016) Xiaodan He et al.   CANCER BIOLOGY & THERAPY

TGF-β-induced stromal CYR61 promotes resistance to gemcitabine in pancreatic ductal adenocarcinoma through downregulation of the nucleoside transporters hENT1 and hCNT3

(2016) Rachel A. Hesler et al.   CARCINOGENESIS

ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth

(2016) Nicola Rath et al.   EMBO Molecular Medicine

Genetics and biology of pancreatic ductal adenocarcinoma

(2016) Haoqiang Ying et al.   GENES & DEVELOPMENT

The diagnostic role of the neutrophil-to-lymphocyte ratio in predicting pancreatic ductal adenocarcinoma in patients with pancreatic diseases

(2016) Kota Arima et al.   International Journal of Clinical Oncology

Neutrophils assist the metastasis of circulating tumor cells in pancreatic ductal adenocarcinoma

(2016) Lianyuan Tao et al.   MEDICINE

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

(2016) Cristovão M. Sousa et al.   NATURE

A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns

(2016) Faiyaz Notta et al.   NATURE

Genomic analyses identify molecular subtypes of pancreatic cancer

(2016) Peter Bailey et al.   NATURE

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

(2016) Hanane Laklai et al.   NATURE MEDICINE

Pancreatic stellate cells regulate blood vessel density in the stroma of pancreatic ductal adenocarcinoma

(2016) Francesco Di Maggio et al.   PANCREATOLOGY

KRAS-related proteins in pancreatic cancer

(2016) Karen M. Mann et al.   PHARMACOLOGY & THERAPEUTICS

Key players in pancreatic cancer-stroma interaction: Cancer-associated fibroblasts, endothelial and inflammatory cells

(2016) Michael Friberg Bruun Nielsen et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Macrophage PI3K  Drives Pancreatic Ductal Adenocarcinoma Progression

(2016) M. M. Kaneda et al.   Cancer Discovery

Microenvironment mediated alterations to metabolic pathways confer increased chemo-resistance in CD133+ tumor initiating cells

(2016) Alice Nomura et al.   Oncotarget

Angiogenesis in pancreatic ductal adenocarcinoma: A controversial issue

(2016) Vito Longo et al.   Oncotarget

The conflicting roles of tumor stroma in pancreatic cancer and their contribution to the failure of clinical trials: a systematic review and critical appraisal

(2015) Maarten F. Bijlsma et al.   CANCER AND METASTASIS REVIEWS

The receptor for advanced glycation end products (RAGE) enhances autophagy and neutrophil extracellular traps in pancreatic cancer

(2015) B A Boone et al.   CANCER GENE THERAPY

Collagen type V promotes the malignant phenotype of pancreatic ductal adenocarcinoma

(2015) Sonja Berchtold et al.   CANCER LETTERS

Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

(2015) J. J. Kamphorst et al.   CANCER RESEARCH

Precision Medicine for Advanced Pancreas Cancer: The Individualized Molecular Pancreatic Cancer Therapy (IMPaCT) Trial

(2015) L. A. Chantrill et al.   CLINICAL CANCER RESEARCH

Cancer-associated fibroblasts in pancreatic adenocarcinoma

(2015) Boju Pan et al.   Future Oncology

Final results of a phase Ib study of gemcitabine plus PEGPH20 in patients with stage IV previously untreated pancreatic cancer.

(2015) Sunil R. Hingorani et al.   JOURNAL OF CLINICAL ONCOLOGY

Identification of novel vascular projections with cellular trafficking abilities on the microvasculature of pancreatic ductal adenocarcinoma

(2015) Hexige Saiyin et al.   JOURNAL OF PATHOLOGY

Wnt2 protein plays a role in the progression of pancreatic cancer promoted by pancreatic stellate cells

(2015) Yong Xu et al.   MEDICAL ONCOLOGY

Whole genomes redefine the mutational landscape of pancreatic cancer

(2015) Nicola Waddell et al.   NATURE

Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma

(2015) Richard A Moffitt et al.   NATURE GENETICS

Identification and characterization of the gene expression profiles for protein coding and non-coding RNAs of pancreatic ductal adenocarcinomas

(2015) María Laura Gutiérrez et al.   Oncotarget

Ligand-Occupied Integrin Internalization Links Nutrient Signaling to Invasive Migration

(2015) Elena Rainero et al.   Cell Reports

The Dynamics of Treg/Th17 and the Imbalance of Treg/Th17 in Clonorchis sinensis-Infected Mice

(2015) Chao Yan et al.   PLoS One

Cancer-Stellate Cell Interactions Perpetuate the Hypoxia-Fibrosis Cycle in Pancreatic Ductal Adenocarcinoma

(2015) Mert Erkan et al.   NEOPLASIA

Identifying molecular subtypes related to clinicopathologic factors in pancreatic cancer

(2014) Shinuk Kim et al.   Biomedical Engineering Online

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

Hypoxia-Inducible Factor-1 Promotes Pancreatic Ductal Adenocarcinoma Invasion and Metastasis by Activating Transcription of the Actin-Bundling Protein Fascin

(2014) X. Zhao et al.   CANCER RESEARCH

Fibroblast heterogeneity in the cancer wound

(2014) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Plasticity of Macrophage Function during Tumor Progression: Regulation by Distinct Molecular Mechanisms

(2014) S. K. Biswas et al.   JOURNAL OF IMMUNOLOGY

Effects of the HIF-1α and NF-κB loop on epithelial-mesenchymal transition and chemoresistance induced by hypoxia in pancreatic cancer cells

(2014) ZHUO-XIN CHENG et al.   ONCOLOGY REPORTS

CypA, a Gene Downstream of HIF-1α, Promotes the Development of PDAC

(2014) Huan Zhang et al.   PLoS One

Stromal response to Hedgehog signaling restrains pancreatic cancer progression

(2014) J. J. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

KRAS: feeding pancreatic cancer proliferation

(2014) Kirsten L. Bryant et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mutant KRAS–Induced Expression of ICAM-1 in Pancreatic Acinar Cells Causes Attraction of Macrophages to Expedite the Formation of Precancerous Lesions

(2014) Geou-Yarh Liou et al.   Cancer Discovery

A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma

(2014) Syed Haider et al.   Genome Medicine

Accumulation of Extracellular Hyaluronan by Hyaluronan Synthase 3 Promotes Tumor Growth and Modulates the Pancreatic Cancer Microenvironment

(2014) Anne Kultti et al.   Biomed Research International

Stars and stripes in pancreatic cancer: role of stellate cells and stroma in cancer progression

(2014) Jeremy S. Wilson et al.   Frontiers in Physiology

Cancer-Associated Fibroblasts as Another Polarized Cell Type of the Tumor Microenvironment

(2014) Martin Augsten   Frontiers in Oncology

European cancer mortality predictions for the year 2013

(2013) M. Malvezzi et al.   ANNALS OF ONCOLOGY

3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing

(2013) Paola Longati et al.   BMC CANCER

Upregulation of Wnt5a promotes epithelial-to-mesenchymal transition and metastasis of pancreatic cancer cells

(2013) Haiji Bo et al.   BMC CANCER

Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer

(2013) Y Ino et al.   BRITISH JOURNAL OF CANCER

Synergistic interaction of novel lactate dehydrogenase inhibitors with gemcitabine against pancreatic cancer cells in hypoxia

(2013) M Maftouh et al.   BRITISH JOURNAL OF CANCER

Low-Dose Irradiation Programs Macrophage Differentiation to an iNOS+/M1 Phenotype that Orchestrates Effective T Cell Immunotherapy

(2013) Felix Klug et al.   CANCER CELL

Tumor-associated neutrophils (TAN) develop pro-tumorigenic properties during tumor progression

(2013) Inbal Mishalian et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Cancer heterogeneity—a multifaceted view

(2013) Felipe De Sousa E Melo et al.   EMBO REPORTS

Activated Pancreatic Stellate Cells Sequester CD8+ T Cells to Reduce Their Infiltration of the Juxtatumoral Compartment of Pancreatic Ductal Adenocarcinoma

(2013) Abasi Ene–Obong et al.   GASTROENTEROLOGY

Dissecting cancer heterogeneity – An unsupervised classification approach

(2013) Xin Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Assessment of the stromal contribution to Sonic Hedgehog-dependent pancreatic adenocarcinoma

(2013) Helene Damhofer et al.   Molecular Oncology

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Immune infiltrates as predictive markers of survival in pancreatic cancer patients

(2013) Maria Pia Protti et al.   Frontiers in Physiology

Hedgehog inhibitor decreases chemosensitivity to 5-fluorouracil and gemcitabine under hypoxic conditions in pancreatic cancer

(2012) Hideya Onishi et al.   CANCER SCIENCE

Integrative Survival-Based Molecular Profiling of Human Pancreatic Cancer

(2012) Timothy R. Donahue et al.   CLINICAL CANCER RESEARCH

Polymorphonuclear neutrophils promote dyshesion of tumor cells and elastase-mediated degradation of E-cadherin in pancreatic tumors

(2012) Matthias M. Gaida et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Inhibition of the Hedgehog Pathway Targets the Tumor-Associated Stroma in Pancreatic Cancer

(2012) R. F. Hwang et al.   MOLECULAR CANCER RESEARCH

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

(2012) Andrew V. Biankin et al.   NATURE

Differential macrophage programming in the tumor microenvironment

(2012) Brian Ruffell et al.   TRENDS IN IMMUNOLOGY

Potential plasticity of T regulatory cells in pancreatic carcinoma in relation to disease progression and outcome

(2012) BARBARA VIZIO et al.   Experimental and Therapeutic Medicine

Analysis of Pancreatic Cancer Microenvironment: Role of Macrophage Infiltrates and Growth Factors Expression

(2012) Katarzyna Gardian et al.   Journal of Cancer

Pancreatic stellate cells: a starring role in normal and diseased pancreas

(2012) Minoti V. Apte et al.   Frontiers in Physiology

Neutrophil granulocyte derived MMP-9 is a VEGF independent functional component of the angiogenic switch in pancreatic ductal adenocarcinoma

(2011) Dirk Bausch et al.   ANGIOGENESIS

A critical role for autophagy in pancreatic cancer

(2011) Shenghong Yang et al.   Autophagy

Elevated myeloid-derived suppressor cells in pancreatic, esophageal and gastric cancer are an independent prognostic factor and are associated with significant elevation of the Th2 cytokine interleukin-13

(2011) Rachel F. Gabitass et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Hypoxia Predicts Aggressive Growth and Spontaneous Metastasis Formation from Orthotopically Grown Primary Xenografts of Human Pancreatic Cancer

(2011) Q. Chang et al.   CANCER RESEARCH

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

(2011) T. R. Cox et al.   Disease Models & Mechanisms

Distribution and Clinical Significance of Th17 Cells in the Tumor Microenvironment and Peripheral Blood of Pancreatic Cancer Patients

(2011) Songbing He et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exocytosis of azurophil and arginase 1-containing granules by activated polymorphonuclear neutrophils is required to inhibit T lymphocyte proliferation

(2011) R. Rotondo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Discoidin domain receptor 2 is a critical regulator of epithelial–mesenchymal transition

(2011) Logan A. Walsh et al.   MATRIX BIOLOGY

Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy

(2011) Eric A Collisson et al.   NATURE MEDICINE

Role of Pancreatic Stellate Cells in Pancreatic Cancer Metastasis

(2010) Zhihong Xu et al.   AMERICAN JOURNAL OF PATHOLOGY

Pancreatic stellate cells promote epithelial-mesenchymal transition in pancreatic cancer cells

(2010) Kazuhiro Kikuta et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neutrophils: Cinderella of innate immune system

(2010) V. Kumar et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The extracellular matrix at a glance

(2010) C. Frantz et al.   JOURNAL OF CELL SCIENCE

Neutrophils responsive to endogenous IFN-β regulate tumor angiogenesis and growth in a mouse tumor model

(2010) Jadwiga Jablonska et al.   JOURNAL OF CLINICAL INVESTIGATION

Induction of Th17 Cells in the Tumor Microenvironment Improves Survival in a Murine Model of Pancreatic Cancer

(2010) J. L. Gnerlich et al.   JOURNAL OF IMMUNOLOGY

A Six-Gene Signature Predicts Survival of Patients with Localized Pancreatic Ductal Adenocarcinoma

(2010) Jeran K. Stratford et al.   PLOS MEDICINE

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Desmoplasia of Pancreatic Ductal Adenocarcinoma

(2009) Stephen Pandol et al.   Clinical Gastroenterology and Hepatology

Significance of M2-Polarized Tumor-Associated Macrophage in Pancreatic Cancer

(2009) Hiroshi Kurahara et al.   JOURNAL OF SURGICAL RESEARCH

Type I collagen promotes epithelial–mesenchymal transition through ILK-dependent activation of NF-κB and LEF-1

(2009) Damian Medici et al.   MATRIX BIOLOGY

Intrinsic chemoresistance to gemcitabine is associated with constitutive and laminin-induced phosphorylation of FAK in pancreatic cancer cell lines

(2009) Wu Huanwen et al.   Molecular Cancer

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

(2009) H. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Pancreatic Stellate Cells: Partners in Crime with Pancreatic Cancer Cells

(2008) A. Vonlaufen et al.   CANCER RESEARCH

Cancer-Associated Stromal Fibroblasts Promote Pancreatic Tumor Progression

(2008) R. F. Hwang et al.   CANCER RESEARCH

TGFβ in Cancer

(2008) Joan Massagué   CELL

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Sonic Hedgehog Promotes Desmoplasia in Pancreatic Cancer

(2008) J. M. Bailey et al.   CLINICAL CANCER RESEARCH

CXCL8/IL-8 and CXCL12/SDF-1α co-operatively promote invasiveness and angiogenesis in pancreatic cancer

(2008) Yoichi Matsuo et al.   INTERNATIONAL JOURNAL OF CANCER

Hypoxia induces a hedgehog response mediated by HIF-1α

(2008) Maarten F. Bijlsma et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Pancreatic Ductal Adenocarcinoma: Cellular Origin, Signaling Pathways and Stroma Contribution

(2008) Inmaculada Hernńdez-Muñoz et al.   PANCREATOLOGY

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE

Macrophage activation and polarization

(2007) Fernando Oneissi Martinez   Frontiers in Bioscience-Landmark