Accumulation of Extracellular Hyaluronan by Hyaluronan Synthase 3 Promotes Tumor Growth and Modulates the Pancreatic Cancer Microenvironment

Hyperglycemia, intracellular hyaluronan synthesis, cyclin D3 and autophagy

(2014) Aimin Wang et al.   Autophagy

Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor -1α in hepatocellular carcinoma

(2013) Lin Zhang et al.   BMC CANCER

Hyaluronan, fluid pressure and stromal resistance in pancreas cancer

(2013) P P Provenzano et al.   BRITISH JOURNAL OF CANCER

Hyaluronan production enhances shedding of plasma membrane-derived microvesicles

(2013) Kirsi Rilla et al.   EXPERIMENTAL CELL RESEARCH

Deregulation of hyaluronan synthesis, degradation and binding promotes breast cancer

(2013) P. Heldin et al.   JOURNAL OF BIOCHEMISTRY

Hyaluronan Synthase 1 (HAS1) Requires Higher Cellular UDP-GlcNAc Concentration than HAS2 and HAS3

(2013) Kirsi Rilla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hedgehog signaling regulates hypoxia induced epithelial to mesenchymal transition and invasion in pancreatic cancer cells via a ligand-independent manner

(2013) Jianjun Lei et al.   Molecular Cancer

KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization

(2013) H. Yoshida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Hyaluronan Synthase-3 Decreases Subcutaneous Colon Cancer Growth by Increasing Apoptosis

(2012) Brian P. Teng et al.   Anti-Cancer Agents in Medicinal Chemistry

Hydration Dynamics of Hyaluronan and Dextran

(2012) Johannes Hunger et al.   BIOPHYSICAL JOURNAL

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

(2012) Michael A Jacobetz et al.   GUT

Efficient TGFβ-induced epithelial–mesenchymal transition depends on hyaluronan synthase HAS2

(2012) H Porsch et al.   ONCOGENE

Therapeutic Targeting of Hyaluronan in the Tumor Stroma

(2012) Anne Kultti et al.   Cancers

Hyaluronan Synthase HAS2 Promotes Tumor Progression in Bone by Stimulating the Interaction of Breast Cancer Stem-Like Cells with Macrophages and Stromal Cells

(2011) H. Okuda et al.   CANCER RESEARCH

Transcriptional and post-translational regulation of hyaluronan synthesis

(2011) Raija H. Tammi et al.   FEBS Journal

HAS3-induced accumulation of hyaluronan in 3D MDCK cultures results in mitotic spindle misorientation and disturbed organization of epithelium

(2011) Kirsi Rilla et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Inhibition of hyaluronan synthesis in breast cancer cells by 4-methylumbelliferone suppresses tumorigenicity in vitro and metastatic lesions of bone in vivo

(2011) Hiroshi Urakawa et al.   INTERNATIONAL JOURNAL OF CANCER

Mitotic spindle misorientation in cancer - out of alignment and into the fire

(2011) J. C. Pease et al.   JOURNAL OF CELL SCIENCE

Inhibition of Oesophageal Squamous Cell Carcinoma Progression by in vivo Targeting of Hyaluronan Synthesis

(2011) Sören Twarock et al.   Molecular Cancer

Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma

(2010) Timo K Nykopp et al.   BMC CANCER

The Activity of Hyaluronan Synthase 2 Is Regulated by Dimerization and Ubiquitination

(2010) Eugenia Karousou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enzymatic Depletion of Tumor Hyaluronan Induces Antitumor Responses in Preclinical Animal Models

(2010) C. B. Thompson et al.   MOLECULAR CANCER THERAPEUTICS

Hyaluronan-CD44 Interactions in Cancer: Paradoxes and Possibilities

(2009) B. P. Toole   CLINICAL CANCER RESEARCH

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased Hyaluronan Production and Decreased E-Cadherin Expression by Cytokine-Stimulated Keratinocytes Lead to Spongiosis Formation

(2009) Tomoyuki Ohtani et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Hyaluronan Constitutively Regulates Activation of COX-2-mediated Cell Survival Activity in Intestinal Epithelial and Colon Carcinoma Cells

(2008) Suniti Misra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyaluronidases in cancer biology

(2008) Robert Stern   SEMINARS IN CANCER BIOLOGY

Hyaluronan in human tumors: Pathobiological and prognostic messages from cell-associated and stromal hyaluronan

(2008) Raija H. Tammi et al.   SEMINARS IN CANCER BIOLOGY

Significance of Tumor-Associated Stroma in Promotion of Intratumoral Lymphangiogenesis

(2007) Hiroshi Koyama et al.   AMERICAN JOURNAL OF PATHOLOGY