Proteomic analysis of Medulloblastoma reveals functional biology with translational potential

The whole-genome landscape of medulloblastoma subtypes

(2017) Paul A. Northcott et al.   NATURE

Karyopherinβ1 regulates proliferation of human glioma cells via Wnt/β-catenin pathway

(2016) Ting Lu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Medulloblastoma Genotype Dictates Blood Brain Barrier Phenotype

(2016) Timothy N. Phoenix et al.   CANCER CELL

Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer

(2016) Hui Zhang et al.   CELL

Targeting translation: eIF4E as an emerging anticancer drug target

(2016) Chunwan Lu et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Active medulloblastoma enhancers reveal subgroup-specific cellular origins

(2016) Charles Y. Lin et al.   NATURE

Proteogenomics connects somatic mutations to signalling in breast cancer

(2016) Philipp Mertins et al.   NATURE

2016 update of the PRIDE database and its related tools

(2016) Juan Antonio Vizcaíno et al.   NUCLEIC ACIDS RESEARCH

Dual role of the integrated stress response in medulloblastoma tumorigenesis

(2016) Sarrabeth Stone et al.   Oncotarget

Signalling to eIF4E in cancer

(2015) N. Siddiqui et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Targeting the PI3K/AKT/mTOR Signaling Pathway in Medulloblastoma

(2015) V. Dimitrova et al.   CURRENT MOLECULAR MEDICINE

MKL1 potentiates lung cancer cell migration and invasion by epigenetically activating MMP9 transcription

(2015) X Cheng et al.   ONCOGENE

CRMP1 Inhibits Proliferation of Medulloblastoma and Is Regulated by HMGA1

(2015) Kay Ka-Wai Li et al.   PLoS One

Knockdown of EphB1 receptor decreases medulloblastoma cell growth and migration and increases cellular radiosensitization

(2015) Shilpa Bhatia et al.   Oncotarget

CD44 Acts as a Signaling Platform Controlling Tumor Progression and Metastasis

(2015) Véronique Orian-Rousseau   Frontiers in Immunology

Notching on Cancer’s Door: Notch Signaling in Brain Tumors

(2015) Marcin Teodorczyk et al.   Frontiers in Oncology

Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma

(2015) Sujatha Venataraman et al.   Oncotarget

Cytogenetic Prognostication Within Medulloblastoma Subgroups

(2014) David J.H. Shih et al.   JOURNAL OF CLINICAL ONCOLOGY

Antitumor function of microRNA-122 against hepatocellular carcinoma

(2014) Kazuhiko Nakao et al.   JOURNAL OF GASTROENTEROLOGY

EphrinB1 expression is dysregulated and promotes oncogenic signaling in medulloblastoma

(2014) Nicole McKinney et al.   JOURNAL OF NEURO-ONCOLOGY

Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing

(2014) Volker Hovestadt et al.   NATURE

Proteogenomic characterization of human colon and rectal cancer

(2014) Bing Zhang et al.   NATURE

Polycomb group gene BMI1 controls invasion of medulloblastoma cells and inhibits BMP-regulated cell adhesion

(2014) Ashirwad Merve et al.   Acta Neuropathologica Communications

DNA methylation profiling of medulloblastoma allows robust subclassification and improved outcome prediction using formalin-fixed biopsies

(2013) Edward C. Schwalbe et al.   ACTA NEUROPATHOLOGICA

Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation arrays

(2013) Volker Hovestadt et al.   ACTA NEUROPATHOLOGICA

customProDB: an R package to generate customized protein databases from RNA-Seq data for proteomics search

(2013) Xiaojing Wang et al.   BIOINFORMATICS

Causal analysis approaches in Ingenuity Pathway Analysis

(2013) Andreas Krämer et al.   BIOINFORMATICS

BET Bromodomain Inhibition of MYC-Amplified Medulloblastoma

(2013) P. Bandopadhayay et al.   CLINICAL CANCER RESEARCH

Reciprocal regulation of microRNA-122 and c-Myc in hepatocellular cancer: Role of E2F1 and transcription factor dimerization partner 2

(2013) Bo Wang et al.   HEPATOLOGY

A molecular biology and phase II trial of lapatinib in children with refractory CNS malignancies: a pediatric brain tumor consortium study

(2013) Maryam Fouladi et al.   JOURNAL OF NEURO-ONCOLOGY

Synergism between Hedgehog-GLI and EGFR Signaling in Hedgehog-Responsive Human Medulloblastoma Cells Induces Downregulation of Canonical Hedgehog-Target Genes and Stabilized Expression of GLI1

(2013) Frank Götschel et al.   PLoS One

Overexpression of HMGA1 deregulates tumor growth via cdc25A and alters migration/invasion through a cdc25A-independent pathway in medulloblastoma

(2012) Kin-Mang Lau et al.   ACTA NEUROPATHOLOGICA

Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas

(2012) Marcel Kool et al.   ACTA NEUROPATHOLOGICA

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Alternative Mechanisms to Initiate Translation in Eukaryotic mRNAs

(2012) Encarnación Martínez-Salas et al.   COMPARATIVE AND FUNCTIONAL GENOMICS

The effect of alpha-v integrin inhibition on the malignant characteristics of medulloblastoma

(2012) Eric M. Thompson et al.   Journal of Neurosurgery-Pediatrics

Super-SILAC Allows Classification of Diffuse Large B-cell Lymphoma Subtypes by Their Protein Expression Profiles

(2012) Sally J. Deeb et al.   MOLECULAR & CELLULAR PROTEOMICS

Subgroup-specific structural variation across 1,000 medulloblastoma genomes

(2012) Paul A. Northcott et al.   NATURE

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

(2012) Cole Trapnell et al.   Nature Protocols

HMGA1 Reprograms Somatic Cells into Pluripotent Stem Cells by Inducing Stem Cell Transcriptional Networks

(2012) Sandeep N. Shah et al.   PLoS One

Global quantification of mammalian gene expression control

(2011) Björn Schwanhäusser et al.   NATURE

The 'invisible hand': regulation of RHO GTPases by RHOGDIs

(2011) Rafael Garcia-Mata et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Comparative Analysis of Proteome and Transcriptome Variation in Mouse

(2011) Anatole Ghazalpour et al.   PLoS Genetics

GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers

(2011) Craig H Mermel et al.   GENOME BIOLOGY

A flexible R package for nonnegative matrix factorization

(2010) Renaud Gaujoux et al.   BMC BIOINFORMATICS

Role of LIM and SH3 Protein 1 (LASP1) in the Metastatic Dissemination of Medulloblastoma

(2010) C. Traenka et al.   CANCER RESEARCH

Integrative Genomic Analysis of Medulloblastoma Identifies a Molecular Subgroup That Drives Poor Clinical Outcome

(2010) Yoon-Jae Cho et al.   JOURNAL OF CLINICAL ONCOLOGY

Medulloblastoma Comprises Four Distinct Molecular Variants

(2010) Paul A. Northcott et al.   JOURNAL OF CLINICAL ONCOLOGY

Wild-Type BRCA1, but not Mutated BRCA1, Regulates the Expression of the Nuclear Form of  -Catenin

(2010) H. Li et al.   MOLECULAR CANCER RESEARCH

Cap- and IRES-independent scanning mechanism of translation initiation as an alternative to the concept of cellular IRESs

(2010) Ivan N. Shatsky et al.   MOLECULES AND CELLS

Super-SILAC mix for quantitative proteomics of human tumor tissue

(2010) Tamar Geiger et al.   NATURE METHODS

Interaction of Hypoxia-Inducible Factor-1α and Notch Signaling Regulates Medulloblastoma Precursor Proliferation and Fate

(2010) Francesca Pistollato et al.   STEM CELLS

Correlations between RNA and protein expression profiles in 23 human cell lines

(2009) Marcus Gry et al.   BMC GENOMICS

Correlation of mRNA and protein in complex biological samples

(2009) Tobias Maier et al.   FEBS LETTERS

The OTT-MAL fusion oncogene activates RBPJ-mediated transcription and induces acute megakaryoblastic leukemia in a knockin mouse model

(2009) Thomas Mercher et al.   JOURNAL OF CLINICAL INVESTIGATION

Integrated Genomics Identifies Five Medulloblastoma Subtypes with Distinct Genetic Profiles, Pathway Signatures and Clinicopathological Features

(2008) Marcel Kool et al.   PLoS One