Cytogenetic Prognostication Within Medulloblastoma Subgroups

DNA methylation profiling of medulloblastoma allows robust subclassification and improved outcome prediction using formalin-fixed biopsies

(2013) Edward C. Schwalbe et al.   ACTA NEUROPATHOLOGICA

Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study

(2013) Pedro Castelo-Branco et al.   LANCET ONCOLOGY

MYC and MYCN amplification can be reliably assessed by aCGH in medulloblastoma

(2013) Franck Bourdeaut et al.   Cancer Genetics

Subgroup-specific alternative splicing in medulloblastoma

(2012) Adrian M. Dubuc et al.   ACTA NEUROPATHOLOGICA

Molecular subgroups of medulloblastoma: an international meta-analysis of transcriptome, genetic aberrations, and clinical data of WNT, SHH, Group 3, and Group 4 medulloblastomas

(2012) Marcel Kool et al.   ACTA NEUROPATHOLOGICA

Genome Sequencing of Pediatric Medulloblastoma Links Catastrophic DNA Rearrangements with TP53 Mutations

(2012) Tobias Rausch et al.   CELL

Molecular subgroups of medulloblastoma

(2012) Paul A Northcott et al.   Expert Review of Neurotherapeutics

Hyperfractionated Versus Conventional Radiotherapy Followed by Chemotherapy in Standard-Risk Medulloblastoma: Results From the Randomized Multicenter HIT-SIOP PNET 4 Trial

(2012) Birgitta Lannering et al.   JOURNAL OF CLINICAL ONCOLOGY

Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations

(2012) Trevor J. Pugh et al.   NATURE

Novel mutations target distinct subgroups of medulloblastoma

(2012) Giles Robinson et al.   NATURE

Dissecting the genomic complexity underlying medulloblastoma

(2012) David T. W. Jones et al.   NATURE

Subgroup-specific structural variation across 1,000 medulloblastoma genomes

(2012) Paul A. Northcott et al.   NATURE

The clinical implications of medulloblastoma subgroups

(2012) Paul A. Northcott et al.   Nature Reviews Neurology

Early recurrence in standard-risk medulloblastoma patients with the common idic(17)(p11.2) rearrangement

(2012) G. A. Bien-Willner et al.   NEURO-ONCOLOGY

Biological and clinical heterogeneity of MYCN-amplified medulloblastoma

(2011) Andrey Korshunov et al.   ACTA NEUROPATHOLOGICA

Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct

(2011) Paul A. Northcott et al.   ACTA NEUROPATHOLOGICA

MYC family amplification and clinical risk-factors interact to predict an extremely poor prognosis in childhood medulloblastoma

(2011) Sarra L. Ryan et al.   ACTA NEUROPATHOLOGICA

Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups

(2011) David W. Ellison et al.   ACTA NEUROPATHOLOGICA

Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples

(2011) Paul A. Northcott et al.   ACTA NEUROPATHOLOGICA

Molecular subgroups of medulloblastoma: the current consensus

(2011) Michael D. Taylor et al.   ACTA NEUROPATHOLOGICA

Chromosome 1q gain is not associated with a poor outcome in childhood medulloblastoma: Requirements for the validation of potential prognostic biomarkers

(2011) Steven C. Clifford et al.   CELL CYCLE

Rapid Diagnosis of Medulloblastoma Molecular Subgroups

(2011) E. C. Schwalbe et al.   CLINICAL CANCER RESEARCH

Adult Medulloblastoma Comprises Three Major Molecular Variants

(2011) Marc Remke et al.   JOURNAL OF CLINICAL ONCOLOGY

FSTL5Is a Marker of Poor Prognosis in Non-WNT/Non-SHH Medulloblastoma

(2011) Marc Remke et al.   JOURNAL OF CLINICAL ONCOLOGY

Chromosome 17 alterations identify good-risk and poor-risk tumors independently of clinical factors in medulloblastoma

(2011) M. G. McCabe et al.   NEURO-ONCOLOGY

Early aging in adult survivors of childhood medulloblastoma: long-term neurocognitive, functional, and physical outcomes

(2011) K. Edelstein et al.   NEURO-ONCOLOGY

Prognostic classification of pediatric medulloblastoma based on chromosome 17p loss, expression of MYCC and MYCN, and Wnt pathway activation

(2011) A. K. Park et al.   NEURO-ONCOLOGY

FISH and chips: the recipe for improved prognostication and outcomes for children with medulloblastoma

(2011) Vijay Ramaswamy et al.   Cancer Genetics

Molecular diagnostics of CNS embryonal tumors

(2010) Stefan M. Pfister et al.   ACTA NEUROPATHOLOGICA

The Genetics of Pediatric Brain Tumors

(2010) Adrian M. Dubuc et al.   Current Neurology and Neuroscience Reports

Impact of radiation avoidance on survival and neurocognitive outcome in infant medulloblastoma

(2010) L. Lafay-Cousin et al.   Current Oncology

Adult and Pediatric Medulloblastomas Are Genetically Distinct and Require Different Algorithms for Molecular Risk Stratification

(2010) Andrey Korshunov et al.   JOURNAL OF CLINICAL ONCOLOGY

Universal Poor Survival in Children With Medulloblastoma Harboring SomaticTP53Mutations

(2010) Uri Tabori et al.   JOURNAL OF CLINICAL ONCOLOGY

TP53 Mutation Is Frequently Associated With CTNNB1 Mutation or MYCN Amplification and Is Compatible With Long-Term Survival in Medulloblastoma

(2010) Elke Pfaff et al.   JOURNAL OF CLINICAL ONCOLOGY

Integrative Genomic Analysis of Medulloblastoma Identifies a Molecular Subgroup That Drives Poor Clinical Outcome

(2010) Yoon-Jae Cho et al.   JOURNAL OF CLINICAL ONCOLOGY

Definition of Disease-Risk Stratification Groups in Childhood Medulloblastoma Using Combined Clinical, Pathologic, and Molecular Variables

(2010) David W. Ellison et al.   JOURNAL OF CLINICAL ONCOLOGY

Medulloblastoma Comprises Four Distinct Molecular Variants

(2010) Paul A. Northcott et al.   JOURNAL OF CLINICAL ONCOLOGY

Subtypes of medulloblastoma have distinct developmental origins

(2010) Paul Gibson et al.   NATURE

Genomics of medulloblastoma: from Giemsa-banding to next-generation sequencing in 20 years

(2010) Paul A. Northcott et al.   Neurosurgical Focus

The Genetic Landscape of the Childhood Cancer Medulloblastoma

(2010) D. W. Parsons et al.   SCIENCE

OTX2 Is Critical for the Maintenance and Progression of Shh-Independent Medulloblastomas

(2009) D. C. Adamson et al.   CANCER RESEARCH

Outcome Prediction in Pediatric Medulloblastoma Based on DNA Copy-Number Aberrations of Chromosomes 6q and 17q and theMYCandMYCNLoci

(2009) Stefan Pfister et al.   JOURNAL OF CLINICAL ONCOLOGY

Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma

(2009) Paul A Northcott et al.   NATURE GENETICS

Integrated Genomics Identifies Five Medulloblastoma Subtypes with Distinct Genetic Profiles, Pathway Signatures and Clinicopathological Features

(2008) Marcel Kool et al.   PLoS One