A Challenge to Aging Society by microRNA in Extracellular Vesicles: microRNA in Extracellular Vesicles as Promising Biomarkers and Novel Therapeutic Targets in Multiple Myeloma

Bifacial effects of engineering tumour cell-derived exosomes on human natural killer cells

(2018) Qi Li et al.   EXPERIMENTAL CELL RESEARCH

Exosomes derived from imatinib-resistant chronic myeloid leukemia cells mediate a horizontal transfer of drug-resistant trait by delivering miR-365

(2018) Qing-Hua Min et al.   EXPERIMENTAL CELL RESEARCH

Exosomes from heat-stressed tumour cells inhibit tumour growth by converting regulatory T cells to Th17 cells via IL-6

(2018) Danfeng Guo et al.   IMMUNOLOGY

Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A

(2018) Kyoko Hashimoto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circulating microRNA expressions can predict the outcome of lenalidomide plus low-dose dexamethasone treatment in patients with refractory/relapsed multiple myeloma

(2017) Seung-Hyun Jung et al.   HAEMATOLOGICA

Cisplatin-resistant lung cancer cell–derived exosomes increase cisplatin resistance of recipient cells in exosomal miR-100–5p-dependent manner

(2017) Xiaobing Qin et al.   International Journal of Nanomedicine

DCOne as an Allogeneic Cell-based Vaccine for Multiple Myeloma

(2017) Rebecca Karp Leaf et al.   JOURNAL OF IMMUNOTHERAPY

Disruption of Circulating Extracellular Vesicles as a Novel Therapeutic Strategy against Cancer Metastasis

(2017) Nao Nishida-Aoki et al.   MOLECULAR THERAPY

Tumour exosomes from cells harbouring PTPRZ1–MET fusion contribute to a malignant phenotype and temozolomide chemoresistance in glioblastoma

(2017) A-L Zeng et al.   ONCOGENE

Hypoxic lung cancer-secreted exosomal miR-23a increased angiogenesis and vascular permeability by targeting prolyl hydroxylase and tight junction protein ZO-1

(2017) Y-L Hsu et al.   ONCOGENE

Cisplatin induces the release of extracellular vesicles from ovarian cancer cells that can induce invasiveness and drug resistance in bystander cells

(2017) Priya Samuel et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche

(2017) Michael P. Plebanek et al.   Nature Communications

Circulating exosomes carrying an immunosuppressive cargo interfere with cellular immunotherapy in acute myeloid leukemia

(2017) Chang-Sook Hong et al.   Scientific Reports

Amphiregulin contained in NSCLC-exosomes induces osteoclast differentiation through the activation of EGFR pathway

(2017) Simona Taverna et al.   Scientific Reports

Circulating microRNA expressions can predict the outcome of lenalidomide plus low-dose dexamethasone treatment in patients with refractory/relapsed multiple myeloma

(2017) Seung-Hyun Jung et al.   HAEMATOLOGICA

Multiple Myeloma-Derived Exosomes Regulate the Functions of Mesenchymal Stem Cells Partially via Modulating miR-21 and miR-146a

(2017) Qian Cheng et al.   Stem Cells International

Resistance to HER2-targeted anti-cancer drugs is associated with immune evasion in cancer cells and their derived extracellular vesicles

(2017) Vanesa G. Martinez et al.   OncoImmunology

Genotoxic stress modulates the release of exosomes from multiple myeloma cells capable of activating NK cell cytokine production: Role of HSP70/TLR2/NF-kB axis

(2017) Elisabetta Vulpis et al.   OncoImmunology

Engineering the pre-metastatic niche

(2017) Brian A. Aguado et al.   Nature Biomedical Engineering

Induction of miR-146a by multiple myeloma cells in mesenchymal stromal cells stimulates their pro-tumoral activity

(2016) Kim De Veirman et al.   CANCER LETTERS

Multiple myeloma exosomes establish a favourable bone marrow microenvironment with enhanced angiogenesis and immunosuppression

(2016) Jinheng Wang et al.   JOURNAL OF PATHOLOGY

Daratumumab, Lenalidomide, and Dexamethasone for Multiple Myeloma

(2016) Meletios A. Dimopoulos et al.   NEW ENGLAND JOURNAL OF MEDICINE

Microenvironment drug resistance in multiple myeloma: emerging new players

(2016) Lucia Di Marzo et al.   Oncotarget

Potential role of exosome-associated microRNA panels and in vivo environment to predict drug resistance for patients with multiple myeloma

(2016) Li Zhang et al.   Oncotarget

Osteoclast-derived microRNA-containing exosomes selectively inhibit osteoblast activity

(2016) Weijia Sun et al.   Cell Discovery

Exosomes as drug delivery vehicles for Parkinson's disease therapy

(2015) Matthew J. Haney et al.   JOURNAL OF CONTROLLED RELEASE

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

Ectosomes and exosomes: shedding the confusion between extracellular vesicles

(2015) Emanuele Cocucci et al.   TRENDS IN CELL BIOLOGY

High serum levels of extracellular vesicles expressing malignancy-related markers are released in patients with various types of hematological neoplastic disorders

(2015) Antonella Caivano et al.   TUMOR BIOLOGY

Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood–brain barrier

(2015) Naoomi Tominaga et al.   Nature Communications

Inhibition of miR-21 restores RANKL/OPG ratio in multiple myeloma-derived bone marrow stromal cells and impairs the resorbing activity of mature osteoclasts

(2015) Maria Rita Pitari et al.   Oncotarget

The bone marrow microenvironment enhances multiple myeloma progression by exosome-mediated activation of myeloid-derived suppressor cells

(2015) Jinheng Wang et al.   Oncotarget

Involvement of multiple myeloma cell-derived exosomes in osteoclast differentiation

(2015) Lavinia Raimondi et al.   Oncotarget

Unraveling the contribution of ectoenzymes to myeloma life and survival in the bone marrow niche

(2014) Valeria Quarona et al.   Annals of the New York Academy of Sciences

Bone marrow stromal cell-derived exosomes as communicators in drug resistance in multiple myeloma cells

(2014) J. Wang et al.   BLOOD

MiR-29b replacement inhibits proteasomes and disrupts aggresome+autophagosome formation to enhance the antimyeloma benefit of bortezomib

(2014) S Jagannathan et al.   LEUKEMIA

miRNA cargo within exosome-like vesicle transfer influences metastatic bone colonization

(2014) Karmele Valencia et al.   Molecular Oncology

Tissue inhibitor of metalloproteinases-1 induces a pro-tumourigenic increase of miR-210 in lung adenocarcinoma cells and their exosomes

(2014) H Cui et al.   ONCOGENE

Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis

(2014) T. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomes are natural carriers of exogenous siRNA to human cells in vitro

(2013) Tatyana A Shtam et al.   Cell Communication and Signaling

Neutral Sphingomyelinase 2 (nSMase2)-dependent Exosomal Transfer of Angiogenic MicroRNAs Regulate Cancer Cell Metastasis

(2013) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer

(2013) Jonathan Welti et al.   JOURNAL OF CLINICAL INVESTIGATION

Plasma cells release membrane microparticles in a mouse model of multiple myeloma

(2013) Tarek Benameur et al.   MICRON

Trash or Treasure: extracellular microRNAs and cell-to-cell communication

(2013) Nobuyoshi Kosaka et al.   Frontiers in Genetics

Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway

(2012) Guanglei Zhuang et al.   EMBO JOURNAL

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

(2012) Shin-ichiro Ohno et al.   MOLECULAR THERAPY

Microvesicles Released from Human Renal Cancer Stem Cells Stimulate Angiogenesis and Formation of Lung Premetastatic Niche

(2011) C. Grange et al.   CANCER RESEARCH

SST0001, a Chemically Modified Heparin, Inhibits Myeloma Growth and Angiogenesis via Disruption of the Heparanase/Syndecan-1 Axis

(2011) Joseph P. Ritchie et al.   CLINICAL CANCER RESEARCH

Competitive Interactions of Cancer Cells and Normal Cells via Secretory MicroRNAs

(2011) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppressing miRNA-15a/-16 expression by interleukin-6 enhances drug-resistance in myeloma cells

(2011) Mu Hao et al.   Journal of Hematology & Oncology

miR-210: The Master Hypoxamir

(2011) YUK C. CHAN et al.   MICROCIRCULATION

Tumor Necrosis Factor Gene-Engineered J558 Tumor Cell–Released Exosomes Stimulate Tumor Antigen P1A-Specific CD8+ CTL Responses and Antitumor Immunity

(2010) Yufeng Xie et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells

(2010) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells

(2010) Fanny Chalmin et al.   JOURNAL OF CLINICAL INVESTIGATION

Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell Migration

(2010) Yujing Zhang et al.   MOLECULAR CELL

A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

(2010) Dongmei Sun et al.   MOLECULAR THERAPY

Functional delivery of viral miRNAs via exosomes

(2010) D. M. Pegtel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomes: proteomic insights and diagnostic potential

(2009) Richard J Simpson et al.   Expert Review of Proteomics

Membrane-bound HSP70-engineered myeloma cell-derived exosomes stimulate more efficient CD8+ CTL- and NK-mediated antitumour immunity than exosomes released from heat-shocked tumour cells expressing cytoplasmic HSP70

(2009) Yufeng Xie et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Shedding microvesicles: artefacts no more

(2009) Emanuele Cocucci et al.   TRENDS IN CELL BIOLOGY

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY