Type 2 Diabetes Mellitus and Cardiovascular Disease: Genetic and Epigenetic Links

HMGA1 is a novel candidate gene for myocardial infarction susceptibility

(2017) Salvatore De Rosa et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

miR-125a-5p Modulates Phenotypic Switch of Vascular Smooth Muscle Cells by Targeting ETS-1

(2017) C. Gareri et al.   JOURNAL OF MOLECULAR BIOLOGY

Hyperglycaemia suppresses microRNA expression in platelets to increase P2RY12 and SELP levels in type 2 diabetes mellitus

(2017) Zsolt Fejes et al.   THROMBOSIS AND HAEMOSTASIS

MicroRNA-126 suppresses inflammation in endothelial cells under hyperglycemic condition by targeting HMGB1

(2017) Song-tao Tang et al.   VASCULAR PHARMACOLOGY

Serum microRNA-1 and microRNA-133a levels reflect myocardial steatosis in uncomplicated type 2 diabetes

(2017) D. de Gonzalo-Calvo et al.   Scientific Reports

MicroRNAs and Cardiovascular Disease in Diabetes Mellitus

(2017) Yue Ding et al.   Biomed Research International

Long non-coding RNA Lethe regulates hyperglycemia-induced reactive oxygen species production in macrophages

(2017) Carlos Zgheib et al.   PLoS One

Regulation of Vascular Smooth Muscle Cell Dysfunction Under Diabetic Conditions by miR-504Significance

(2016) Marpadga A. Reddy et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Variant rs10911021 that associates with coronary heart disease in type 2 diabetes, is associated with lower concentrations of circulating HDL cholesterol and large HDL particles but not with amino acids

(2016) Katherine E. Beaney et al.   Cardiovascular Diabetology

Oscillating glucose induces microRNA-185 and impairs an efficient antioxidant response in human endothelial cells

(2016) Lucia La Sala et al.   Cardiovascular Diabetology

Apolipoprotein E gene polymorphism and risk of type 2 diabetes and cardiovascular disease

(2016) Dalia El-Lebedy et al.   Cardiovascular Diabetology

Clinical Update: Cardiovascular Disease in Diabetes Mellitus

(2016) Cecilia C. Low Wang et al.   CIRCULATION

MicroRNA-181b Improves Glucose Homeostasis and Insulin Sensitivity by Regulating Endothelial Function in White Adipose TissueNovelty and Significance

(2016) Xinghui Sun et al.   CIRCULATION RESEARCH

Epigenetic Changes in Diabetes and Cardiovascular Risk

(2016) Samuel T. Keating et al.   CIRCULATION RESEARCH

MicroRNAs for Restenosis and Thrombosis After Vascular Injury

(2016) Clarice Gareri et al.   CIRCULATION RESEARCH

Lack of miR-133a Decreases Contractility of Diabetic Hearts: A Role for Novel Cross Talk Between Tyrosine Aminotransferase and Tyrosine Hydroxylase

(2016) Shyam Sundar Nandi et al.   DIABETES

2. Classification and Diagnosis of Diabetes

(2016)   DIABETES CARE

The epigenetic signature of systemic insulin resistance in obese women

(2016) Peter Arner et al.   DIABETOLOGIA

HNF-4α regulated miR-122 contributes to development of gluconeogenesis and lipid metabolism disorders in Type 2 diabetic mice and in palmitate-treated HepG2 cells

(2016) Shengnan Wei et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

MicroRNA-24 inhibits high glucose-induced vascular smooth muscle cell proliferation and migration by targeting HMGB1

(2016) Jian Yang et al.   GENE

Long Noncoding RNA: Recent Updates in Atherosclerosis

(2016) Hao Li et al.   International Journal of Biological Sciences

Long noncoding RNA variations in cardiometabolic diseases

(2016) Sariya Dechamethakun et al.   JOURNAL OF HUMAN GENETICS

Role of miRNAs in the pathogenesis and susceptibility of diabetes mellitus

(2016) Naoko Hashimoto et al.   JOURNAL OF HUMAN GENETICS

Exosomal miRNAs in Heart Disease

(2016) Claudio Iaconetti et al.   PHYSIOLOGY

ANRIL: a pivotal tumor suppressor long non-coding RNA in human cancers

(2016) Zheng Li et al.   TUMOR BIOLOGY

Vascular microRNA-204 is remotely governed by the microbiome and impairs endothelium-dependent vasorelaxation by downregulating Sirtuin1

(2016) Ajit Vikram et al.   Nature Communications

Modulation of Circulating MicroRNAs Levels during the Switch from Clopidogrel to Ticagrelor

(2016) Annarita Carino et al.   Biomed Research International

Augmentation of histone deacetylase 3 (HDAC3) epigenetic signature at the interface of proinflammation and insulin resistance in patients with type 2 diabetes

(2016) Chandrakumar Sathishkumar et al.   Clinical Epigenetics

lncRNA H19/miR-675 axis regulates cardiomyocyte apoptosis by targeting VDAC1 in diabetic cardiomyopathy

(2016) Xiangquan Li et al.   Scientific Reports

A polymorphism of HMGA1 protects against proliferative diabetic retinopathy by impairing HMGA1-induced VEGFA expression

(2016) Eusebio Chiefari et al.   Scientific Reports

Platelet-derived miR-103b as a novel biomarker for the early diagnosis of type 2 diabetes

(2015) Mao Luo et al.   ACTA DIABETOLOGICA

Dicer Cleavage by Calpain Determines Platelet microRNA Levels and Function in DiabetesNovelty and Significance

(2015) Amro Elgheznawy et al.   CIRCULATION RESEARCH

MicroRNAs in cardiovascular disease: an introduction for clinicians

(2015) Simon P R Romaine et al.   HEART

Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood

(2015) T. Ronn et al.   HUMAN MOLECULAR GENETICS

Association Between Familial Hypercholesterolemia and Prevalence of Type 2 Diabetes Mellitus

(2015) Joost Besseling et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Long non-coding RNA MALAT1 regulates hyperglycaemia induced inflammatory process in the endothelial cells

(2015) Prasanth Puthanveetil et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

MicroRNA-26a regulates insulin sensitivity and metabolism of glucose and lipids

(2015) Xianghui Fu et al.   JOURNAL OF CLINICAL INVESTIGATION

RNA (Epi)genetics in cardiovascular diseases

(2015) Leonardo Elia et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Clinical applications of epigenetics in cardiovascular disease: the long road ahead

(2015) Stella Aslibekyan et al.   Translational Research

Genetics of cardiovascular and renal complications in diabetes

(2015) Ronald CW Ma   Journal of Diabetes Investigation

HMGA1 overexpression in adipose tissue impairs adipogenesis and prevents diet-induced obesity and insulin resistance

(2015) Altamira Arce-Cerezo et al.   Scientific Reports

A novel mechanism of post-translational modulation of HMGA functions by the histone chaperone nucleophosmin

(2015) Laura Arnoldo et al.   Scientific Reports

Genetic markers of type 2 diabetes: Progress in genome-wide association studies and clinical application for risk prediction

(2015) Xueyin Wang et al.   Journal of Diabetes

An analysis of DNA methylation in human adipose tissue reveals differential modification of obesity genes before and after gastric bypass and weight loss

(2015) Miles C Benton et al.   GENOME BIOLOGY

Cooperation between HMGA1, PDX-1, and MafA is Essential for Glucose-Induced Insulin Transcription in Pancreatic Beta Cells

(2015) Biagio Arcidiacono et al.   Frontiers in Endocrinology

The Association between HMGA1 rs146052672 Variant and Type 2 Diabetes: A Transethnic Meta-Analysis

(2015) Aida Bianco et al.   PLoS One

Cardiovascular microRNAs: as modulators and diagnostic biomarkers of diabetic heart disease

(2014) Shruti Rawal et al.   Cardiovascular Diabetology

Emerging Role of MicroRNAs in Cardiovascular Diseases

(2014) Salvatore De Rosa et al.   CIRCULATION JOURNAL

Circulating Long Noncoding RNA, LIPCAR, Predicts Survival in Patients With Heart Failure

(2014) Regalla Kumarswamy et al.   CIRCULATION RESEARCH

Long Noncoding RNA MALAT1 Regulates Endothelial Cell Function and Vessel Growth

(2014) Katharina M. Michalik et al.   CIRCULATION RESEARCH

Shared Molecular Pathways and Gene Networks for Cardiovascular Disease and Type 2 Diabetes Mellitus in Women Across Diverse Ethnicities

(2014) K. H. K. Chan et al.   Circulation-Cardiovascular Genetics

MicroRNA-130aregulates autophagy of endothelial progenitor cells through Runx3

(2014) Quanfu Xu et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

MicroRNA-29 Fine-tunes the Expression of Key FOXA2-Activated Lipid Metabolism Genes and Is Dysregulated in Animal Models of Insulin Resistance and Diabetes

(2014) C. L. Kurtz et al.   DIABETES

Cdkn2a/p16Ink4a Regulates Fasting-Induced Hepatic Gluconeogenesis Through the PKA-CREB-PGC1  Pathway

(2014) K. Bantubungi et al.   DIABETES

Altered DNA Methylation and Differential Expression of Genes Influencing Metabolism and Inflammation in Adipose Tissue From Subjects With Type 2 Diabetes

(2014) E. Nilsson et al.   DIABETES

Regulation of Inflammatory Phenotype in Macrophages by a Diabetes-Induced Long Noncoding RNA

(2014) M. A. Reddy et al.   DIABETES

Genetic Risk Score Associations With Cardiovascular Disease and Mortality in the Diabetes Heart Study

(2014) Amanda J. Cox et al.   DIABETES CARE

Early Effects of a Hypocaloric, Mediterranean Diet on Laboratory Parameters in Obese Individuals

(2014) Marta Greco et al.   MEDIATORS OF INFLAMMATION

Diabetic dyslipidemia

(2014) Liya Wu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Epigenetic Regulation of Macrophage Polarization by DNA Methyltransferase 3b

(2014) Xiaosong Yang et al.   MOLECULAR ENDOCRINOLOGY

Pathogenic role of lncRNA-MALAT1 in endothelial cell dysfunction in diabetes mellitus

(2014) J-Y Liu et al.   Cell Death & Disease

The complex transcriptional landscape of the anucleate human platelet

(2013) Paul F Bray et al.   BMC GENOMICS

Genetic analysis of haptoglobin polymorphisms with cardiovascular disease and type 2 diabetes in the diabetes heart study

(2013) Jeremy N Adams et al.   Cardiovascular Diabetology

M1 and M2 Macrophages: Oracles of Health and Disease

(2013) Charles Mills   CRITICAL REVIEWS IN IMMUNOLOGY

SIRT1, p66Shc, and Set7/9 in Vascular Hyperglycemic Memory: Bringing All the Strands Together

(2013) F. Paneni et al.   DIABETES

Global estimates of diabetes prevalence for 2013 and projections for 2035

(2013) L. Guariguata et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

IGF2Methylation Is Associated with Lipid Profile in Obese Children

(2013) Annalisa Deodati et al.   Hormone Research in Paediatrics

Non-Coding RNAs: The “Dark Matter” of Cardiovascular Pathophysiology

(2013) Claudio Iaconetti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Association Between a Genetic Variant Related to Glutamic Acid Metabolism and Coronary Heart Disease in Individuals With Type 2 Diabetes

(2013) Lu Qi et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Evidence That an HMGA1 Gene Variant Associates with Type 2 Diabetes, Body Mass Index, and High-Density Lipoprotein Cholesterol in a Hispanic-American Population

(2013) Clive R. Pullinger et al.   Metabolic Syndrome and Related Disorders

The High Mobility Group A proteins contribute to thyroid cell transformation by regulating miR-603 and miR-10b expression

(2013) Paula Mussnich et al.   Molecular Oncology

Unravelling the enigma of T2DM and cardiovascular disease

(2013) Donald W. Bowden et al.   Nature Reviews Endocrinology

Long non-coding RNAs: new players in cell differentiation and development

(2013) Alessandro Fatica et al.   NATURE REVIEWS GENETICS

The FTO Gene rs9939609 Polymorphism Predicts Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis

(2013) Chibo Liu et al.   PLoS One

Decreased platelet miR-223 expression is associated with high on-clopidogrel platelet reactivity

(2013) Rui Shi et al.   THROMBOSIS RESEARCH

A polymorphism of HMGA1 is associated with increased risk of metabolic syndrome and related components

(2013) Eusebio Chiefari et al.   Scientific Reports

Alu Elements in ANRIL Non-Coding RNA at Chromosome 9p21 Modulate Atherogenic Cell Functions through Trans-Regulation of Gene Networks

(2013) Lesca M. Holdt et al.   PLoS Genetics

Distribution of macrophage polarization markers in human atherosclerosis

(2012) J. Lauran Stöger et al.   ATHEROSCLEROSIS

Genetics of Human Cardiovascular Disease

(2012) Sekar Kathiresan et al.   CELL

Antiplatelet Therapy in Patients with Diabetes Mellitus

(2012) Erik L. Grove et al.   Current Vascular Pharmacology

Diabetes Genetic Predisposition Score and Cardiovascular Complications Among Patients With Type 2 Diabetes

(2012) Q. Qi et al.   DIABETES CARE

Pre-Diabetes, Metabolic Syndrome, and Cardiovascular Risk

(2012) Scott M. Grundy   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The HMGA1-IGF-I/IGFBP System: A Novel Pathway for Modulating Glucose Uptake

(2012) Stefania Iiritano et al.   MOLECULAR ENDOCRINOLOGY

Epigenetic Regulation by Long Noncoding RNAs

(2012) J. T. Lee   SCIENCE

HMGA1 is a novel downstream nuclear target of the insulin receptor signaling pathway

(2012) Eusebio Chiefari et al.   Scientific Reports

HMGA1 drives stem cell, inflammatory pathway, and cell cycle progression genes during lymphoid tumorigenesis

(2011) Andrew Schuldenfrei et al.   BMC GENOMICS

High-Mobility Group A1 Protein

(2011) Mandy Bloch et al.   CIRCULATION RESEARCH

Increased MicroRNA-1 and MicroRNA-133a Levels in Serum of Patients With Cardiovascular Disease Indicate Myocardial Damage

(2011) Yasuhide Kuwabara et al.   Circulation-Cardiovascular Genetics

Individual and cumulative effect of type 2 diabetes genetic susceptibility variants on risk of coronary heart disease

(2011) R. Pfister et al.   DIABETOLOGIA

Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells

(2011) L. Pirola et al.   GENOME RESEARCH

Hypermethylation at loci sensitive to the prenatal environment is associated with increased incidence of myocardial infarction

(2011) Rudolf P Talens et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Functional Variants of the HMGA1 Gene and Type 2 Diabetes Mellitus

(2011) Eusebio Chiefari   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Genetic Susceptibility to Coronary Heart Disease in Type 2 Diabetes

(2011) Lu Qi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Molecular Mechanisms of Long Noncoding RNAs

(2011) Kevin C. Wang et al.   MOLECULAR CELL

Differentially expressed microRNAs and their target genes in the hearts of streptozotocin-induced diabetic mice

(2011) Bing Hu   Molecular Medicine Reports

9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response

(2011) Olivier Harismendy et al.   NATURE

Non-coding RNAs in human disease

(2011) Manel Esteller   NATURE REVIEWS GENETICS

Genomics of Cardiovascular Disease

(2011) Christopher J. O'Donnell et al.   NEW ENGLAND JOURNAL OF MEDICINE

Downregulation of HMGA-targeting microRNAs has a critical role in human pituitary tumorigenesis

(2011) D Palmieri et al.   ONCOGENE

Single Nucleotide Polymorphisms of TCF7L2 Are Linked to Diabetic Coronary Atherosclerosis

(2011) Axel Muendlein et al.   PLoS One

Determination of the Human Cardiomyocyte mRNA and miRNA Differentiation Network by Fine-Scale Profiling

(2011) Joshua E. Babiarz et al.   STEM CELLS AND DEVELOPMENT

Oxidative Stress as Pathogenesis of Cardiovascular Risk Associated with Metabolic Syndrome

(2010) Hajime Otani   ANTIOXIDANTS & REDOX SIGNALING

Circulating MicroRNAs in Patients With Coronary Artery Disease

(2010) Stephan Fichtlscherer et al.   CIRCULATION RESEARCH

Plasma MicroRNA Profiling Reveals Loss of Endothelial MiR-126 and Other MicroRNAs in Type 2 Diabetes

(2010) Anna Zampetaki et al.   CIRCULATION RESEARCH

Association between the rs4880 superoxide dismutase 2 (C>T) gene variant and coronary heart disease in diabetes mellitus

(2010) D.A. Jones et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice

(2010) Axel Visel et al.   NATURE

miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1

(2010) Jian-Xun Wang et al.   NATURE MEDICINE

Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus

(2010) Christopher G. Bell et al.   PLoS One

Pseudogene-mediated posttranscriptional silencing of HMGA1 can result in insulin resistance and type 2 diabetes

(2010) Eusebio Chiefari et al.   Nature Communications

Chromosome 9p21 SNPs Associated with Multiple Disease Phenotypes Correlate with ANRIL Expression

(2010) Michael S. Cunnington et al.   PLoS Genetics

Functional Analysis of the Chromosome 9p21.3 Coronary Artery Disease Risk Locus

(2009) Olga Jarinova et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

HMGA molecular network: From transcriptional regulation to chromatin remodeling

(2009) Riccardo Sgarra et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Adiponectin and Cardiovascular Disease

(2009) Rei Shibata et al.   CIRCULATION JOURNAL

Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated With Gene-Activating Epigenetic Marks That Coexist on the Lysine Tail

(2009) D. Brasacchio et al.   DIABETES

Transcriptional activity of the murine retinol-binding protein gene is regulated by a multiprotein complex containing HMGA1, p54nrb/NonO, protein-associated splicing factor (PSF) and steroidogenic factor 1 (SF1)/liver receptor homologue 1 (LRH-1)

(2009) Adriana Bianconcini et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

miR-145 and miR-143 regulate smooth muscle cell fate and plasticity

(2009) Kimberly R. Cordes et al.   NATURE

Existence of a microRNA pathway in anucleate platelets

(2009) Patricia Landry et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TCF7L2 Polymorphism rs7903146 Is Associated with Coronary Artery Disease Severity and Mortality

(2009) André Gustavo P. Sousa et al.   PLoS One

Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection

(2009) A. Zernecke et al.   Science Signaling

miR-126 Regulates Angiogenic Signaling and Vascular Integrity

(2008) Jason E. Fish et al.   DEVELOPMENTAL CELL

The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis

(2008) Shusheng Wang et al.   DEVELOPMENTAL CELL

TCF7L2 single nucleotide polymorphisms, cardiovascular disease and all-cause mortality: the Atherosclerosis Risk in Communities (ARIC) study

(2008) S. J. Bielinski et al.   DIABETOLOGIA

The insulin receptor: a new anticancer target for peroxisome proliferator-activated receptor-  (PPAR ) and thiazolidinedione-PPAR  agonists

(2008) V Costa et al.   ENDOCRINE-RELATED CANCER

Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants

(2008) K. L. Mohlke et al.   HUMAN MOLECULAR GENETICS