Redox-Dependent Inflammation in Islet Transplantation Rejection

Islet damage during isolation as assessed by miRNAs and the correlation of miRNA levels with posttransplantation outcome in islet autotransplantation

(2018) Prathab Balaji Saravanan et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Immunomodulatory and protective effects of adipose tissue-derived mesenchymal stem cells in an allograft islet composite transplantation for experimental autoimmune type 1 diabetes

(2017) Jamal Mohammadi Ayenehdeh et al.   IMMUNOLOGY LETTERS

Interferon alpha impairs insulin production in human beta cells via endoplasmic reticulum stress

(2017) Angela Lombardi et al.   JOURNAL OF AUTOIMMUNITY

Sirolimus induces depletion of intracellular calcium stores and mitochondrial dysfunction in pancreatic beta cells

(2017) Angela Lombardi et al.   Scientific Reports

Glial cell-line derived neurotrophic factor protects human islets from nutrient deprivation and endoplasmic reticulum stress induced apoptosis

(2017) Shadab Abadpour et al.   Scientific Reports

Hybrid Congregation of Islet Single Cells and Curcumin-Loaded Polymeric Microspheres as an Interventional Strategy to Overcome Apoptosis Associated with Pancreatic Islets Transplantation

(2016) Shiva Pathak et al.   ACS Applied Materials & Interfaces

Characterization of Innate Immunity in an Extended Whole Blood Model of Human Islet Allotransplantation

(2016) Maria Hårdstedt et al.   CELL TRANSPLANTATION

Direct and indirect allograft recognition

(2016) Christine M. Lin et al.   Current Opinion in Organ Transplantation

Biopatterned CTLA4/Fc Matrices Facilitate Local Immunomodulation, Engraftment, and Glucose Homeostasis After Pancreatic Islet Transplantation

(2016) Wensheng Zhang et al.   DIABETES

The molecular mechanisms of TLR-signaling cooperation in cytokine regulation

(2016) Qian Liu et al.   IMMUNOLOGY AND CELL BIOLOGY

NADPH Oxidase–Derived Superoxide Provides a Third Signal for CD4 T Cell Effector Responses

(2016) Lindsey E. Padgett et al.   JOURNAL OF IMMUNOLOGY

Beyond knockout: A novel homodimerization-targeting MyD88 inhibitor prevents and cures type 1 diabetes in NOD mice

(2016) Xue Zhang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Developmental endothelial locus-1 modulates platelet-monocyte interactions and instant blood-mediated inflammatory reaction in islet transplantation

(2016) Jong-Hyung Lim et al.   THROMBOSIS AND HAEMOSTASIS

Imatinib prevents beta cell deathin vitrobut does not improve islet transplantation outcome

(2016) Aileen J. F. King et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

Reparixin, a CXCR1/2 inhibitor in islet allotransplantation

(2016) Rena L. Pawlick et al.   Islets

Antiaging Glycopeptide Protects Human Islets Against Tacrolimus-Related Injury and Facilitates Engraftment in Mice

(2015) Boris L. Gala-Lopez et al.   DIABETES

Accessory cells for β-cell transplantation

(2015) W. Staels et al.   DIABETES OBESITY & METABOLISM

Treatment of diabetes with encapsulated pig islets: an update on current developments

(2015) Hai-tao Zhu et al.   Journal of Zhejiang University-SCIENCE B

Exendin-4 protects rat islets against loss of viability and function induced by brain death

(2015) Rodrigo Carlessi et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Minireview: Directed Differentiation and Encapsulation of Islet β-Cells—Recent Advances and Future Considerations

(2015) Hubert M. Tse et al.   MOLECULAR ENDOCRINOLOGY

Coaggregates of Regulatory T Cells and Islet Cells Allow Long-term Graft Survival in Liver Without Immunosuppression

(2015) Naohiro Takemoto et al.   TRANSPLANTATION

Cyanidin-3-O-Glucoside Enhanced the Function of Syngeneic Mouse Islets Transplanted Under the Kidney Capsule or Into the Portal Vein

(2015) Haolei Cai et al.   TRANSPLANTATION

Cell-laden Polymeric Microspheres for Biomedical Applications

(2015) Wenyan Leong et al.   TRENDS IN BIOTECHNOLOGY

Therapy of type 1 diabetes with CD4+CD25highCD127-regulatory T cells prolongs survival of pancreatic islets — Results of one year follow-up

(2014) Natalia Marek-Trzonkowska et al.   CLINICAL IMMUNOLOGY

Nutrient regulation of insulin secretion and action

(2014) Philip Newsholme et al.   JOURNAL OF ENDOCRINOLOGY

TLR-Activated B Cells Suppress T Cell-Mediated Autoimmunity

(2014) V. Lampropoulou et al.   JOURNAL OF IMMUNOLOGY

Alleviation of Instant Blood-Mediated Inflammatory Reaction in Autologous Conditions Through Treatment of Human Islets with NF-κB Inhibitors

(2014) Mazhar A. Kanak et al.   TRANSPLANTATION

Cotransplantation With Myeloid-Derived Suppressor Cells Protects Cell Transplants

(2014) Yusuke Arakawa et al.   TRANSPLANTATION

Hydrogen-Bonded Multilayers of Tannic Acid as Mediators of T-Cell Immunity

(2014) Veronika Kozlovskaya et al.   Advanced Healthcare Materials

Redox Control of Inflammation in Macrophages

(2013) Bernhard Brüne et al.   ANTIOXIDANTS & REDOX SIGNALING

Microencapsulation of cells, including islets, within stable ultra-thin membranes of maleimide-conjugated PEG-lipid with multifunctional crosslinkers

(2013) Yuji Teramura et al.   BIOMATERIALS

Transcriptional regulation by hypoxia inducible factors

(2013) Veronica L. Dengler et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

The Impact of Oxidative Stress on Islet Transplantation and Monitoring the Graft Survival by Non-Invasive Imaging

(2013) K. M. Ramkumar et al.   CURRENT MEDICINAL CHEMISTRY

Exendin-4 Protects Hypoxic Islets From Oxidative Stress and Improves Islet Transplantation Outcome

(2013) M. Padmasekar et al.   ENDOCRINOLOGY

The Role of Metallothionein in Oxidative Stress

(2013) Branislav Ruttkay-Nedecky et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hypoxic resistance of hypodermically transplanted pancreatic islets by using cell-absorbable antioxidant Tat-metallothionein

(2013) Hae Song Jung et al.   JOURNAL OF CONTROLLED RELEASE

Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials

(2013) Antoinette Moran et al.   LANCET

Clinical application of regulatory T cells in type 1 diabetes

(2013) Natalia Marek-Trzonkowska et al.   PEDIATRIC DIABETES

Restoration of the Unfolded Protein Response in Pancreatic   Cells Protects Mice Against Type 1 Diabetes

(2013) F. Engin et al.   Science Translational Medicine

Ultrathin Polymeric Coatings Based on Hydrogen-Bonded Polyphenol for Protection of Pancreatic Islet Cells

(2012) Veronika Kozlovskaya et al.   ADVANCED FUNCTIONAL MATERIALS

Redox Regulation of T-Cell Function: From Molecular Mechanisms to Significance in Human Health and Disease

(2012) Pravin Kesarwani et al.   ANTIOXIDANTS & REDOX SIGNALING

Islet  -Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model

(2012) S. A. Tersey et al.   DIABETES

Dysregulated TLR3-dependent signaling and innate immune activation in superoxide-deficient macrophages from nonobese diabetic mice

(2012) Maria C. Seleme et al.   FREE RADICAL BIOLOGY AND MEDICINE

Role of complement and NK cells in antibody mediated rejection

(2012) Takurin Akiyoshi et al.   HUMAN IMMUNOLOGY

B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6–producing B cells

(2012) Tom A. Barr et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MyD88: A Critical Adaptor Protein in Innate Immunity Signal Transduction

(2012) N. Warner et al.   JOURNAL OF IMMUNOLOGY

Update on Islet Cell Transplantation for Type 1 Diabetes

(2012) Avinash Agarwal et al.   SEMINARS IN INTERVENTIONAL RADIOLOGY

STAT3 signaling pathway is necessary for cell survival and tumorsphere forming capacity in ALDH+/CD133+ stem cell-like human colon cancer cells

(2011) Li Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Caspase-8 and Bid: Caught in the act between death receptors and mitochondria

(2011) Chahrazade Kantari et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The pro- and anti-inflammatory properties of the cytokine interleukin-6

(2011) Jürgen Scheller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Endothelial Colony-Forming Cell Coating of Pig Islets Prevents Xenogeneic Instant Blood-Mediated Inflammatory Reaction

(2011) Jae Hyeon Kim et al.   CELL TRANSPLANTATION

Evidence of Endoplasmic Reticulum Stress Mediating Cell Death in Transplanted Human Islets

(2011) Sarita Negi et al.   CELL TRANSPLANTATION

Mitochondria-targeted Antioxidants Protect Pancreatic β-cells against Oxidative Stress and Improve Insulin Secretion in Glucotoxicity and Glucolipotoxicity

(2011) Sangbin Lim et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Oxidative Stress and Redox Modulation Potential in Type 1 Diabetes

(2011) Meghan M. Delmastro et al.   Clinical & Developmental Immunology

Control of instant blood-mediated inflammatory reaction to improve islets of Langerhans engraftment

(2011) Bo Nilsson et al.   Current Opinion in Organ Transplantation

Superoxide Production by Macrophages and T Cells Is Critical for the Induction of Autoreactivity and Type 1 Diabetes

(2011) T. C. Thayer et al.   DIABETES

The combination of metallothionein and superoxide dismutase protects pancreatic β cells from oxidative damage

(2011) Leejin Park et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Co-stimulation modulation with abatacept in patients with recent-onset type 1 diabetes: a randomised, double-blind, placebo-controlled trial

(2011) Tihamer Orban et al.   LANCET

Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases

(2011) M. Cargnello et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Chemistry and biology of reactive oxygen species in signaling or stress responses

(2011) Bryan C Dickinson et al.   Nature Chemical Biology

Effects of Imatinib Mesylate (Gleevec) on Human Islet NF-kappaB Activation and Chemokine Production In Vitro

(2011) Dariush Mokhtari et al.   PLoS One

Advances in metal-induced oxidative stress and human disease

(2011) Klaudia Jomova et al.   TOXICOLOGY

Myeloid-Derived Suppressor Cells Protect Islet Transplants by B7-H1 Mediated Enhancement of T Regulatory Cells

(2011) Hong-Shiue Chou et al.   TRANSPLANTATION

B- to Plasma-Cell Terminal Differentiation Entails Oxidative Stress and Profound Reshaping of the Antioxidant Responses

(2010) Milena Bertolotti et al.   ANTIOXIDANTS & REDOX SIGNALING

Inhibition of the NEMO/IKKβ association complex formation, a novel mechanism associated with the NF-κB activation suppression by Withania somnifera’s key metabolite withaferin A

(2010) Abhinav Grover et al.   BMC GENOMICS

Immune Cell Populations in Nonhuman Primate Islets

(2010) Lane C. K. Coffey et al.   CELL TRANSPLANTATION

Redox Modulation Protects Islets From Transplant-Related Injury

(2010) M. M. Sklavos et al.   DIABETES

Mesenchymal Stem Cells Enhance Allogeneic Islet Engraftment in Nonhuman Primates

(2010) D. M. Berman et al.   DIABETES

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Anthocyanins from Chinese Bayberry Extract Protect β Cells from Oxidative Stress-Mediated Injury via HO-1 Upregulation

(2010) Bo Zhang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

NADPH Oxidase Deficiency Regulates Th Lineage Commitment and Modulates Autoimmunity

(2010) H. M. Tse et al.   JOURNAL OF IMMUNOLOGY

Genetics, pathogenesis and clinical interventions in type 1 diabetes

(2010) Jeffrey A. Bluestone et al.   NATURE

Inhibition of Inflammatory Cytokine-Induced Response in Human Islet Cells by Withaferin A

(2010) H. Peng et al.   TRANSPLANTATION PROCEEDINGS

Role of Increased ROS Dissipation in Prevention of T1D

(2009) Jing Chen et al.   Annals of the New York Academy of Sciences

Sustained Src Inhibition Results in Signal Transducer and Activator of Transcription 3 (STAT3) Activation and Cancer Cell Survival via Altered Janus-Activated Kinase-STAT3 Binding

(2009) B. Sen et al.   CANCER RESEARCH

The Effect of Composite Pig Islet-Human Endothelial Cell Grafts on the Instant Blood-Mediated Inflammatory Reaction

(2009) Hyoung-Il Kim et al.   CELL TRANSPLANTATION

Current Advances and Travails in Islet Transplantation

(2009) D. M. Harlan et al.   DIABETES

Marginal mass islet transplantation with autologous mesenchymal stem cells promotes long-term islet allograft survival and sustained normoglycemia

(2009) Mario G. Solari et al.   JOURNAL OF AUTOIMMUNITY

Transient Oxidative Stress Damages Mitochondrial Machinery Inducing Persistent β-Cell Dysfunction

(2009) Ning Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defining critical inflammatory parameters for endotoxin impurity in manufactured alginate microcapsules

(2009) Joyce C. Breger et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function

(2009) Mark D. Pescovitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Novel aspects in the regulation of the leukocyte adhesion cascade

(2009) Emmanouil Chavakis et al.   THROMBOSIS AND HAEMOSTASIS

Islet transplantation and antioxidant management: A comprehensive review

(2009) Seyed-Sajad Mohseni Salehi Monfared   WORLD JOURNAL OF GASTROENTEROLOGY

The Clinical Impact of Islet Transplantation

(2008) P. Fiorina et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Building and operating an antibody factory: Redox control during B to plasma cell terminal differentiation

(2008) Silvia Masciarelli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Impact of mitochondrial calcium on the coupling of metabolism to insulin secretion in the pancreatic β-cell

(2008) A WIEDERKEHR et al.   CELL CALCIUM

Reactive Oxygen Species Production in Energized Cardiac Mitochondria During Hypoxia/Reoxygenation

(2008) Paavo Korge et al.   CIRCULATION RESEARCH

Formation of Composite Endothelial Cell-Mesenchymal Stem Cell Islets: A Novel Approach to Promote Islet Revascularization

(2008) U. Johansson et al.   DIABETES

Redox modulation inhibits CD8 T cell effector function

(2008) Martha M. Sklavos et al.   FREE RADICAL BIOLOGY AND MEDICINE

Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells

(2008) Paolo Monti et al.   JOURNAL OF CLINICAL INVESTIGATION

Fasting glucose improvement under dasatinib treatment in an accelerated phase chronic myeloid leukemia patient unresponsive to imatinib and nilotinib

(2008) M. Breccia et al.   LEUKEMIA RESEARCH

Layer-by-Layer Assembly of a Conformal Nanothin PEG Coating for Intraportal Islet Transplantation

(2008) John T. Wilson et al.   NANO LETTERS

Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice

(2008) C. Louvet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exendin-4 Does Not Promote Beta-Cell Proliferation or Survival During the Early Post-Islet Transplant Period in Mice

(2008) M.F. Crutchlow et al.   TRANSPLANTATION PROCEEDINGS

Imatinib mesylate improves insulin sensitivity and glucose disposal rates in rats fed a high-fat diet

(2007) Robert Hägerkvist et al.   CLINICAL SCIENCE