The Role for Myc in Coordinating Glycolysis, Oxidative Phosphorylation, Glutaminolysis, and Fatty Acid Metabolism in Normal and Neoplastic Tissues

Succinate dehydrogenase (SDH) deficiency, Carney triad and the epigenome

(2018) Nikolaos Settas et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Fire and water: Tumor cell adaptation to metabolic conditions

(2017) Rob A. Cairns et al.   EXPERIMENTAL CELL RESEARCH

Novel Advances in Understanding of Molecular Pathogenesis of Hepatoblastoma: A Wnt/β-Catenin Perspective

(2017) Danielle Bell et al.   GENE EXPRESSION

Targeting Tumor Adaption to Chronic Hypoxia: Implications for Drug Resistance, and How It Can Be Overcome

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sequential adaptive changes in a c-Myc-driven model of hepatocellular carcinoma

(2017) James M. Dolezal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

c-Myc-Dependent Cell Competition in Human Cancer Cells

(2017) Manish S. Patel et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH

(2017) Andrew M Intlekofer et al.   Nature Chemical Biology

Succinate: An initiator in tumorigenesis and progression

(2017) Ting Zhao et al.   Oncotarget

Fatty acid metabolism in breast cancer subtypes

(2017) Marie E. Monaco   Oncotarget

Mitochondrial respiratory gene expression is suppressed in many cancers

(2017) Ed Reznik et al.   eLife

MYC Deregulation in Primary Human Cancers

(2017) Manpreet Kalkat et al.   Genes

Controlling the Master: Chromatin Dynamics at the MYC Promoter Integrate Developmental Signaling

(2017) Olga Zaytseva et al.   Genes

MYC, Cell Competition, and Cell Death in Cancer: The Inseparable Triad

(2017) Simone Di Giacomo et al.   Genes

Targeting MYC Dependence by Metabolic Inhibitors in Cancer

(2017) Himalee S. Sabnis et al.   Genes

Limits of aerobic metabolism in cancer cells

(2017) Jorge Fernandez-de-Cossio-Diaz et al.   Scientific Reports

From Ancient Pathways to Aging Cells—Connecting Metabolism and Cellular Senescence

(2016) Christopher D. Wiley et al.   Cell Metabolism

PKM2, cancer metabolism, and the road ahead

(2016) Talya L Dayton et al.   EMBO REPORTS

Coordinated Activities of Multiple Myc-dependent and Myc-independent Biosynthetic Pathways in Hepatoblastoma

(2016) Huabo Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling

(2016) Sergiy M. Nadtochiy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Pathology and Glycolytic Shift during Proximal Tubule Atrophy after Ischemic AKI

(2016) R. Lan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Isocitrate dehydrogenase mutations in myeloid malignancies

(2016) B C Medeiros et al.   LEUKEMIA

Structure of a Complete ATP Synthase Dimer Reveals the Molecular Basis of Inner Mitochondrial Membrane Morphology

(2016) Alexander Hahn et al.   MOLECULAR CELL

Reductive carboxylation supports redox homeostasis during anchorage-independent growth

(2016) Lei Jiang et al.   NATURE

c-Myc Sustains Transformed Phenotype and Promotes Radioresistance of Embryonal Rhabdomyosarcoma Cell Lines

(2016) G. L. Gravina et al.   RADIATION RESEARCH

Mitochondrial Cristae: Where Beauty Meets Functionality

(2016) Sara Cogliati et al.   TRENDS IN BIOCHEMICAL SCIENCES

MutantIDH: a targetable driver of leukemic phenotypes linking metabolism, epigenetics and transcriptional regulation

(2016) Francine E Garrett-Bakelman et al.   Epigenomics

Abnormal lipid processing but normal long-term repopulation potential of myc-/- hepatocytes

(2016) Lia R. Edmunds et al.   Oncotarget

Mitochondrial DNA copy number variation across human cancers

(2016) Ed Reznik et al.   eLife

Fundamentals of cancer metabolism

(2016) R. J. DeBerardinis et al.   Science Advances

MicroRNA-449a enhances radiosensitivity by downregulation of c-Myc in prostate cancer cells

(2016) Aihong Mao et al.   Scientific Reports

Drosophila Myc: A master regulator of cellular performance

(2015) Daniela Grifoni et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Small-molecule inhibitors of the Myc oncoprotein

(2015) Steven Fletcher et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

5-Hydroxymethylcytosine: An epigenetic mark frequently deregulated in cancer

(2015) Leonie I. Kroeze et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Reduced Expression of MYC Increases Longevity and Enhances Healthspan

(2015) Jeffrey W. Hofmann et al.   CELL

Lactate promotes glutamine uptake and metabolism in oxidative cancer cells

(2015) Jhudit Pérez-Escuredo et al.   CELL CYCLE

Hypoxia Induces Production of L-2-Hydroxyglutarate

(2015) Andrew M. Intlekofer et al.   Cell Metabolism

Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression

(2015) Zhaoyong Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Molecular Pathways: IDH2 Mutations--Co-opting Cellular Metabolism for Malignant Transformation

(2015) E. M. Stein   CLINICAL CANCER RESEARCH

Molecular Pathways: Is AMPK a Friend or a Foe in Cancer?

(2015) D. G. Hardie   CLINICAL CANCER RESEARCH

Hepatic lipid droplet biology: Getting to the root of fatty liver

(2015) Douglas G. Mashek et al.   HEPATOLOGY

Metabolism pathways in chronic lymphocytic leukemia

(2015) Uri Rozovski et al.   LEUKEMIA & LYMPHOMA

Electron Transfer Pathways in Cholesterol Synthesis

(2015) Todd D. Porter   LIPIDS

Mitochondrial dependency in progression of acute myeloid leukemia

(2015) Nandini Pal Basak et al.   MITOCHONDRION

Targeting the translation machinery in cancer

(2015) Mamatha Bhat et al.   NATURE REVIEWS DRUG DISCOVERY

p53 in survival, death and metabolic health: a lifeguard with a licence to kill

(2015) Flore Kruiswijk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metabolic reprogramming in glioblastoma: the influence of cancer metabolism on epigenetics and unanswered questions

(2015) Sameer Agnihotri et al.   NEURO-ONCOLOGY

Isocitrate dehydrogenase mutations in gliomas

(2015) Matthew S. Waitkus et al.   NEURO-ONCOLOGY

Glutaminolysis as a target for cancer therapy

(2015) L Jin et al.   ONCOGENE

MYC and metabolism on the path to cancer

(2015) Annie L. Hsieh et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Pyruvate kinase: Function, regulation and role in cancer

(2015) William J. Israelsen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Structurally diverse c-Myc inhibitors share a common mechanism of action involving ATP depletion

(2015) Huabo Wang et al.   Oncotarget

Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids

(2015) Huabo Wang et al.   Oncotarget

Cancer: Mitochondrial Origins

(2015) George B. Stefano et al.   MEDICAL SCIENCE MONITOR

Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression

(2015) Richard Ventura et al.   EBioMedicine

Dichloroacetate and cancer: New home for an orphan drug?

(2014) Shyam Kankotia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Cell turnover in the repopulated rat liver: distinct lineages for hepatocytes and the biliary epithelium

(2014) Fabio Marongiu et al.   CELL AND TISSUE RESEARCH

Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells

(2014) Sudha Mannava et al.   CELL CYCLE

Activation of β-Catenin and Yap1 in Human Hepatoblastoma and Induction of Hepatocarcinogenesis in Mice

(2014) Junyan Tao et al.   GASTROENTEROLOGY

c-Myc Programs Fatty Acid Metabolism and Dictates Acetyl-CoA Abundance and Fate

(2014) Lia R. Edmunds et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Are oxidative stress mechanisms the common denominator in the progression from hepatic steatosis towards non-alcoholic steatohepatitis (NASH)?

(2014) Zoon Tariq et al.   LIVER INTERNATIONAL

Targeting of the MYCN Protein with Small Molecule c-MYC Inhibitors

(2014) Inga Müller et al.   PLoS One

Redox control of glutamine utilization in cancer

(2014) L Alberghina et al.   Cell Death & Disease

MYC Regulation of Cell Growth through Control of Transcription by RNA Polymerases I and III

(2014) K. J. Campbell et al.   Cold Spring Harbor Perspectives in Medicine

An Overview of MYC and Its Interactome

(2014) M. Conacci-Sorrell et al.   Cold Spring Harbor Perspectives in Medicine

Structures of mitochondrial oxidative phosphorylation supercomplexes and mechanisms for their stabilisation

(2013) Yuriy Chaban et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Acidic extracellular microenvironment and cancer

(2013) Yasumasa Kato et al.   Cancer Cell International

Stem cell metabolism in tissue development and aging

(2013) N. Shyh-Chang et al.   DEVELOPMENT

Role of Myc in hepatocellular proliferation and hepatocarcinogenesis

(2013) Aijuan Qu et al.   JOURNAL OF HEPATOLOGY

Cardiac glutaminolysis: a maladaptive cancer metabolism pathway in the right ventricle in pulmonary hypertension

(2013) Lin Piao et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells

(2013) H. Zirath et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myc-induced AMPK-phospho p53 pathway activates Bak to sensitize mitochondrial apoptosis

(2013) A. I. Nieminen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Accessorizing the human mitochondrial transcription machinery

(2013) Megan L. Bestwick et al.   TRENDS IN BIOCHEMICAL SCIENCES

Alterations in c-Myc phenotypes resulting from dynamin-related protein 1 (Drp1)-mediated mitochondrial fission

(2013) M Sarin et al.   Cell Death & Disease

Hypoxic Regulation of Hand1 Controls the Fetal-Neonatal Switch in Cardiac Metabolism

(2013) Ross A. Breckenridge et al.   PLOS BIOLOGY

The function and the role of the mitochondrial glycerol-3-phosphate dehydrogenase in mammalian tissues

(2012) Tomáš Mráček et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation

(2012) Guoliang Qing et al.   CANCER CELL

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

MYC Regulation of CHK1 and CHK2 Promotes Radioresistance in a Stem Cell-like Population of Nasopharyngeal Carcinoma Cells

(2012) W.-J. Wang et al.   CANCER RESEARCH

Cancer metabolism: Key players in metabolic reprogramming

(2012) Tomoyoshi Soga   CANCER SCIENCE

Oncogene-induced senescence results in marked metabolic and bioenergetic alterations

(2012) Celia Quijano et al.   CELL CYCLE

Pyruvate Kinase M2: Multiple Faces for Conferring Benefits on Cancer Cells

(2012) M. Tamada et al.   CLINICAL CANCER RESEARCH

Hypertrophy and Unconventional Cell Division of Hepatocytes Underlie Liver Regeneration

(2012) Yuichiro Miyaoka et al.   CURRENT BIOLOGY

Links between metabolism and cancer

(2012) C. V. Dang   GENES & DEVELOPMENT

ATP Depletion Triggers Acute Myeloid Leukemia Differentiation through an ATR/Chk1 Protein-dependent and p53 Protein-independent Pathway

(2012) Amitabha Chakrabarti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduction of fatty acid oxidation and responses to hypoxia correlate with the progression of de-differentiation in HCC

(2012) MASATAKE TANAKA et al.   Molecular Medicine Reports

Deregulated MYC expression induces dependence upon AMPK-related kinase 5

(2012) Lidan Liu et al.   NATURE

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial Structure, Function and Dynamics Are Temporally Controlled by c-Myc

(2012) J. Anthony Graves et al.   PLoS One

Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health

(2011) David C. Chan   Annual Review of Genetics

SDH mutations in cancer

(2011) Chiara Bardella et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Myc Posttranscriptionally Induces HIF1 Protein and Target Gene Expression in Normal and Cancer Cells

(2011) M. R. Doe et al.   CANCER RESEARCH

Lactate: A Metabolic Key Player in Cancer

(2011) F. Hirschhaeuser et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Liver mitochondrial function and redox status in an experimental model of non-alcoholic fatty liver disease induced by monosodium l-glutamate in rats

(2011) Murilo de Oliveira Lazarin et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

The Sleeping Beauty transposon system: a non-viral vector for gene therapy

(2011) E. L. Aronovich et al.   HUMAN MOLECULAR GENETICS

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Mitochondrial respiratory chain complexes: apoptosis sensors mutated in cancer?

(2011) A Lemarie et al.   ONCOGENE

Acute Myeloid Leukemia WithIDH1orIDH2Mutation

(2010) Keyur P. Patel et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Turning on a Fuel Switch of Cancer: hnRNP Proteins Regulate Alternative Splicing of Pyruvate Kinase mRNA

(2010) M. Chen et al.   CANCER RESEARCH

Organ size determination and the limits of regulation

(2010) Ben Z. Stanger   CELL CYCLE

AMP-activated Protein Kinase Mediates Apoptosis in Response to Bioenergetic Stress through Activation of the Pro-apoptotic Bcl-2 Homology Domain-3-only Protein BMF

(2010) Seán M. Kilbride et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation

(2010) E. L. Carr et al.   JOURNAL OF IMMUNOLOGY

HIF-1 and HIF-2 transcription factors — Similar but not identical

(2010) Agnieszka Loboda et al.   MOLECULES AND CELLS

Pathology of nonalcoholic fatty liver disease

(2010) Elizabeth M. Brunt   Nature Reviews Gastroenterology & Hepatology

Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells

(2010) M. G. Vander Heiden et al.   SCIENCE

Mitochondrial fusion proteins: Dual regulators of morphology and metabolism

(2010) Antonio Zorzano et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Randle cycle revisited: a new head for an old hat

(2009) Louis Hue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities

(2009) C. V. Dang et al.   CLINICAL CANCER RESEARCH

Hydrodynamic Gene Delivery to the Liver: Theoretical and Practical Issues for Clinical Application

(2009) Greta Sawyer et al.   CURRENT GENE THERAPY

Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases

(2009) H. Chen et al.   HUMAN MOLECULAR GENETICS

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

(2009) Charles J. David et al.   NATURE

c-Myc activates multiple metabolic networks to generate substrates for cell-cycle entry

(2009) F Morrish et al.   ONCOGENE

Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer

(2009) R J DeBerardinis et al.   ONCOGENE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

(2009) T. Hitosugi et al.   Science Signaling

Supramolecular organization of protein complexes in the mitochondrial inner membrane

(2008) Janet Vonck et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Hematopoietic Stem Cell Function and Survival Depend on c-Myc and N-Myc Activity

(2008) Elisa Laurenti et al.   Cell Stem Cell

Brick by brick: metabolism and tumor cell growth

(2008) Ralph J DeBerardinis et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Quantifying Reductive Carboxylation Flux of Glutamine to Lipid in a Brown Adipocyte Cell Line

(2008) Hyuntae Yoo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crosstalk between c-Myc and ribosome in ribosomal biogenesis and cancer

(2008) Mu-Shui Dai et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Differential effects of energy stress on AMPK phosphorylation and apoptosis in experimental brain tumor and normal brain

(2008) Purna Mukherjee et al.   Molecular Cancer

Respiratory Active Mitochondrial Supercomplexes

(2008) Rebeca Acín-Pérez et al.   MOLECULAR CELL

Modelling Myc inhibition as a cancer therapy

(2008) Laura Soucek et al.   NATURE

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA