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Title
Targeting MYC Dependence by Metabolic Inhibitors in Cancer
Authors
Keywords
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Journal
Genes
Volume 8, Issue 4, Pages 114
Publisher
MDPI AG
Online
2017-03-31
DOI
10.3390/genes8040114
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Note: Only part of the references are listed.- Therapeutic applications of dichloroacetate and the role of glutathione transferase zeta-1
- (2017) Margaret O. James et al. PHARMACOLOGY & THERAPEUTICS
- The OncoPPi network of cancer-focused protein–protein interactions to inform biological insights and therapeutic strategies
- (2017) Zenggang Li et al. Nature Communications
- Targeting MYC in cancer therapy: RNA processing offers new opportunities
- (2016) Cheryl M. Koh et al. BIOESSAYS
- 4EBP1/c-MYC/PUMA and NF- B/EGR1/BIM pathways underlie cytotoxicity of mTOR dual inhibitors in malignant lymphoid cells
- (2016) S. Yun et al. BLOOD
- Drugging the addict: non‐oncogene addiction as a target for cancer therapy
- (2016) Remco Nagel et al. EMBO REPORTS
- Inhibitor of differentiation 1 transcription factor promotes metabolic reprogramming in hepatocellular carcinoma cells
- (2016) Bal Krishan Sharma et al. FASEB JOURNAL
- Mechanistic Target of Rapamycin (mTOR) Inhibition Synergizes with Reduced Internal Ribosome Entry Site (IRES)-mediated Translation of Cyclin D1 and c-MYC mRNAs to Treat Glioblastoma
- (2016) Brent Holmes et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Synergistic cell death in FLT3-ITD positive acute myeloid leukemia by combined treatment with metformin and 6-benzylthioinosine
- (2016) Himalee S. Sabnis et al. LEUKEMIA RESEARCH
- The HK2 Dependent “Warburg Effect” and Mitochondrial Oxidative Phosphorylation in Cancer: Targets for Effective Therapy with 3-Bromopyruvate
- (2016) Paweł Lis et al. MOLECULES
- Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer
- (2016) Roman Camarda et al. NATURE MEDICINE
- Suppression of c-Myc and RRM2 expression in pancreatic cancer cells by the sphingosine kinase-2 inhibitor ABC294640
- (2016) Clayton S. Lewis et al. Oncotarget
- Non-immunosuppressive triazole-based small molecule induces anticancer activity against human hormone-refractory prostate cancers: the role in inhibition of PI3K/AKT/mTOR and c-Myc signaling pathways
- (2016) Wohn-Jenn Leu et al. Oncotarget
- Icariside II, a natural mTOR inhibitor, disrupts aberrant energy homeostasis via suppressing mTORC1-4E-BP1 axis in sarcoma cells
- (2016) Chao Zhang et al. Oncotarget
- Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer
- (2016) Jianchang Qian et al. Oncotarget
- Anti-tumor activity of metformin: from metabolic and epigenetic perspectives
- (2016) Xilan Yu et al. Oncotarget
- Synergistic induction of cell death in haematological malignancies by combined phosphoinositide-3-kinase and BET bromodomain inhibition
- (2015) Steven Tinsley et al. BRITISH JOURNAL OF HAEMATOLOGY
- Co-targeting of Akt and Myc inhibits viability of lymphoma cells from Lck-Dlx5 mice
- (2015) Yinfei Tan et al. CANCER BIOLOGY & THERAPY
- Lactate dehydrogenase 5: An old friend and a new hope in the war on cancer
- (2015) Katarzyna Augoff et al. CANCER LETTERS
- Lactate promotes glutamine uptake and metabolism in oxidative cancer cells
- (2015) Jhudit Pérez-Escuredo et al. CELL CYCLE
- Oncogenic Myc Induces Expression of Glutamine Synthetase through Promoter Demethylation
- (2015) Alex J. Bott et al. Cell Metabolism
- Current views on inducing synthetic lethal RNAi responses in the treatment of cancer
- (2015) Apollo D. Kacsinta et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- mTOR Complex 2 Stabilizes Mcl-1 Protein by Suppressing Its Glycogen Synthase Kinase 3-Dependent and SCF-FBXW7-Mediated Degradation
- (2015) Junghui Koo et al. MOLECULAR AND CELLULAR BIOLOGY
- Metabolic targeting of oncogene MYC by selective activation of the proton-coupled monocarboxylate family of transporters
- (2015) L Gan et al. ONCOGENE
- The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming
- (2015) Liem Phan et al. Nature Communications
- Structurally diverse c-Myc inhibitors share a common mechanism of action involving ATP depletion
- (2015) Huabo Wang et al. Oncotarget
- Tumor suppressor NDRG2 inhibits glycolysis and glutaminolysis in colorectal cancer cells by repressing c-Myc expression
- (2015) Xinyuan Xu et al. Oncotarget
- Inhibition of BET bromodomains as a therapeutic strategy for cancer drug discovery
- (2015) Lei-lei Fu et al. Oncotarget
- Dual mTOR inhibitor MLN0128 suppresses Merkel cell carcinoma (MCC) xenograft tumor growth
- (2015) Aarthi Kannan et al. Oncotarget
- A combination of temsirolimus, an allosteric mTOR inhibitor, with clofarabine as a new therapeutic option for patients with acute myeloid leukemia
- (2015) Francesca Chiarini et al. Oncotarget
- Mitochondrial p32 is upregulated in Myc expressing brain cancers and mediates glutamine addiction
- (2015) Valentina Fogal et al. Oncotarget
- Dichloroacetate and cancer: New home for an orphan drug?
- (2014) Shyam Kankotia et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma
- (2014) J. Kummetha Venkata et al. BLOOD
- 2-Deoxy-D-glucose targeting of glucose metabolism in cancer cells as a potential therapy
- (2014) Dongsheng Zhang et al. CANCER LETTERS
- Sphingosine Kinase 2 Promotes Acute Lymphoblastic Leukemia by Enhancing MYC Expression
- (2014) C. T. Wallington-Beddoe et al. CANCER RESEARCH
- Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases
- (2014) Tomoyuki Mashimo et al. CELL
- Acetate Dependence of Tumors
- (2014) Sarah A. Comerford et al. CELL
- Direct role of nucleotide metabolism in C-MYC-dependent proliferation of melanoma cells
- (2014) Sudha Mannava et al. CELL CYCLE
- The mTORC1/S6K1 Pathway Regulates Glutamine Metabolism through the eIF4B-Dependent Control of c-Myc Translation
- (2014) Alfredo Csibi et al. CURRENT BIOLOGY
- c-Myc Programs Fatty Acid Metabolism and Dictates Acetyl-CoA Abundance and Fate
- (2014) Lia R. Edmunds et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Capillary nano-immunoassay for Akt 1/2/3 and 4EBP1 phosphorylation in acute myeloid leukemia
- (2014) Himalee Sabnis et al. Journal of Translational Medicine
- Glycolytic inhibitor 2-deoxy-d-glucose suppresses cell proliferation and enhances methylprednisolone sensitivity in non-Hodgkin lymphoma cells through down-regulation of HIF-1α and c-MYC
- (2014) Yu-Yang Pang et al. LEUKEMIA & LYMPHOMA
- AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation
- (2014) Valentina Cianfanelli et al. NATURE CELL BIOLOGY
- A long noncoding RNA connects c-Myc to tumor metabolism
- (2014) Chiu-Lien Hung et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis
- (2014) William W Wheaton et al. eLife
- Galloflavin suppresses lactate dehydrogenase activity and causes MYC downregulation in Burkitt lymphoma cells through NAD/NADH-dependent inhibition of sirtuin-1
- (2013) Marina Vettraino et al. ANTI-CANCER DRUGS
- Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas
- (2013) J. Shortt et al. BLOOD
- PDK1 inhibition is a novel therapeutic target in multiple myeloma
- (2013) S Fujiwara et al. BRITISH JOURNAL OF CANCER
- Blocking Lactate Export by Inhibiting the Myc Target MCT1 Disables Glycolysis and Glutathione Synthesis
- (2013) J. R. Doherty et al. CANCER RESEARCH
- Metformin targets c-MYC oncogene to prevent prostate cancer
- (2013) Tunde Akinyeke et al. CARCINOGENESIS
- A Central Role for mTOR in Lipid Homeostasis
- (2013) Dudley W. Lamming et al. Cell Metabolism
- Small-molecule inhibitors of human LDH5
- (2013) Carlotta Granchi et al. Future Medicinal Chemistry
- 2-Deoxyglucose treatment complements the cisplatin- or BH3-only mimetic-induced suppression of neuroblastoma cell growth
- (2013) Jiin-Haur Chuang et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- SIRT4 Protein Suppresses Tumor Formation in Genetic Models of Myc-induced B Cell Lymphoma
- (2013) Seung Min Jeong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Targeting lactate metabolism for cancer therapeutics
- (2013) Joanne R. Doherty et al. JOURNAL OF CLINICAL INVESTIGATION
- Triplex-forming oligonucleotides targeting c-MYCpotentiate the anti-tumor activity of gemcitabine in a mouse model of human cancer
- (2013) Stephen B. Boulware et al. MOLECULAR CARCINOGENESIS
- New Aspects of an Old Drug – Diclofenac Targets MYC and Glucose Metabolism in Tumor Cells
- (2013) Eva Gottfried et al. PLoS One
- Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers
- (2013) M. Pourdehnad et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells
- (2013) H. Zirath et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Carbon Source and Myc Expression Influence the Antiproliferative Actions of Metformin
- (2012) S. Javeshghani et al. CANCER RESEARCH
- Activation of Ras/PI3K/ERK Pathway Induces c-Myc Stabilization to Upregulate Argininosuccinate Synthetase, Leading to Arginine Deiminase Resistance in Melanoma Cells
- (2012) W.-B. Tsai et al. CANCER RESEARCH
- c-Myc and Cancer Metabolism
- (2012) D. M. Miller et al. CLINICAL CANCER RESEARCH
- Role of monocarboxylate transporters in human cancers: state of the art
- (2012) Céline Pinheiro et al. JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
- A Small-Molecule Inhibitor of Glucose Transporter 1 Downregulates Glycolysis, Induces Cell-Cycle Arrest, and Inhibits Cancer Cell Growth In Vitro and In Vivo
- (2012) Y. Liu et al. MOLECULAR CANCER THERAPEUTICS
- MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors
- (2012) Kivanç Birsoy et al. NATURE GENETICS
- Metformin elicits anticancer effects through the sequential modulation of DICER and c-MYC
- (2012) Giovanni Blandino et al. Nature Communications
- Combination of PI3K/mTOR Inhibitors: Antitumor Activity and Molecular Correlates
- (2011) M. Mazzoletti et al. CANCER RESEARCH
- Galloflavin (CAS 568-80-9): A Novel Inhibitor of Lactate Dehydrogenase
- (2011) Marcella Manerba et al. ChemMedChem
- Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress
- (2011) K. Zaugg et al. GENES & DEVELOPMENT
- The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia
- (2011) L Willems et al. LEUKEMIA
- c-Myc dependent expression of pro-apoptotic Bim renders HER2-overexpressing breast cancer cells dependent on anti-apoptotic Mcl-1
- (2011) Mario Campone et al. Molecular Cancer
- Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells
- (2011) Ramon C Sun et al. Molecular Cancer
- The Combination of RAD001 and NVP-BEZ235 Exerts Synergistic Anticancer Activity against Non-Small Cell Lung Cancer In Vitro and In Vivo
- (2011) Cheng-Xiong Xu et al. PLoS One
- The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop
- (2011) A. Menssen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting GLUT1 and the Warburg Effect in Renal Cell Carcinoma by Chemical Synthetic Lethality
- (2011) D. A. Chan et al. Science Translational Medicine
- Carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase: Biological activities and selective toxicities
- (2010) Omar N. Al Safarjalani et al. BIOCHEMICAL PHARMACOLOGY
- Dual Inhibition of PI3K and mTORC1/2 Signaling by NVP-BEZ235 as a New Therapeutic Strategy for Acute Myeloid Leukemia
- (2010) N. Chapuis et al. CLINICAL CANCER RESEARCH
- Mitochondrial p32 Protein Is a Critical Regulator of Tumor Metabolism via Maintenance of Oxidative Phosphorylation
- (2010) V. Fogal et al. MOLECULAR AND CELLULAR BIOLOGY
- c-Myc Is Required for the ChREBP-Dependent Activation of Glucose-Responsive Genes
- (2010) Pili Zhang et al. MOLECULAR ENDOCRINOLOGY
- AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity
- (2009) C. M. Chresta et al. CANCER RESEARCH
- Everolimus (RAD001): an mTOR inhibitor for the treatment of metastatic renal cell carcinoma
- (2009) Stéphane Oudard et al. Expert Review of Anticancer Therapy
- cAMP opposes the glucose-mediated induction of the L-PK gene by preventing the recruitment of a complex containing ChREBP, HNF4α, and CBP
- (2009) Susan J. Burke et al. FASEB JOURNAL
- Inhibition of mammalian target of rapamycin signaling potentiates the effects of all-transretinoic acid to induce growth arrest and differentiation of human acute myelogenous leukemia cells
- (2009) Chie Nishioka et al. INTERNATIONAL JOURNAL OF CANCER
- Akt and c-Myc Differentially Activate Cellular Metabolic Programs and Prime Cells to Bioenergetic Inhibition
- (2009) Yongjun Fan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
- (2009) Ping Gao et al. NATURE
- Identification of 6-Benzylthioinosine as a Myeloid Leukemia Differentiation-Inducing Compound
- (2008) D. N. Wald et al. CANCER RESEARCH
- Blockade of mTOR signaling potentiates the ability of histone deacetylase inhibitor to induce growth arrest and differentiation of acute myelogenous leukemia cells
- (2008) C Nishioka et al. LEUKEMIA
- A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death
- (2008) T. E. Wood et al. MOLECULAR CANCER THERAPEUTICS
- Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
- (2008) D. R. Wise et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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