Mitochondrial respiratory chain complexes: apoptosis sensors mutated in cancer?

Dysregulation of sphingolipid metabolism in cancer

(2011) Lindsay K. Ryland et al.   CANCER BIOLOGY & THERAPY

Bnip3 impairs mitochondrial bioenergetics and stimulates mitochondrial turnover

(2011) S Rikka et al.   CELL DEATH AND DIFFERENTIATION

Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy

(2011) Lan-Feng Dong et al.   FREE RADICAL BIOLOGY AND MEDICINE

α-Tocopheryl succinate causes mitochondrial permeabilization by preferential formation of Bak channels

(2010) Lubomir Prochazka et al.   APOPTOSIS

Hypoxia and mitochondrial oxidative metabolism

(2010) Giancarlo Solaini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The quinone-binding and catalytic site of complex II

(2010) Elena Maklashina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The Warburg and Crabtree effects: On the origin of cancer cell energy metabolism and of yeast glucose repression

(2010) Rodrigo Diaz-Ruiz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Calcium signalling-dependent mitochondrial dysfunction and bioenergetics regulation in respiratory chain Complex II deficiency

(2010) E Mbaya et al.   CELL DEATH AND DIFFERENTIATION

Specific disintegration of complex II succinate:ubiquinone oxidoreductase links pH changes to oxidative stress for apoptosis induction

(2010) A Lemarie et al.   CELL DEATH AND DIFFERENTIATION

miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity

(2010) M-P Puisségur et al.   CELL DEATH AND DIFFERENTIATION

Warburg tumours and the mechanisms of mitochondrial tumour suppressor genes. Barking up the right tree?

(2010) Jean-Pierre Bayley et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

SDHB loss predicts malignancy in pheochromocytomas/sympathethic paragangliomas, but not through hypoxia signalling

(2010) Annika Blank et al.   ENDOCRINE-RELATED CANCER

Familial neonatal isolated cardiomyopathy caused by a mutation in the flavoprotein subunit of succinate dehydrogenase

(2010) Aviva Levitas et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Complex I: Inhibitors, inhibition and neurodegeneration

(2010) A.H.V. Schapira   EXPERIMENTAL NEUROLOGY

Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal β cells

(2010) Dmitry Akhmedov et al.   FASEB JOURNAL

Reactive oxygen species, cellular redox systems, and apoptosis

(2010) Magdalena L. Circu et al.   FREE RADICAL BIOLOGY AND MEDICINE

SDHA is a tumor suppressor gene causing paraganglioma

(2010) Nelly Burnichon et al.   HUMAN MOLECULAR GENETICS

Mitochondrial Targeting of Vitamin E Succinate Enhances Its Pro-apoptotic and Anti-cancer Activity via Mitochondrial Complex II

(2010) Lan-Feng Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SDHAF2 mutations in familial and sporadic paraganglioma and phaeochromocytoma

(2010) Jean-Pierre Bayley et al.   LANCET ONCOLOGY

Succinate dehydrogenase – Assembly, regulation and role in human disease

(2010) Jared Rutter et al.   MITOCHONDRION

Mitochondrial reactive oxygen species generation by the SDHC V69E mutation causes low birth weight and neonatal growth retardation

(2010) Takamasa Ishii et al.   MITOCHONDRION

The causes of cancer revisited: “Mitochondrial malignancy” and ROS-induced oncogenic transformation – Why mitochondria are targets for cancer therapy

(2010) Stephen J. Ralph et al.   MOLECULAR ASPECTS OF MEDICINE

Heteroplasmic mitochondrial DNA mutations in normal and tumour cells

(2010) Yiping He et al.   NATURE

Hypoxia-regulated microRNA-210 modulates mitochondrial function and decreases ISCU and COX10 expression

(2010) Z Chen et al.   ONCOGENE

Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations

(2010) K. A. Janeway et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Modulation of Glioblastoma with Dichloroacetate

(2010) E. D. Michelakis et al.   Science Translational Medicine

Structure and Organization of Mitochondrial Respiratory Complexes: A New Understanding of an Old Subject

(2009) Giorgio Lenaz et al.   ANTIOXIDANTS & REDOX SIGNALING

Cytochrome c oxidase deficiency: Patients and animal models

(2009) Francisca Diaz   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial complex I deficiency: from organelle dysfunction to clinical disease

(2009) F. Distelmaier et al.   BRAIN

Complex II inhibition by 3-NP causes mitochondrial fragmentation and neuronal cell death via an NMDA- and ROS-dependent pathway

(2009) G Liot et al.   CELL DEATH AND DIFFERENTIATION

Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis

(2009) Jianxin Lu et al.   CELL RESEARCH

Fenretinide induces mitochondrial ROS and inhibits the mitochondrial respiratory chain in neuroblastoma

(2009) Roos Cuperus et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Suppression of Tumor Growth In vivo by the Mitocan  -tocopheryl Succinate Requires Respiratory Complex II

(2009) L.-F. Dong et al.   CLINICAL CANCER RESEARCH

A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis

(2009) J. S. Park et al.   HUMAN MOLECULAR GENETICS

The Succinate Dehydrogenase Genetic Testing in a Large Prospective Series of Patients with Paragangliomas

(2009) Nelly Burnichon et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mutations in the C. elegans Succinate Dehydrogenase Iron–Sulfur Subunit Promote Superoxide Generation and Premature Aging

(2009) Jingzhou Huang et al.   JOURNAL OF MOLECULAR BIOLOGY

An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis

(2009) Francien H van Nederveen et al.   LANCET ONCOLOGY

Mutations in the heme b-binding residue of SDHC inhibit assembly of respiratory chain complex II in mammalian cells

(2009) Anthony Lemarie et al.   MITOCHONDRION

The Warburg effect and mitochondrial stability in cancer cells

(2009) Vladimir Gogvadze et al.   MOLECULAR ASPECTS OF MEDICINE

Caspase-independent Mitochondrial Cell Death Results from Loss of Respiration, Not Cytotoxic Protein Release

(2009) Lydia Lartigue et al.   MOLECULAR BIOLOGY OF THE CELL

Mitocans, a class of emerging anti-cancer drugs

(2009) Stephen J. Ralph et al.   MOLECULAR NUTRITION & FOOD RESEARCH

SDHAF1, encoding a LYR complex-II specific assembly factor, is mutated in SDH-defective infantile leukoencephalopathy

(2009) Daniele Ghezzi et al.   NATURE GENETICS

The Warburg Effect Is Genetically Determined in Inherited Pheochromocytomas

(2009) Judith Favier et al.   PLoS One

Mitochondrial Complex II Dysfunction Can Contribute Significantly to Genomic Instability after Exposure to Ionizing Radiation

(2009) Disha Dayal et al.   RADIATION RESEARCH

SDH5, a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma

(2009) H.-X. Hao et al.   SCIENCE

IF1: setting the pace of the F1Fo-ATP synthase

(2009) Michelangelo Campanella et al.   TRENDS IN BIOCHEMICAL SCIENCES

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Respiratory-chain diseases related to complex III deficiency

(2008) Paule Bénit et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

(2008) E D Michelakis et al.   BRITISH JOURNAL OF CANCER

Cells Silenced for SDHB Expression Display Characteristic Features of the Tumor Phenotype

(2008) A. M. Cervera et al.   CANCER RESEARCH

HIF and reactive oxygen species regulate oxidative phosphorylation in cancer

(2008) Eric Hervouet et al.   CARCINOGENESIS

Granzyme A Cleaves a Mitochondrial Complex I Protein to Initiate Caspase-Independent Cell Death

(2008) Denis Martinvalet et al.   CELL

Roles of p53, Myc and HIF-1 in Regulating Glycolysis — the Seventh Hallmark of Cancer

(2008) S. J. Yeung et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

RECENT ADVANCES IN THE GENETICS OF PHAEOCHROMOCYTOMA AND FUNCTIONAL PARAGANGLIOMA

(2008) Anne-Paule Gimenez-Roqueplo et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Reactive oxygen species act remotely to cause synapse loss in a Drosophila model of developmental mitochondrial encephalopathy

(2008) J. D. Mast et al.   DEVELOPMENT

Age-related alterations in oxidatively damaged proteins of mouse skeletal muscle mitochondrial electron transport chain complexes

(2008) Kashyap B. Choksi et al.   FREE RADICAL BIOLOGY AND MEDICINE

The kinesin KIF1B  acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor

(2008) S. Schlisio et al.   GENES & DEVELOPMENT

Induction of Immunological Tolerance by Apoptotic Cells Requires Caspase-Dependent Oxidation of High-Mobility Group Box-1 Protein

(2008) Hirotaka Kazama et al.   IMMUNITY

Mitochondrial Oxidative Phosphorylation Is Regulated by Fructose 1,6-Bisphosphate

(2008) Rodrigo Díaz-Ruiz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transcriptional Regulation of SDHa Flavoprotein by Nuclear Respiratory Factor-1 Prevents Pseudo-hypoxia in Aerobic Cardiac Cells

(2008) Claude A. Piantadosi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Tyrosine Nitration of the Flavin Subunit Is Associated with Oxidative Modification of Mitochondrial Complex II in the Post-ischemic Myocardium

(2008) Chwen-Lih Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial dysfunction by complex II inhibition delays overall cell cycle progression via reactive oxygen species production

(2008) Hae-Ok Byun et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Germline SDHB Mutations and Familial Renal Cell Carcinoma

(2008) C. Ricketts et al.   JNCI-Journal of the National Cancer Institute

The reemergence of nitric oxide and cancer

(2008) David A. Wink et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

α-Tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II

(2008) L-F Dong et al.   ONCOGENE

Leigh and Leigh-Like Syndrome in Children and Adults

(2008) Josef Finsterer   PEDIATRIC NEUROLOGY

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

(2008) K. Ishikawa et al.   SCIENCE

Mitochondria in cancer: Not just innocent bystanders

(2008) Christian Frezza et al.   SEMINARS IN CANCER BIOLOGY

Mitochondria as targets for cancer chemotherapy

(2008) Vladimir Gogvadze et al.   SEMINARS IN CANCER BIOLOGY

Molecular Mechanism of Proton Translocation by Cytochrome c Oxidase

(2007) Ilya Belevich et al.   ANTIOXIDANTS & REDOX SIGNALING