Controlling the Master: Chromatin Dynamics at the MYC Promoter Integrate Developmental Signaling

Far Upstream Element Binding Protein Plays a Crucial Role in Embryonic Development, Hematopoiesis, and Stabilizing Myc Expression Levels

(2016) Weixin Zhou et al.   AMERICAN JOURNAL OF PATHOLOGY

Parsing Myc Paralogs in Oncogenesis

(2016) Haritha Mathsyaraja et al.   CANCER CELL

The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity

(2016) BaoHan T. Vo et al.   CANCER CELL

Insulated Neighborhoods: Structural and Functional Units of Mammalian Gene Control

(2016) Denes Hnisz et al.   CELL

Enhancer Control of Transcriptional Bursting

(2016) Takashi Fukaya et al.   CELL

MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-Catenin Signaling Transcripts By Recruiting CDK7 and RNA Methyltransferase

(2016) Valeriya Posternak et al.   MOLECULAR CANCER RESEARCH

Snapshots of transcription initiation

(2016) Steven Hahn et al.   NATURE

Defining the essential function of FBP/KSRP proteins:DrosophilaPsi interacts with the mediator complex to modulateMYCtranscription and tissue growth

(2016) Linna Guo et al.   NUCLEIC ACIDS RESEARCH

The PSI–U1 snRNP interaction regulates male mating behavior inDrosophila

(2016) Qingqing Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic gene regulation by Janus kinase 1 in diffuse large B-cell lymphoma

(2016) Lixin Rui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of proto-oncogenes by disruption of chromosome neighborhoods

(2016) D. Hnisz et al.   SCIENCE

BET Bromodomain Inhibition Releases the Mediator Complex from Select cis -Regulatory Elements

(2016) Anand S. Bhagwat et al.   Cell Reports

MYC activation and BCL2L11 silencing by a tumour virus through the large-scale reconfiguration of enhancer-promoter hubs

(2016) C David Wood et al.   eLife

Different promoter affinities account for specificity in MYC-dependent gene regulation

(2016) Francesca Lorenzin et al.   eLife

The Quest for Targets Executing MYC-Dependent Cell Transformation

(2016) Markus Hartl   Frontiers in Oncology

Drosophila Myc: A master regulator of cellular performance

(2015) Daniela Grifoni et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

MicroRNAs as regulators and mediators of c-MYC function

(2015) Rene Jackstadt et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Myc and cell cycle control

(2015) Gabriel Bretones et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

S6 Kinase is essential for MYC-dependent rDNA transcription in Drosophila

(2015) Naomi C. Mitchell et al.   CELLULAR SIGNALLING

A Role for the Serine/Arginine-Rich (SR) Protein B52/SRSF6 in Cell Growth and Myc Expression in Drosophila

(2015) Céline Fernando et al.   GENETICS

DrosophilaLow Temperature Viability Protein 1 (LTV1) Is Required for Ribosome Biogenesis and Cell Growth Downstream ofDrosophilaMyc (dMyc)

(2015) Wonho Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Real-time observation of the initiation of RNA polymerase II transcription

(2015) Furqan M. Fazal et al.   NATURE

The Mediator complex: a central integrator of transcription

(2015) Benjamin L. Allen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Taming of the beast: shaping Myc-dependent amplification

(2015) Elmar Wolf et al.   TRENDS IN CELL BIOLOGY

Defective Hfp-dependent transcriptional repression of dMYC is fundamental to tissue overgrowth in Drosophila XPB models

(2015) Jue Er Amanda Lee et al.   Nature Communications

Single-Stranded DNA-Binding Transcriptional Regulator FUBP1 Is Essential for Fetal and Adult Hematopoietic Stem Cell Self-Renewal

(2015) Uta Rabenhorst et al.   Cell Reports

Muscle niche-driven Insulin-Notch-Myc cascade reactivates dormant Adult Muscle Precursors in Drosophila

(2015) Rajaguru Aradhya et al.   eLife

A Role for the Serine/Arginine-Rich (SR) Protein B52/SRSF6 in Cell Growth and Myc Expression in Drosophila

(2015) Céline Fernando et al.   GENETICS

c-MYC–miRNA circuitry

(2014) Jiangchuan Tao et al.   CELL CYCLE

Regulation of c-Myc protein stability by proteasome activator REGγ

(2014) S Li et al.   CELL DEATH AND DIFFERENTIATION

Mei-P26 Mediates Tissue-Specific Responses to the Brat Tumor Suppressor and the dMyc Proto-Oncogene in Drosophila

(2014) Ana Ferreira et al.   GENETICS

The Kto-Skd Complex Can RegulateptcExpression by Interacting withCubitus interruptus(Ci) in the Hedgehog Signaling Pathway

(2014) Feifei Mao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolution of acquired resistance to anti-cancer therapy

(2014) Jasmine Foo et al.   JOURNAL OF THEORETICAL BIOLOGY

Notch4 promotes gastric cancer growth through activation of Wnt1/β-catenin signaling

(2014) Cuijuan Qian et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The Metazoan-Specific Mediator Subunit 26 (Med26) Is Essential for Viability and Is Found at both Active Genes and Pericentric Heterochromatin in Drosophila melanogaster

(2014) S. K. Marr et al.   MOLECULAR AND CELLULAR BIOLOGY

TFIIH Phosphorylation of the Pol II CTD Stimulates Mediator Dissociation from the Preinitiation Complex and Promoter Escape

(2014) Koon Ho Wong et al.   MOLECULAR CELL

Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles

(2014) Susanne Walz et al.   NATURE

Long-range enhancers regulating Myc expression are required for normal facial morphogenesis

(2014) Veli Vural Uslu et al.   NATURE GENETICS

An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia

(2014) Birgit Knoechel et al.   NATURE GENETICS

A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia

(2014) Daniel Herranz et al.   NATURE MEDICINE

Dynamically in the loop

(2014) Darren J. Burgess   NATURE REVIEWS GENETICS

CTCF: an architectural protein bridging genome topology and function

(2014) Chin-Tong Ong et al.   NATURE REVIEWS GENETICS

Long-range enhancer activity determinesMycsensitivity to Notch inhibitors in T cell leukemia

(2014) Yumi Yashiro-Ohtani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis

(2014) Daniela Annibali et al.   Nature Communications

Genome Recognition by MYC

(2014) A. Sabo et al.   Cold Spring Harbor Perspectives in Medicine

MYC Activation Is a Hallmark of Cancer Initiation and Maintenance

(2014) M. Gabay et al.   Cold Spring Harbor Perspectives in Medicine

Drosophila melanogaster Hox Transcription Factors Access the RNA Polymerase II Machinery through Direct Homeodomain Binding to a Conserved Motif of Mediator Subunit Med19

(2014) Muriel Boube et al.   PLoS Genetics

Mutual interaction between YAP and c-Myc is critical for carcinogenesis in liver cancer

(2013) Weifan Xiao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

(2013) Jakob Lovén et al.   CELL

Drosophila Myc integrates multiple signaling pathways to regulate intestinal stem cell proliferation during midgut regeneration

(2013) Fangfang Ren et al.   CELL RESEARCH

Brk regulates wing disc growth in part via repression of Myc expression

(2013) Nikolaos Doumpas et al.   EMBO REPORTS

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation

(2013) J. Shi et al.   GENES & DEVELOPMENT

Emerging Paradigms in the Development of Resistance to Tyrosine Kinase Inhibitors in Lung Cancer

(2013) Justin F. Gainor et al.   JOURNAL OF CLINICAL ONCOLOGY

BRD4 Coordinates Recruitment of Pause Release Factor P-TEFb and the Pausing Complex NELF/DSIF To Regulate Transcription Elongation of Interferon-Stimulated Genes

(2013) M. C. Patel et al.   MOLECULAR AND CELLULAR BIOLOGY

Burkitt’s lymphoma-associated c-Myc mutations converge on a dramatically altered target gene response and implicate Nol5a/Nop56 in oncogenesis

(2013) V H Cowling et al.   ONCOGENE

A subset of Drosophila Myc sites remain associated with mitotic chromosomes colocalized with insulator proteins

(2013) Jingping Yang et al.   Nature Communications

Cellular MYCro Economics: Balancing MYC Function with MYC Expression

(2013) D. Levens   Cold Spring Harbor Perspectives in Medicine

Mechanisms and insights into drug resistance in cancer

(2013) Hiba Zahreddine et al.   Frontiers in Pharmacology

Three-Dimensional Folding and Functional Organization Principles of the Drosophila Genome

(2012) Tom Sexton et al.   CELL

c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells

(2012) Zuqin Nie et al.   CELL

Transcriptional Amplification in Tumor Cells with Elevated c-Myc

(2012) Charles Y. Lin et al.   CELL

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

A structural perspective on Mediator function

(2012) Laurent Larivière et al.   CURRENT OPINION IN CELL BIOLOGY

Dissecting the mechanisms of Notch induced hyperplasia

(2012) Alexandre Djiane et al.   EMBO JOURNAL

Hypoxia and hypoxia-inducible factors in glioblastoma multiforme progression and therapeutic implications

(2012) Liuqi Yang et al.   EXPERIMENTAL CELL RESEARCH

3C-based technologies to study the shape of the genome

(2012) Wouter de Laat et al.   METHODS

Gene Density, Transcription, and Insulators Contribute to the Partition of the Drosophila Genome into Physical Domains

(2012) Chunhui Hou et al.   MOLECULAR CELL

Topological domains in mammalian genomes identified by analysis of chromatin interactions

(2012) Jesse R. Dixon et al.   NATURE

TFIIH: when transcription met DNA repair

(2012) Emmanuel Compe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MicroRNA-34a Modulates c-Myc Transcriptional Complexes to Suppress Malignancy in Human Prostate Cancer Cells

(2012) Soichiro Yamamura et al.   PLoS One

BRD4 is an atypical kinase that phosphorylates Serine2 of the RNA Polymerase II carboxy-terminal domain

(2012) B. N. Devaiah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA miR-308 regulates dMyc through a negative feedback loop in Drosophila

(2012) K. Daneshvar et al.   Biology Open

Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo

(2011) Federica Parisi et al.   BMC BIOLOGY

A Protein Complex Network of Drosophila melanogaster

(2011) K.G. Guruharsha et al.   CELL

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

Cohesin Selectively Binds and Regulates Genes with Paused RNA Polymerase

(2011) Avery Fay et al.   CURRENT BIOLOGY

Requirements for mediator complex subunits distinguish three classes of notch target genes at the Drosophila wing margin

(2011) Florence Janody et al.   DEVELOPMENTAL DYNAMICS

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

(2011) Johannes Zuber et al.   NATURE

The Action Mechanism of the Myc Inhibitor Termed Omomyc May Give Clues on How to Target Myc for Cancer Therapy

(2011) Mauro Savino et al.   PLoS One

Cell-Type Independent MYC Target Genes Reveal a Primordial Signature Involved in Biomass Accumulation

(2011) Hongkai Ji et al.   PLoS One

A Myc Network Accounts for Similarities between Embryonic Stem and Cancer Cell Transcription Programs

(2010) Jonghwan Kim et al.   CELL

Hfp inhibits Drosophila myc transcription and cell growth in a TFIIH/Hay-dependent manner

(2010) N. C. Mitchell et al.   DEVELOPMENT

Positive regulation of c-Myc by cohesin is direct, and evolutionarily conserved

(2010) Jenny M. Rhodes et al.   DEVELOPMENTAL BIOLOGY

Evidence for a Growth-Stabilizing Regulatory Feedback Mechanism between Myc and Yorkie, the Drosophila Homolog of Yap

(2010) Ricardo M. Neto-Silva et al.   DEVELOPMENTAL CELL

The miRNA machinery targets Mei-P26 and regulates Myc protein levels in the Drosophila wing

(2010) Héctor Herranz et al.   EMBO JOURNAL

Identification of Genes Affecting Wing Patterning Through a Loss-of-Function Mutagenesis Screen and Characterization of med15 Function During Wing Development

(2010) A. Terriente-Felix et al.   GENETICS

Myc interacts with Max and Miz1 to repress C/EBPδ promoter activity and gene expression

(2010) Junling Si et al.   Molecular Cancer

c-MYC coordinately regulates ribosomal gene chromatin remodeling and Pol I availability during granulocyte differentiation

(2010) Gretchen Poortinga et al.   NUCLEIC ACIDS RESEARCH

Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma

(2010) P. K. Mazur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-range enhancers on 8q24 regulate c-Myc

(2010) J. Sotelo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The human Mediator complex: a versatile, genome-wide regulator of transcription

(2010) Dylan J. Taatjes   TRENDS IN BIOCHEMICAL SCIENCES

The TRIM-NHL Protein TRIM32 Activates MicroRNAs and Prevents Self-Renewal in Mouse Neural Progenitors

(2009) Jens C. Schwamborn et al.   CELL

Control of Wing Size and Proportions by Drosophila Myc

(2009) D. C. Wu et al.   GENETICS

Overexpression of the far upstream element binding protein 1 in hepatocellular carcinoma is required for tumor growth

(2009) Uta Rabenhorst et al.   HEPATOLOGY

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

(2008) Anne Wilson et al.   CELL

Nutritional Control of Protein Biosynthetic Capacity by Insulin via Myc in Drosophila

(2008) Aurelio A. Teleman et al.   Cell Metabolism

Hematopoietic Stem Cell Function and Survival Depend on c-Myc and N-Myc Activity

(2008) Elisa Laurenti et al.   Cell Stem Cell

Placental rescue reveals a sole requirement for c-Myc in embryonic erythroblast survival and hematopoietic stem cell function

(2008) N. C. Dubois et al.   DEVELOPMENT

A Wingless and Notch double-repression mechanism regulates G1–S transition in the Drosophila wing

(2008) Héctor Herranz et al.   EMBO JOURNAL

Myc's broad reach

(2008) M. Eilers et al.   GENES & DEVELOPMENT

CDK8 is a colorectal cancer oncogene that regulates β-catenin activity

(2008) Ron Firestein et al.   NATURE

Modelling Myc inhibition as a cancer therapy

(2008) Laura Soucek et al.   NATURE

The functional response of upstream DNA to dynamic supercoiling in vivo

(2008) Fedor Kouzine et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Oncogenes and Cancer

(2008) Carlo M. Croce   NEW ENGLAND JOURNAL OF MEDICINE

Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex

(2008) Henri-Marc Bourbon   NUCLEIC ACIDS RESEARCH

Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13

(2008) I. Carrera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA