Natural killer cells in liver diseases

The Clinical Features of Patients with Chronic Hepatitis C Virus Infections Are Associated with Killer Cell Immunoglobulin-Like Receptor Genes and Their Expression on the Surface of Natural Killer Cells

(2018) Ariel Podhorzer et al.   Frontiers in Immunology

Functional restoration of CD56bright NK cells facilitates immune control via IL-15 and NKG2D in patients under antiviral treatment for chronic hepatitis B

(2017) Tao Chen et al.   Hepatology International

Porcine NK cells display features associated with antigen-presenting cells

(2017) Steffi De Pelsmaeker et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mouse models of acute and chronic hepacivirus infection

(2017) Eva Billerbeck et al.   SCIENCE

CCL3 Enhances Antitumor Immune Priming in the Lymph Node via IFNγ with Dependency on Natural Killer Cells

(2017) Frederick Allen et al.   Frontiers in Immunology

Natural killer cells in hepatocellular carcinoma: current status and perspectives for future immunotherapeutic approaches

(2017) Min Yu et al.   Frontiers of Medicine

Adaptive immunity in the liver

(2016) Zongwen Shuai et al.   Cellular & Molecular Immunology

Basic liver immunology

(2016) Bin Gao   Cellular & Molecular Immunology

Exosomes mediate hepatitis B virus (HBV) transmission and NK-cell dysfunction

(2016) Yinli Yang et al.   Cellular & Molecular Immunology

Liver immunology and its role in inflammation and homeostasis

(2016) Mark W Robinson et al.   Cellular & Molecular Immunology

Liver-infiltrating CD11b−CD27− NK subsets account for NK-cell dysfunction in patients with hepatocellular carcinoma and are associated with tumor progression

(2016) Qiong-Fang Zhang et al.   Cellular & Molecular Immunology

Modulation of liver tolerance by conventional and nonconventional antigen-presenting cells and regulatory immune cells

(2016) Andrea Kristina Horst et al.   Cellular & Molecular Immunology

Natural killer cells contribute to hepatic injury and help in viral persistence during progression of hepatitis B e-antigen-negative chronic hepatitis B virus infection

(2016) S. Ghosh et al.   CLINICAL MICROBIOLOGY AND INFECTION

Phenotype and functions of conventional and non-conventional NK cells

(2016) Timothy K Erick et al.   CURRENT OPINION IN IMMUNOLOGY

Tissue-resident and memory properties of human T-cell and NK-cell subsets

(2016) Enrico Lugli et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tissue-resident Eomeshi T-betlo CD56bright NK cells with reduced proinflammatory potential are enriched in the adult human liver

(2016) Cathal Harmon et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Rapid decrease in hepatitis C viremia by direct acting antivirals improves the natural killer cell response to IFNα

(2016) Elisavet Serti et al.   GUT

Impact of natural killer cells on chronic hepatitis C and hepatocellular carcinoma

(2016) Tomohide Tatsumi et al.   HEPATOLOGY RESEARCH

Enhancing NK cell cytotoxicity by miR-182 in hepatocellular carcinoma

(2016) Mohamed M. Abdelrahman et al.   HUMAN IMMUNOLOGY

Human liver-resident CD56bright/CD16neg NK cells are retained within hepatic sinusoids via the engagement of CCR5 and CXCR6 pathways

(2016) Kelly Hudspeth et al.   JOURNAL OF AUTOIMMUNITY

Immunity, tolerance and autoimmunity in the liver: A comprehensive review

(2016) Derek G. Doherty   JOURNAL OF AUTOIMMUNITY

EomeshiNK Cells in Human Liver Are Long-Lived and Do Not Recirculate but Can Be Replenished from the Circulation

(2016) Antonia O. Cuff et al.   JOURNAL OF IMMUNOLOGY

NK Cells Restrain Spontaneous Antitumor CD8+T Cell Priming through PD-1/PD-L1 Interactions with Dendritic Cells

(2016) Ximena L. Raffo Iraolagoitia et al.   JOURNAL OF IMMUNOLOGY

NK Cells Help Induce Anti–Hepatitis B Virus CD8+T Cell Immunity in Mice

(2016) Meijuan Zheng et al.   JOURNAL OF IMMUNOLOGY

Murine liver-resident group 1 innate lymphoid cells regulate optimal priming of anti-viral CD8 + T cells

(2016) Peter D. Krueger et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Concerted action of IFN-α and IFN-λ induces local NK cell immunity and halts cancer growth

(2016) Ahmed Lasfar et al.   Oncotarget

The proto-oncogene Myc drives expression of the NK cell-activating NKp30 ligand B7-H6 in tumor cells

(2016) Sonja Textor et al.   OncoImmunology

High NKG2A expression contributes to NK cell exhaustion and predicts a poor prognosis of patients with liver cancer

(2016) Cheng Sun et al.   OncoImmunology

Overview of the special issue on HBV immunity

(2015) Antonio Bertoletti et al.   Cellular & Molecular Immunology

Liver natural killer cells: subsets and roles in liver immunity

(2015) Hui Peng et al.   Cellular & Molecular Immunology

Activated natural killer cells accelerate liver damage in patients with chronic hepatitis B virus infection

(2015) Q. Zheng et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Hepatitis C viral infection is associated with activated cytolytic natural killer cells expressing high levels of T cell immunoglobulin- and mucin-domain-containing molecule-3.

(2015) Lucy Golden-Mason et al.   CLINICAL IMMUNOLOGY

Successful Interferon-Free Therapy of Chronic Hepatitis C Virus Infection Normalizes Natural Killer Cell Function

(2015) Elisavet Serti et al.   GASTROENTEROLOGY

Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+T cells

(2015) Pamela M. Odorizzi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Composition, Development, and Function of Uterine Innate Lymphoid Cells

(2015) Jean-Marc Doisne et al.   JOURNAL OF IMMUNOLOGY

Tissue-Resident NK Cells Mediate Ischemic Kidney Injury and Are Not Depleted by Anti–Asialo-GM1 Antibody

(2015) Francisco Victorino et al.   JOURNAL OF IMMUNOLOGY

Accumulation of Cytotoxic CD16+NK Cells in Simian Immunodeficiency Virus-Infected Lymph Nodes Associated withIn SituDifferentiation and Functional Anergy

(2015) Jamie L. Schafer et al.   JOURNAL OF VIROLOGY

NK cell exhaustion: bad news for chronic disease?

(2015) Jamie L. Schafer et al.   Oncotarget

Cytotoxic Cells Kill Intracellular Bacteria through Granulysin-Mediated Delivery of Granzymes

(2014) Michael Walch et al.   CELL

NK cell receptor imbalance and NK cell dysfunction in HBV infection and hepatocellular carcinoma

(2014) Cheng Sun et al.   Cellular & Molecular Immunology

Type I Interferon Protects Antiviral CD8+ T Cells from NK Cell Cytotoxicity

(2014) Haifeng C. Xu et al.   IMMUNITY

Type I Interferons Protect T Cells against NK Cell Attack Mediated by the Activating Receptor NCR1

(2014) Josh Crouse et al.   IMMUNITY

Vγ2Vδ2 T-cell co-stimulation increases natural killer cell killing of monocyte-derived dendritic cells

(2014) Cristiana Cairo et al.   IMMUNOLOGY

Regulatory NK Cells Suppress Antigen-Specific T Cell Responses

(2014) G. Deniz et al.   JOURNAL OF IMMUNOLOGY

Mutational escape of CD8+ T cell epitopes: implications for prevention and therapy of persistent hepatitis virus infections

(2014) Joerg Timm et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Tissue-resident natural killer cells and their potential diversity

(2014) Dorothy K. Sojka et al.   SEMINARS IN IMMUNOLOGY

Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells

(2014) Dorothy K Sojka et al.   eLife

Reversal of NK-Cell Exhaustion in Advanced Melanoma by Tim-3 Blockade

(2014) I. P. da Silva et al.   Cancer Immunology Research

Controlling Natural Killer Cell Responses: Integration of Signals for Activation and Inhibition

(2013) Eric O. Long et al.   Annual Review of Immunology

Characterization of the liver-draining lymph nodes in mice and their role in mounting regional immunity to HBV

(2013) Meijuan Zheng et al.   Cellular & Molecular Immunology

NK cell-based immunotherapy for malignant diseases

(2013) Min Cheng et al.   Cellular & Molecular Immunology

The liver works as a school to educate regulatory immune cells

(2013) Fenglei Li et al.   Cellular & Molecular Immunology

NK cells in immunotolerant organs

(2013) Haoyu Sun et al.   Cellular & Molecular Immunology

Natural killer cells: multifaceted players with key roles in hepatitis C immunity

(2013) Lucy Golden-Mason et al.   IMMUNOLOGICAL REVIEWS

Subsets of human natural killer cells and their regulatory effects

(2013) Binqing Fu et al.   IMMUNOLOGY

The role of natural killer cells in autoimmune liver disease: A comprehensive review

(2013) Kelly Hudspeth et al.   JOURNAL OF AUTOIMMUNITY

Liver-resident NK cells confer adaptive immunity in skin-contact inflammation

(2013) Hui Peng et al.   JOURNAL OF CLINICAL INVESTIGATION

KLRG1 Negatively Regulates Natural Killer Cell Functions through the Akt Pathway in Individuals with Chronic Hepatitis C Virus Infection

(2013) J. M. Wang et al.   JOURNAL OF VIROLOGY

Natural Killer Cell-Dependent Anti-Fibrotic Pathway in Liver Injury via Toll-Like Receptor-9

(2013) Lina Abu-Tair et al.   PLoS One

Natural killer cells regulate diverse T cell responses

(2013) Sarah Q. Crome et al.   TRENDS IN IMMUNOLOGY

NK Cells: A Double-Edged Sword in Chronic Hepatitis B Virus Infection

(2013) Mala K. Maini et al.   Frontiers in Immunology

Rapid development of exhaustion and down-regulation of eomesodermin limit the antitumor activity of adoptively transferred murine natural killer cells

(2012) S. Gill et al.   BLOOD

Blocking the Natural Killer Cell Inhibitory Receptor NKG2A Increases Activity of Human Natural Killer Cells and Clears Hepatitis B Virus Infection in Mice

(2012) Fenglei Li et al.   GASTROENTEROLOGY

Natural killer cells in liver disease

(2012) Zhigang Tian et al.   HEPATOLOGY

Regulatory NK cells in autoimmune disease

(2012) Zhigang Tian et al.   JOURNAL OF AUTOIMMUNITY

Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell–mediated deletion

(2012) Dimitra Peppa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Two lymph nodes draining the mouse liver are the preferential site of DC migration and T cell activation

(2012) Louise Barbier et al.   JOURNAL OF HEPATOLOGY

The Depletion of NK Cells Prevents T Cell Exhaustion to Efficiently Control Disseminating Virus Infection

(2012) K. D. Cook et al.   JOURNAL OF IMMUNOLOGY

NK cells from HCV-infected patients effectively induce apoptosis of activated primary human hepatic stellate cells in a TRAIL-, FasL- and NKG2D-dependent manner

(2012) Andreas Glässner et al.   LABORATORY INVESTIGATION

Natural Killer Cells Are Characterized by the Concomitantly Increased Interferon-γ and Cytotoxicity in Acute Resolved Hepatitis B Patients

(2012) Juanjuan Zhao et al.   PLoS One

The role of innate immunity in HBV infection

(2012) Qiuju Han et al.   Seminars in Immunopathology

TGF-β1 Down-Regulation of NKG2D/DAP10 and 2B4/SAP Expression on Human NK Cells Contributes to HBV Persistence

(2012) Cheng Sun et al.   PLoS Pathogens

Surface Expression of HLA-G is Involved in Mediating Immunomodulatory Effects of Placenta-Derived Multipotent Cells (PDMCs) towards Natural Killer Lymphocytes

(2011) Ko-Jiunn Liu et al.   CELL TRANSPLANTATION

Interaction between Toll-like receptors and natural killer cells in the destruction of bile ducts in primary biliary cirrhosis

(2011) Shinji Shimoda et al.   HEPATOLOGY

CD11b and CD27 reflect distinct population and functional specialization in human natural killer cells

(2011) Binqing Fu et al.   IMMUNOLOGY

Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity

(2011) Emilie Mamessier et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: CD8+ T Cell Priming in the Absence of NK Cells Leads to Enhanced Memory Responses

(2011) K. Soderquest et al.   JOURNAL OF IMMUNOLOGY

Hepatitis B virus suppresses the functional interaction between natural killer cells and plasmacytoid dendritic cells

(2011) C. C. Shi et al.   JOURNAL OF VIRAL HEPATITIS

Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity

(2011) P. A. Lang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD62L expression identifies a unique subset of polyfunctional CD56dim NK cells

(2010) K. Juelke et al.   BLOOD

Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK-cell differentiation uncoupled from NK-cell education

(2010) N. K. Bjorkstrom et al.   BLOOD

CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK-cell subset

(2010) S. Lopez-Verges et al.   BLOOD

Increased natural killer cell cytotoxicity and NKp30 expression protects against hepatitis C virus infection in high-risk individuals and inhibits replication in vitro

(2010) Lucy Golden-Mason et al.   HEPATOLOGY

Absence of mouse 2B4 promotes NK cell–mediated killing of activated CD8+ T cells, leading to prolonged viral persistence and altered pathogenesis

(2010) Stephen N. Waggoner et al.   JOURNAL OF CLINICAL INVESTIGATION

Innate immunity defines the capacity of antiviral T cells to limit persistent infection

(2010) Daniel M. Andrews et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3) mediates natural killer cell suppression in chronic hepatitis B

(2010) Ying Ju et al.   JOURNAL OF HEPATOLOGY

Viral load reduction improves activation and function of natural killer cells in patients with chronic hepatitis B

(2010) Eric T.T.L. Tjwa et al.   JOURNAL OF HEPATOLOGY

Intrahepatic IL-10 Maintains NKG2A + Ly49 − Liver NK Cells in a Functionally Hyporesponsive State

(2010) Matthew G. Lassen et al.   JOURNAL OF IMMUNOLOGY

Critical role for the chemokine receptor CXCR6 in NK cell–mediated antigen-specific memory of haptens and viruses

(2010) Silke Paust et al.   NATURE IMMUNOLOGY

Blockade of Immunosuppressive Cytokines Restores NK Cell Antiviral Function in Chronic Hepatitis B Virus Infection

(2010) Dimitra Peppa et al.   PLoS Pathogens

The Liver as a Lymphoid Organ

(2009) Ian Nicholas Crispe   Annual Review of Immunology

Maturation of mouse NK cells is a 4-stage developmental program

(2009) L. Chiossone et al.   BLOOD

CD94 surface density identifies a functional intermediary between the CD56bright and CD56dim human NK-cell subsets

(2009) J. Yu et al.   BLOOD

NK cell-mediated killing of target cells triggers robust antigen-specific T cell-mediated and humoral responses

(2009) P. Krebs et al.   BLOOD

Natural Killer Cell Functional Dichotomy in Chronic Hepatitis B and Chronic Hepatitis C Virus Infections

(2009) Barbara Oliviero et al.   GASTROENTEROLOGY

Consistent beneficial effects of killer cell immunoglobulin-like receptor 2DL3 and group 1 human leukocyte antigen-C following exposure to hepatitis C virus

(2009) Susanne Knapp et al.   HEPATOLOGY

Activating receptors promote NK cell expansion for maintenance, IL-10 production, and CD8 T cell regulation during viral infection

(2009) Seung-Hwan Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD4 T cells: fates, functions, and faults

(2008) J. Zhu et al.   BLOOD

Characterisation of TNF-related apoptosis-inducing ligand in peripheral blood in patients with primary biliary cirrhosis

(2008) Yan Liang et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Functional impairment in circulating and intrahepatic NK cells and relative mechanism in hepatocellular carcinoma patients

(2008) Lun Cai et al.   CLINICAL IMMUNOLOGY

Liver sinusoidal endothelial cells veto CD8 T cell activation by antigen-presenting dendritic cells

(2008) Frank A. Schildberg et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TLR-dependent cross talk between human Kupffer cells and NK cells

(2008) Zhengkun Tu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Up on the tightrope: natural killer cell activation and inhibition

(2008) Lewis L Lanier   NATURE IMMUNOLOGY

Functions of natural killer cells

(2008) Eric Vivier et al.   NATURE IMMUNOLOGY