Mutational escape of CD8+ T cell epitopes: implications for prevention and therapy of persistent hepatitis virus infections

Can hepatitis C virus infection be eradicated in people who inject drugs?

(2014) Jason Grebely et al.   ANTIVIRAL RESEARCH

T-cell immunity and hepatitis C virus reinfection after cure of chronic hepatitis C with an interferon-free antiviral regimen in a chimpanzee

(2014) Benoit Callendret et al.   HEPATOLOGY

High-Programmed Death-1 Levels on Hepatitis C Virus-Specific T Cells during Acute Infection Are Associated with Viral Persistence and Require Preservation of Cognate Antigen during Chronic Infection

(2014) A. Rutebemberwa et al.   JOURNAL OF IMMUNOLOGY

Hepatitis C Virus Immune Escape via Exploitation of a Hole in the T Cell Repertoire

(2014) M. Wolfl et al.   JOURNAL OF IMMUNOLOGY

Will There Be a Vaccine to Prevent HCV Infection?

(2014) Jonathan Honegger et al.   SEMINARS IN LIVER DISEASE

Enhancing Virus-Specific Immunity In Vivo by Combining Therapeutic Vaccination and PD-L1 Blockade in Chronic Hepadnaviral Infection

(2014) Jia Liu et al.   PLoS Pathogens

HIV escape mutations occur preferentially at HLA-binding sites of CD8 T-cell epitopes

(2013) Corine Bronke et al.   AIDS

Hepatitis C Virus Vaccines Among People Who Inject Drugs

(2013) Andrea L. Cox et al.   CLINICAL INFECTIOUS DISEASES

A Molecular Basis for the Control of Preimmune Escape Variants by HIV-Specific CD8+ T Cells

(2013) Kristin Ladell et al.   IMMUNITY

Loss of immune escape mutations during persistent HCV infection in pregnancy enhances replication of vertically transmitted viruses

(2013) Jonathan R Honegger et al.   NATURE MEDICINE

A Randomized, Double-Blind, Placebo-Controlled Assessment of BMS-936558, a Fully Human Monoclonal Antibody to Programmed Death-1 (PD-1), in Patients with Chronic Hepatitis C Virus Infection

(2013) David Gardiner et al.   PLoS One

Adaptation of CD8 T Cell Responses to Changing HIV-1 Sequences in a Cohort of HIV-1 Infected Individuals Not Selected for a Certain HLA Allele

(2013) Julia Roider et al.   PLoS One

Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1)

(2013) M. J. Fuller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combination of DNA Prime – Adenovirus Boost Immunization with Entecavir Elicits Sustained Control of Chronic Hepatitis B in the Woodchuck Model

(2013) Anna D. Kosinska et al.   PLoS Pathogens

Factors That Determine the Antiviral Efficacy of HCV-Specific CD8+ T Cells Ex Vivo

(2012) Bianca Seigel et al.   GASTROENTEROLOGY

Broadly directed virus-specific CD4+T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence

(2012) Julian Schulze zur Wiesch et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Susceptibility to chronic hepatitis C virus infection is influenced by sequence differences in immunodominant CD8+ T cell epitopes

(2012) Susanne Ziegler et al.   JOURNAL OF HEPATOLOGY

Widespread Impact of HLA Restriction on Immune Control and Escape Pathways of HIV-1

(2012) J. M. Carlson et al.   JOURNAL OF VIROLOGY

TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection

(2012) Huabiao Chen et al.   NATURE IMMUNOLOGY

A Poxvirus Vaccine Is Safe, Induces T-Cell Responses, and Decreases Viral Load in Patients With Chronic Hepatitis C

(2011) François Habersetzer et al.   GASTROENTEROLOGY

CD8+ T-Cell Response Promotes Evolution of Hepatitis C Virus Nonstructural Proteins

(2011) Marianne Ruhl et al.   GASTROENTEROLOGY

Molecular footprints reveal the impact of the protective HLA-A*03 allele in hepatitis C virus infection

(2011) K. Fitzmaurice et al.   GUT

Human leukocyte antigen B27 selects for rare escape mutations that significantly impair hepatitis C virus replication and require compensatory mutations

(2011) Christoph Neumann-Haefelin et al.   HEPATOLOGY

Transmission of Clonal Hepatitis C Virus Genomes Reveals the Dominant but Transitory Role of CD8+ T Cells in Early Viral Evolution

(2011) B. Callendret et al.   JOURNAL OF VIROLOGY

Escape from a Dominant HLA-B*15-Restricted CD8+ T Cell Response against Hepatitis C Virus Requires Compensatory Mutations outside the Epitope

(2011) M. Ruhl et al.   JOURNAL OF VIROLOGY

Compensatory Mutations Restore the Replication Defects Caused by Cytotoxic T Lymphocyte Escape Mutations in Hepatitis C Virus Polymerase

(2011) C. Oniangue-Ndza et al.   JOURNAL OF VIROLOGY

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Constrained Pattern of Viral Evolution in Acute and Early HCV Infection Limits Viral Plasticity

(2011) Katja Pfafferott et al.   PLoS One

Viral suppression of multiple escape mutants by de novo CD8+ T cell responses in a human immunodeficiency virus-1 Infected elite suppressor

(2011) Karen A O'Connell et al.   Retrovirology

Dual Function of the NK Cell Receptor 2B4 (CD244) in the Regulation of HCV-Specific CD8+ T Cells

(2011) Verena Schlaphoff et al.   PLoS Pathogens

Spontaneous Control of HCV Is Associated With Expression of HLA-B*57 and Preservation of Targeted Epitopes

(2010) Arthur Y. Kim et al.   GASTROENTEROLOGY

Effect of immune pressure on hepatitis C virus evolution: Insights from a single-source outbreak

(2010) Shahzma Merani et al.   HEPATOLOGY

Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity

(2010) Rachel H. McMahan et al.   JOURNAL OF CLINICAL INVESTIGATION

Lack of Original Antigenic Sin in Recall CD8+ T Cell Responses

(2010) D. Zehn et al.   JOURNAL OF IMMUNOLOGY

Early Selection in Gag by Protective HLA Alleles Contributes to Reduced HIV-1 Replication Capacity That May Be Largely Compensated for in Chronic Infection

(2010) M. A. Brockman et al.   JOURNAL OF VIROLOGY

The Major Genetic Determinants of HIV-1 Control Affect HLA Class I Peptide Presentation

(2010)   SCIENCE

Coexpression of PD-1, 2B4, CD160 and KLRG1 on Exhausted HCV-Specific CD8+ T Cells Is Linked to Antigen Recognition and T Cell Differentiation

(2010) Bertram Bengsch et al.   PLoS Pathogens

Divergent adaptation of hepatitis C virus genotypes 1 and 3 to human leukocyte antigen-restricted immune pressure

(2009) Andri Rauch et al.   HEPATOLOGY

Degree of cross-genotype reactivity of hepatitis C virus-specific CD8+ T cells directed against NS3

(2009) Silvia Giugliano et al.   HEPATOLOGY

Protective effect of human leukocyte antigen B27 in hepatitis C virus infection requires the presence of a genotype-specific immunodominant CD8+ T-cell epitope

(2009) Christoph Neumann-Haefelin et al.   HEPATOLOGY

Evolution of HLA-B*5703 HIV-1 escape mutations in HLA-B*5703–positive individuals and their transmission recipients

(2009) Hayley Crawford et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hepatitis C Virus (HCV) Sequence Variation Induces an HCV-Specific T-Cell Phenotype Analogous to Spontaneous Resolution

(2009) V. Kasprowicz et al.   JOURNAL OF VIROLOGY

HLA-Associated Viral Mutations Are Common in Human Immunodeficiency Virus Type 1 Elite Controllers

(2009) T. Miura et al.   JOURNAL OF VIROLOGY

Negative Immune Regulator Tim-3 Is Overexpressed on T Cells in Hepatitis C Virus Infection and Its Blockade Rescues Dysfunctional CD4+ and CD8+ T Cells

(2009) L. Golden-Mason et al.   JOURNAL OF VIROLOGY

Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade

(2009) Nobuhiro Nakamoto et al.   PLoS Pathogens

Transmission of HIV-1 Gag immune escape mutations is associated with reduced viral load in linked recipients

(2008) Paul A. Goepfert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Analysis of the Evolutionary Forces in an Immunodominant CD8 Epitope in Hepatitis C Virus at a Population Level

(2008) C. Neumann-Haefelin et al.   JOURNAL OF VIROLOGY

HLA-B57/B*5801 Human Immunodeficiency Virus Type 1 Elite Controllers Select for Rare Gag Variants Associated with Reduced Viral Replication Capacity and Strong Cytotoxic T-Lymphotye Recognition

(2008) T. Miura et al.   JOURNAL OF VIROLOGY

Escape from HLA-B*08-Restricted CD8 T Cells by Hepatitis C Virus Is Associated with Fitness Costs

(2008) S. Salloum et al.   JOURNAL OF VIROLOGY

Stable Cytotoxic T Cell Escape Mutation in Hepatitis C Virus Is Linked to Maintenance of Viral Fitness

(2008) Luke Uebelhoer et al.   PLoS Pathogens