Annexin A2 binds to endosomes and negatively regulates TLR4-triggered inflammatory responses via the TRAM-TRIF pathway

Annexin A2 Regulates Autophagy inPseudomonas aeruginosaInfection through the Akt1–mTOR–ULK1/2 Signaling Pathway

(2015) Rongpeng Li et al.   JOURNAL OF IMMUNOLOGY

Erlotinib protects against LPS-induced Endotoxicity because TLR4 needs EGFR to signal

(2015) Sarmishtha De et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atg7 deficiency impairs host defense against Klebsiella pneumoniae by impacting bacterial clearance, survival and inflammatory responses in mice

(2014) Yan Ye et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

A Promiscuous Lipid-Binding Protein Diversifies the Subcellular Sites of Toll-like Receptor Signal Transduction

(2014) Kevin S. Bonham et al.   CELL

Cholesterol-Rich Membrane Rafts and Lyn Are Involved in Phagocytosis during Pseudomonas aeruginosa Infection

(2014) S. Kannan et al.   JOURNAL OF IMMUNOLOGY

Multistrain Probiotic Modulation of Intestinal Epithelial Cells' Immune Response to a Double-Stranded RNA Ligand, Poly(I·C)

(2013) Chad MacPherson et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Defective immunogenic cell death of HMGB1-deficient tumors: compensatory therapy with TLR4 agonists

(2013) T Yamazaki et al.   CELL DEATH AND DIFFERENTIATION

Proteome-wide Quantification and Characterization of Oxidation-Sensitive Cysteines in Pathogenic Bacteria

(2013) Xin Deng et al.   Cell Host & Microbe

TLR2 and TLR4 in Autoimmune Diseases: a Comprehensive Review

(2013) Yu Liu et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Lyn regulates inflammatory responses inKlebsiella pneumoniaeinfection via the p38/NF-κB pathway

(2013) Xuefeng Li et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Decreased Levels of miR-224 and the Passenger Strand of miR-221 Increase MBD2, Suppressing Maspin and Promoting Colorectal Tumor Growth and Metastasis in Mice

(2013) Kefei Yuan et al.   GASTROENTEROLOGY

The TLR4 antagonist Eritoran protects mice from lethal influenza infection

(2013) Kari Ann Shirey et al.   NATURE

Met-induced membrane blebbing leads to amoeboid cell motility and invasion

(2013) A Laser-Azogui et al.   ONCOGENE

Pirin is an iron-dependent redox regulator of NF- B

(2013) F. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of clathrin/dynamin-dependent internalization interferes with LPS-mediated TRAM–TRIF-dependent signaling pathway

(2012) Yanyan Wang et al.   CELLULAR IMMUNOLOGY

Constitutive MHC class I molecules negatively regulate TLR-triggered inflammatory responses via the Fps–SHP-2 pathway

(2012) Sheng Xu et al.   NATURE IMMUNOLOGY

The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock

(2012) Ezra Aksoy et al.   NATURE IMMUNOLOGY

Defining the subcellular sites of innate immune signal transduction

(2012) Jonathan C. Kagan   TRENDS IN IMMUNOLOGY

The GOLD domain-containing protein TMED7 inhibits TLR4 signalling from the endosome upon LPS stimulation

(2012) Sarah L. Doyle et al.   Nature Communications

Annexin A2 binds to endosomes following organelle destabilization by particulate wear debris

(2012) Brian Scharf et al.   Nature Communications

A novel pathway for human endothelial cell activation by antiphospholipid/anti- 2 glycoprotein I antibodies

(2011) K. L. Allen et al.   BLOOD

CD14 Controls the LPS-Induced Endocytosis of Toll-like Receptor 4

(2011) Ivan Zanoni et al.   CELL

Endosome maturation

(2011) Jatta Huotari et al.   EMBO JOURNAL

Abnormal Trafficking and Degradation of TLR4 Underlie the Elevated Inflammatory Response in Cystic Fibrosis

(2011) E. M. Bruscia et al.   JOURNAL OF IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Incidence, Risk Factors, and Outcomes of Klebsiella pneumoniae Bacteremia

(2009) Bonnie L. Meatherall et al.   AMERICAN JOURNAL OF MEDICINE

Annexin A2 is involved in antiphospholipid antibody-mediated pathogenic effects in vitro and in vivo

(2009) Z. Romay-Penabad et al.   BLOOD

Annexin A2 tetramer activates human and murine macrophages through TLR4

(2009) J. F. A. Swisher et al.   BLOOD

Dual 12/15- and 5-Lipoxygenase Deficiency in Macrophages Alters Arachidonic Acid Metabolism and Attenuates Peritonitis and Atherosclerosis in ApoE Knock-out Mice

(2009) Daniel Poeckel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Broad DNA repair responses in neural injury are associated with activation of the IL-6 pathway in cholesterol-fed rabbits

(2009) Min Wu et al.   JOURNAL OF NEUROCHEMISTRY

Annexin A2 Regulates Phagocytosis of Photoreceptor Outer Segments in the Mouse Retina

(2009) Ah-Lai Law et al.   MOLECULAR BIOLOGY OF THE CELL

Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21

(2009) Frederick J Sheedy et al.   NATURE IMMUNOLOGY

Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling

(2008) Natsuko Tanimura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles

(2008) J. Dalli et al.   BLOOD

Annexin A2 Binding to Endosomes and Functions in Endosomal Transport Are Regulated by Tyrosine 23 Phosphorylation

(2008) Etienne Morel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Annexin A2: biology and relevance to the antiphospholipid syndrome

(2008) E Cockrell et al.   LUPUS

Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

(2008) Benjamin L. Ebert et al.   NATURE

TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-β

(2008) Jonathan C Kagan et al.   NATURE IMMUNOLOGY